As immigration continues throughout the world nurses will work with patients from cultures that are unknown to them. Therefore, it is necessary to have a model and theoretical framework to assess a patient from a culture different from that of the nurse. Additionally, it is advantageous to have a model that all health care practitioners can use. This article presents a description and use of the Purnell Model for Cultural Competence in practice, education, administration, and research. Nurses, physicians, and other health care practitioners can use this Model with the 12 domains in the hospital, in the home, or in the community. Also, they can use the Model in medicine, surgery, pediatrics, obstetrics, or psychiatry.