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Background: In this study, it was aimed to compare the oxidative stress levels of individuals who do bodybuilding exercises, normal weight sedentary, overweight and obese individuals and nor- mal weight individuals who do regular physical exercise. Materials and Methods: 122 male volunteers aged between 18-45 years were included in the study. Participants were divided into 4 different groups according to the type of exercise they were interested in and their Body Mass Index. Oxidative stress levels in individuals doing bodybu- ilding exercises were compared with sedentary normal weight, obese individuals and normal we- ight individuals doing regular physical exercise. Serum thiol-disulfide parameters were measured to determine oxidative stress levels. Results: It was observed that dynamic thiol / disulfide homeostasis was achieved in participants with normal weight and regular exercise, but dynamic thiol / disulfide homeostasis was impaired in the group doing bodybuilding exercise. Conclusions: The results of the experiment show that we should avoid heavy exercises such as bodybuilding, and that regular and normal exercises should be encouraged. [ABSTRACT FROM AUTHOR]

Aim: Obesity is a more common and important health problem in childhood. We aimed to determine sociodemographic and clinical factors contributing weight loss. Material and Methods: Medical records of 120 obese patients (6-18 years old) applied at least twice for follow-up between 2012 ( January)-2016 (September) were reviewed. Age, gender, socioeconomic status, family obesity, comorbidities, medications, operations, exercise frequency, screen time, physical examination findings and biochemical/hormone values [thyroid hormone, fasting insulin/glucose, cholesterol levels, Homeostasis model assesment insulin resistance (HOMA-IR), oral glucose tolerance test results (if applied) were recorded. Patients with a difference between the initial and last body mass index standart deviation higher than -0.2 were defined as "the good losing weight" group; the rest as "the poorly losing weight" group. The SPSS 22.0 program was used for analyzes. Results: Puberty stage showed a significant difference (p=0,019); 65% of patients in the poorly losing weight group but 54% of other group were at stage 4-5 . The initial body mass index standart deviation and exercise frequency were higher in the good losing weight group, the last measured body mass index standart deviation was lower (p=0). In the other group, baseline HOMA-IR was higher (p=0.037); there were more metformin-initiated patients but the difference was not significant. Conclusion: We observed that exercise frequency was higher in cases with good weight loss; therefore, we consider that increasing physical activity is an important step. Other crucial outcomes are that the initial body mass index standart deviation is higher while HOMA-IR is lower in those cases and that puberty stage is higher in poorly weight losing patients. [ABSTRACT FROM AUTHOR]

Aim: To determine the relationship of leptin with vitamin D and parathormone (PTH) levels in postmenopausal women who have no osteoporosis and to evaluate the effect of these three parameters on bone mineral dansity and bone homeostasis. Methods: Sixty-eight postmenopausal patients with no osteoporosis, who attended the general internal medicine, geriatric and endocrinology outpatient clinics between November 2013 and June 2014, were included in the study. The patients were divided into two groups according to vitamin D levels. Results: Group 1 consisted of 27 patients with low vitamin D levels and group 2 consisted of 41 patients with normal vitamin D levels. Two groups were similar in terms of age, age of menopause and body mass index (BMI). The mean PTH level and the mean leptin level in group 1 were statistically significantly higher than in group 2 (p= 0.01; p=0.01, respectively). There was no significant correlation between leptin and PTH in group 1 (r=0.16, p=0.4), however, a positive correlation was observed in group 2 (r=0.46, p=0.002). We found a significant positive correlation between leptin and BMI in both groups (r=0.40, p< 0.01). No significant correlation was found between leptin and vitamin D in both groups. Conclusion: In our study, the high leptin levels in postmenapasaul women having low vitamin D levels without osteoporosis or obesity may suggest the role of leptin in the prevention of osteoporosis. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the effect of continuous positive airway pressure (CPAP) treatment on metabolic syndrome and insuline resistance in patients with obstructive sleep apnea syndrome (OSAS). Materials and Methods: This study evaluated retrospectively with 30 patients who received OSAS diagnosis following polysomnography between the years January 2016 - January 2017, whose Respiratory Disturbance Index were above 15, and who were between the ages of 18-78, having no diabetes, chronic liver and kidney disease, malignancy and mental retardation. The anthropometric measures and blood values of these patients before the CPAP treatment and 3 months afterwards were evaluated in their controls. The effect of CPAP treatment on metabolic syndrome and insulin resistance assessed by homeostatic model assessment index was investigated Results: It has been observed that the body mass index (BMI) decreases significantly following the CPAP treatment. No significant changes were found in the anthropometric measurements including the neck circumference, waist circumference, hip circumference, and waist/hip ratios as well as insulin resistance and metabolic syndrome parameters (before of treatment BMI: 31.33±5.58, post treatment BMI: 30.83±7.13, p=0.03). The ESS evaluating the subjective daytime sleepiness following the CPAP treatment has decreased significantly. Conclusion: Although this study didn't improve insulin resistance with assessed homeostatic model assessment, and metabolic syndrome, a significant improvement in BMI and ESS was demonstrated in post treatment. Long-term studies with more cases and with high compliance are needed to demonstrate the effects of CPAP treatment on metabolic syndrome in OSAS patients. [ABSTRACT FROM AUTHOR]