23 results on '"*ACUTE leukemia"'
Search Results
2. Hematolog Olmayanlar için Çocukluk Çağında Akut Löseminin Tanısal İpuçları.
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Koç, Begüm Şirin, Tekkeşin, Funda, Merter, Tuba, Yıldırım, Ülkü Miray, Asarcıklı, Fikret, Aydoğdu, Selime, and Kılıç, Suar Çakı
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ACUTE leukemia , *BLOOD cell count , *CANCER diagnosis , *PHYSICIANS , *EARLY diagnosis , *LEG pain , *LYMPHADENITIS - Abstract
Objective: Acute leukemia is the most common type of malignancy in childhood. Fever, malaise, hepatosplenomegaly and lymphadenopathy are among the most common presentations of leukemia. It is of vital importance for the physician, who is the first to evaluate the patient, to comprehend/ understand about the presenting findings of acute leukemia for early diagnosis and treatment. We aimed to emphasize the significant clues which point to acute leukemia in childhood for non-hematologist physicians. Materials and Methods: All children aged 0-18 years who were diagnosed with acute leukemia in our clinic between May 2017 and February 2021 were included. The complaints, physical examination findings and blood test results of all patients diagnosed with acute leukemia at their admission were retrospectively analyzed. Results: The files of 62 children with acute leukemia were analyzed. The male/female ratio was 1.58, and the mean age was 6±4.93 years (min-max 1-17 years). The median time of onset of complaints was 15 days. The most common complaints were fatigue (85.5%), fever (51.1%) and leg pain (33.8%). The most common findings on physical examination were pallor (74.2%), hepatosplenomegaly(43.1%) and lymphadenopathy (37.1%). At admission, all of the patients had abnormalities of complete blood counts in at least one series. 79% of the patients had anemia (hb<10g/dl), 69.4% had thrombocytopenia (<100000/mm3) and 67.7% of the patients had neutropenia (<1500/mm3). The most common abnormality in the biochemical tests was elevated LDH values (median LDH: 576IU/L). Conclusion: Recognizing the most common presentation findings of childhood leukemia by the first physician is an important step for early diagnosis and treatment in childhood leukemia. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Flow cytometric evaluation and outcomes of pediatric acute leukemia patients
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İbrahim Bayram, Serhan Küpeli, Burcu Genç, Gülay Sezgin, Atila Tanyel,i, and Ayşe Özkan
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akut lösemi ,akım sitometri ,prognoz ,acute leukemia ,flow cytometry ,prognosis ,Medicine (General) ,R5-920 - Abstract
Purpose: In this study, the outcomes and flow cytometry results of childhood acute leukemia patients and their relationship with the prognosis and other clinical conditions was investigated. Materials and Methods: A total of 93 patients, including 69 acute lymphoblastic leukemia (ALL) and 24 acute myeloid leukemia (AML) patients diagnosed at our hospital between January 2008 and November 2013, were included. Results: 5-year overall survival (OS) was 66% in ALL patients and 80% in AML patients. When leukemia patients were classified flow cytometrically according to their cell surface antigens (CD); 5-year OS was 77% in CD2(+) patients and 58% in CD2(-) patients. Five-year OS was 82% in patients with CD10(+) and 61% in patients with CD10(-). However, the results were not statistically significant (p>0.05). ALL patients were divided into two groups as ALL with positive T cell markers and ALL with positive B cell markers in the foreground and evaluated accordingly, and the OS of ALL patients with positive T cell markers in the foreground was lower than ALL patients with positive B cell markers in the 5 year (59% and 75%, respectively) (p =0.518). On the other hand, AML patients were divided into two groups as AML with positive lymphoid markers and AML with negative lymphoid markers, and the 5 year OS of AML patients with positive lymphoid markers was higher than AML patients with negative lymphoid markers (83% and 70%, respectively) (p = 0.638). These results were not statistically significant. Conclusion: In the flow cytometric evaluation of our patients with leukemia, it was found that patients with CD10(+) had a better 5-year OS and patients with CD2(+) had a lower 5-year OS. The results of patients with positive B cell markers were better in ALL patients, and the results of patients with positive lymphoid markers were better in AML patients.
