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The eccrine porocarcinoma (EPC) is a cancer of the sweat glands in the skin, with a diverse clinical presentation that includes plaques, ulcerated nodules, and polypoid lesions. Symptoms may involve itching, pain, and inflammation, in addition to signs of malignancy such as ulcers, bleeding, rapid growth, or pain. Histopathology shows the proliferation of atypical cells with malignant features, including pleomorphism and nuclear hyperchromasia. It can metastasize to distant organs, with common sites being bone, bladder, retroperitoneum, among others. Survival depends on the tumor size, with worse prognosis for tumors larger than 4 cm. The primary treatment is surgical removal, especially in early stages, with lymph node dissection in cases of involvement. Mohs micrographic surgery is used for localized cases. Radiation therapy and chemotherapy may be options in cases of metastasis or recurrence. Long-term follow-up is crucial, and ongoing research is needed to improve treatment strategies. [ABSTRACT FROM AUTHOR]

The mammary glands are modified compound branched tubulo-alveolar sweat glands; whose main function is milk production. They are much more developed in women, and in men they are in a rudimentary state. Breast development begins in the 5th week of intrauterine development by an ectodermal thickening from the armpit to the groin and, by the sixth/seventh week, it condenses to a single pair of mammary ridges. At birth, the glands consist of a series of inactive ducts. At puberty, under the influence of estrogen and progesterone, acini are developed form terminal ducts. It is during pregnancy where the functional differentiation of the gland takes place to prepare the alveoli for lactation. The mammary glands are composed of 15 and 20 ducts (galactophores) that emerge from the nipple, and towards the depth of the mammary tissue they form the terminal duct-lobular unit composed of terminal ducts and acini. The ducts and acini are covered by a luminal cubic epithelial layer and a basal/myoepithelial layer. Understanding embryonic development, anatomy, physiology, and hormonal regulation of the breast is essential to understand the normal function of this organ, and to adequately interpret benign and malignant processes. [ABSTRACT FROM AUTHOR]

The article titled "Frequency of the F508del Mutation in the CFTR Gene Associated with Cystic Fibrosis in Individuals from the Quindío Department, March to October 2020" analyzes the prevalence of the F508del mutation in the Quindío region, Colombia. Cystic fibrosis is a genetic disease that affects the airways, pancreas, and sweat glands. The study aims to determine the frequency of this mutation in individuals from Armenia, Quindío, during the period from March to October 2020. The results showed that none of the participants had the F508del mutation, indicating that the frequency of the mutation in the studied population is zero. The article highlights the importance of early diagnosis of cystic fibrosis and the search for effective molecular tests to improve neonatal screening and therapeutic options. [Extracted from the article]

Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Tubular adenoma is a benign sweat gland tumor. It consists of a benign dermal nodule with dilated ducts, with size variation and lined by two or more layers of cuboidal and columnar epithelial cells that project unto the lumen in a papillary pattern. CLINICAL CASE: 73-year old female patient, who presented a exophytic skin lesion on the lateral side of the right ankle, with a ten-year evolution, along with an occasional pruritus. The lesion was extirpated with a clinical diagnosis of verruca vulgaris and histopathologically diagnosed as a tubular adenoma. One year after of surgery the patient is in good health, without recurrence or symptoms of the disease. CONCLUSIONS: The epidermis presented histopathological changes similar to a common wart, this being an uncommon presentation in a tubular adenoma. Tubular adenoma is a rare tumor, this one being the first reported in Mexico. [ABSTRACT FROM AUTHOR]

Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mucinous carcinoma is a rare malignant entity of the eccrine glands, first described in 1952. It is a slow growth tumor, characterized by the production of mucin in the tumor islets. It is described as asymptomatic nodules located on the head, neck, around the eyelids and on the scalp that may relapse over time. The treatment of choice is surgical resection. There is no standardized surgical approach but the resection with 1 cm margins and Mohs surgery are frequently used. We present the case of a man who presents with a chronic multilobulated lesion in the external ocular angle after being treated with surgical resection, indicating relapse. The patient is diagnosed with a biopsy that shows a histopathologic pattern characteristic of mucin. Work up rules out metastatic involvement and surgical management of deferred Mohs is performed. [ABSTRACT FROM AUTHOR]

This is a 54-year-old patient who started with an injury to the vulva at the level of the scar of the raffia for about four years, which evolves and abscess, what has been treated several times, without improvement, so it continued with bleeding and pain in the region of the vulva. He decided to go to the Gynecological Consultation of the Mariana Grajales Hospital of Santa Clara, and she was diagnosed with a lesion in the vulvar fork of 3 cm, raised, with indurated and ulcerated edges. The clinical characteristics of the lesion are resolved in the Gynecology Room and a vulvectomy is performed with bilateral inguinal lymphadenectomy. The histological diagnosis consisted of a syringocistadenocarcinoma of the ulcerated infiltrating papillary vulva. Syringocistadenocarcinoma papilliferum is a malignant tumor derived from the sweat glands extremely infrequent. It is located, predominantly, in the head and neck and may develop a papilliferous syringocistadenoma or a sebaceous neva of Jadassohn; Its location in the vulva is uncommon. [ABSTRACT FROM AUTHOR]

