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In a phenomenon as complex as drug dependence there is no doubt that affective and emotional aspects are involved. However, there has been little research to date on these emotional aspects, especially in specific relation to everyday affective stimuli, unrelated to drug use. In this work we investigate whether the consumption of narcotic substances causes changes in the emotional response to powerful unconditional natural stimuli, such as those of a sexual nature. To this end, I.A.P.S. images with explicit erotic content were shown to 84 drug-dependent males, in separate groups according to preferred substance. These groups' results were compared with each other and with the values obtained by non-consumers. The results indicate that drug abusers respond differently to visual stimuli with erotic content compared to non-consumers, and that there are also differences in response among consumers according to preferred substance.