Search

Context: Periodontitis causes pocket formation, gingival recession, and destruction of periodontal ligaments and alveolar bone. Periodontitis disturbs the attachment of periodontal ligaments to the maxillary and mandibular bones. The α-mangostin has shown role-playing in the bone remodeling process. Aims: To evaluate the potential of α-mangostin induce the TGFβ1 titer associated with the increased mandibular bone volume on the alveolar bone remodeling of periodontitis of Rattus novergicus. Methods: The α-mangostin used to the single administration dosage on the rat periodontitis model on the 7 and 14 days. TGF-β1 titer tested by enzyme-linked immunosorbent assay, while the X-Ray Micro-CT/Micro Computed Tomography examined the volume’s development of the mandibular bone. Results: At the 7 days, 0.5 and 1% of α-mangostin had a better effect to increase the bone volume, and TGF-β1 titer has linearity of bone development at concentrations of 0.5 to 2%. At 14 days, 1 and 2% of α-mangostin exhibited a better effect on inducing an increase in mandibular bone volume and TGF-β1 titer. The linearity of both occurs at concentrations of 0.5 to 1%. The Micro-CT of the mandibular bone showed callus or new bone formation at the edge of each treatment group’s lesion as an indicator of bone remodeling. Conclusions: α-Mangostin induced an increase in the TGF-β1 titer, which was in line with the rise in the volume of the mandibular bone of Rattus novergicus.

After the Arab Spring, in the early 2010s, street art burst onto the urban scene filling meters and meters of walls in the major cities of Tunisia, Libya, Egypt, Syria and many other Arab countries. Specifically, our focus is on a very particular case: the Israeli West Bank wall (better known as the Israelian Security Fence/Palestinian Apartheid Wall). This study aims to examine how a wall that was born as an element of separation, closure and marginalization, over time has become a means of openness and communication, but above all the manifesto of a condition and a social malaise visible to the eyes of the whole world. All thanks to the messages traced or engraved on the wall that ordinary people, local artists and international street artists wanted to leave to express their thought and communicate them in a context that is certainly not trivial. The messages that follow one another, mostly iconographic, are often intertwined with slogans purposely written in English that refer to international events or personalities. Graffiti techniques merges Western influences with a distinct national heritage, recognising local history and shaping a future open to new influences.DOI: https://doi.org/10.20365/disegnarecon.24.2020.19