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OBJECTIVE: To show reports on the surgical treatment of vitiligo with melanocytes, the cell culture techniques used and which is the most used technique. METHODOLOGY: PubMed, Ovid, Clinical Trials, Cochrane, and SciELO were searched up to 2021 for human clinical studies in patients with vitiligo, comparing the efficacy of melanocyte transplantation. We used the keywords "vitiligo" AND "transplantation". The Cochrane risk of bias tool was applied for quality assessment. RESULTS: Five hundred fifty-seven articles were found. We excluded 497 studies, only 8 studies met the inclusion criteria. CONCLUSIONS: Autologous cell transplantation from cultured melanocytes is an effective treatment, but is limited by its invasive feature. More standardized clinical trials are required to assess repigmentation following cell transplantation. [ABSTRACT FROM AUTHOR]

Vitiligo is the most common acquired skin depigmentation. It is characterized by acromic macules that affect the self-image of patients and negatively impact their quality of life. Among the theories about the etiopathogenesis of vitiligo, is autoimmunity. Vitamin D deficiency has been demonstrated in numerous autoimmune diseases. Vitamin D is an essential hormone with pleiotropic effects, and especially antiapoptotic functions and modifiers of the proliferation and differentiation of melanocytes. Hypothetically, it can play a coadjuvant role in the repigmentation of vitiliginous lesions. The immunoregulatory activity of vitamin D could be used in the treatment of vitiligo. Next, there is a review of the subject on vitiligo, its relationship with the concentrations of vitamin D and the influences that could have on the physiopathology. In addition, its possible use as a therapeutic tool for vitiligo is analyzed. The behavior of vitamin D levels in deficiency and insufficiency ranges between vitiligo patients and healthy controls are controversial, some show lower levels in the vitiligo group and others do not show differences between the groups. Despite the above, recent studies suggest a relationship between vitamin D insufficiency in patients with vitiligo and a higher risk of suffering from other autoimmune diseases and that the use of high doses of vitamin D in patients with vitiligo could improve the repigmentation. The information reviewed allows us to conclude that the relationship between vitiligo and vitamin D levels requires more studies to clarify its role in immunopathogenesis and the likelihood of recommending its therapeutic use. [ABSTRACT FROM AUTHOR]

Vitiligo is an adquired pigmentary disorder of unknown etiology clinically characterized by a variable distribution pattern of achromic macules that are due to the absence of functional melanocytes in the epidermis. There are multiple therapeutic options and the goal is to achieve the best clinical outcome with the least adverse effects. Nowadays, evidence points out that narrow band UVB phototherapy is the treatment of choice in patients with moderate to severe vitiligo. In this review we will discuss the different treatment options in vitiligo based in the best evidence with special attention on phototherapy. [ABSTRACT FROM AUTHOR]

Vitiligo is defined as an acquired, chronic, pigmentary disorder characterized by white macules that usually increase in size over time. These correspond to an epidermal melanocyte loss of function, and in some cases, to those in the hair follicle. The worldwide prevalence is of 0.5 to 2%, affecting all races and men and women equally. Multiple theories that try to explain the pathogenesis of the disease have been proposed, among them, biochemical, neural and autoimmune hypothesis, the latter being the most popular. The different theories may converge to contribute to melanocyte loss, supporting a multifactorial etiology referred to as the convergence theory. The diagnosis is clinical and may be aided by the use of Wood's lamp. We have a great quantity of treatments available that bear advantages and disadvantages, but none with 100% effectiveness in all patients. [ABSTRACT FROM AUTHOR]