1. La célula B en la patogenia de la artritis reumatoide.
- Author
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Díaz-González, José Federico and Amaro, Iván Ferraz
- Subjects
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B cells , *ANTIGEN presenting cells , *RHEUMATOID arthritis , *IMMUNOGLOBULINS , *ANTIGENS - Abstract
Classically, B-cells have been considered to play a secondary role in the pathogenesis of rheumatoid arthritis, restricted to the production of auto-antibodies. Nevertheless, the unexpected good clinical response that the systemic depletion of B-cells has demonstrated in a well-controlled clinical trial in patients with rheumatoid arthritis has revitalized the interest in this cell type in the pathogenesis of this autoimmune disease. Several evidences suggest that B-cells can regulate the course of the immune response through antibody production independent mechanisms. These mechanisms include antigen presentation and the release of soluble factors such as proinflammatory cytokines, metalloproteinases, and chemokines. This artide reviews experimental data supporting that the participation of B-cells in the pathogenesis of rheumatoid arthritis occurs through multiple mechanisms. [ABSTRACT FROM AUTHOR]
- Published
- 2007