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Background: Weber-Christian disease is a recurrent, non-suppurative, febrile nodular panniculitis, more frequent in young women. It is characterized by recurrent outbreaks of subcutaneous nodules, distributed symmetrically. It has an idiopathic origin, or it is secondary to pancreatic disease, physicochemical agents or alpha-1 antitrypsin deficiency. It can affect any tissue with body fat. Histologically is a lobular panniculitis without vasculitis. Case report: 23-year-old woman. She was admitted with subcutaneous painful nodules in pelvic, gluteus and forearms, with erythematous and hyperpigmented plaques; ecchymosis in the right upper eyelid and bilateral hyposphagma; fever of 38 °C; diaphoresis and oral ulcers, not painful. The hemogram showed pancytopenia, elevation of acute phase reagents, amylase and normal lipase. Blood culture was negative. Antinuclear antibodies and complement were normal. Computed tomography of the abdomen showed disseminated hyperdensity in subcutaneous tissue. The biopsy showed lobular panniculitis without vasculitis compatible with Weber-Christian panniculitis. The patient was treated with steroids and immunosuppressive therapy. Conclusions: Infectious etiology and other causes of erythematous nodules were ruled out through clinical evolution and complementary studies. The patient presented spontaneous involution in several weeks and sometimes the lesions evolved to sterile abscesses, in addition to systemic clinical manifestations. Corticosteroid therapy was deemed successful. [ABSTRACT FROM AUTHOR]

Sarcoidosis is a multiorgan systemic disease characterized by non caseating epithelioid-cell granulomas in all or several organs that may cause loss of function and fibrosis. Skin involvement occurs in about 25% of cases and represents a dermatologic masquerader with a wide range of clinical presentation -classified as specific and non-specific skin lesions-. The clinical diagnosis may be complex due to the intermitent inflamation on the affected organs and should be verified through histopathologic and imaging compatible studies. We report a challenging case with cutaneous involvement. [ABSTRACT FROM AUTHOR]

An observational and descriptive study of 50 patients with reactional states of leprosy, admitted in the Dermatology Service of "Dr. Juan Bruno Zayas Alfonso" Teaching General Hospital in Santiago de Cuba was carried out during the five year period 2009-2013, in order to characterize them according to some clinical and epidemiological variables, for which the calculation percentage and the Pearson correlation test of were also used. The male sex (56.0%), the age group 30-49 (48.0%) and the clinical variety dimorpha lepromatous (40.0%) prevailed in the series; it was also observed that the reactional states appeared mainly after the treatment (64.0%), in general with just one episode (58.0%), and that the reversion reaction was more common (32.0%), with a higher frequency in the severe type (69.0%). [ABSTRACT FROM AUTHOR]

Relapsing polychondritis is a disease of unknown etiology characterized by episodic inflammation of cartilaginous tissues. More rarely, it has been described as a paraneoplastic phenomenon mainly associated with myelodysplastic syndromes or other haematologic diseases. We present a case of relapsing polychondritis associated to low degree lymphoplasmocytic lymphoma whose picture was punctuated by cutaneous erythema nodosum and anterior uveitis. The clinical evolution was satisfactory with glucocorticoids and rituximab treatment. [ABSTRACT FROM AUTHOR]