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Objective: Recurrence and scar formation are the key leftover problems in the treatment of verrucous epidermal nevus (VEN). The objective of this study was to assess the long-term efficacy of bleomycin with triamcinolone acetonide in reducing the recurrence of VEN and scar formation after treatment. Methods: Bleomycin and triamcinolone were injected percutaneously into the lesion, and the drug was evenly distributed in the lesion. Several treatment courses were carried out according to the size and hyperplasia of the lesion. Necessary laser treatment was performed. Patients were followed up for 2–5 years. Results: The results showed that 83% of the patients were cured. The recurrence rate was 17%. The recurrence was localized and accounted for 3%–6% of the original lesion area. Scar formation accounted for 3.4%. Other complications did not occur. The patients or his/her guardian were satisfied with the treatment effect. Conclusion: Bleomycin with triamcin acetonide can significantly improve the cure rate of VEN and reduce the recurrence rate and scar formation. This method is a good option for VEN treatment.