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Colorectal cancer (CRC) is a cancer of uncontrolled cell growth in the colon. In Colombia, CRC according to "New global cancer data: GLOBOCAN 2018" ranks fifth with an incidence of 5.6% and a mortality of 7.4%, and in the department of Caldas - Colombia it has an incidence of 16%. This paper presents a narrative review of the literature on synthetic routes and nanoencapsulation, based on the most widely used chemical treatments against CRC, based on selected documents using the keywords: nanoencapsulation + colorectal cancer, synthetic pathways + colorectal cancer, drug + chemotherapy + colorectal cancer and using Scopus and Web of Science. Three drugs were selected whose synthetic routes present fewer stages, with better yields and use of commercially available reagents, of low cost and that do not pollute the environment. This is how the synthesis of 5- fluorouracil and oxaliplatin is described, using chemical products and the synthesis of irinotecan from semi-synthetic products derived from a natural product. Reports were found on nanoencapsulation, which allows the production of nanovehicles with better clinical results, such as polymeric noparticlesontaining 5-fluorouracil, solid lipid nanoparticles encapsulating oxaliplatin, and liposomes encapsulating irinotecan. Finally, it has been reported that the polymeric nanoencapsulation of 5-fluorouracil (5-FU) induces a pronounced reduction in tumor volume; additionally, the use of solid lipid nanoparticles loaded with oxaliplatin decreases its cytotoxicity; and, in addition, irinotecan in its liposomal form decreases tumor growth. [ABSTRACT FROM AUTHOR]

Always have been told that: there is not tiny enemies, this statement couldn't be more true when we are talking about the fight between the body and different pathogen agents, cellular mutations, and dangerous substances. Right now our knowledge allow us to handle the matter at nanoscale (1/1.000'000.000 m) sizes. The nanotechnology develop this knowledge and be able to improve things as new materials, small amount of material to build devices, better performance with maximal efficiency of devices, and others [1], [2]. Using nanotechnology to solve health problems is call nanomedicine [2], [3]. This paper review nanotechnologic develops apply to diseases with high mortality and treatments that doesn't solve the problem deeply they just handle the disease with partial solutions. Therefore, nanomedicine will have greater impact in the future, improving the health issues of humanity. [ABSTRACT FROM AUTHOR]