Copyright of Revista Salud UIS is the property of Universidad Industrial de Santander and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to describe the clinical-pathological characteristics of the cases of Eccrine Porocarcinoma (EP) found in the Instituto Nacional de Enfermedades Neoplásicas (INEN), a cross-sectional study was carried out, including all EP cases recorded between 1998 and 2009. A revision of the clinical-pathological records identified and a new reading of the pathology slides of the cases found were performed. 19 EP cases were found, the median age of which was 64 years (range: 37-98). EP was primarily found on male patients (57.9%) and was most commonly located on the foot (21.1%), followed by the head, thorax and thigh (15.8%, respectively). In one case, EP was located on the gluteal region, and showed an unusually invasive behavior and rectal involvement. We conclude that EP is a rather uncommon entity in Peru. Its most common location is on the foot and it affects mostly male patients for the most part. [ABSTRACT FROM AUTHOR]

The eccrine porocarcinoma is a malignant tumor of sweat glands, which is somewhat unusual; it can be developed as a primary tumor or by the transformation of a benign eccrine poroma. It mainly affects lower extremities and is usually portrayed as a partly ulcerated or verrucous polypoid tumor. We communicate two cases with a diagnosis of eccrine porocarcinoma. The first-one was a 54-year-old male with a skin disease located in pubis, consisting of a infiltrated plaque, well defined with an evolution of eight years. The second case corresponded to a 94-year-old female with an exophytic lesion in buttock with evolution of three months. In both cases the histopathological study revealed accumulation of malignant cells with an invasive pattern, ductal and eccrine differentiation with cytologic pleomorphism corroborating the diagnosis of eccrine porocarcinoma. We also carried out immunohistochemistry staining. In both patients the treatment was surgical removal. [ABSTRACT FROM AUTHOR]

Eccrine poroma is a benign tumor that can be a pitfall in the diagnosis of malign tumors including melanoma. Dermoscopy is a useful technique in the discrimination of numerous benign and malign tumors, and even the characteristic vascular pattern of eccrine poroma has not been established yet, there are some vascular patterns that can be of value in distinguishing it. We report five cases where we found these patterns. [ABSTRACT FROM AUTHOR]

Malignant nodular hydradenoma, or clear cells hydradenocarcinoma, is a rare anexial tumor arising from transformed ecrine sweat glands. This tumor has a similar histological appearance of a nodular benign hydradenoma; it is more frequently found in the armpit, the head and neck of subjects older than 40 years age. Appears as a single mass and rarely as multiple neoplasias. Immuohistochemically these tumors are reactive to keratin, EMA, CEA, S-100 proteins and vicentin. Clinical case: A male 52 years old patient with a history of previous right hand spiroadenoma complained about a tumor located in his right armpit. Physical examination revealed a 6 x 8 cm painless mass at the right armpit adhered to deep tissues with irregular borders. A biopsy of the lesion was taken that revealed at the dermis neoplasic cells originated from skin cells, showing ecrine differentiation. The lesion presented coalescent Iobules surrounded by a fibrous capsule of hyaline appearance and trabecules extending between the lobes. Immunostaining resulted positive to CEA, P63 and QAE/AE3 staining for neoplasic cells. The patient underwent a surgical procedure and 10x10 cm white-brownish soft tumor was excised, together with local lymphatic ganglia at levels I,II, III; pectoralis minor resection and careful preservation of the Iongus thoracic nerve. Anatomical pathology showed methastatic undifferentiated malignant cells. [ABSTRACT FROM AUTHOR]

Clear cell hydradenoma or nodular hydradenoma is an eccrine sweat gland benign neoplasm that grows more frequently in the head and can be morphologically variable. We present the case of a 44 year-old woman with a hemispheric neoplasm in the head. The histopathological diagnosis was a clear cell hydradenoma. [ABSTRACT FROM AUTHOR]

The hidradenoma is a rare adnexal tumor, and its histogenesis is uncertain, because although initially attributed eccrine origin, confirmed by enzymatic findings, recent reports have described the decapitation secretion in tubular differentiation areas, which would result in some cases of apocrine differentiation. It is often located on the face, neck and trunk. It grows slowly and is usually asymptomatic. Although it often occurs in middle-aged women, there are reports in the literature with a wide age range from 3 to 93 years and it has a low incidence of developing malignancy. We report the case of a woman with a hidradenoma. [ABSTRACT FROM AUTHOR]

We report a case of a 32 year-old woman, who consulted to present for 6 months and multiple and itchy nodules in both labia majora, itching that was exacerbated during menstruation. The pathological study showed a dermal proliferation of small ducts lined by a double layer of normotipic cuboidal cells, and surrounded by a fibrous stroma compatibes a syringoma. [ABSTRACT FROM AUTHOR]

A case of an eccrine poroma is described in a 77 year-old patient with a painful lesion on his right foot, with easy bleeding and limitation for deambulation. Histology reported eccrine poroma. A review of current literature is made. [ABSTRACT FROM AUTHOR]