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Our aim is to perform clinicopathological analysis of premalignant and malignant lesions of the eye and adnexa diagnosed in a tertiary clinic. The files of the patients who underwent surgery and sent specimens to pathology laboratory at Inönü University Faculty ofMedicine, Department of Ophthalmology betweenMarch 2010 and July 2020 were reviewed retrospectively. Demographic, clinical and histopathological data of cases with premalignant and malignant lesions were recorded. A total of 136 patients, 64 (47.1%) female and 72 (52.9%) male, were included in the study. The mean age of the patients was 73.6±14.7 (11-101) years. Premalignant lesions were detected in 58 patients (42.6%) and malignant lesions were detected in 78 patients (57.4%). The most common premalignant lesions were conjunctival or corneal intraepithelial neoplasia, carcinoma in situ, while the most common malignant lesions were basal cell carcinoma, squamous cell carcinoma, and lymphoma. In our clinic, the most commonly diagnosed premalignant lesion of the eyes and adnexa was conjunctival intraepithelial neoplasia, and the malignant lesion was basal cell carcinoma. [ABSTRACT FROM AUTHOR]

Background and Design: Micrographic surgery is an intraoperative microscope-controlled surgery which aims at the excision of the entire tumor by achieving 100% control of the surgical margins with horizontal sectioning. In micrographic surgery, the healthy skin is preserved maximally due to the stepwise excision of the tumor using narrow margins. Due to its highest cure rates and maximal tissue preserving properties, it is the treatment of choice for high-risk non-melanoma skin cancers. Micrographic surgery is not routinely included in the dermatologic surgical procedures in Turkey. The aim of this study was to provide the availability of micrographic surgery for selected patients. Materials and Methods: During 2010-2015, 116 non-melanoma skin cancers that belong to 102 patients (53 male, 49 female) were treated with micrographic surgery. All tumors were located on the head or neck, and exhibiting at least one high-risk factor for recurrence. Micrographic surgery was performed with the Munich method between 2010 and 2013, and with Mohs surgery between 2013 and 2015. Results: The mean age of patients was 65.86±12.33 years (range: 33-90 years). The localization of the tumors was the head (n=112) and the neck (n=4). The number of micrographic surgery sessions to eliminate the tumor was 1 session for 55 (47.41%), 2 sessions for 55, and more than 2 sessions for 8 (6.89%) of the tumors. Six of the defects were left for secondary intention healing, 31 were repaired primarily and 13 defects were repaired with full thickness skin grafts whereas 66 were repaired with flaps. Conclusion: The results of this study showed that microscopic eradication of non-melanoma skin cancer necessitates more than one session for more than half of the cases, illuminating that microscopic extension of non-melanoma skin cancer beyond clinically apparent tumor is very likely. The results support that for tumors located on the head and neck where healthy skin should be preserved maximally for functional and cosmetic reasons, the use of micrographic surgery is a necessity. [ABSTRACT FROM AUTHOR]

A considerable number of dermatolologist in Turkey perform standard surgical excision of non-melanoma skin cancer and repair the defects functionally and cosmetically. It is possible to appropriately treat most basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) with standard excision and even with curettage and electrodessication. However, for a group of patients at high risk of recurrence, standard excision cannot provide the desired oncologic cure rates. In order to increase the possibility of oncologic cure, it is recommended that high risk BCCs and SCCs should be excised with larger than 4-6 mm safety margins. On the other hand the most common localization for BCCs and SCCs are the face, and using safety margins larger than 4-6 mm on the face might contradict with the principles of tissue-preserving surgical approach. A more unfavorable situation is that the oncologic cure rates remain below 80% for high-risk BCC and SCC even after standard excisions with safety margins of wider than 4-6 mm. The goal of Mohs micrographic surgery is complete tumor removal with maximum preservation of healthy tissue.. Mohs micrographic surgery is a staged surgery that enables 100% assessment of the entire lateral and deep surgical margins microscopically in minutes after excision with horizontally cut frozen sections for residual cancer. Thus, it increases the oncologic cure rate especially for a certain group of patients with high-risk BCC and SCC. The aim of this paper was to review the Mohs technique, the most thorough method for treating BCC and SCC. [ABSTRACT FROM AUTHOR]

A considerable number of dermatolologist in Turkey perform standard surgical excision of non-melanoma skin cancer and repair the defects functionally and cosmetically. It is possible to appropriately treat most basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) with standard excision and even with curettage and electrodessication. However, for a group of patients at high risk of recurrence, standard excision cannot provide the desired oncologic cure rates. In order to increase the possibility of oncologic cure, it is recommended that high risk BCCs and SCCs should be excised with larger than 4-6 mm safety margins. On the other hand the most common localization for BCCs and SCCs are the face, and using safety margins larger than 4-6 mm on the face might contradict with the principles of tissue-preserving surgical approach. A more unfavorable situation is that the oncologic cure rates remain below 80% for high-risk BCC and SCC even after standard excisions with safety margins of wider than 4-6 mm. The goal of Mohs micrographic surgery is complete tumor removal with maximum preservation of healthy tissue.. Mohs micrographic surgery is a staged surgery that enables 100% assessment of the entire lateral and deep surgical margins microscopically in minutes after excision with horizontally cut frozen sections for residual cancer. Thus, it increases the oncologic cure rate especially for a certain group of patients with high-risk BCC and SCC. The aim of this paper was to review the Mohs technique, the most thorough method for treating BCC and SCC. [ABSTRACT FROM AUTHOR]