71 results on '"SKELETAL muscle"'
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2. Mechanisms of muscle tissue adaptation in response to the influence of low-dose ionizing radiation
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H. Stepanov, Ye. Dubna, R. Vastyanov, E. Mokriienko, and E. Buriachkivskyi
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muscle tissue ,skeletal muscle ,cardiac muscle ,ionizing irradiation ,energy ,adaptation ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Mechanisms of interaction of ionizing radiation with biological objects are a chain of successive physical and physico-chemical changes, which manifest themselves in the form of excitation, primary and secondary ionization of molecules. Biosynthesis of ATP, which is carried out by a system of oxidation-reduction enzymes localized in the inner membrane of mitochondria - the respiratory chain, belongs to the vital processes that are directly disturbed under the action of ionizing radiation. The high degree of damage to this system is due to the significant radiosensitivity of metal-containing enzymes. The purpose of the work is to study the formation of the adaptive response of muscle tissue of sexually mature rats to the influence of ionizing radiation at a dose of 0.5 Gy. It was concluded that a day after irradiation with the dose of 0.5 Gy, the content of contractile proteins in skeletal muscle decreases slightly. On the 15th day, the content of contractile proteins began to decrease. By the 30th day, the content of contractile proteins decreased by 22.9% for myosin, by more than 11% for actin, and by 7 and 8% for troponin and tropomyosin, respectively, compared to the values of the intact group. A similar picture is observed in the cardiac muscle. Mg2+,Ca2+-ATP-ase activity of actomyosin, starting from the 1st day was shown to be increased in both the skeletal and cardiac muscles, reaching its peak in the cardiac muscle on the 15th day, in contrast to the skeletal muscle, where this indicator reached its peak on the 7th day. The authors conclude that irradiation of sexually mature animals with the dose of 0.5 Gy forms an adaptive response that is accompanied by an increase in Mg2+,Ca2+-ATP-ase activity due to the formation of a strong form of binding between F-actin and myosin, actin monomers go into the typical for actomyosin “turned on stage”, and the myosin heads acquire an ordered orientation in the muscle fiber. According to author’s idea, the data obtained indicated the benefit and reasonability of using in post-radiation dysfunctions complex pharmacological treatment drugs that are able to normalize intracellular homeostasis, eliminate probable acidic changes initiated by radiation exposure, activate the processes of intramuscle energy generation and which have protective properties in relation to the muscular system.
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- 2024
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3. The substance that enhances exercise performance and increases muscle mass
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- 2024
4. What is glutamine and what happens in the body when it is ingested?
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- 2024
5. Muscle hypertrophy in athlete training from a medical point of view - what do we know
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Jan Biłogras, Katarzyna Kostelecka, Łukasz Bryliński, Marcin Wais, Dariusz Gruca, and Konrad Warchoł
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skeletal muscle ,hypertrophy ,testosteron ,growth hormone ,cortisol ,IGF1 ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Introduction Hypertrophy is the process of increasing the mass of a tissue. In this article, we focused on the impact of the mechanisms of muscle hypertrophy, its effect on the human body, correlation with the course of diseases and tolerance of treatment. We considered the benefits of having well-developed, and also touched on the problems of underdeveloped muscle mass. Results The main factors causing hypertrophy are resistance exercise training, mechanotransduction, metabolic pathways, ribosomal biogenesis, gene expression and the impact of hormones. The beneficial effect of high concentrations of testosterone and growth hormone, also IGF1, on skeletal muscle hypertrophy has been proven. On the other side, the studies have shown that high concentrations of glucocorticoids, such as cortisol are associated with reduced muscle mass. There are many positive aspects of a well-developed muscle mass such as an impact on the prognosis in patients with cancers and sometimes reduces mortality among them. The problems of low muscle mass and sarcopenia are also mentioned. Low muscle mass can affect the poor prognosis of diseases such as cancer, hepatic cirrhosis and COVID-19. Postoperative complications are more common in patients with low muscle mass. One way to prevent this process may be to introduce resistance exercise training in patients struggling with problems of muscular atrophy. Conclusion Skeletal muscles have multiple functions in the human body. In addition to movement, they play a role in molecular processes like hormonal regulation. In addition, they can, when well developed, positively influence healing processes and the course of disease.
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- 2023
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6. Peculiarities of the relationship between the terminal site of glycolysis and the initial segment of gluconeogenesis in the myocardium and skeletal muscles of animals irradiated at different doses
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G. Stepanov, R. Vastyanov, A. Kostina, and E. Mokriienko
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irradiated animals ,skeletal muscle ,myocardium ,glcolysis ,gluconeogenesis ,pathophysiological mechanisms ,Education ,Sports ,GV557-1198.995 ,Medicine - Abstract
Existing types of muscles differ not only structurally, but also metabolically (direction of energy exchange, choice of biosubstrates, dependence on the action of mediators, hormones, etc.). A number of studies have been devoted to the study of the impact of ionizing radiation on metabolism in muscle tissue. After irradiation, thickened muscle cells with enlarged nuclei appear in the heart muscle, the number of which does not decrease for 6 months, which indicates a violation of nuclear-cytoplasmic relations in myocardial cells. Phosphoenolpyruvate carboxykinase which ensures the utilization of cytoplasmic oxaloacetate and its transformation into phosphoenolpyruvate, completes the initial stage of gluconeogenesis and can limit the rate of gluconeogenesis from lactate. It should be emphasized that phosphoenolpyruvate carboxykinase is more active in skeletal muscles, where the activity of pyruvate kinase and lactate dehydrogenase is increased. The purpose of the work is to investigate the peculiarities of the relationship between the terminal site of glycolysis and the initial segment of gluconeogenesis in the myocardium and skeletal muscles of animals irradiated at different doses. The authors proved that in animals irradiated at a dose of 0.5 Gy, the activity of pyruvate kinase in the myocardium and skeletal muscle increases compared to intact animals. In the blood, on the contrary, there is a decrease in the activity of this enzyme compared to intact animals. When animals are irradiated at a dose of 1.0 Gy, diametrically opposite changes are observed. When animals are irradiated at a dose of 0.5 Gy, there is a slight decrease in the activity of lactate dehydrogenase in the myocardium and blood against the background of an increase in the activity of this enzyme in skeletal muscle. Irradiation of animals at a dose of 1.0 Gy leads to an acute increase in lactate dehydrogenase activity in the myocardium and skeletal muscle. The data obtained revealed that in animals irradiated at a dose of 0.5 Gy, the activity of phosphoenolpyruvate carboxykinase in skeletal muscle increases, while in cardiac muscle, on the contrary, its activity decreases as well as in blood. With an increase in the radiation dose to 1.0 Gy, diametrically opposite changes in the activity of phosphoenolpyruvate carboxykinase are observed. The authors concluded that outlined changes in the waу of intramuscular glycolysis and gluconeogenesis reactions show the pathophysiologcal mechanisms of biochemical supply restructuring as the result of ionizing irradiation influence. From the fundamental point of view these results show the direction of pathophysiologically oriented pharmacological correction of radiation-provoked muscle disturbances.
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- 2023
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7. Deciphering how our motor system ages provides clues to slowing its deterioration
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- 2024
8. Detailed atlas of skeletal muscle aging useful for prevention achieved
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- 2024
9. Eating to live: What does it mean to be physically active?
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- 2024
10. Organ donors can issue free digital authorization at registry offices
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- 2024
11. Temperature influence on a linear array of coupled Sal'nikov oscillators: the muscle fiber scenario
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Daniel Barragán and Pablo Ochoa-Botache
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skeletal muscle ,cardiomyocytes ,contraction ,heat pulses ,Sal'nikov model ,thermal gradient ,Technology ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Muscles are thermogenic organs for adult mammals and birds but can also be thermosensitive. In this respect, recent research has shown the excitability of cardiac muscle tissue when irradiated with infrared laser light. Likewise, intrinsic muscle function should give place to local thermal gradients, either because of Ca2+-ATPase thermoregulatory mechanisms or, specifically in the skeletal muscle, after intense exercise. Alongside internal thermal gradients, muscle fatigue characterizes by stressful cellular conditions. Similar to stress-like conditions has been documented in myocytes from rats, the emergence of oscillations of important biochemical species [1]. We show how a thermal gradient or a thermal pulse influences the dynamics of biochemical oscillations in a simplified biochemical model of muscle fiber and discuss the consequences in a living muscle. For this purpose, each simplified sarcomere behavior is governed according to a modified Sal'nikov model, as proposed in a previous paper [2].
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- 2022
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12. L-GLUTAMINE SUPPLEMENTATION ASSOCIATED WITH MODERATE AEROBIC TRAINING IMPROVES BIOMETRIC, GLYCEMIC PROFILE AND THE ANTIOXIDANT DEFENSE
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Analú Bender dos Santos, Lílian Corrêa Costa-Beber, Eloisa Gabriela de Pelegrin Basso, Pauline Brendler Goettems Fiorin, Renan Daniel Bueno Basso, Maicon Machado Sulzbacher, Mirna Stela Ludwig, and Thiago Gomes Heck
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glucose intolerance ,oxidative stress ,HSP70 ,skeletal muscle ,adiposity ,Medicine (General) ,R5-920 - Abstract
Introduction: L-glutamine is a non-essential amino acid, whose intrinsic pool of appears to be depleted during catabolic conditions, such as intense or high duration exercise, and to avoid the exercise- related benefits. Therefore, its supplementation could provide an additional source of L-glutamine and prevent these effects. However, the oral intake of its free form has been discouraged, despites of some evidences reporting positive effects. Objective: to verify whether the L-glutamine supplementation (in its free form) could provide an additional improvement in biometric, glycemic and redox parameters, in animals undergoing moderate aerobic training (MAT). Methods: 28 Swiss male mice were divided into four groups: Cont (n=7), Ex (n=7), Glut (n=8), and Ex+Glut (n=6). Glut and Ex+Glut received gastric gavage of L-glutamine (1g/kg), while Cont and Ex groups received 100 µL of PBS one hour before exercising, five days/week, six weeks. Ex and Ex+Glut underwent moderate swimming, while Cont and Glut remained sedentary, for the same period. Mice started swimming with 2% of body weight attached to the tail during 20 min, and ended the experiment with 4% during 60 min. Results: L-glutamine supplementation increased the gastrocnemius mass and improved the glucose tolerance in animals submitted to MAT. It improved the antioxidant status in gastrocnemius, liver and pancreas, and declined it in adipose tissue in animals undergoing MAT. The drop of adipose antioxidant defense was associated with adiposity, while pancreas antioxidant activity was inversely associated with the glucose intolerance. Conclusion: L-glutamine (free form) improves biometric and glucose parameters, and enhances antioxidant activities.
