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Background: The use of antimicrobial agents in the treatment of infectious diseases, has been an unprecedented event, this favorably changed the panorama of adult morbidity and mortality. For some years there has been a great concern about the increase in resistance to antimicrobials, due to the excessive use of them in pharmacotherapy. Objective: To describe the characteristics of consumption and prescription patterns of antibiotics (ATB) of group J01 in medium and high complexity hospitals of the Department of Atlántico in Colombia. Methods: Descriptive-longitudinal study during one year of study (June 2016 to June 2017). Diagnostics, prescribed antibiotics, quality of the prescription and duration of treatment associated with the prescription of antibiotics of group J01 were evaluated. A census was conducted in five clinics of the Department of Atlántico. Results: 8241 patients were followed up with antibiotic treatment of group J01, during the twelve (12) month period of the study. 38 antibiotics were identified in 12465 prescriptions during the study year, with at least one antibiotic for systemic use. Cefredine was the antibiotic with the highest percentage of prescriptions performed, followed by penicillins. Only 59.4% of antibiotic prescriptions were evaluated as an adequate prescription. The duration of antibiotic treatment, 61.2% had a period of antibiotic use between 1 and 5 days, followed by 24.9% that lasted between 6 and 10 days. Conclusion: The most prescribed antibiotics correspond to first and third generation cephalosporins, followed by penicillin inhibitors + beta-lactamase inhibitors. [ABSTRACT FROM AUTHOR]