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Background: In this study, it was aimed to compare the oxidative stress levels of individuals who do bodybuilding exercises, normal weight sedentary, overweight and obese individuals and nor- mal weight individuals who do regular physical exercise. Materials and Methods: 122 male volunteers aged between 18-45 years were included in the study. Participants were divided into 4 different groups according to the type of exercise they were interested in and their Body Mass Index. Oxidative stress levels in individuals doing bodybu- ilding exercises were compared with sedentary normal weight, obese individuals and normal we- ight individuals doing regular physical exercise. Serum thiol-disulfide parameters were measured to determine oxidative stress levels. Results: It was observed that dynamic thiol / disulfide homeostasis was achieved in participants with normal weight and regular exercise, but dynamic thiol / disulfide homeostasis was impaired in the group doing bodybuilding exercise. Conclusions: The results of the experiment show that we should avoid heavy exercises such as bodybuilding, and that regular and normal exercises should be encouraged. [ABSTRACT FROM AUTHOR]