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- 2020
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13. Meat quality and its association with muscle fibers
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Cruz Elena Enriquez Valencia, César Urón Castro, and Juliana Andrea Cuetia Londoño
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tenderness ,bos taurs ,myosin ,skeletal muscle ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
This review makes an in-depth and updated exploration of the type of muscle fiber and its association with the quality characteristics of beef in bovines. Over the years, it has been shown that the characteristics considered as meat quality, especially tenderness, are associated with specific muscle factors such as fat content, collagen, proteolytic activity systems and type of muscle fiber. Each type of fiber has different functional, structural, metabolic, chemical, and morphological characteristics, which can alter post-mortem biochemical processes and consequently affect meat tenderness mechanisms. Currently, the latest biotechnological studies that include proteome and interactome associated with bioinformatics confirm this fact, the tenderness of meat depends on the breed and the contractile and metabolic properties specific to each muscle, properties which are incorporated according to the type of muscle fiber.
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- 2016
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14. Effects of GaAs laser and stretching on muscle contusion in rats
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Daniela Gallon Corrêa, Juliana T. Okita, Hilana Rickli Fiuza Martins, and Anna Raquel Silveira Gomes
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Skeletal Muscle ,Muscle Stretching Exercises ,Wounds and Injuries ,Low-Level Light Therapy ,Rats ,Therapeutics. Pharmacology ,RM1-950 - Abstract
ABSTRACT Laser and stretching are used to treat skeletal muscle injuries. This study aimed to evaluate the effects of GaAs laser and stretching in the morphology of the tibialis anterior (TA) muscle after contusion. Thirty-six male rats (349±23g) were divided into six groups (n=6): control group (CG); lesion group (LG); lesion and laser group (LLG); lesion and stretching group (LSG); lesion, laser and stretching group (LLSG); and stretching group (SG). TA was wounded by a contusion apparatus. We used GaAs laser 4.5 J/cm2 dose for 32 s each, beginning 48 h after lesion, for 7 days, once a day. Manual passive stretching was applied by 10 repetitions for 1 minute, initiating on the 8th day, once a day, 3 times a week, during 3 weeks. After 4 weeks, rats were euthanized and we analyzed: muscle weight and length, cross sectional area of muscle fibers (CSAMF), serial sarcomere number (SSN), sarcomere length, and percentage of connective tissue. Comparisons among groups were made by ANOVA and post hoc Tukey tests, with the significance level set at ≤ 0.05. The serial sarcomere number of LLSG was higher than LSG. The sarcomere length of LSG was superior to LLG, LLSG, and SG. SG increased SSN compared to CG, while the percentage of connective tissue of SG decreased in comparison to LLSG. Thus, the sarcomerogenesis of injured muscles was enhanced by laser therapy, stretching, and association of both. The stretching protocol was enough to increase SSN of intact muscles.
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- 2016
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15. Influence of the lateral pterygoid muscle on the growth of the mandibular condilar cartilage
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Juan G. Quirós, Luis Javier Pérez Osorio, and Juan C. Calderón
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skeletal muscle ,maxillofacial development ,growth factors ,Medicine ,Medicine (General) ,R5-920 - Abstract
At the end of the last century, a model to explain clinical observations related to the mandibular growth was developed. According to it, the lateral pterigoid muscle (LPM) was one of the main modulators of the differentiation of mesenquimal cells inside the condyle to condroblasts or osteoblasts, and therefore of the growth of the mandibular condilar cartilage (CCM). The main components of the model were the humoral and the mechanical. Nowadays, the humoral would include growth factors such as IGF-I, FGF-2 and VEGF, which seem to be involved in mandibular growth. Since skeletal muscle can secrete these growth factors, there is a possibility that LPM modulates the growth of CCM by a paracrine or endocrine mechanism. The mechanical component derived from the observations that both the blood flow inside the temporomandibular joint (ATM) and the action of the retrodiscal pad on the growth of the CCM, depend, in part, on the contractile activity of the LPM. Despite the fact that there are some results suggesting hat LPM is activated under conditions of mandibular protrusion, there is no full agreement on whether this can stimulate the growth of CCM. In this review, the contributions and limitations of the works related to mandibular growth are discussed and a model which integrates the available information to explain the role of the LPM in the growth of the CCM is proposed.
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- 2013
16. Avaliação do trofismo muscular de sóleos de ratos wistar após compressão nervosa e tratamento com corrente de alta voltagem Evaluación del tropismo del músculo sóleo de ratas wistar después de la compresión del nervio y tratamiento con corriente de alto voltaje Assessment of wistar rats' soleus muscle trophism after nerve compression and treatment with high-voltage current
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Gladson Ricardo Flor Bertolini, Elisangela Lourdes Artifon, Lígia Inez da Silva, Lucinéia de Fátima Chasko Ribeiro, and Rose Meire Costa Brancalhão
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Neuropatía ciática ,músculo esquelético ,paresia ,estimulación eléctrica transcutánea del nervio ,Neuropatia ciática ,estimulação elétrica nervosa transcutânea ,Sciatic neuropathy ,skeletal muscle ,paresis ,transcutaneous eletric nerve stimulation ,Sports ,GV557-1198.995 - Abstract
OBJETIVO: avaliar a corrente de alta voltagem sobre o trofismo de sóleos de ratos com compressão de nervo isquiático. Dezoito ratos distribuídos em: GS - compressão nervosa e simulacro; GP+ - compressão e tratado com corrente anódica; GP- - compressão e catódica. Ao final, os sóleos foram dissecados e pesados em balança analítica. Em seguida foram montadas lâminas de cortes transversais, observadas em microscópio óptico de luz comum e digitalizadas, para análise do menor diâmetro de 100 fibras por músculo. RESULTADOS: todos os grupos apresentaram menor trofismo pelas duas formas de avaliação (p0,05). CONCLUSÃO: a corrente de alta voltagem não inibiu a hipotrofia em sóleos submetidos à compressão nervosa.OBJETIVO: Evaluar la corriente de alto voltaje en el tropismo del sóleo de ratas con la compresión del nervio ciático. Dieciocho ratas se dividieron en: GS - compresión del nervio y la falsa; GP+ - compresión y tratados con corriente anódica; GP- - compresión y el cátodo. Por último, fueron los sóleos disecados y pesados en una balanza analítica. Luego diapositivas de secciones transversales fueron montadas para la observación al microscopio de luz común y digitalizadas para el análisis de menor diámetro de 100 fibras por músculo. RESULTADOS: Todos los grupos mostraron menor tropismo, las dos formas de evaluación (p 0,05). CONCLUSIÓN: La corriente de alto voltaje no inhibe la atrofia en el músculo sóleo se sometieron a la compresión del nervio.AIM: to evaluate the high voltage current on the tropism of rats soleus with sciatic nerve compression. Eighteen rats were divided into: GS - nerve compression and sham; GP + - compression and treated with anodic current; GP - compression and cathode. Finally, the soleus were dissected and weighed on an analytical balance. Then slides were mounted cross sections observed in light microscope and digitized for analysis of smaller diameter of 100 fibers per muscle. RESULTS: All groups showed lower tropism, the two forms of assessment (p 0.05). CONCLUSION: The high voltage current did not inhibit atrophy in soleus underwent nerve compression.
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- 2012
17. Riesgo biomecánico en operarios y personal administrativo en una empresa del sector energético en Colombia
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Zipaquirá Vargas, Angel Alexander, Rueda Arévalo, María Clemencia, and Hernández Herrera, Gilma Norela
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Enfermedades laborales ,Promoción de salud ,Salud laboral ,biomechanic risk ,Músculo esquelético ,Riesgo biomecánico ,risk factors ,electricity ,Electricidad ,Sistema musculoesquelético ,skeletal muscle ,Salud ocupacional ,Industria energética ,Factores de riesgo - Abstract
RESUMEN Introducción: Los trastornos musculoesqueléticos se pueden presentar por características del trabajo y generan costos elevados por pago de incapacidades, seguros, indemnizaciones, pagos de servicios en atención médica y días de trabajo perdidos. Objetivo: Determinar la prevalencia de los síntomas osteomusculares y factores de riesgo biomecánico en personal operativo (linieros) y administrativo de una empresa de energía en Colombia. Metodología: Estudio de corte transversal llevado a cabo en 160 trabajadores (66 operativos y 94 administrativos). Se incluyeron variables sociodemográficas y las relacionadas con los síntomas osteomusculares y factores de riesgo biomecánicos. Se utilizó el cuestionario validado ERGOPAR para la prevención de trastornos musculoesqueléticos de origen laboral creado por Instituto Sindical de Trabajo, Ambiente y Salud de España (ISTAS). Se usaron medidas de tendencia central y dispersión según la naturaleza de las variables y se revisaron las asociaciones con la prueba de Chi Cuadrado de Pearson, para la cual se definió un nivel de significación α 0.05 Resultados: El promedio de edad en el personal administrativo fue de 43,85 años (D.S 9,7) y el del operativo de 42,77 años (D.S 9,8) con tiempo promedio en el cargo de 10,96 años (D.S 8,06) y 13 años (D.S 7,95) respectivamente. Se presentó una prevalencia del 80,3% para dolor lumbar en personal operativo (linieros) mayor que en personal administrativo (72,2%). Las variables que mostraron asociación estadística con los síntomas musculoesqueléticos fueron: sexo y presencia de síntomas de molestia o dolor lumbar (valor p 0.013), nivel de escolaridad con cuello, hombros y/o espalda dorsal (p 0.043), antigüedad en el cargo con presencia de síntomas en cuello, hombros y/o espalda dorsal (p 0,030), rodillas (p 0,003) y pies (p 0,007). Conclusiones: La población objeto de estudio presenta prevalencias altas de molestia o dolor en grupo axila, aumentando en trabajadores que están entre los 3 y 12 años de permanencia en el cargo, observándose mayores prevalencias en el personal operativo (liniero). El personal presenta asociaciones entre antigüedad en el cargo con la presencia de síntomas de molestia o dolor en cuello, hombros y/o espalda dorsal, rodillas y pies. Al 46,25% del total de los trabajadores por lo menos un síntoma en uno de los segmentos corporales les ha impedido alguna vez realizar la labor, siendo el personal operativo quien presenta mayores impedimentos por presencia de síntomas al momento de realizar las tareas. El 67% del personal administrativo y el 75,8% del operativo mencionan que las molestias o dolores se han producido por las tareas del puesto de trabajo. Teniendo en cuenta los resultados, se recomienda formular estrategias para la prevención de aparición de síntomas musculoesqueléticos y/o factores de riesgo biomecánico en los trabajadores, priorizando la intervención en el personal operativo The study found the prevalence of the musculoskeletal symptoms and the biomechanic risk in the operator staff and the administrative staff in an energy company in Colombia. A transversal study is presented in 160 workers. Measures of central tendency and dispersión were used. And the association were proved with Chi Pearson’s square with a signification level of 0.05. Associations were found: : genre and presence of low-backpain (value p 0.013), education level and pain in the neck, shoulders and back dorsal (p 0.043), seniority in the position with presence of symptoms In the neck, shoulders and back dorsal (p 0.030), knees (p 0,003) and foot (p 0.007). The population shows high prevalence of pain in neck, shoulders, dorsal and lower-back, hands and wrist .this prevalence increases in the workers whose permanence on their position is between 3 and 12 years. 2019-08-01 06:01:01: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2019-08-11
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- 2022
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18. Morphological and Morphometric Study of the Muscle Fibers and Neuromuscular Junctions of the Extensor Digitorum Longus in Aged Rats Submitted to Maternal Protein Restriction/Estudio Morfologico y Morfometrico de las Fibras Musculares y de las Intersecciones Neuromusculares del Musculo Extensor Largo de los Dedos de Ratas de Edad Avanzada Sometidas a la Restriccion Proteica Materna
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Jeronimo, L.C., Confortim, H.D., Centenaro, L.A., Brancalhao, R.M.C., Pinheiro, P.F.F., Matheus, S.M.M., and Torrejais, M.M.
