1. Tea polyphenols improve glucose metabolism in ceruloplasmin knockout mice via decreasing hepatic iron deposition
- Author
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Lei Ying, Liu Yan, Zhou Huimin, Li Min, Zhang Xiaojuan, Wang Zhanjian, and Zhou Yaru
- Subjects
Tea polyphenols ,CP-/- mice ,iron overload ,insulin resistance ,Polifenoles del té ,ratones CP-/- ,Nutrition. Foods and food supply ,TX341-641 ,Food processing and manufacture ,TP368-456 - Abstract
The present study aimed to investigate the role of tea polyphenols (TP) playing in glucose metabolism in male ceruloplasmin knockout mice (CP−/−), an iron-overloaded model. Compared to wild-type CP+/+ mice, CP−/− mice exhibited hyperglycemia, insulin resistance and excess iron deposition in liver tissue. Increased hepatic oxidative stress (P＜0.05), apoptosis, and reduced gene expression of insulin receptor substrate 2 (IRS2) and glucose transporter 2 (GLUT2) were found in CP−/− mice (P＜0.05). TP treatment may ameliorate hepatic iron overload, oxidative stress and apoptosis, improve insulin sensitivity by upregulating IRS2 and GLUT2 expressions. TP administration could improve glucose homeostasis in CP−/− mice by alleviating hepatic iron-overload, oxidative stress, hepatocyte apoptosis, and restoring insulin signaling pathway.
- Published
- 2022
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