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Chronic liver disease is one of the main public health problems, with a global prevalence of approximately 45% and mainly affects patients with diabetes and obesity. The aim of the study is to identify liver tests as diagnostic aids for liver disease. Adults over 50 years of age in Latin America. Methodology The type of research is descriptive and systematic documentary, and for its implementation the bibliographic search of indexed scientific articles from reliable sources such as PubMed, Elsevier, Scielo, Redalyc, Google Scholar, Microsoft Academic was selected. The results obtained at the time of this publication show that hepatitis is one of the most frequently occurring diseases in the studies investigated, and increased mortality from liver disease has also been observed worldwide. Evidence suggests that one of the most common risk factors for developing liver disease in older adults is a family history of hepatitis C, followed by sociodemographic factors. [ABSTRACT FROM AUTHOR]

Objective: To determine the enzymatic biochemical parameters (glutamic pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST), alkaline phosphatase (ALP), gamma glutamyltransferase (γ-GT), and lactate dehydrogenase (LDH)) in children with acute lymphoblastic leukemia (ALL) before cancer treatment. Material and Methods: A prospective experimental, observational, cross-sectional study was conducted in 30 children between 2 and 15 years old, from several Neoplastic Centers in Lima. Blood collection was performed in BD red cap Vacutainer tubes, processed in the semi-automated analyzer BIOTEC® EMP-168, with Wiener Lab Group enzyme reagents under the modified method Szaaz and UV-Optimized by IFCC, SSCC and SFBC. Finally, coding and tabulation was performed. Results: 60% were boys and 46.7% are between the ages of 2-6 years. Serum levels of AST were increased by 33.3% in boys and 50% in girls. Serum ALT values were increased in 33.3% of boys and 41.7% of girls; only 25% of girls showed increased levels of γ-GT values; ALP was increased in 44.4% of boys and 66.7% of girls. Moreover LDH levels were increased in 55.6% of boys and 41.7% of girls. Conclusion: The enzymatic tests LDH, AST, ALT and ALP are increased in children with ALL compared to normal values due to tumor lysis syndrome characterized by electrolyte abnormalities, and as a result of the massive destruction of tumor cells and rapid release of large amounts of intracellular elements. [ABSTRACT FROM AUTHOR]