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- 2016
19. Esteróide anabolizante inibe a angiogênese induzida pelo treinamento físico de natação em músculo sóleo de ratos normotensos Anabolic steroid impairs the angiogenesis induced by swimming training in soleus muscle of normotensive rats
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Ursula Paula Reno Soci, Fernanda Roberta Roque Redondo, Tiago Fernandes, Kátia De Angelis, Maria Cláudia Irigoyen, Marcele Coelho, and Edilamar Menezes de Oliveira
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Doping ,Fluxo sanguíneo ,Capilares ,Músculo esquelético ,Treinamento físico ,Natação ,Blood flow ,Capillary ,Skeletal muscle ,Swimming training ,Sports ,GV557-1198.995 - Abstract
Os esteróides anabolizantes androgênicos (EAA) são sintéticos de testosterona desenvolvidos para fins terapêuticos. São também utilizados por populações fisicamente ativas, que normalmente excedem nas doses, o que potencializa danos à saúde. Para estudar alguns dos efeitos de EAA sobre o sistema cardiovascular, ratos "Wistar" foram divididos em quatro grupos: sedentário controle (SC), sedentário anabolizado (SA), treinado controle (TC) e treinado anabolizado (TA). Foram avaliados os efeitos da associação do uso de EAA (Decanoato de nandrolona - 5 mg/kg sc, 2x/sem) e do treinamento físico de natação (TFN - 60 min/dia, 5x/sem, durante 10 sem) sobre o débito cardíaco (DC) e fluxo sanguíneo basal (DCbasal, Qbasal) e após infusão do vasodilatador acetilcolina (DC Ach, Q Ach) para observar a vasodilatação endotélio dependente (QAch), razão capilar/fibra (rc/f) e expressão do fator de crescimento endotelial vascular (VEGF) em músculo sóleo (predominância de fibras oxidativas). A testosterona plasmática aumentou nos grupos com uso de EAA e foi observada bradicardia de repouso como efeito do TFN. O DC foi menor para o Grupo TA, tanto na condição basal quanto sob infusão de Ach. O Qbasal não foi diferente entre os grupos no músculo estudado. O QAch foi maior no grupo TC, entretanto, no grupo TA este efeito benéfico do TFN foi prejudicado pela associação com o EAA. Aumento da rc/f e VEGF foi observado somente no grupo TC. Estes resultados sugerem que a associação do EAA ao TFN atenua a angiogênese e arteriogênese observadas como efeito do treinamento físico aeróbio e causa prejuízo ao fluxo sanguíneo muscular, o que poderia predispor o praticante de esportes e atividades físicas e usuário destas substâncias a problemas vasculares.Androgenic anabolic steroids (EAA) are synthetic derivatives of testosterone, used in therapeutic dosages in medical practice and in high doses by physically active people that could be health damaging. To study the effects of EAA on the cardiovascular system, Wistar rats were randomized into Sedentary Control (SC), Sedentary Steroid (SA), Trained Control (TC) and Trained Steroid (TA) groups. We evaluated the effects of swimming training (60min/day, 5x/week during 10 week) and AAS (nandrolone decanoate - 5 mg/kg sc, 2x/week) on cardiac output, basal blood flow (Qb, DC basal) and after injection of a vasodilator to observe the endothelium dependent vasodilatation (acetylcholine - Q Ach)(Q Ach, DC Ach), capillary to fiber ratio (r c/f) and vascular-endothelial growth factor expression (VEGF) in soleus muscle (oxidative fibers). Serum testosterone increased in SA and TA. Exercise training significantly decreased resting heart rate. Qb was not different among groups, and QAch was higher in TC group, however in TA group this beneficial effect of swimming exercise training was lost by association with EAA. Rc/f and VEGF were higher only in TC group. These results suggest that swimming training associated with EAA inhibit angiogenesis and arteriogenesis observed as effects of aerobic training, and impairs the red skeletal muscle blood flow which predispose physically active AAS users to vascular diseases.
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- 2009
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20. Cultural organization of disease and semantic structures in skeletal muscle diseases of Mapuche population, Chile/Organizacion cultural de la enfermedad y estructuras semanticas: enfermedades musculo-esqueleticas de la poblacion Mapuche de Chile
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Herrera, Aldo Vidal and Alarcon, Ana Maria
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- 2014
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21. Mecanismos celulares e moleculares que controlam o desenvolvimento e o crescimento muscular Cellular and molecular mechanisms that control muscular development and growth
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Maeli Dal Pai Silva and Robson Francisco Carvalho
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crescimento e desenvolvimento muscular ,fatores reguladores miogênicos ,músculo esquelético ,muscle development and growth ,myogenic regulatory factors ,skeletal muscle ,Animal culture ,SF1-1100 - Abstract
O músculo estriado esquelético é formado pela associação de fibras musculares com a matriz extracelular. Esse tecido possui alta plasticidade e o conhecimento das características morfológicas, da miogênese, e da dinâmica do crescimento é importante para o entendimento da morfofisiologia bem como para a seleção de animais visando a melhoria na produção de carne. A maioria dos músculos estriados originam-se de células precursoras do mesoderma a partir dos somitos do embrião e o controle da diferenciação ocorre pela ação de fatores indutores ou inibidores. Um grupo de fatores transcricionais, pertencentes à família MyoD tem um papel central na diferenciação muscular. Coletivamente chamados de Fatores de Regulação Miogênica (MRFs), são conhecidos quatro tipos: MyoD, myf-5, miogenina e MRF4. Esses fatores ligam-se à seqüências de DNA conhecidas como Ebox (CANNTG) na região promotora de vários genes músculo-específicos, levando à expressão dos mesmos. As células embrionárias com potencial para diferenciação em células musculares (células precursoras miogênicas) expressam MyoD e Myf-5 e são denominadas de mioblastos. Essas células proliferam, saem do ciclo celular, expressam miogenina e MRF4, que regulam a fusão e a diferenciação da fibra muscular. Uma população de mioblastos que se diferencia mais tardiamente, as células miossatélites, são responsáveis pelo crescimento muscular no período pós natal, que pode ocorrer por hiperplasia e hipertrofia das fibras. As células satélites quiescentes não expressam os MRFs, porém, sob a ação de estímulos como fatores de crescimento ou citocinas, ocorre a ativação desse tipo celular que prolifera e expressa os MRFs de maneira similar ao que ocorre com as células precursoras miogênicas durante a miogênese. Os mecanismos de crescimento muscular são regulados pela expressão temporal dos (MRFs), que controlam a expressão dos genes relacionados com o crescimento muscular.Skeletal muscle consists predominantly of muscle fibers surrounded by a connective tissue layer. This tissue has a great plasticity, and the knowledge of the morphological characteristics, myogenesis, and growth dynamics is important to the understanding of its physiology and to the farm animal selection for meat production. Most skeletal muscles are derived from mesodermal precursor cells originated from the somites. During embryonic development, specification of mesodermal precursor cells to the myogenic lineage is regulated by positive and negative signals from surrounding tissues. Specification to the myogenic lineage requires the up-regulation of four muscle-specific transcriptional factors (MyoD, Myf5, myogenin, and MRF4), called myogenic regulatory factors (MRFs), which have a well-defined role in skeletal muscle development and differentiation. The MRFs belong to the basic helix-loop-helix (bHLH) super family of transcription factors, that forms heterodimers and bind to the E-box (CANNTG) DNA sequence motif found in the promoters of many muscle specific genes. Specification to the myogenic lineage requires the up-regulation of the MRFs MyoD and Myf5. Proliferative MyoD and/or Myf5 positive myogenic cells are termed myoblasts. Proliferating myoblasts withdraw from the cell cycle to become terminally differentiated myocytes that express the "late" MRFs, myogenin and MRF4. Specialized populations of myogenic stem cells, termed satellite cells, arise during the late stages of embryogenesis are highly active during the postnatal muscle growth, which may occur by muscle fiber hyperplasia or hypertrophy. Quiescent satellite cells do not express detectable levels of MRF; however, during muscle growth, in response to several growth factors, activated satellite cells proliferate and express the MRFs in a similar manner to muscle precursor cells during skeletal muscle development. Muscle growth mechanisms are controlled by the temporally expression of muscle growth related genes induced by the MRFs.
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- 2007
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22. El factor inducible por la hipoxia y la actividad física hypoxia-inducible factor and physical activity
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Juan Camilo Calderón Vélez
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especies reactivas de oxígeno ,factor inducible por hipoxia ,hipoxia ,músculo esquelético ,hypoxia ,hypoxia-inducible factor ,reactive oxygen species ,skeletal muscle ,Medicine ,Medicine (General) ,R5-920 - Abstract
Los animales superiores dependen de un adecuado flujo de oxígeno. Los mecanismos involucrados en los procesos de percibir la hipoxia y responder a ella se han ido aclarando, desde hace unos 15 años, con el descubrimiento de las subunidades α y β del factor inducible por la hipoxia (HIF, por su sigla en inglés) y de las hidroxilasas involucradas en su regulación. Las especies reactivas de oxígeno (ERO), al parecer, también participan en el proceso de percibir y responder a la hipoxia. Las células musculares podrían ser un modelo útil para estudiar la interrelación hipoxia-ERO-HIF- respuesta celular, con importantes implicaciones básico-clínicas. Sin embargo, apenas comienza el estudio de esta relación en el músculo esquelético. Se revisan en este artículo algunos aspectos interesantes de la investigación en el músculo esquelético y se plantean algunas preguntas e hipótesis que podrían ser evaluadas en este tipo de células. Higher animals depend on an adequate oxygen flux. Mechanisms involved in the process of sensing and responding to hypoxia have become clearer in the last 15 years with the discovery of the y hypoxia-inducible factor (HIF) subunits and hydroxylases involved in their regulation. Reactive oxygen species seem to play some role in the process of sensing and responding to hypoxia. Skeletal muscle cells seem to be a suitable model for studying the hypoxia-reactive oxygen species-HIF-cellular response relationship. Its study has important basic and clinic implications. However, the study of this relationship just begins. Some interesting aspects regarding skeletal muscle research are reviewed in this article, and some questions and hypotheses suitable for being evaluated with muscle cells are discussed.