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- 2021
4. Kronik Lenfositik Lösemiye Bağlı Ortaya Çıkan Bir Lösemi Kutis Olgusu.
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KILINÇ, Fadime, KURTOĞLU, Gözde, ORHUN, Sibel, AKBAŞ, Ayşe, and ŞENER, Sertaç
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CHRONIC lymphocytic leukemia , *CANCER cells , *ACUTE leukemia , *B cells , *BONE marrow , *CHRONIC leukemia - Abstract
Chronic lymphocytic leukemia (CLL); neoplasm of mature B cells characterized by progressive accumulation of monoclonal B lymphocytes in blood, bone marrow, lymph gland, liver and spleen. Leukemia may cause nonspecific skin lesions or leukemic skin infiltration. Leukemia cutis is the infiltration of the skin with malignant leukemic cells. It is most commonly seen in acute myelomonocytic leukemia in adults and it is rare in CLL. Skin lesions are seen in 25% of patients with CLL and leukemia cutis is less than 5%. Leukemic skin infiltrations can be seen as macules, papules, plaques, nodules, ulcers or blisters. Skin lesions indicate the recurrence of a malignant disease in remission and are important for treatment planning. It may also appear as the first sign of malignancy. Here; leukemic skin infiltration in a male patient with CLL in remission is presented because it suggests relapse and is rare. [ABSTRACT FROM AUTHOR]
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- 2021
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5. Akut Lösemili Çocuklarda Konjenital Malformasyon Sıklığı: Tek Merkez Raporu.
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Güler, Salih, Temuroğlu, Aytül, Evim, Melike Sezgin, Baytan, Birol, and Güneş, Adalet Meral
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NERVOUS system abnormalities , *NOSOLOGY , *LYMPHOBLASTIC leukemia , *SEX distribution , *CONSANGUINITY , *EARLY diagnosis , *DISEASE risk factors , *DISEASE complications , *CHILDREN - Abstract
Introduction:Leukemia is a multifactorial disease. Some genetic syndromes is well known related to leukemia. We evaluated non-syndromic malformation and leukemia relation. Materials and Methods: 288 patients diagnosed with acute leukemia are included the study. 201 patients with non-malign hematologic disease are accepted as a control. Syndromic children were excluded both group. All children were examined according to ICD-10th, Chapter XVII for congenital malformation. The type and number of malformations were compared both group. Results: There were no differences between leukemia and control group in terms of age at diagnosis, gender, consanguinity between parents, parents age at birth, family history of cancer and pregnancies of mother. Congenital malformations were more observed in leukemic population (p<0.001). The most common malformation in the control group was on the skin. Whereas the most common malformation in leukemic children was seen in the circulatory system, second region was skin. Having circulatory system malformation explained 12.53 high of the leukemia risk. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Akut Lenfoblastik Lösemide İmmunfenotipleme ve Klinik ile İlişkisi.
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Garipardıç, Mesut, Karakaş, Zeynep, Tuna, Rumeysa, and Ünüvar, Ayşegül
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LYMPHOBLASTIC leukemia , *T cells , *ACUTE leukemia , *AGE groups , *WOMEN patients - Abstract
Objective: To evaluate the relationship between immunophenotyping and clinical characteristics of children diagnosed with acute lymphoblastic leukemia (ALL). Method: The relationship between immunophenotyping results examined by flowcytometry and clinical features of 192 patients under 18 years who were diagnosed with ALL between 1989 and 2007 in our center were evaluated. Results: Of the patients, 79 (41,1%) were girls and 113 (58,9%) were boys. The cases were divided into two groups as those with precursor-B cell ALL, and precursor T cell ALL groups. Cases of precursor B, and T-ALL were seen in 27,6% of male, and 14,2% of female patients (p=0,038) Age groups were also evaluated according to age groups. All patients under 1 year of age were in the precursor-B cell ALL group, while 82,9% of the cases between 1 and 10 years were in precursor-B cell ALL group, and 17,1% of them in T cell ALL group. Still 58% of the cases above .10 years of age were in the precursor-B cell ALL group, and 41,4% were in the T cell ALL group. Hyperleukocytosis, extramedullary involvement, lymphadenopathy and mediastinal mass were significantly more frequent in the T cell ALL group. The frequency of T cell ALL was found to decrease over time. Conclusion: Acute lymphoblastic leukemia is more frequently seen in males when compared with females. The incidence of T cell ALL increases in male children, and those aged over 10 years of age. The frequency of lymphadenomegaly, mediastinel mass, extramedullary involvement and hyperleukocytosis is significantly increases in the T cell ALL group compared to the precursor B-cell ALL group. It is thought that the decrease in the frequency of T cell ALL over the years may be related to the improvement in socio-economic level. [ABSTRACT FROM AUTHOR]
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- 2019
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7. Akut lösemili hastalarda perianal hastalıkların prevalansı ve güncel yönetimi.
