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Copyright of Anuario Calderoniano is the property of Anuario Calderoniano and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Diablotexto Digital is the property of Diablotexto Digital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

La fibrosis pulmonar idiopática (FPI) es una enfermedad pulmonar intersticial de carácter mortal. Estudios recientes han identificado el papel clave de la interacción entre las células epiteliales, mesenquimales, inmunitarias y endoteliales desreguladas en la FPI. Además, algunas mutaciones genéticas y ciertos factores ambientales (por ejemplo, el tabaquismo) se han asociado con el desarrollo de la FPI. Con el reciente desarrollo de la tecnología de secuenciación, también se ha señalado que la epigenética, como vínculo intermedio entre la expresión genética y los impactos ambientales, está implicada en la fibrosis pulmonar. Aunque se desconoce la etiología de la FPI, en los últimos años han surgido blancos y agentes terapéuticos novedosos para el tratamiento de la FPI, y el éxito del lanzamiento de la pirfenidona y el nintedanib ha demostrado que la terapia contra la FPI tiene un futuro prometedor. Por lo tanto, nuestro objetivo es conocer en profundidad los mecanismos moleculares subyacentes y los factores patogénicos de la FPI, lo que sería útil para el diagnóstico de la FPI, el desarrollo de fármacos antifibróticos y un mejor pronóstico para los pacientes con FPI. En este estudio resumimos el mecanismo patogénico, los blancos terapéuticos y los ensayos clínicos considerando múltiples tipos de células y mutaciones genéticas, así como factores epigenéticos y ambientales. [ABSTRACT FROM AUTHOR]

Objective: Small intracranial aneurysms are increasingly being detected; however, a prediction model for their rupture is rare. Random forest modeling was used to predict the rupture status of small middle cerebral artery (MCA) aneurysms with morphological features. Methods: From January 2009 to June 2020, we retrospectively reviewed patients with small MCA aneurysms (<7mm). The aneurysms were randomly split into training (70%) and internal validation (30%) cohorts. Additional independent datasets were used for the external validation of 78 small MCA aneurysms from another four hospitals. Aneurysm morphology was determined using computed tomography angiography (CTA). Prediction models were developed using the random forest and multivariate logistic regression. Results: A total of 426 consecutive patients with 454 small MCA aneurysms (<7mm) were included. A multivariate logistic regression analysis showed that size ratio (SR), aspect ratio (AR), and daughter dome were associated with aneurysm rupture, whereas aneurysm angle and multiplicity were inversely associated with aneurysm rupture. The areas under the receiver operating characteristic (ROC) curves (AUCs) of random forest models using the five independent risk factors in the training, internal validation, and external validation cohorts were 0.922, 0.889, and 0.92, respectively. The randomforest model outperformed the logistic regression model (p = 0.048). A nomogram was developed to assess the rupture of small MCA aneurysms. Conclusion: Randomforestmodeling is a good tool for evaluating the rupture status of small MCA aneurysms and may be considered for the management of small aneurysms. [ABSTRACT FROM AUTHOR]

In this study, we investigate the mediating effects of children's Internet use on the relationship between family socioeconomic status and their academic achievement, and whether the mediating effects vary across different academic subjects. We used the data from the China Family Panel Studies on the socioeconomic status of children's families, children's Internet use, and their academic performance. In the 2014 sample, there were 2,686 participants (females=1,272). In 2016, there were 2,330 participants (females=1,069), and in 2018, there were 2,485 participants (females=1,151). The socioeconomic status and the Internet use were measured by a questionnaire. Standardized tests measured the academic performance. Our findings showed that family socioeconomic status was positively related to math performance, but not significantly related to Chinese performance. The results also indicated that Internet use did not significantly mediate the relationship between family socioeconomic status in 2014 and math performance in 2016, while the frequency of Internet use to study in 2016 partly mediated the relationship between family socioeconomic status in 2016 and math performance in 2018. Our findings suggest that Internet use can only mediate the relationship between family socioeconomic status and math performance and the mediating effects become stronger over time. [ABSTRACT FROM AUTHOR]

The new demands of scientific-technical development have led to the need for a greater presence of higher education institutions (HEI) in scientific research. This induces the active participation of universities to respond to society's demands and implement changes in their processes. The People's Republic of China (PRC), from the educational policy developed during the last decades, attributes importance to this issue as one of its main tasks. The idea that knowledge is a substantial source of wealth has permeated the way in which the ideal Chinese society is thought of. In this sense, it is necessary to train the professors of the Advertising career at Harbin Normal University. The purpose of this article is to analyze some of the theoretical references for the study of the research skills of the professors of this career, from the philosophical and pedagogical points of view. [ABSTRACT FROM AUTHOR]

Copyright of Historia y Comunicación Social is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