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- 2007
23. Fractal Analysis of Skeletal Muscle Tissue of Rats Subjected to Stretch Injury/Analisis Fractal de Tejido Muscular Esqueletico en Ratas Sometidas a Lesion por Estiramiento
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Ozaki, Guilherme, Camargo, Regina Celi Trindade, Koike, Tatiana Emy, Garcia, Thiago Alves, Castoldi, Robson Chacon, and Filho, Jose Carlos Silva Camargo
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- 2015
24. Effects of Passive Smoking Associated with Physical Exercise in the Skeletal Muscles of Rats During Pregnancy and Lactation/Efectos del Tabaquismo Pasivo Asociado con el Ejercicio Fisico en los Musculos Esqueleticos de Ratas Durante la Gestacion y Lactancia
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Valsoni, Bruna Corral Garcia, Bonfim, Mariana Rotta, Camargo, Regina Celi Trindade, de Abreu, Luiz Carlos, Souza, Doroteia Rossi Silva, and Filho, Jose Carlos Silva Camargo
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- 2015
25. Propuesta para la prevención de los desórdenes musculo esqueléticos en meseros y cocineros del Serrezuela Country Club
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López Jurado, Lency Marcela, Gonzalez Roncancio, Adriana Paola, Cruz Acosta, Maria Paula, and Castiblanco Aldana, July Patricia
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Risk ,Wellness ,Musculo Esqueletico ,Health ,Collaborators ,Skeletal muscle ,Salud ,Colaboradores ,Bienestar ,Riesgo - Abstract
En este trabajo se plantea una propuesta para la prevención de los desórdenes músculo esqueléticos en meseros y cocineros del Serrezuela Country Club, con el fin de mejorar el ambiente laboral, áreas de trabajo, bienestar y salud de los colaboradores de dicha empresa. Se darán a conocer estrategias para la mitigación de estos riesgos y se implementara una de las tan conocidas estrategias ARO. In this project, a proposal is proposed for the prevention of musculoskeletal disorders in waiters and cooks of the Serrezuela Country Club, in order to improve the work environment, work areas, well-being and health of the employees of said company. Strategies to mitigate these risks will be announced and one of the well-known ARO strategies will be implemented. Resumen Abstract Palabras claves Keywords del trabajo Problema de investigación Descripción del problema Formulación del problema Objetivos Objetivo general Objetivos específicos Justificación y delimitación Justificación Delimitación Limitación Marcos de referencia Estado del arte Estado del arte internacional Estado del arte nacional Marco teórico Marco legal Hipótesis Diseño metodológico Fases del diseño metodológico Fase 1 Investigación sobre los peligros y valorar los riesgos a los que se encuentran expuestos los meseros y cocineros del Serrezuela Country Club Metodología ARO Objetivo Estrategia de trabajo Gestión de un plan estratégico Plan de Prevención de Riesgos Conclusiones Recomendaciones Análisis costo – beneficio Referencias Pregrado Especialista en Gerencia de la Seguridad y Salud en el Trabajo Administración de empresas (Virtual)
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- 2021
26. Prevención de riesgos músculo esqueléticos para los trabajadores de una empresa de servicios de alimentación
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Salazar Alvarez, Ingrid Briyi and Pena Meneses, Gilma Rocio
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Food service ,Trauma músculo esquelético ,Company ,Prevención de riesgos ,Strategy ,Skeletal muscle ,Estrategia ,Risk prevention ,Servicio de alimentos ,Empresa - Abstract
Diseñar un programa de prevención de riesgos músculo esquelético para los trabajadores de una empresa de servicios de alimentos. Esta monografía presenta una serie de reflexiones y estrategias para prevenir las lesiones músculo esqueléticas de los trabajadores de una empresa de servicios de alimentos. Para ello se hace un análisis cualitativo, exploratorio y de corte documental, en dos momentos: i) el abordaje de los distintos planteamientos previos, teóricos, conceptuales y legales alrededor del tema, y ii) la revisión de la información disponible y actualizada sobre los posibles riesgos físicos relacionados con los traumas músculo esqueléticos y los manejos que les dan algunas empresas de servicios de alimentos en Bogotá. Los resultados indican que los trabajadores vinculados a estas empresas están expuestos a altas demandas físicas (mala postura, sobre-esfuerzo y repetición) y que para minimizar los riesgos se deben definir e implementar estrategias de prevención con medidas técnicas y organizacionales, para lo cual se presentan algunas recomendaciones específicas. This monograph presents a series of reflections and strategies to prevent musculoskeletal injuries of workers in a company type of food services. To this end, a qualitative, exploratory and documentary analysis is made, in two moments: (i) the approach of the different previous, theoretical, conceptual and legal approaches around the topic, and (ii) reviewing available and up-to-date information on possible physical risks related to musculoskeletal trauma and the handling of it by some food service companies in Bogota. The results indicate that workers associated with these companies are exposed to high physical demands (poor posture, over-exertion and repetition) and that in order to minimize risks, prevention strategies should be defined and implemented with technical and organizational measures, for which specific recommendations are presented.
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- 2020
27. Ultrastructural aspects of equine exertional rhabdomyolysis
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Luis Eduardo Sucre, Héctor José Finol, and Kent Thompson
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thoroughbred racehorses ,skeletal muscle ,ultrastructural changes ,exertional rhabdomyolysis ,Cattle ,SF191-275 ,Veterinary medicine ,SF600-1100 - Abstract
An electron microscope study was carried out with left Gluteus medius muscle samples, of fifty-one (51) mares (3-4 years old). Sixteen (16) of these were inactive (approximately 4 months), and with no signs or symptoms of exertional rhabdomyolysis ER (control group), the other thirty-five (35) mares with (ER), were in training at the “La Rinconada” Racetrack (Caracas-Venezuela). Fifteen (15) had sub-clinical phases of the disease, three (3) showed clinical episodes, and seventeen (17) showed recent episodes (approximately 8 days) of ER (chronic periods of the syndrome). Three phases of the process were observed in the left Gluteus medius muscle: Phase 1 atrophy, phase 2 segmental necrosis and phase 3 regeneration. In some cases all three phases were found in the same animal. Ultra-structural aspects of these three phases are discussed and related to some possible etiologic mechanisms.
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- 2010
28. Gastrocnemius skeletal muscle microvasculature and neuromuscular junction alterations in mice with experimental acute chagas infection
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Ana Lugo de Yarbuh, Cesare Colasante, Maritza Alarcón, and Elio Moreno
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trypanosoma cruzi ,acute Chagas´disease ,skeletal muscle ,microvasculature ,ischaemia ,neuromuscular junction ,Cattle ,SF191-275 ,Veterinary medicine ,SF600-1100 - Abstract
A light and transmission electron microscopy study was performed in skeletal muscles (SM) Gastrocnemius (G) from mice experimentally infected with Trypanosoma cruzi to determine changes on microvessels (MV) and neuromuscular junction (NMJ) of G. In this study 10 male (mus musculus) (20 g) were infected subcutaneally with 1.104 bloodstream trypomastigotes M/DID/Ve/02/DSM strain. Five mice were kept as uninfected controls. The parasites induced a complete paralysis of the rear limbs and death while still in the acute Chagas´disease. The histopathology of SM showed inflammatory cell infiltration by mononuclear and polymorphonuclear leukocytes associated with marked parasitism in the muscle fibers of G. Indirect immunofluorescence revealed interstitial IgG deposit as bands regularly spaced along the nerve terminals at 40 days postinfection (pi). At this time T. cruzi antigens and intracellular amastigotes nests were also observed. The marked inflammatory response and morphological changes in the SM were confirmed by transmission electron microscopy. Capillary ultrastructure was seen to be altered, with points of cell cytoplasm discontinuity that appear to represent holes in the microvessel walls. This finding coincided with amastigote nests in myofibers, close contacts between trypomastigotes and endothelial cells and marked thickening of the basement membrane of the muscle vessels. Loss of capillary lumen and a process of ischemia also were observed in the SM of infected mice. The neuromuscular junction showed degeneration of intramuscular nerve fibers, reduction in the axon caliber, swollen mitochondrial, increase in the actin filaments and microtubules in the axoplasm, and swelling of the Schwann cells. Increase in the nerve terminal perimeter and most of the synaptic vesicles were localized near the presynaptic active zones and scarces in the axoplasm. At this stage of infection the changes findings in MV and NMJ of G infected with T. cruzi, as well as ischemia and alterations in the presynaptic membrane densities in the active zones, shows that the abnormal mice NMJ is associated with an activity dependent modulation of the neurotransmission, producing abnormal motor activity and paralysis of the rear limbs mice while still in the acute Chagas´disease. Â
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- 2010
29. Estudio comparativo de caracteristicas metabolicas del M. gluteus medius en equinos y bovinos
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Hernández, Noelina, Torres, Sonia H., De Sanctis, Juan B., Pulido M., M. Magdalena, and Sucre P., Luis E.
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- 2004
30. Anormalidades ultraestructurales de la musculatura esqueletica en ratones infectados con Toxoplasma gondii y tratados con ciclofosfamida
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Bruzual, Elizabeth, Finol, Héctor J., and Arcay, Lucila
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- 2002
31. Rabdomiolisis por ejercicio en el caballo pura sangre de carrera venezolano: analisis histoquimico, bioquimico y hematologico
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Sucre P., Luis Eduardo, Finol, Héctor José, Hecker de Torres, Sonia, Hernández, Noelina, and Segundo Jordán, Luis
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- 2001
32. Caracteristicas histoquimicas y bioquimicas del M.G. medius de los Caballos Pura Sangre venezolanos en relacion a la edad
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Sucre P., Luis Eduardo, Hecker de Torres, Sonia, and Hernández, Noelina
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- 2000
33. Anormalidades ultraestructurales en el musculo gluteo medio de un caballo pura sangre de carrera, asociadas con corticoterapia prolongada
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Sucre Párraga, Luis Eduardo and Finol, Héctor José
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- 2000
34. Analisis ultraestructural del musculo Gluteus medius del caballo de tiro mestizo chileno, sometido a trabajo de labranza posterior a un periodo prolongado de inactividad
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Sucre P., Luis Eduardo, José Finol, Héctor, Pérez, Rubén F., and Pacheco, Italo
- Published
- 1999
35. Mecanismos fisiopatológicos de la sarcopenia en la EPOC
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Paulo Sergio, Walter Sepúlveda-Loyola, and Vanessa S. Probst
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medicine.medical_specialty ,Sarcopenia ,Population ,Disease ,Systemic inflammation ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,inflamación ,medicine ,enfermedad pulmonar obstructiva crónica ,030212 general & internal medicine ,education ,education.field_of_study ,COPD ,business.industry ,polimorfismos genéticos ,Respiratory disease ,Skeletal muscle ,General Medicine ,musculoskeletal system ,medicine.disease ,body regions ,medicine.anatomical_structure ,estrés oxidativo ,Cardiology ,medicine.symptom ,business ,human activities ,Oxidative stress - Abstract
Resumen La sarcopenia es una enfermedad caracterizada por la pérdida de masa muscular, fuerza muscular y rendimiento físico, siendo la principal causa de fragilidad en los adultos mayores. La sarcopenia es altamente prevalente en individuos con enfermedad pulmonar obstructiva crónica (EPOC) que conduce a un mal pronóstico y una mayor mortalidad en esta población. La presencia de sarcopenia en la EPOC es probablemente el resultado de la interacción entre factores externos e internos como la inflamación sistémica, el estrés oxidativo y los polimorfismos genéticos, frecuentemente observados en individuos con esta enfermedad respiratoria. Esta revisión resume el conocimiento sobre los mecanismos patogénicos asociados con la sarcopenia en la EPOC.
