The development of treatment of HIV/AIDS infection and its administration imply a great cost to public and private health systems, therefore, it is very important to insist on prevention as a measure of control of the problem. In this aspect of prevention, sexual behavior has an important role and may be divided into a planned and controlled sexual conduct (condom use, monogamy) and an impulsive and irresponsible one (non-safe sex). In order to avoid risky sexual behavior, it is important how able (self-efficacy) a person is to control and plan his/her sexual conduct. Objective: To show some differences between men and women, in teenagers from health centers, about self-efficacy in sexual behavior to prevent AIDS; the attitude towards the condom's use, planning of sexual relations and monogamy, satisfaction with information about sex and its main source, as well other variables of sexual conducts. Material and methods: A self-administered questionnaire was used, it was integrated by Self-Efficacy Scale for AIDS by Kasen, Vaughan and Walter (1992) with a scale of 22 questions. This scale has been adapted to Spanish and has been studied first by Ochoa, Sayés and Villamarinin 1995 and then by López Rosales, et al, 1999, modified to 27 elements (SEA-27) by Lopez Rosales and Moral de la Rubia; more 23 questions about important aspect of sexual behavior related to HIV transmission. This study was co-relational with a non-experimental design of transversal type. It was performed in a non-probabilistic sample of incidental type of 962 teenagers from 58 public health centers in Monterrey. Results: in women the age of sexual relations' beginning is 15 years and in men, 13 years, 74% of both groups say that their first relation was at home: 76% do not use condom; before 18 years old men have, or average, three sexual partners and women, two. Conclusions: In programs of AIDS prevention, women should develop a higher assertively to request the condom use. Men should develop a higher consciousness of the danger of the disease transmission when they commit risky behaviors, as well as reflect on the attitude of "taking advantage of" any opportunity of sexual contact without caring whether it is of high risk or not. [ABSTRACT FROM AUTHOR]