1. [The presence of a psychiatric diagnosis could alter the epigenetic clock in monozygotic twins].
- Author
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Martínez-Magaña JJ, Genis-Mendoza AD, Santana D, Tóvilla-Zárate CA, Lanzagorta N, and Nicolini H
- Subjects
- Aging, DNA Methylation, Epigenesis, Genetic, Humans, Mental Disorders diagnosis, Mental Disorders genetics, Twins, Monozygotic
- Abstract
Background: The acceleration of the epigenetic clock has been associated with a reduction in life expectancy. Individuals diagnosed with a psychiatric disorder have a reduction in life expectancy, and some studies have correlated it with accelerated aging., Objective: The present study aims to explore whether the presence of any psychiatric disorder could accelerate the epigenetic clock in monozygotic twins., Methods: A total of 15 pairs of monozygotic twins were included. Epigenetic age in peripheral blood cells was estimated by previously published algorithms, using the 450K Beadchip microarray., Results: We found that in twins with a diagnosis of a psychiatric disorder, the epigenetic clock could increase compared to their twin without a psychiatric disorder., Discussion and Conclusion: The presence of some psychiatric disorder could accelerate the epigenetic clock in homozygous twins, but studies with larger samples are required to clarify this relationship., (Copyright © 2021 SEGG. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2021
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