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- 2019
36. Lipotoxicidad en músculo esquelético y su relación con la resistencia insulínica. Estudios en un modelo experimental de síndrome metabólico
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Maria Eugenia Oliva, María Eugenia D’Alessandro, María del Rosario Ferreira, and Victoria Aiassa
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medicine.medical_specialty ,CIENCIAS MÉDICAS Y DE LA SALUD ,RESISTENCIA INSULINICA ,medicine.medical_treatment ,Ciencias de la Salud ,chemistry.chemical_compound ,MUSCULO ESQUELETICO ,DIETA RICA EN SACAROSA ,purl.org/becyt/ford/3.3 [https] ,Insulin resistance ,Internal medicine ,medicine ,LIPOTOXICIDAD ,Carnitine ,General Environmental Science ,Adiponectin ,Triglyceride ,Chemistry ,Insulin ,Skeletal muscle ,medicine.disease ,Otras Ciencias de la Salud ,medicine.anatomical_structure ,Endocrinology ,Lipotoxicity ,General Earth and Planetary Sciences ,purl.org/becyt/ford/3 [https] ,Metabolic syndrome ,medicine.drug - Abstract
Introducción: el acúmulo de lípidos en el músculo esquelético seencuentra estrechamente vinculado con el desarrollo de la resistenciainsulínica. Esta última cumple un rol patogénico central enel desarrollo de numerosos desórdenes metabólicos incluidos enel síndrome metabólico.Objetivos: analizar algunas vías metabólicas implicadas en elacúmulo de lípidos en el músculo esquelético y su asociacióncon la resistencia insulínica en un modelo experimental quemimetiza el fenotipo del síndrome metabólico humano.Materiales y métodos: ratas macho Wistar recibieron una dietacontrol (DC) o una dieta rica en sacarosa (DRS) durante seismeses. Al final del período experimental se analizó en músculoesquelético gastrocnemio: contenido de triglicéridos (TG),acil-CoA de cadena larga y diacilglicerol, actividad enzimáticacarnitina palmitoil transferasa muscular (M-CPT1, M-CPT2 yM-CPT total) y masa proteica del PPARα, AMPK y AMPKp. Sedeterminaron los niveles séricos de TG, AGNE, glucosa, insulina,TNFα y adiponectina. La sensibilidad insulínica se midió porla técnica clamp euglucémica-hiperinsulinémica.Resultados: en los animales alimentados con DRS la dislipemia,hiperglucemia moderada, insensibilidad insulínica e incrementodel contenido de especies lipídicas en el músculo esqueléticose acompañaron de una disminución en la actividadenzimática M-CPT1 y M-CPT total, y un descenso de la masaproteica del PPARα. Además se observó una reducción de lamasa proteica de la AMPKp, la cual se correlacionó con bajosniveles de adiponectina y elevados niveles de TNFα séricos.Conclusiones: los resultados aportan nuevos datos sobre algunosmecanismos involucrados en el desarrollo de la lipotoxicidad en elmúsculo esquelético en ratas dislipémicas insulinorresistentes. Fil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ferreira Cordoneda, Maria del Rosario. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Aiassa, Victoria. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina Fil: D´Alessandro, María Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Química Biológica; Argentina
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- 2019
37. Síntomas osteomusculares y factores relacionados en el oficio de cotero : revisión sistemática, 2009 - 2019
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Perez Patiño, Yeison Yesid and Varona-Uribe, Marcela
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Esfuerzo físico ,Estibador ,Effort Physical ,Skeletal Muscle ,Ingeniería & operaciones afines ,Salud laboral ,Stevedore ,Risk Factors ,Músculo Esquelético ,Ergonomics ,Ergonomía ,Bracero ,Cotero ,Salud ocupacional ,Occupational Health ,Sistema muscular ,Factores de riesgo - Abstract
Introducción: El término cotero se acuñó social y culturalmente en Colombia para definir a una población de trabajadores que realizan las labores de carga y descarga de mercancía y productos en los centros de abastos y plazas de mercado del país. Esta población, del sector económico informal, debido a la forma rudimentaria en que realiza las actividades propias de su trabajo puede presentar síntomas osteomusculares en razón a la fuerte carga e intensidad física que requiere la actividad de cotero. Objetivo: Identificar los síntomas osteomusculares y los factores relacionados en trabajadores con el oficio de cotero. Materiales y métodos: Se realizó una revisión sistemática en la que se emplearon los términos de búsqueda Factores de Riesgo, Ergonomía, Músculoesquelético, Esfuerzo Físico y Salud laboral. La búsqueda se realizó en las bases de datos (PubMed, Cochrane, Google Académico y Scielo), en idiomas inglés, español y portugués, publicados en el periodo 2009 – 2019, a texto completo. Se incluyeron en total 36 artículos. Resultados: Los síntomas osteomusculares más frecuentes al final de la jornada de trabajo de los coteros fueron: dolor (65,7%), seguido por fatiga (21,6%) y disconfor (14,2%). La prevalencia de dolor por segmento fue en región dorsal de 76,9%, lumbar de 73,1%, cuello de 50,0%, brazos/antebrazos de 38,8%, hombros de 33,6%, manos de 32,1%, codos de 24,6% y pies de 18,7%. Conclusiones: El tiempo en la ocupación de cotero es un factor de riesgo determinante en la aparición de síntomas osteomusculares, los estudios evidenciaron exceso de peso de las cargas manipuladas por los coteros, las cuales están entre los 25 kilos hasta los 160 kilos, y bipedestación para la realización total del trabajo Introduction: The term cotero was coined socially and culturally in Colombia to define a population of workers who carry out the loading and unloading of merchandise and products in the markets and markets of the country. This population, of the informal economic sector, due to the rudimentary way in which it carries out the activities of its work, can present musculoskeletal symptoms due to the strong physical load and intensity required by the cotero activity. Objective: To identify musculoskeletal symptoms and related factors in workers with the trade of cotero. Materials and methods: A systematic review was carried out in which the search terms Risk Factors, Ergonomics, Musculoskeletal, Physical Effort and Occupational Health were used. The search was carried out in the databases (PubMed, Cochrane, Google Scholar and Scielo), in English, Spanish and Portuguese, published in the period 2009 - 2019, in full text. A total of 36 articles were included. Results: The most frequent musculoskeletal symptoms at the end of the working day of the coteros were: pain (65.7%), followed by fatigue (21.6%) and disconfor (14.2%). The prevalence of pain by segment was in the dorsal region of 76.9%, lumbar of 73.1%, neck of 50.0%, arms / forearms of 38.8%, shoulders of 33.6%, hands of 32, 1%, 24.6% elbows and 18.7% feet. Conclusions: The time in the cotero occupation is a determinant risk factor in the appearance of musculoskeletal symptoms, the studies showed excess weight of the loads manipulated by the coteros, which are between 25 kilos up to 160 kilos, and bipedestación for the total realization of the work 2021-07-20 01:01:02: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2021-07-19 2019-08-02 13:00:01: Script de automatizacion de embargos. Correo en el repo el 18 jul 2019 Apreciado Humberto, Mediante el presente correo electrónico solicito que se haga un embargo del articulo que deposite el día de hoy en el repositorio de la universidad previa autorización del mismo por parte de la doctora Marcela Varona tutora, el embargo es por 2 años.
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- 2019
38. Aspectos patológicos del músculo esquelético debido a la infección experimental por Trypanosoma cruzi
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Lugo de Yarbuh A and Colasante C
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Chagas' disease ,skeletal muscle ,nerve fibers ,motor activity ,Enfermedad de Chagas ,músculo esquelético ,fibra nerviosa ,placa motora ,Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
ABSTRACT: Clinical observations were made of mice in the acute stage of infection produced by three Trypanosoma cruzi strains. Mice infected with Dm74 suffered complete paralysis of the rear limbs followed by death, while still in the acute stage of Chagas' disease. Hystological analysis of skeletal muscle showed intense inflammatory infiltrates of mononuclear and polymorphonuclear leukocytes, fibroblasts, free red blood cells and IgG deposits in the interstilium of Gastrocnemius (G). Local miofibrillic disintegration and changes in microvessels, nerve fibers and the neuromuscular junction of G were also observed. These results indicate that the acute infection with T. cruzi may cause progressive damage in parasite infected muscle fiber and lead to loss of mobility. RESUMEN: En este estudio se muestran los signos clínicos desarrollados por ratones durante la fase aguda de la infección producida por tres cepas de Trypanosoma cruzi. Los ratones infectados con la cepa Dm74 sufrieron alteración de la movilidad de los miembros posteriores y murieron durante la fase aguda de la infección. El análisis histológico del músculo esquelético mostró infiltrado inflamatorio de leucocitos mononucleares y polimorfonucleares, fibroblastos, eritrocitos libres y depósitos de IgG en el espacio intersticial del Gastrocnemius (G). La desintegración de las micro ti brillas y cambios en la microvasculatura, fibras nerviosas y en la unión neuromuscular del G fueron también observados. Estos resultados indican que la infección aguda producida por T. cruzi causa daño progresivo en la fibra muscular esquelética y alteración de la actividad motora.
