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A key aspect in the study of regional disparities in Mexico is the potential leveling of economic and spatial inequalities. That original concern is associated with the sharpening of regional antagonisms and the generation of focuses of political and social tension. In this respect, a special interest exists to understand the spatial heterogeneity, i.e., as certain processes differ between regions and to what extent the spatial units —states, municipalities, cities, regions, etc —could mutually influence the adoption of certain social and economic practices, thus conditioning their dynamic response within the regional system. The analysis of these issues has been diluted in the literature under current methodological and theoretical biases. Although several studies in Mexico reflect a concern for spatial change, big lags exist due to a lack of consideration for spatially explicit methods of data analysis. [ABSTRACT FROM AUTHOR]