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Background: Self-efficacy is one of the factors that play a role in supporting the mother’s success in giving exclusive breastfeeding (EBF). The low self-efficacy of the mothers can be influenced by intrinsic and extrinsic factors. For three years, the EBF rate in Puskesmas Tanah Kalikedinding Surabaya has not the target reached yet. Aim: This study was conducted to analyze the relationships between intrinsic and extrinsic factors of mother’s self-efficacy in giving exclusive breastfeeding. Methods and Material: Analytic observational study was carried out with the design of cross sectional and quantitative approach. Sampling was done in Puskesmas Tanah Kalikedinding Surabaya by using consecutive sampling method. Interviews were conducted to 54 postpartum mothers by using questionnaires. The independent variables of the study were intrinsic factors including level of education, type of occupation and level of knowledge. Extrinsic factor consisted of the supports from the husband and health officers based on respondent’s perception. The dependent variable was the rate of breastfeeding self-efficacy (BSE) of the mother. The analysis of quantitative data was done by using chi square test. Results: The results show that the majority of postpartum mothers had a high level of self-efficacy in providing EBF. There is a relationship between the mother’s level of education with the mother’s self-efficacy with p = 0.013. Mothers who did not work had higher level of self-efficacy than the working mothers. Mothers with medium and high levels of knowledge had high self-efficacy in giving EBF. However, low self-efficacy mothers were also found among the highly educated ones. The results also show that the low support from the husband was caused by his tendency of giving material supports. Besides, the home visit rate by the health officers only reached 13%. Conclusion: Level of education was the only one factor related to mother’s self-efficacy in giving EBF in Puskesmas Tanah Kalikedinding Surabaya.