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- 2000
39. Benefits of skeletal-muscle exercise training in pulmonary arterial hypertension: The WHOLEi + 12 trial
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Angela Flox-Camacho, Diego Munguía-Izquierdo, Carmen Fiuza-Luces, Pilar Escribano-Subías, Carlos A. Quezada-Loaiza, Alfredo Santalla, Fabian Sanchis-Gomar, Alejandro Lucia, Ignacio Ara, Paz Sanz-Ayan, Alejandro Santos-Lozano, Laura González-Saiz, and María Morán
- Subjects
Adult ,Male ,medicine.medical_specialty ,Weakness ,Adolescent ,Hypertension, Pulmonary ,030204 cardiovascular system & hematology ,Breathing Exercises ,Bench press ,law.invention ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Clinical endpoint ,Humans ,Medicine ,Leg press ,Exercise ,Aged ,Retrospective Studies ,Exercise Tolerance ,business.industry ,VO2 max ,Skeletal muscle ,Resistance Training ,Middle Aged ,Aparato respiratorio ,Respiratory Muscles ,medicine.anatomical_structure ,030228 respiratory system ,Quality of Life ,Physical therapy ,Cardiology ,Female ,Analysis of variance ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Hipertensión pulmonar ,Pulmones - Enfermedades - Abstract
Pulmonary arterial hypertension is often associated with skeletal-muscle weakness. The purpose of this randomized controlled trial was to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure-load exercises on upper/lower-body muscle power and other functional variables in patients with this disease. Participants were allocated to a control (standard care) or intervention (exercise) group (n = 20 each, 45 ± 12 and 46 ± 11 years, 60% women and 10% patients with chronic thromboembolic pulmonary hypertension per group). The intervention included five, three and six supervised (inhospital) sessions/week of aerobic, resistance and inspiratory muscle training, respectively. The primary endpoint was peak muscle power during bench/leg press; secondary outcomes included N-terminal pro-brain natriuretic peptide levels, 6-min walking distance, five-repetition sit-to-stand test, maximal inspiratory pressure, cardiopulmonary exercise testing variables (e.g., peak oxygen uptake), health-related quality of life, physical activity levels, and safety. Adherence to training sessions averaged 94 ± 0.5% (aerobic), 98 ± 0.3% (resistance) and 91 ± 1% (inspiratory training). Analysis of variance showed a significant interaction (group × time) effect for leg/bench press (P < 0.001/P = 0.002), with both tests showing an improvement in the exercise group (P < 0.001) but not in controls (P > 0.1). We found a significant interaction effect (P < 0.001) for five-repetition sit-to-stand test, maximal inspiratory pressure and peak oxygen uptake (P < 0.001), indicating a training-induced improvement. No major adverse event was noted due to exercise. An 8-week exercise intervention including aerobic, resistance and specific inspiratory muscle training is safe for patients with pulmonary arterial hypertension and yields significant improvements in muscle power and other functional variables. Sin financiación 4.034 JCR (2017) Q2, 41/128 Cardiac and Cardiovascular Systems 1.200 SJR (2017) Q1, 78/369 Cardiology and Cardiovascular Medicine No data IDR 2017 UEM
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- 2017
40. Enseñanza - Aprendizaje del concepto músculo esquelético en estudiantes de grado décimo
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Ortiz Gallego, Alejandro and Salazar Buitrago, John Jairo (Thesis advisor)
- Subjects
61 Ciencias médicas ,Medicina / Medicine and health ,Educación física - enseñanza secundaria - tesis y disertaciones académicas ,Physical education and training - education, secondary - dissertations, academic ,Skeletal muscle ,37 Educación / Education ,5 Ciencias naturales y matemáticas / Science ,Unidad Didáctica ,Músculo esquelético - Abstract
El siguiente trabajo presenta el diseño e implementación de una Unidad Didáctica (UD), que constó de seis guías sobre el concepto de músculo esquelético aplicado a estudiantes de grado décimo de la Institución Educativa Rural José Antonio Galán de la ciudad de Manizales, en pro de mejorar el proceso Enseñanza – Aprendizaje, permitiendo así, que los estudiantes construyan y evalúen su propio conocimiento a través de las fases de cada una de las guías presentadas en la unidad didáctica (objetivos, actividades, reflexiones y evaluación) por medio de actividades grupales que favorecieron el trabajo colaborativo y para la cual se realizó el análisis del pre test y pos test Abstract: Teaching - Learning musculoskeletal concept in graders tenth students paper introduces and designs the implementation a Didactic Unit, which includes six guides; each guide with the musculoskeletal concept applied to tenth graders in José Antonio Galán Rural High School. It is also important to clarify that The Didactic Unit main goal is the improvement of the teaching - learning process. The methodology used in this academic paper is basically interactive, with a diagnostic and a post test, also this methodology is centered on team and cooperative students` work. Besides, every guide allows students to construct and evaluate their own knowledge throughout its phases which are objectives, activities, reflexions and evaluations Maestría
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- 2017
41. Influencia del músculo pterigoideo lateral en el crecimiento del cartílago condilar mandibular
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Quiros, Juan G., Pérez Osorio, Luis Javier, and Calderón, Juan C.
- Subjects
lcsh:R5-920 ,músculo esquelêtico ,lcsh:R ,lcsh:Medicine ,stomatognathic system ,growth factors ,músculo esquelético ,desenvolvimento maxilar ,skeletal muscle ,fatores de crescimento ,maxillofacial development ,lcsh:Medicine (General) ,desarrollo maxilofacial ,factores de crecimiento - Abstract
A finales del siglo pasado se desarrolló un modelo para explicar observaciones clínicas relacionadas con el crecimiento mandibular, según el cual el músculo pterigoideo lateral (LPM) era uno de los principales moduladores de la diferenciación de las células mesenquimales del cóndilo mandibular a condroblastos u osteoblastos y por lo tanto del crecimiento del cartílago condilar mandibular (CCM). Dos grandes componentes eran los pilares fundamentales del modelo: el humoral y el mecánico. En la actualidad, el componente humoral estaría dado por factores de crecimiento como el IGF-I, el FGF-2 y el VEGF, los cuales parecen estar involucrados en el crecimiento mandibular. Debido a que el músculo esquelético tiene un papel como órgano secretor de ellos, se abre la posibilidad de que el LPM regule el crecimiento del CCM por un mecanismo paracrino o endocrino mediado por estos factores. El componente mecánico nació de las observaciones de que tanto el flujo sanguíneo dentro de la articulación temporomandibular como la acción de la almohadilla retrodiscal en el crecimiento del CCM depende, en parte, de la actividad contráctil del LPM. A pesar de que hay evidencia de que el LPM se activa en situaciones de adelantamiento mandibular, no hay consenso sobre si esto estimula el crecimiento del CCM. En esta revisión se discuten los aportes y limitaciones de los trabajos relacionados con el crecimiento mandibular y se propone un modelo que integra la información disponible para explicar el papel del LPM en el crecimiento del CCM. At the end of the last century, a model to explain clinical observations related to the mandibular growth was developed. According to it, the lateral pterigoid muscle (LPM) was one of the main modulators of the differentiation of mesenquimal cells inside the condyle to condroblasts or osteoblasts, and therefore of the growth of the mandibular condilar cartilage (CCM). The main components of the model were the humoral and the mechanical. Nowadays, the humoral would include growth factors such as IGF-I, FGF-2 and VEGF, which seem to be involved in mandibular growth. Since skeletal muscle can secrete these growth factors, there is a possibility that LPM modulates the growth of CCM by a paracrine or endocrine mechanism. The mechanical component derived from the observations that both the blood flow inside the temporomandibular joint and the action of the retrodiscal pad on the growth of the CCM, depend, in part, on the contractile activity of the LPM. Despite the fact that there are some results suggesting that LPM is activated under conditions of mandibular protrusion, there is no full agreement on whether this can stimulate the growth of CCM. In this review, the contributions and limitations of the works related to mandibular growth are discussed and a model which integrates the available information to explain the role of the LPM in the growth of the CCM is proposed. No fim do século passado desenhou-se um modelo para esclarecer as observações clínicas envolvidas no crescimento da mandíbula, no qual o músculo pterigoideo lateral (LPM) foi um dois moduladores principais da diferenciação das células messenquimais do côndilo mandibular em condroblastos ou osteoblastos e porém do crescimento da cartilagem condilar mandibular (CCM). Dois componentes principais possui o modelo: o humoral e o mecânico. Na atualidade, há evidência que o componente humoral é dado pelos fatores de crescimento IGF-1, IGF2 e VEGF que estimulam diretamente o crescimento mandibular. Devido a que o músculo esquelético pode desempenhar uma função endócrina fica aberta a possibilidade que o LPM regule o crescimento do CCM por mecanismos paracrinos ou autocrinos, mediante a secreção desses fatores de crescimento que estimulam diretamente o crescimiento mandibular. O componente mecânico é derivado das observações do que tanto o fluxo sanguíneo na articulação tempo-mandibular quanto a ação da almofadinha retro-discal no crescimento do CCM, dependem parcialmente da atividade contrátil do LPM. Embora, há evidências que o LPM é ativado pelo adiantamento mandibular, ainda não há consenso sob seu possível papel na estimulação do crescimento do CCM. Esta revisão tem o objetivo de discutir as evidencias e limitações de trabalhos relativos ao crescimento mandibular e propõe-se um modelo que integra a informação disponível para explicar a função do IPM no crescimento do CCM.
- Published
- 2013
42. Músculo esquelético y lesión por reperfusión. Ultraestructura, alteración y regeneración: Revisión sistemática
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Rosero, Doris H, Salazar, Liliana, and Tovar, Maria Ana
- Subjects
angiogenesis ,myoblasts ,isquemia ,ischemia ,músculo esquelético ,reperfusión ,skeletal muscle ,angiogénesis ,mioblastos ,reperfusion - Abstract
Introducción: La función tisular se basa en la asociación celular y la comunicación mediante uniones intercelulares o la matriz extracelular, que compone el tejido conectivo. La isquemia conlleva a cambios de lesión a los cuales las células responden según duración e intensidad del estímulo de lesión. En periodos cortos de isquemia y prolongados de reperfusión, el tejido muscular estriado esquelético presenta cambios en la predominancia de los tipos de fibras musculares y en los componentes de la matriz extracelular intramuscular. Objetivo: Establecer los cambios que se presentan en el músculo esquelético durante la reperfusión prolongada, tanto en las fibras musculares como en su matriz extracelular. Métodos: Se realizó una revisión sistemática mediante la búsqueda de artículos en inglés y español publicados en revistas indexadas en las bases de datos Ovid Medline, PubMed, Wiley y Science Direct. Los descriptores MESH utilizados fueron skeletal muscle, ischemia, reperfusion, fiber type fast twitch, fiber type slow twitch, sarcomere and myoblast. Se acoplaron los términos histology y tissue. Resultados: Se seleccionaron 81 publicaciones y se complementó con imágenes de músculos esqueléticos provenientes de muestras procesadas en el Laboratorio de Histología de la Universidad del Valle, Colombia. Conclusión: La recuperación del músculo durante la reperfusión seguida de isquemia, tiende hacia el patrón histológico y funcional normal. En algunos casos es un proceso lento y que aún después de varios meses no ha finalizado. Así mismo, pueden persistir alteraciones leves o moderadas en la contracción muscular, dados los cambios que se presentan en la matriz extracelular intramuscular. Introduction: The tissue function is based on the cell association and communication through junctions or the extracellular matrix, which comprises connective tissue. Ischemia injury leads to changes to which the cells respond and it depends on duration and intensity of stimulus injury. In short periods of prolonged ischemia and reperfusion, skeletal striated muscle tissue shows changes in the predominance of muscle fiber types and components of the extracellular matrix intramuscular. Objective: To determine the changes which occur in skeletal muscle during prolonged reperfusion in both muscle fibers in its extracellular matrix. Methods: A systematic review was performed by searching for articles in English and Spanish published in journals indexed in databases Ovid Medline, PubMed, Science Direct and Wiley. MeSH descriptors used were skeletal muscle, ischemia, reperfusion, fast twitch fiber type, slow twitch fiber type, sarcomere and myoblast. The terms tissue and histology were coupled. Results: 81 relevant publications were selected and supplemented with images of skeletal muscles from samples processed at the Laboratory of Histology of the Universidad del Valle, Colombia. Conclusion: The recovery of muscle during ischemia followed by reperfusion, tends toward the normal histological and functional pattern. In some cases it is a slow process and even after several months has not been completed. Likewise, they may persist mild or moderate alterations in muscle contraction, given the changes that occur in the intramuscular extracellular matrix.
