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BACKGROUND: Nasal T-cell/natural killer cell lymphomas are rare, aggressive neoplasms, predominantly in males, presenting between 40 and 80 years of age. Mexico and Peru are the countries with the highest incidence in Latin America. These lymphomas have an almost exclusively extranodal presentation, the classic presentation involves palatal perforation. The most affected sites in order of frequency are the gastrointestinal tract, skin, and testicles. In the skin, the nasal cavity, nasopharynx and palate are affected. CLINICAL CASE: A 24-year-old female patient began her condition with nasal obstruction, anosmia and epistaxis, later she presented an increase in volume in the region of the right nostril, local pain, as well as fever spikes quantified up to 39°C. The tumor extended to the oral cavity and included the floor of the maxillary sinus, anterior nasal spine and the palate with an ulceration of 1 cm in its anterior portion. The histopathological study of the biopsy reported a nasal-type extranodal T/NK cell lymphoma with extensive necrosis, so it was decided to send her to the Hematology service, where chemotherapy and radiotherapy were given. CONCLUSIONS: Extranodal T/NK lymphomas are a diagnostic challenge that require a high index of clinical suspicion; the differential diagnosis includes other neoplasms, citotósuch as nasopharyngeal squamous cell carcinoma, as well as infectious processes such as fungal. In this patient, mucormycosis was suspected at first, so antifungal treatment was started without response. [ABSTRACT FROM AUTHOR]

A case of nasal plasmacytoma with history of chronic unilateral epistaxis in a twenty-one month old, male, Akita dog, weighing 30 kg is described. Clinical examination and biopsy of the visible tumor in the left nasal cavity were performed. The location and extent of the tumor were determined by head and neck computer tomography. Histopathological and immune-histochemical (IHC) analyses of tumoral tissue were performed. Computer tomography showed a mass with soft tissue density of 10 cm long x 3.5 cm in diameter and low uptake of the contrast medium that entirely compromised the right nasal cavity and part of the rear portion of the left choana. The histopathological analysis revealed the presence of numerous pleomorphic round cells with little cytoplasm, surrounded by a scarce network of connective tissue, and a low mitotic index. The IHC analysis was negative for CD3 and CD20 antigens or T and B lymphocytes, respectively. Clinical and computer tomography findings, such as the results of the histopathology of the tumoral tissue were consistent with a low-grade malignancy extramedular plasmacytoma. [ABSTRACT FROM AUTHOR]