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Neurologists have not found brain pathological or radiological lesions that can explain any of the phenomena that occur in migraine. Magnetic resonance imaging (MRI) can detect hyperintensity signals in the white matter and infarct-like lesions more frequently in brains of people with migraine than in healthy people, but these alterations are not pathognomonic of migraine. However, the programs of post-processing of MRI images acquired in tensor-diffusion are discovering subtle alterations in the brain of people with migraine that do not appear in healthy people: (i) alterations in density, surface, and thickness of the cerebral cortex in cortical morphometric studies; (ii) white matter anisotropy alterations; (iii) alterations of connectivity; and (iv) iron deposits. The regions of greatest interest in the network of the pain are: (i) pain perception: cortex somatosensory, thalamus; (ii) modulation of pain: brainstem; and (iii) processing of pain: posterior parietal cortex, insula, thalamus, amygdala, prefrontal cortex, anterior cingulate cortex, etc. The old dogma of neurology that the brains of people with migraine present no alterations is wobbling. Here we present an update of the application of biomedical engineering in the study of the brain of people with migraine. [ABSTRACT FROM AUTHOR]