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Gündüz, Mehmet, Bakanay, Şule Mine, Yaman, Samet, Usta, Ahmet, Özen, Mehmet, Yıkılmaz, Aysun Şentürk, Kaya, Selin Küçükyurt, Doğan, Servihan, Akıncı, Sema, and Dilek, İmdat
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Aim: Perianal infection is one of the most important causes of infection in acute leukemia which puts the life of patients at risk, increases their morbidity and impairs quality of life. Material and Method: At the Ankara Atatürk Training and Research Hospital Hematology Clinic, 125 patients who received standard chemotherapy for acute leukemia between 2009 and 2017 werestudied, retrospectively. Results: Of these 125 acute leukemia patients, 25 (20%) developed perianal disease and 13 (10,4%) developed perianal infection. Perianal disease and infection developed in 34% and 21% of patients with ALL; in 16% and 7% of patients with AML (p=0.03 and p=0.04), respectively. Perianal disease was present in 29% of the patients with a leukocyte count greater than 10,000 at diagnosis, but remained at 12% in those with a leukocyte count below 10,000 (p=0.02). Perianal disease and perianal infection developed in 64% and 69% of the patients during induction and at a median of 13 days (range: 1-40) and 17 days (range: 3-34), respectively. It was observed that 60% of the patients with perianal disease had fever, 28% had positive blood culture, 16% had sepsis and 20% required surgical treatment. Among 7 patients with perianal disease and positive blood cultures, all had Gram (-) bacilli (5 Klebsiella pneumonia and 2 E. coli). Of the 6 patients who had masses in physical examination under went pelvic magnetic resonance imaging (MRI). All patients diagnosed with abscesses on MRI. Five patients who under went surgery; 3 abscess drainage, 1 colostomy and 1 polypectomy was performed. Conclusion: It was observed that perianal disease and infection developed more frequently in ALL patients compared with AML patients; perianal disease could be controlled mainly with conservative treatment and MRI could be an important guide in the management of these patients. [ABSTRACT FROM AUTHOR]
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- 2018
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8. Akut Lösemili Çocuklarda Antrasiklin Kullanımına Bağlı Kardiyotoksisitenin Değerlendirilmesi.
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Biral, Burcu, Kaya, Zühre, Oğuz, Deniz, Koçak, Ülker, Yenicesu, İdil, and Gürsel, Türkiz
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Objective: The major problem in the long term follow up of children who survive acute leukemia is chemotherapy related organ toxicity. Anthracycline related cardiotoxicity is one of the most important cause of morbidity and mortality for those patients. Therefore, we investigate echocardiographic (echo) data for the detection of acute, early and late anthracycline toxicity in patients with acute leukemia, who were diagnosed and treated in our clinic over the last decade. Method: Echocardiographic data and risk factors of 21 acute myeloid leukemia (AML) patients treated with MRC-12 protocol and 80 acute lymphoid leukemia (ALL) patients treated with BFM-95 protocol were recorded before chemotherapy (T0) and within 3-6 months (T1), 6-12 months (T2), 12-24 months (T3) of treatment and after 24 months (T4) of treatment in our study. Results: We did not observe acute cardiac toxicity in any cases. The values of mitral E/A-velocity (vel) and tricuspid E/A vel were significantly lower in patients with leukemia in T2 than in control (p<0.05). The values of mitral E/A-vel, tricuspid E/A vel, ejection fraction and fractional shortening were significantly lower in patients with leukemia in T3 than in control and in T0 (p<0.05). It has been found that 10-15% of all patients who developed cardiac toxicity on long term follow-up were anthracycline exposure at a dose of more than 550 mg/m2 and relapsed AML cases. Conclusion: Our study suggests that the standard echocardiographic examination used in the toxicity grading is still cheap and noninvasive test which may be preferred in the first place in the long term follow-up of acute leukemia patients. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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9. Akut Lösemi Hastalarının Demografik Özellikleri ve Tedavi Sırasında Görülen Komplikasyonları: Tek Merkez Deneyimi.
