1. [Better cure for anxiety, sleep disorders, epilepsy?].
- Author
-
Korpi ER, Wisden W, and Lüddens H
- Subjects
- Anticonvulsants therapeutic use, Humans, Hypnotics and Sedatives therapeutic use, Receptors, GABA chemistry, Anti-Anxiety Agents therapeutic use, Anxiety Disorders drug therapy, Benzodiazepines therapeutic use, Epilepsy drug therapy, Receptors, GABA drug effects, Sleep Wake Disorders drug therapy
- Abstract
Gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter, is characterised by rapid effects that are mediated via GABAA, receptors. These receptors are also targets for many drugs including benzodiazepines, barbiturates and general anaesthetics. Recognition of the heterogeneity of GABAA receptors has opened up new possibilities for the development of more selective therapeutic agents. In particular, subtype-specific receptor ligands varying in intrinsic activity are likely to give rise to fewer side effects than do currently available drugs.
- Published
- 1997