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Objective: was to select quinoa accessions as possible positive reaction differentials to mildew that identify the variability of Peronospora Variabilis Gaum as a pathogen collected in five departments and evaluated in Cusco. Material and methods: mildew samples were collected from the altiplano (Puno), inter-Andean valleys (Cusco, Apurímac, Ayacucho), and coast (Arequipa), obtaining 175 mildew samples. The installation of the experiment was with 100 accessions of quinoa from the Germplasm Bank of EEA Andenes in cultivated fields during two productive campaigns. For its evaluation, quinoa descriptors were used and agronomic characteristics, yield, reaction to mildew (P. Variabilis), ALJDPC (area under the disease growth curve), and saponin percentage were evaluated. In addition, virulence tests and severity evéduations were performed after inoculating quinoa accessions with mildew in the greenhouse. Results: the morphoagronomic evaluation allowed selecting the following genotypes cis possible differentials with a positive reaction to mildew: RR.GG.41 for isolates from Ayacucho, RR.GG.09 for isolates from Apurímac, RR.GG. 16 for isolates from Apurímac and Arequipa, RR. .GG.57 for isolates from Puno and Apurímac, RR.GG.26 for isolates from Ayacucho and Apurímac, RR.GG.38 for isolates from Cusco cind Arequipa RR.GG.43 for isolates from Puno cind Arequipa, RR. GG .76 for isolates from Cusco and Arequipa and the quinoa accessions RR.GG. 11, RR.GG.22, RR.GG.55, RR.GG.64 for the 142 isolates obtciined from the 175 samples of the five departments Conclusions: the identification of twelve possible differential plants allows knowing the variability of the pathogen in the coastal, inter-Andean, and high plateau valleys. [ABSTRACT FROM AUTHOR]