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KARBUZ, Adem, YARALI, Neşe, IŞIK, Pamir, BAY, Ali, KARA, Abdurrahman, and TUNÇ, Bahattin
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Objective: Our aim was to retrospectively analyze the epidemiological, clinical and laboratory features of patients who were diagnosed as acute leukemia and received chemotherapy in our hospital in a five-year period. All the systemic complications of these patients were also reviewed in order to contribute to the therapeutic approaches to such patients. Material and Methods: A total of 97 patients who were followed by the pediatric hematology department between January 2004 and December 2008 were included in our study. The patients' demographic, clinical, laboratory, radiological and echocardiographic characteristics at the time of diagnosis were documented. Finally, 94 of these patients were evaluated in terms of their systemic complications. results: The mean age was 6.0±4.1 (2 months -17 years) (min - max). Males made up 64.9% and females 35.1% of all cases. The diagnoses were acute lymphoblastic leukemia in 84.5% and acute myeloid leukemia in 15.5% of the patients. While the most common complaints were fever (63.9%) and fatigue (57.7%), the most common findings on physical examination were hepatomegaly (77.3%) and pallor (68%) at the time of diagnosis. The complications observed during chemotherapy in the patients were at least one episode of febrile neutropenic attack in 90%, five-fold increase in hepatic enzymes in 82.9%, mucositis in 43.6%, allergy to L-asparaginase in 28.7%, and compliance problems in 9.5%. conclusion: Childhood leukemia has a potential to cause complications in many organ systems due to both the disease itself and the chemotherapeutics used for the treatment. Multidisciplinary management and follow-up are required in the follow-up of children with acute leukemia. [ABSTRACT FROM AUTHOR]
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- 2017
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10. Congenital malformation in children with acute leukemia: Single center report
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Salih Güler, Aytül Temuroğlu, Melike Evim Sezgin, Birol Baytan, Çocuk Hematoloji Anabilim Dalı., Adalet Meral Güneş, Tıp Fakültesi, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematoloji Anabilim Dalı., Güler, Salih, Temuroğlu, Aytül, Sezgin, Melike, Baytan, Birol, and Güneş, Adalet Meral
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medicine.medical_specialty ,Acute leukemia ,business.industry ,Konjenital malformasyon ,Gastroenterology ,Internal medicine ,Pediatrics, Perinatology and Child Health ,Medicine ,Congenital malformation ,Akut lösemi ,business ,Children ,Çocuk - Abstract
Giriş: Lösemi, multifaktöriyel bir hastalıktır. Bazı genetik sendromların lösemi sıklığını artırdığı iyi bilinmektedir. Biz çalışmamızda sendromik olmayan malformasyon ile lösemi ilişkisini değerlendirdik. Gereç ve Yöntem: Akut lösemi tanısı almış 288 hasta çalışmaya dahil edildi. Malign olmayan hematolojik hastalığı olan 201 hasta kontrol grubu olarak kabul edildi. Sendromik çocuklar her iki grupta da dışlandı. Tüm çocuklar ICD-10, Bölüm XVII’ye göre konjenital malformasyon açısından muayene edildi. Her iki grupta malformasyonların tipi ve sayısı karşılaştırıldı. Bulgular: Tanı anındaki yaş, cinsiyet, ebeveynler arasında akrabalık, anne babanın doğum yaşı, ailede kanser öyküsü ve annenin önceki gebelikleri açısından lösemi ve kontrol grubu arasında fark yoktu. Lösemili popülasyonda konjenital malformasyonlar daha fazla görüldü (p
