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Introduction: primary cutaneous B-cell lymphoma is a rare neoplastic proliferation of immunophenotype B lymphocytes; its pathogenic mechanisms are unknown. Patient information: a 77-year-old male patient is presented, who approximately three months ago started with erythematous-violaceous, infiltrated, multifocal plaques, located on the posterior trunk, in addition to a violaceous tumor, with neoformation vessels on its surface, which was accompanied by weight loss. He was evaluated multidisciplinary and after biopsy of the lesion and staging studies it was concluded asDiffuse lymphoma of primary cutaneous large B-cell. Polychemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone and monoclonal antibody: rituximab was indicated as treatment, with favorable evolution. Conclusions: this disease, even being unfrequent, with a good prognosis and relatively easy therapeutic management, should be suspected and diagnosed in time; the connotations that its diagnosis and treatment imply for the patient should not be forgotten. [ABSTRACT FROM AUTHOR]

Mycosis fungoides and Sezary syndrome are part of the heterogeneous group of cutaneous T-cell lymphomas. To date, the specific event that precipitates malignant transformation has not been exactly known, nor have the events that divert localized disease to leukemoid forms. With the advances in the study of microRNAs -small fragments of RNA that fulfill post-transcriptional regulatory functions- and the recognition of their participation in the pathophysiology of hematological and solid malignancies, studies that seek to determine the role of the aberrations of her expression have multiplied. This review aims to summarize some of the microRNAs, such as miR-21, miR-22, miR-155, miR-181 and miR-214, their functions and their possible utility for the diagnosis and staging of these types of cutaneous lymphomas. [ABSTRACT FROM AUTHOR]

Mycosis fungoides and the Sèzary syndrome are the most frequent cutaneous T-cell lymphomas; they have a slowly progressive course and impact negatively the quality of life of patients. In early stages, healing is anecdotal and in advanced cases they may compromise patient's life. Current treatment options reduce the symptoms and achieve temporary remission. For early stages we propose the use of therapies targeted to the skin as topical steroids, PUVA photochemotherapy, and localized radiation therapy, and others not available in our environment such as chemotherapy and topical bexarotene, and for more advanced stages, combined therapies aimed to the skin with systemic therapies such as alpha interferon, and chemotherapy vorinostat. [ABSTRACT FROM AUTHOR]

The most frequent types of cutaneous T-cell lymphomas (CTCL) in the practice of dermatology are mycosis fungoides and Sézary syndrome. It is important for the clinician to be acquainted with the initial management in a patient with the diagnosis of cutaneous T-cell lymphoma in order to make a proper staging and begin the correct treatment. We review the different laboratory and imaging studies to be done. We also review the different therapeutic options such as topic and systematic treatments, their indications, side-effects and doses. At present, modifiers of biological response offer an alternative in the management of these patients. [ABSTRACT FROM AUTHOR]

Congenital ichthyosiform erythroderma is a rare congenital disease, inherited in an autosomal recessive fashion, characterized by a global hyperkeratinization over erythroderma. It has been associated to other manifestations, such as ectropion, eclabium and syndactyly. The case of a male newborn with clinical characteristics compatible with the disease is presented. Symptomatic management with the topical application of emollients and the systemic treatment with oral retinoids is also discussed [ABSTRACT FROM AUTHOR]