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Introduction: Deep brain stimulation represents a surgical alternative in patients with advanced Parkinson's disease who present progression of motor symptoms, drug resistance or evident adverse effects with the consequent improvement in function and quality of life. Objectives: To evaluate the effect of deep brain stimulation in the subthalamic nucleus on the motor symptoms of patients with Parkinson's disease according to section III of the pre- and postoperative UPDRS scale. Material and methods: An observational, descriptive, longitudinal, ambispective study was carried out, including 21 patients in whom a baseline preoperative evaluation was performed UPDRS OFF and a postoperative evaluation at 12 months UPDRS ON. To compare the measurements, it was used according to the distributions of the data with the Mann-Whitney-Wilcoxon U test with respect to the UPDRS, considering a statistical signiicance of p < 0.05. Results: The average age was 64.0 ± 10.49 years, with an average symptom evolution of 8.76 ± 3.56 years. Deep brain stimulation in the subthalamic nucleus showed a reduction in motor symptoms at 12 months UPDRS ON with respect to baseline measurements UPDRS OFF 23.19 ± 16.18 vs 47.42 ± 20.82 p < 0.001. Conclusions: Cerebral stimulation of both hic.org.mx subthalamic nuclei represents an effective intervention in the surgical management of patients with Parkinson's disease severely affected by signiicantly reducing motor symptoms. [ABSTRACT FROM AUTHOR]