- Published
- 2021
11. CD79a, CD56 ve CD5 ko-ekspresyonu gösteren ve bifenotipik lösemi ile karışan AML M1'li çocuk olgu.
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Yıldırım, Ayşen Türedi and Gülen, Hüseyin
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Biphenotypic acute leukemia (BAL) is defined as the existence of multiple antigen coexpression in leukemic blasts or two different types of blast population. In this study, a patient who was first diagnosed with BAL and later with acute myeloid leukemia M1 (AML-M1) is presented. The patient was four-year-old male and had complaints about high fever, fatigue, lack of appetite, and weight loss for two months. % 96 L2 type blasts were identified in bone marrow aspiration, and positive values for CD79a, CD56, CD5, CD13, CD33, and MPO were observed in flow-cytometry. These findings, evaluated on the basis of "European Group for the Immunological Characterization of Leukemias (EGIL)" criteria, suggested BAL. As the steroid treatment returned no response, the flow-cytometry findings were reevaluated based on "World Health Organization (WHO)" criteria. BAL was excluded and AML M1 was considered as a diagnosis. The positive values for CD79a, CD56 , and CD5 were evaluated as coexpression. Chemotherapy was given as AML treatment, and the dramatic response was reported. This case is presented to show that, using EGIL criteria to evaluate BAL may be misleading , and thus using WHO criteria to evaluate BAL may be more appropriate. [ABSTRACT FROM AUTHOR]
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- 2015
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12. Akut lenfoblastik lösemi tedavisinde düşük dozda metotreksatın beyin komplikasyonlarına etkisi.
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Apak, Hilmi, Ekici, Barışş, Albayram, Sait, Erginöz, Ethem, Celkan, Tiraje, özkan, Alp, özdemir, Gül Nihal, and Yıldız, İnci
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METHOTREXATE , *LYMPHOBLASTIC leukemia , *IMMUNOSUPPRESSIVE agents , *PHOTOTHERAPY , *MEDICAL electronics , *HOSPITAL radiological services , *CENTRAL nervous system , *MEDICAL care , *ELECTROENCEPHALOGRAPHY - Abstract
Aim: The aim of this study is to determine the possible side effects of central nervous system (CNS) prophylactic treatment in childhood leukemia by using cranial imaging techniques. Material and Method: Data collected from records of 90 patients diagnosed as acute lymphoblastic leukemia (ALL) and treated according to BFM-90 or TR-ALL 2000 protocols which used lowered dose of methotrexate , between January 1991 and December 2004. Gender, age at diagnosis, immunophenotype, cranial radiation doses, risk groups, intrathecal treatment modalities, neurological and electroencephalography (EEG) findings, imaging interval and techniques were recorded. These variables were analyzed for their role in cranial lesions. Patiens with CNS leukemia and mature B-cell phenotype were excluded. Results: Ninety patients were enrolled in the study. Sixty three patients had up to 18 Gy cranial radiation, whereas in 27 patients radiation was not utilized. Eleven doses of Intrathecal methotrexate were administered to 77 patients and 13 patients had more intensive regimen. No patients demonstrated cortical atrophy or calcifications. Mild white matter changes (WMC) were observed in eight patients. Only one patient had moderate changes. Eight of the nine patients with WMC had radiotherapy but no significant correlation was found (p>0.05). There were also no significant relation of WMA with gender, age at diagnosis, treatment protocol, risk groups, intrathecal therapy, neurologic symptoms, EEG finding and imaging techniques (p>0.05). Conclusions: Intrathecal treatment does not cause cortical atrophy. White matter changes are not influenced by systemic methotrexate dose but radiotherapy may have an additive effect. Short interval between CNS prophylaxis and imaging can be responsible for the limitation of our study at detecting the late effects of radiotherapy. A new study aiming at investigating the late effects of radiotherapy by performing late imaging studies may be more informative. [ABSTRACT FROM AUTHOR]
- Published
- 2009
13. Akut Miyeloid Lösemili Bir Hastada Subaortik Kitle: Aspergilloma.
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Karakaya, Ekrem, Kaya, Mehmet Güngör, Duran, Mustafa, Kılınç, Yusuf, Inanç, Tuğrul, