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Your search keyword '"Receptors, Glutamate drug effects"' showing total 3 results
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3 results on '"Receptors, Glutamate drug effects"'

2. [Future cure of hearing disorders? Gene therapy and stem cell implantation are possible new therapeutic alternatives].

Author

Duan ML, Ulfendahl M, Ahlberg A, Pyykkö I, and Borg E

Subjects
Animals, Cochlea metabolism, Cochlea physiology, Cochlea physiopathology, Cytoprotection drug effects, Ear, Inner metabolism, Ear, Inner physiology, Ear, Inner physiopathology, Hearing Loss, Noise-Induced etiology, Hearing Loss, Noise-Induced genetics, Hearing Loss, Noise-Induced surgery, Hearing Loss, Noise-Induced therapy, Hearing Loss, Sensorineural etiology, Hearing Loss, Sensorineural genetics, Hearing Loss, Sensorineural surgery, Humans, Nerve Growth Factors administration & dosage, Nerve Growth Factors physiology, Nitric Oxide administration & dosage, Nitric Oxide physiology, Reactive Oxygen Species physiology, Receptors, Glutamate drug effects, Receptors, Glutamate physiology, Cochlear Implants, Fetal Tissue Transplantation methods, Fetal Tissue Transplantation trends, Genetic Therapy methods, Genetic Therapy trends, Hearing Loss, Sensorineural therapy
Abstract

Hearing loss is a very common disorder; nearly 10 per cent of the population is affected. Recently, a few findings such as the roles of neurotrophins, nitric oxide, reactive oxygen species and glutamate receptors in the peripheral hearing system have been highlighted. In this review, focus is set on possible mechanisms of peripheral hearing disorders, and on recent advances to prevent and treat hearing loss. Clinically useful treatment strategies, especially gene therapy and the use of embryonic stem cells, are particularly stressed.

Published
2000

3. [The biological mechanisms underlying alcohol dependence].

Author

Alling C

Subjects
Alcohol-Related Disorders etiology, Alcohol-Related Disorders physiopathology, Alcoholism etiology, Alcoholism physiopathology, Animals, Brain drug effects, Brain metabolism, Brain physiopathology, Humans, Mice, Receptors, Dopamine drug effects, Receptors, Dopamine metabolism, Receptors, GABA drug effects, Receptors, GABA metabolism, Receptors, Glutamate drug effects, Receptors, Glutamate metabolism, Receptors, N-Methyl-D-Aspartate drug effects, Receptors, N-Methyl-D-Aspartate metabolism, Receptors, Opioid drug effects, Receptors, Opioid metabolism, Receptors, Serotonin drug effects, Receptors, Serotonin metabolism, Alcohol-Related Disorders metabolism, Alcoholism metabolism, Receptors, Neurotransmitter drug effects, Receptors, Neurotransmitter metabolism, Signal Transduction drug effects
Abstract

Recent advances in neuroscience have enabled alcohol dependence to be investigated at cellular and molecular levels. Alcohol exerts biological effects by interacting with cell membranes and receptors, and modifies the function of proteins which regulate signal transduction, intracellular pathways, and gene expression. Adaptation to the acute effects of alcohol constitutes a major determinant of the development of increased tolerance, withdrawal syndrome and dependence. Important targets for alcohol include transmitter-regulated ion channels, receptors coupled to guanosine triphosphate-binding proteins, second messengers, and gene transcription factors. Studies of rodents bred for alcohol sensitivity or resistance have uncovered molecules of importance for the development of alcohol dependence, and certain ethanol-sensitive genes have been identified.

Published
1999

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