- Published
- 2015
43. Prevalencia de los síntomas osteomusculares y los factores de riesgo asociados, en trabajadores de una empresa de geomática, Colombia 2014
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Camargo Salinas, Monica, Hernández Herrera, Gilma Norela, and Rueda Arévalo, María Clemencia
- Subjects
Factor de riesgo ,Risk factor system ,Skeletal muscle pain ,Prevalence ,Sistema músculo esquelético ,Skeletal muscle ,Prevalencia ,Enfermedades [Sistema muscular] ,Enfermedades ,Enfermedades profesionales ,Dolor musculo esquelético ,Riesgos laborales - Abstract
Objetivo Identificar la prevalencia de síntomas osteomusculares, por segmentos y los factores de riesgo asociados, en los trabajadores de una empresa de Geomática, en Colombia en el año 2014. Metodología Se llevó a cabo un estudio descriptivo de corte transversal con una población de 169 trabajadores, distribuidos en 2 grupos, el grupo de campo que desarrolla actividades de topografía y el grupo de oficina donde se realizan procesamiento de datos en Geomática y actividades administrativas. A cada trabajador se le aplicó el cuestionario ERGOPAR que interroga la exposición o factores de riesgo y la presencia de síntomas osteomusculares. Resultados: El personal de oficina presenta mayor frecuencia de síntomas osteomusculares en el cuello 72%, la región lumbar 55%, los codos 17,7%, las manos y muñecas 57.3%. Presentándose con mayor frecuencia en las mujeres los síntomas en cuello 80% y manos 64%, mientras que los mayores porcentajes en personal de campo se presentan en las piernas 21%, las rodillas 26% y pies 11,5%. Se encontró asociación significativa entre la sedestación durante más de cuatro horas, con dolor en cuello (p=0.02) y dolor en región lumbar (p=0.03); inclinar el cuello hacia delante durante más de cuatro horas, con dolor en el cuello (p=0.006); repetir cada pocos segundos la flexión de muñecas (p=001) y utilizar los dedos de manera intensiva por más de 4 horas (p=0.01) con dolor en manos y las variables jornada laboral y puesto de trabajo con dolor en pies. Conclusiones La prevalencia de síntomas osteomusculares en los trabajadores de la empresa estudiada es alta. Dado que se encontró asociación significativa con las variables sociodemográficas y laborales. La alta prevalencia de sintomatología puede ser explicada por la exposición a carga física laboral, por posturas de trabajo, por movimientos repetitivos y características propias de género. Target: To identify the prevalence of muskuloskeletal symptoms by segments and the associate risk factors, into the workers of a Geomatics company, in Colombia in the year 2014. Methodology: A descriptivwe cross-sectional study took place, with a population of 169 workers, divided into two groups. The field group wich carries out tophography activities, and the office group where data processing is performed in Geomatics and administrative activities. To each one of the workers it was applied the “Ergopar Questionnaire”, which asks about the exposure to risk factors and also about the presence of musculoskeletal symptoms. Results: The “office staff” has higher frequency of symptoms of musculoskeletal symptoms in the neck, with 72%, in the lumbar region 55%, in the elbows 17.7%, the hands and the wrists 57.3% . Appearing more often the symptoms in women with an 80% in the neck, and in the hands with 64% . While the highest percentages in “field staff”, are presented in the legs in 21%, in the knees 26%, and feet 11.5%. A significant association was found among the sitting position for more than four hours, with neck pain (p=0.02) and lumbar region pain(p=003). Tilt your neck forward for more than four hours with neck pain (p=0.006), repeat every few seconds the bending of wrists (p=001)and use the fingers intensively for more than four hours (p=0,01) with pain in your hands and variable working hours and job station with feet pain. Conclusions: The prevalence of musculoskeletal symptoms in the staff of the workers in the company tested is high, since significant association with socio demographic and labor variables was found. The high prevalence of symptomatology can be explained by the exposure to physical workload, work postures, for repetitive movements and gender own characterisctics Universidad Del Rosario
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- 2015
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44. Feeding effects of cottonseed and its co-products on the meat proteome from ram lambs
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Tiago do Prado Paim, Pauline Viana, Mauricio Fraga van Tilburg, Arlindo de Alencar Moura, Jurandir Rodrigues de Souza, Concepta McManus, Adibe Luiz Abdalla, and Helder Louvandini
- Subjects
gossypol ,dehydrogenase ,skeletal muscle ,sheep ,feedlot ,Agriculture (General) ,S1-972 - Abstract
ABSTRACT: Gossypol easily pairs with lysine side chains and enzymes involved in the cellular growth process. The effect of gossypol (a compound present in cotton co-products) in ruminant metabolism and meat quality is not yet clear. This study was undertaken in order to evaluate the effects of cotton co-products in lamb muscle proteome. Twenty-four Santa Inês ram lambs, 5-months old (20.6 ± 1.9 kg), were randomly assigned to four treatments: control (without cottonseed), whole cottonseed, cottonseed meal and high oil cottonseed meal. At 95 days into the experiment, lambs were slaughtered and samples from Longissimus dorsi were collected. Proteins were extracted and analyzed by 2-D electrophoresis. Spots showing a significant effect from the treatment (the “treatment effect”) and present in more than 90 % of the samples were identified using mass spectrometry. Cotton co-products decreased the abundance of aldehyde and malate dehydrogenases, creatine kinase M-type and Adenosine triphosphate (ATP) synthase. They also increased four proteins related to muscle contraction. Thus, feeding cotton co-products to lambs changed the abundance of important muscle proteins. A cotton co-product diet induced a negative impact on the energy supply of muscle cells and, consequently, the abundance of ATP dependent proteins (contractile apparatus) increased, probably in order to offset and maintain muscle function. These proteomic changes can promote our understanding of alterations in the sensorial properties of meat due to cotton co-product diets in further investigations.
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45. Resistencia a la insulina y efecto sobre la excitabilidad y contracción del músculo esquelético en rata
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Raymundo Velasco-Rodríguez, Carlos Enrique Tene-Pérez, Mario Del Toro-Equihua, and Clemente Vásquez
- Subjects
insulin resistance ,skeletal muscle ,muscle contraction ,muscle excitability ,Medicine (General) ,R5-920 - Abstract
Introducción: la resistencia a la insulina es una condición metabólica que afecta múltiples tejidos entre ellos al músculo esquelético. El propósito del presente trabajo es analizar si la resistencia a la insulina inducida experimentalmente en ratas, modifica la excitabilidad y las propiedades contráctiles del músculo esquelético. Métodos: se incluyeron 22 ratas Sprague Dawley sanas para formar 2 grupos: Al grupo experimental (n=10) se le indujo resistencia a la insulina mediante la administración oral de prednisona (45mg/Kg.) durante 7 días. Al grupo control (n=12) se le administró solo agua. En ambos grupos se compararon principalmente los parámetros de la contractura muscular: tensión al pico, tensión total, activación contráctil y grado de excitabilidad muscular mediante una curva de umbrales así como su respuesta a una infusión continua de insulina intravenosa. Los experimentos fueron realizados en músculo gastrocnemio utilizando registros de tensión isométrica y estimulación eléctrica. Se analizaron las varianzas entre grupos para utilizar prueba t de Students o U de Mann Whitney, determinándose diferencias significativas entre ambos grupos cuando p
46. Prevalencia del dolor del aparato locomotor en trabajadores que manipulan carga en una empresa de servicios aeroportuarios y mensajería especializada en Cartagena (Colombia)
- Author
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Carmona Portocarrero, Lilia, Alvis Estrada, Luis, and Castillo ávila, Irma
- Subjects
work ,occupational health ,salud laboral ,Musculo esquelético ,lesiones ,skeletal muscle ,trabajo ,injuries - Abstract
Objetivo: Determinar la prevalencia y el comportamiento de dolor musculoesquelético en trabajadores que manipulan y levantan cargas de una empresa de servicios de mensajería especializada y servicios aeroportuarios mediante aplicación del Cuestionario Nórdico. Materiales y métodos: Se llevó a cabo un estudio descriptivo. Se aplicó el Cuestionario Nórdico a 74 hombres de 98 manipuladores de carga de una empresa de servicios aeroportuarios, sin límite en el tiempo de labor ni en la edad. Se evaluó las condiciones de trabajo para riesgo ergonómico. La información se analizó mediante el paquete estadístico SPSS versión 16.0®, y se obtuvo frecuencias simples para variables cualitativas, además de obtener medidas de tendencia central y dispersión en las variables cuantitativas. Resultados: Se encontró que la prevalencia de dolor musculoesquelético de la población objeto de estudio fue del 88 % (65 trabajadores); 42 trabajadores presentaron dolor en más de un segmento corporal y 23 solo en uno. La región lumbar tuvo la mayor prevalencia, con el 70 % (52 casos), seguida por muñecas! manos, con el 30 % (22 casos), y cuello, con el 28 % (21 casos), en el mismo periodo. Conclusiones: Se recomienda, entre otros aspectos, generar medidas de control en el individuo y en el ambiente de trabajo, como la capacitación activa y frecuente de los trabajadores que están expuestos; además, la creación de herramientas que mejoren el sistema de manipulación de cargas y equipos de trabajo que disminuyan el esfuerzo físico. Objetive: to determine the prevalence and behavior of musculoskeletal pain in workers handling and loads up in an airport services and specialist courier company by applying Nordic Questionnaire. Materials and Methods: It was conducted a descriptive study. Nordic Questionnaire was administered to 74 men of 98 cargo handlers an airport services company, with no limit on work time or age. We assessed working conditions for ergonomic risks. The data was analyzed using SPSS® version 16.0, obtaining frequency distributions for qualitative variables, in addition to obtaining measures of central tendency and dispersion for quantitative variables. Results: It was found that the prevalence of musculoskeletal pain in the study population was 88% (65 workers). 42 workers had pain in more than one body segment and 23 in only one. The lumbar region had the highest prevalence with 70% (52 cases) followed by wrists / hands with 30% (22 cases) and neck with 28% (21 cases) in the same period. Conclusions: It is recommended, among other actions, to generate control measures in the individual and the work environment as active and frequent training of workers who are exposed. It is also recommended to create tools to improve the cargo handling system and work teams that reduce physical exertion.
