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Objective: To analyse the incidence and risk of recurrent major adverse cardiovascular events (MACE), level of risk factor control, treatment persistence and cost of the CNIC polypill version containing acetylsalicylic acid (ASA) 100 mg, atorvastatin 20 mg (A20), and ramipril 2.5, 5.0 or 10 mg in secondary cardiovascular prevention patients. Method: Subanalysis of the observational, retrospective, multicentre, NEPTUNO study in patients treated for two years with the CNIC polypill A20, the same monocomponents as single drugs, equipotent drugs, and other therapies. Results: 922 patients were included in each group. The risk of recurrent MACE was lower among CNIC A20 polypill users than all others (21%, 23% and 26% increased risk among the monocomponents, equipotent or other therapy cohorts, respectively; p < 0.05). The magnitude of the mean change in low-density lipoprotein cholesterol and blood pressure, as well as the increase in the proportion of patients achieving target goals, was also greater among patients treated with the CNIC A20 polypill than in any of the other cohorts (all p < 0.001). Treatment persistence was significantly higher in patients treated with the CNIC A20 polypill (p < 0.001) and was a less costly strategy than any other therapeutic option. Conclusions: In patients in secondary cardiovascular prevention, the CNIC A20 polypill (ASA 100 mg, atorvastatin 20 mg, and ramipril 2.5, 5.0 or 10 mg) constitutes a valid therapeutic option with similar benefits and outcomes to the version of the polypill with atorvastatin 40 mg. [ABSTRACT FROM AUTHOR]

Copyright of Revista Médica de Risaralda is the property of Universidad Tecnologica de Pereira and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Latinoamericana de Hipertension is the property of Revista Latinoamericana de Hipertension and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de la ALAD is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Ibuprofen is a non-steroidal anti-inflammatory with anti-inflammatory, analgesic and antipyretic properties. The safety of ibuprofen was revised in 2006 and finally in 2015 it was confirmed that administration of high doses of ibuprofen is associated with an increased risk of arterial thrombosis. Objectives: Testing the use of ibuprofen by users of the community pharmacy. Material and methods: Data from this study descriptive, observational and cross-sectional are obtained from questionnaire of regular customers of the pharmacy in particular before signing a consent form and then being given advice through an information leaflet. Results: 40 people were included exceeding the inclusion criteria, of which only one person had ibuprofen as chronic treatment. 82.5% used doses of 600 mg and 15.0% of 400 mg with a predominant dosage, every 8 hours, in both cases. 55.0% of people used ibuprofen until the pain subsided and uses were varied, being headache in first position. Discussion: No one can corroborate what dose is most prevalent in other countries, but we can clarify that the dose of 600 mg is not marketed in some of them, such as France. This turns out to be the most used doses among the survey respondents exceeding the maximum dose of 1200 mg per day recommended by AEMPS to avoid a possible cardiovascular risk. Moreover, all ibuprofen indications that respondents used are correct, except of the cold that in Spain is not supported. Compared to other countries, we can see that this use is accepted in the United States and the United Kingdom by the relevant agencies of medication. [ABSTRACT FROM AUTHOR]

Objective: To review the available evidence those relate diabetes with the risk of stroke, and the role of glycaemic control according to some strategies in risk reduction of stroke. Development: Diabetes is associated with relative risk of ischemic stroke between 1.8 and 6, but for hemorrhagic stroke the association is controversial. Women with diabetes type 1 have more risk than those with diabetes type 2. Moreover, diabetes predict extend hospital stay and greater mortality and incapacity in stroke patients and patients who die due stroke have higher levels of HbA1c and glycaemia. Besides, almost 9% of stroke recurrences were attribute to diabetes, because of that diabetes was included in prognosis scales of stroke recurrences. Even though, intensive treatment for glycaemia levels in diabetes type 1 patients was associate with lower levels of HbA1c and microalbuminuria and risk reduction of cardiovascular events in 42%, big trials about intensive treatment for type 2 diabetic patients reduce microvascular complications but not major cardiovascular events. Nevertheless, strict control of blood pressure, use of "statins", and type DASH diet lead to an important reduction of stroke risk in patients with diabetes type 2. [ABSTRACT FROM AUTHOR]