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INTRODUCTION: One of the most common endocrinological diseases in pregnant women is autoimmune thyroid pathology. It is associated with important maternal, fetal and neonatal complications. OBJECTIVE: To describe the characteristics and impact of maternal autoimmune thyroid disease in newborns. MATERIALS AND METHODS: Observational, longitudinal, descriptive and retrospective study of 200 newborns who's mothers suffered from autoimmune thyroid pathologies for the period spanning from January 2019 to December 2020. RESULTS: 6.64% had autoimmune thyroid pathology. 66.5% presented autoimmune thyroid disease prior to pregnancy and with a diagnosis of hypothyroidism in 83.5%. 33.5% developed thyroid alteration during pregnancy, with a diagnosis of hypothyroidism in 97%. The mean value of maternal hormones was: median TSH: 3.14 mIU/ml; mean T4: 0.79 ± 0.17 ng/dl. In neonates the mean hormone levels at 15 days of life were: TSH: 4.16 ± 2.26 mIU/ml; T4: 1.2 ± 0.19 ng/dl. Three patients (children who's mothers had autoimmune hypothyroidism) were diagnosed with congenital hypothyroidism. CONCLUSIONS: The implementation of a standard actuation protocol, complementary to neonates screening, becomes necessary. [ABSTRACT FROM AUTHOR]

Chronic spontaneous urticaria is a condition that persists for more than six weeks, it occurs in the absence of an identifiable triggering factor and from the pathogenic activation of mast cells and basophils. The possibility of autoimmune etiology in up to 40 % of patients is presented, followed by subclinical infections and psychological factors. Two main mechanisms of the pathogenesis of chronic urticaria have been proposed: the former is the dysregulation of intracellular signaling pathways within mast cells and basophils, which leads to defects in the traffic or function of these cells. The latter is the development of autoantibodies against FcεRIα or IgE, in both mast cells and basophils. Numerous autoimmune diseases such as systemic lupus erythematosus, polymyositis, dermatomyositis, and rheumatoid arthritis have been associated with chronic urticaria; however, autoimmune thyroid disease deserves a special mention. A higher prevalence of antithyroid antibodies has been found, regardless of thyroid function (euthyroidism, hypo and hyperthyroidism) in patients with chronic spontaneous urticaria. Several infections have been linked to chronic urticaria. The best evidence is for Helicobacter pylori infection. Finally, stress is associated with the onset of the disease through the activation of the sympathetic and adrenomedullary system and the hypothalamic-pituitary- adrenal axis. Diagnosis may vary in different regions of the world, but the common feature is the completion of a thorough medical history. [ABSTRACT FROM AUTHOR]

Copyright of Revista Latinoamericana de Hipertension is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Autoimmune polyglandular syndromes are rare conditions characterized by the coexistence of at least t wo autoimmune glandular diseases. They can be classified in type 1 (or juvenile) and type II and III (or adult). Type 2 or Schmidt's syndrome is characterized by Addison's disease, autoimmune thyroid disease and/or type 1 diabetes mellitus and may be associated with other disorders of autoimmune nature, such as vitiligo, autoimmune hepatitis, myasthenia gravis, pernicious anemia, celiac disease or alopecia areata, among others. We communicate the case of a 61 year-old woman with vitiligo diagnosed with Addison's disease and Hashimoto's thyroiditis (Schmidt's syndrome). [ABSTRACT FROM AUTHOR]

Objective: To describe the clinical characteristics, thyroid function profile and autoimmune markers in patients with Graves' disease (GD) treated at the endocrine service of a general hospital. Material and methods: Descriptive and retrospective study in patients with GD treated at the Hospital Nacional Cayetano Heredia during 2005, identified in the Daily Registry of Attention and Other Activities of the Endocrine Service. For statistical analysis, SPSS software was used. Results: We reviewed 111 medical charts. The mean age was 40.6 ± 14 years. 71.2% were women. Twenty three patients (20.7%) reported familial history of autoinmune disease. The mean time of disease was 18.9 ± 30.4 months before diagnosis. The most frequent symptoms were: tremor, thin skin, palpitations and weight loss. The mean thyroid weight was 69 ± 27.5 grams. In 38.7% exophthalmos was present and 18.9% had myxedema. Hormonal profile showed suppressed TSH, elevated levels of free T4 and total T3. In 8.6.7% autoantibodies against thyroid peroxidase (anti-TPO) were positive. The initial treatment included thionamides in 95.5% of patients. Further statistical analysis showed that women had more frequent familiar history of autoinmune thyroid disease than men (,27.8% vs. 9.4%) (p = 0.04). Conclusions: Most of our patients with GD were women between third and sixth decade of life. The estimated weight of the thyroid gland was three times the normal weight and ophthalmopathy and myxedema were frequent, Most of our patients had positive autoimmune markers and the initial treatment included thionamides. [ABSTRACT FROM AUTHOR]

Autoimmune poliglandular syndrome is an infrequent pathology that is characterized by the coexistence of two or more endocrine insufficiencies due to an autoimmune mechanism. We present a patient with autoimmune poliglandular syndrome type IIIc, who presents with autoimmune thyroid disease, vitiligo, and diabetes mellitus type i. [ABSTRACT FROM AUTHOR]