PURPOSE: To evaluate the upper airway and surrounding structures under intraluminal pressure using cephalometry combined with Muller's maneuver in obstructive sleep apnea and hypopnea syndrome (OSAHS) patients with different severity. METHODS: Thirty-nine male patients were enrolled in our department during June 2011 to February 2012. Polysomnography (PSG) and anthropometric measurements data were recorded prior to the study. The lateral cephalograms of each patient were obtained during both the end-expiration phase and Muller's maneuver phase. The patients enrolled were classified into 3 groups according to the results of apnea-hypopnea index (AHI), including mild group (n=11), moderate group (n=14), and severe group (n=14). Craniofacial and upper airway structures were measured in lateral cephalometry by application of Cassos 2001 computed aided measurement software before and after the patients practicing Müller's maneuver. The data was analysed using SAS 9.13 software package. RESULTS: Muller's maneuver had a great influence on the upper airway and surrounding tissue, including increased thickness of the uvula, reduction in the anteroposterior dimension of retropalatal and increased vertical distance of the hyoid bone to the mandible in all groups (P<0.05). In addition, Müller's maneuver also had an impact on the length of the upper airway, which was more significant in severe cases. CONCLUSIONS: Cephalometry combined with Müller's maneuver can display how the intraluminal pressure function on the upper airway and surrounding tissues, and they also can distinguish some minor differences of the upper airway in patients with different security. Supported by Research Fund of Science and Technology Commission of Shanghai Municipality (11140902001). [ABSTRACT FROM AUTHOR]

Copyright of Óptica Pura y Aplicada is the property of Sociedad Espanola de Optica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

En este artículo se presenta un nuevo enfoque sobre la evaluación de los riesgos de inundación a largo plazo, de acuerdo con el informe sobre predicciones de inundaciones de UK Foresight Future Flooding. Un modelo morfodinámico ha sido desarrollado para simular procesos como el transito de avenidas, el transporte de sedimentos y la evolución correspondiente de los cauces. El modelo se emplea un doble enfoque, con un planteamientorefinado del mojado y secado; usando dos formulas de la velocidad incipiente devehículos inundados bajo distintos escenariospara comprobar la estabilidad de vehículos en avenidas; y un modelo numérico integrado ha sido desarrollado para predecir avenidas y los riesgos correspondientes a personas (niños y adultos) y de la propiedad (vehículos y edificios). [ABSTRACT FROM AUTHOR]

Thermodynamic functions, including enthalpy (Hθ) and entropy (Sθ) for 76 polychlorophenazines (PCPZs) in the gas state at 298.15 K and 101.325 kPa, have been calculated using the B3LYP/6-31G* level with Gaussian 03 program, and considered on solvation affects. Total free energy in water (Gw) was calculated with the same program. Based on these data, the isodesmic reactions were designed to calculate the standard formation heat (Δf Hθ) and standard free energy of formation in water (Δf Gwθ). The dependences of these thermodynamic parameters on the numbers and positions of chlorine substitution (NPCS) were discussed. It is suggested that Sθ , Δf Hθ, and Δf Gwθ of PCPZs varied greatly with NPCS. Moreover, the values of molar heat capacity at constant pressure (Cp,m) from 200 to 1800 K for PCPZ congeners were calculated using a statistical thermodynamics calculation program based on Gaussian output files, and the temperature-dependence relation of Cp,m was obtained using the least-squares method. In addition, according to the relative magnitude of their Δf Gwθ, the relative stability order of PCPZ congeners was theoretically proposed. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the effect of Fufang Danshen Mingmu (FDM) on streptozotocin-induced diabetic retinopathy rats. Methods: Diabetic retinopathy model rats were prepared using a single intraperitoneal injection of a freshly prepared solution of streptozotocin (50 mg/kg). The rats were randomly divided into 6 groups of ten rats each: negative control group, control group, reference group (glibenclamide, 1 mg/kg) as well as FDM groups, (50, 100 and 200 mg/kg body weight). Blood glucose and plasma insulin levels were determined. Oxidative stress was evaluated in liver and kidney as lipid peroxidation (LPO), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase (CAT). Blood serum levels of creatinine and urea were determined in both diabetic control and treated rats. Results: Compared with diabetic rats, oral administration of FDM at a dose of 200 mg/kg daily for 30 days resulted in a significant decrease in fasting blood glucose (120.21 ± 3.37 mg/dL, p < 0.05) and increased insulin level (13.31 ± 0.67 uU/mL, p < 0.05). Furthermore, it significantly reduced biochemical parameters (serum creatinine, 0.86 ±0.24 mg/dL, p < 0.05) and serum urea (41.86±1.59 mg/dL, p < 0.05). Conclusion: The results indicate that FDM normalizes impaired antioxidant status in streptozotocininduced diabetic retinopathy rats, and also exerts a protective effect against lipid peroxidation by scavenging free radicals. [ABSTRACT FROM AUTHOR]