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Background: Vitamin D dependent rickets type I is a rare hereditary disease due to a mutation in CYP27B1 encoding the 1α-hydroxylase gene. Clinically, the condition is characterized by hypocalcemic rickets in early infancy due to a deficit in the production of the vitamin D active metabolite 1,25-dihydroxy-vitamin D 3 ., Case Report: We report the case of a patient diagnosed at 11 months with follow-up until 9 years of age., Conclusions: The pathophysiology of the disease and the relevance of early diagnosis and management are discussed., (Copyright © 2015. Publicado por Masson Doyma México S.A.)

A case of a upper extremity pilomatrixoma (calcifying epithelioma of Malherbe) clinically confused with a secondary reaction to the dog antigen application presented in a young woman and diagnosed following surgically excised is presented. On cytologic examination, basaloid cells, multinucleated giant cells and deposits of calcium were identified. Adjacent to the basaloid cells were acellular masses suggestive of ghost cells.

In order to warn the health authorities in our region about the economic damages that a hemorrhagic dengue epidemic may cause, it was decided to study and publish the estimated cost of the Cuban epidemic in 1981, during which 344,203 diseased were reported, 10312 severe cases and 158 deceased. Economic costs include hospitalization expenses, assistance in emergency units, social security, expenses in out-patient treatment, goods not produced and expenses in the anti-vector campaign. Probably, this epidemic which could be controlled in about 4 months, has been the one causing most economic damages to date.