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- 2013
47. Influência do músculo pterigóideo lateral no crescimento cartilagem condilar na mandíbula
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Quirós, Juan G., Pérez Osorio, Luis Javier, and Calderón-Villegas, Juan-Jacobo
- Subjects
lcsh:R5-920 ,Factores de crecimiento ,Maxillofacial development ,lcsh:R ,Skeletal muscle ,lcsh:Medicine ,Desarrollo maxilofacial ,Desenvolvimento maxilar ,Músculo esquelético ,Fatores de crescimento ,músculo esquelético ,Growth factors ,lcsh:Medicine (General) ,Músculo esquelêtico ,desarrollo maxilofacial ,factores de crecimiento - Abstract
A finales del siglo pasado se desarrolló un modelo para explicar observaciones clínicas relacionadas con el crecimiento mandibular, según el cual el músculo pterigoideo lateral (LPM) era uno de los principales moduladores de la diferenciación de las células mesenquimales del cóndilo mandibular a condroblastos u osteoblastos y por lo tanto del crecimiento del cartílago condilar mandibular (CCM). Dos grandes componentes eran los pilares fundamentales del modelo: el humoral y el mecánico. En la actualidad, el componente humoral estaría dado por factores de crecimiento como el IGF-I, el FGF-2 y el VEGF, los cuales parecen estar involucrados en el crecimiento mandibular. Debido a que el músculo esquelético tiene un papel como órgano secretor de ellos, se abre la posibilidad de que el LPM regule el crecimiento del CCM por un mecanismo paracrino o endocrino mediado por estos factores. El componente mecánico nació de las observaciones de que tanto el flujo sanguíneo dentro de la articulación temporomandibular como la cción de la almohadilla retrodiscal en el crecimiento del CCM depende, en parte, de la actividad contráctil del LPM. A pesar de que hay evidencia de que el LPM se activa en situaciones de adelantamiento mandibular, no hay consenso sobre si esto estimula el crecimiento del CCM. En esta revisión se discuten los aportes y limitaciones de los trabajos relacionados con el crecimiento mandibular y se propone un modelo que integra la información disponible para explicar el papel del LPM en el crecimiento del CCM. At the end of the last century, a model to explain clinical observations related to the mandibular growth was developed. According to it, the lateral pterigoid muscle (LPM) was one of the main modulators of the differentiation of mesenquimal cells inside the condyle to condroblasts or osteoblasts, and therefore of the growth of the mandibular condilar cartilage (CCM). The main components of the model were the humoral and the mechanical. Nowadays, the humoral would include growth factors such as IGF-I, FGF-2 and VEGF, which seem to be involved in mandibular growth. Since skeletal muscle can secrete these growth factors, there is a possibility that LPM modulates the growth of CCM by a paracrine or endocrine mechanism. The mechanical component derived from the observations that both the blood flow inside the temporomandibular joint (ATM) and the action of the retrodiscal pad on the growth of the CCM, depend, in part, on the contractile activity of the LPM. Despite the fact that there are some results suggesting hat LPM is activated under conditions of mandibular protrusion, there is no full agreement on whether this can stimulate the growth of CCM. In this review, the contributions and limitations of the works related to mandibular growth are discussed and a model which integrates the available information to explain the role of the LPM in the growth of the CCM is proposed. No fim do século passado desenhou-se um modelo para esclarecer as observações clínicas envolvidas no crescimento da mandíbula, no qual o músculo pterigoideo lateral (LPM) foi um dois moduladores principais da diferenciação das células messenquimais do côndilo mandibular em condroblastos ou osteoblastos e porém do crescimento da cartilagem condilar mandibular (CCM). Dois componentes principais possui o modelo: o humoral e o mecânico. Na atualidade, há evidência que o componente humoral é dado pelos fatores de crescimento IGF-1, IGF2 e VEGF que estimulam diretamente o crescimento mandibular. Devido a que o músculo esquelético pode desempenhar uma função endócrina fica aberta a possibilidade que o LPM regule o crescimento do CCM por mecanismos paracrinos ou autocrinos, mediante a secreção desses fatores de crescimento que estimulam diretamente o crescimiento mandibular. O componente mecânico é derivado das observações do que tanto o fluxo sanguíneo na articulação tempo-mandibular quanto a ação da almofadinha retro-discal no crescimento do CCM, dependem parcialmente da atividade contrátil do LPM. Embora, há evidências que o LPM é ativado pelo adiantamento mandibular, ainda não há consenso sob seu possível papel na estimulação do crescimento do CCM. Esta revisão tem o objetivo de discutir as evidencias e limitações de trabalhos relativos ao crescimento mandibular e propõe-se um modelo que integra a informação disponível para explicar a função do IPM no crescimento do CCM.
- Published
- 2013
48. Relaciones entre capilares, fibras musculares esqueléticas y células satélites durante la regeneración
- Author
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Ruz Caracuel, Ignacio, Leiva Cepas, Fernando, Luque Carabot, Evelio, Jimena Medina, Ignacio, and Peña Amaro, José
- Subjects
Regeneración muscular ,Muscle regeneration ,Satellite cells ,Skeletal muscle ,Muscle capillaries ,Células satélites ,Capilares musculares ,Músculo esquelético - Abstract
Introducción: En este estudio se analizan las modificaciones en las relaciones topográficas de los capilares con las fibras musculares y células satélites durante la fase de remodelación de la regeneración muscular. Material y métodos: Los músculos tibial anterior de ratas Wistar, lesionados por inyección intramuscular de miotóxico, fueron analizados a los 5, 7 y 20 días postlesión en microscopía de luz y electrónica. En cortes semifinos teñidos con azul de toluidina fueron analizadas la densidad capilar, densidad de fibras e índice capilar/fibra; sobre micrografías electrónicas se analizaron las distancias de difusión entre capilares-fibras musculares regenerativas y capilares-células satélites, así como el número de células satélites junto a un capilar. Resultados: A los 5 días postlesión la densidad capilar y la densidad de fibras se encontraron significativamente incrementadas así como las distancias de difusión entre los capilares con las fibras regenerativas y células satélites; además sólo un 47% de las células satélites se situaban junto a un capilar. A partir del día 7 postlesión todos los parámetros se aproximaron a los valores controles, normalizándose a los 20 días postlesión. Conclusión: Estos hallazgos indican que al inicio de la fase de remodelación la mayor densidad capilar no parece estar ligada a mayores necesidades de oxigenación de las fibras musculares regenerativas y células satélites Estos resultados están en buena relación con recientes estudios que señalan que bajas concentraciones de oxígeno favorecen la miogénesis., Introduction: This study analyzes the modifications in topographic relations among capillaries, skeletal muscle fibers and satellite cells during the remodeling phase of muscle regeneration. Material and methods: Tibial anterior muscles of Wistar rats were injured by intramuscular myotoxic injection and analyzed 5, 7 and 20 days postlesion under light and electron microscopy. Capillary density, fiber density, and capillary/fiber index were analyzed in toluidine blue semithin sections; diffusion distances between capillaries-regenerative muscle fibers and capillaries-satellite cells, as well as the number of satellite cells beside a capillary, were analyzed on electron micrographics. Results: At day 5 postlesion capillary density and fiber density DF are significantly increased as well as diffusion distances of capillaries in relation to regenerative fibers and satellite cells; moreover only the 47% of satellite cells are beside a capillary. From day 7 postlesion, all the parameters approach normal values, becoming normal at day 20 postlesion. Conclusion: These findings show that high capillary density at the beginning of the remodeling phase is not related to an increase in the oxygenation requirement of regenerative muscle fibers and satellite cells. These results are in good relation with recent studies that point out that low oxygen concentrations contribute to myogenesis.
- Published
- 2013
49. Physical exercise as an efficient intervention in frail elderly persons
- Author
-
Casas Herrero, Álvaro, Izquierdo Redín, Mikel, Universidad Pública de Navarra. Departamento de Ciencias de la Salud, Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila, and Gobierno de Navarra / Nafarroako Gobernua
- Subjects
Aging ,Frailty ,Capacidad aeróbica ,Envejecimiento ,Skeletal muscle ,Serum hormones ,Body composition ,Resistance exercise ,Entrenamiento de fuerza ,Gait speed ,Fragilidad ,Aerobic capacity ,Older adults ,Strength ,Strength training ,Protein synthesis - Abstract
El síndrome de la fragilidad define a los ancianos vulnerables que tienen un riesgo elevado de sufrir eventos adversos. Su fisiopatología y etiopatogenia es compleja, pero actualmente disponemos de medidas sencillas de capacidad funcional para su evaluación. La inactividad física, que frecuentemente asocia el envejecimiento, es uno de los factores fundamentales que contribuye a la aparición de sarcopenia, aspecto central de la fragilidad. Los programas de ejercicio físico multicomponente y, particularmente el entrenamiento de la fuerza, constituyen las intervenciones más eficaces para retrasar la discapacidad y otros eventos adversos. Así mismo, han demostrado su utilidad en otros dominios frecuentemente asociados a este síndrome como las caídas, el deterioro cognitivo y la depresión. Sin embargo, es necesario investigar cuáles son los componentes óptimos de un programa de fuerza en el frágil, así como la óptima relación dosis-respuesta que permita desarrollar guías clínicas específicas de actividad física para este grupo poblacional. Frailty is a state of vulnerability that involves an increased risk of adverse events in older adults. It is a condition with a complex etiology and pathophysiology. At present, there are functional tools for its assessment that are simple and reliable. Physical inactivity is a major risk factor for sarcopenia, a core aspect of frailty. Currently, mulicomponent exercise programs, and especially resistance exercise, are the most relevant interventions to slow down disability and other adverse outcomes. Moreover, these programs are valuable interventions in other frailty domains such as falls, cognitive decline and depression. However, in frail aged patients it is necessary to explore optimal resistance training components and develop specific clinical guides of physical activity for this target population. Este trabajo se ha realizado en parte gracias a los proyectos de investigación del Ministerio de Salud, Instituto de Salud Carlos III, Departamento de Salud del Gobierno de Navarra, Consejo Superior de Deportes y Ministerio de Economía y Competitividad I+D+I (2008-2011) del de España (RD06/013/1003 and 87/2010, 008/EPB10/11 y DEP2011-24105), respectivamente.
- Published
- 2012
50. Oxidative stress in soleus and extensor digitorum longus (EDL) muscles of spontaneously hypertensive rats
- Author
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Hernández, Noelina, De Sanctis, Juan B, Losada, Mercedes, Torres, Sonia H, Sosa, Amparo, and Rivas, Miriam
- Subjects
hipertensión arterial ,arterial hypertension ,sintasas del óxido nítrico ,estrés oxidativo ,oxidative stress ,músculo esquelético ,skeletal muscle ,+[TNF-img/fbpe/ic/v52n3/art05ecalfa.gif"> [TNF-, nitric oxide synthases ,+[TNF-img/fbpe/ic/v52n3/art05ecalfa.gif"> [TNF- - Abstract
Las enfermedades sistémicas crónicas afectan el músculo esquelético, siendo la inflamación y el estrés oxidativo algunos de los mecanismos involucrados. El efecto de la hipertensión arterial esencial sobre el músculo esquelético no es bien conocido. Se estudiaron los músculos soleo y extensor digitorum longus (EDL) de ratas espontáneamente hipertensas (SHR), comparadas con las controles normotensas Wistar Kyoto (WKY). Se determinaron los niveles de nitritos y nitratos en µmoles/mg-proteína; las sintasas del óxido nítrico: endotelial (eNOS); neuronal (nNOS); e inducible (iNOS), nitrotirosina y el factor de necrosis tumoral-alfa (TNF-α) en ng/mg-proteína. En las SHR, en el soleo y el EDL respectivamente, se incrementó la nitrotirosina (24,4 ± 5,0 vs. 3,3 ± 0,3, p
- Published
- 2011
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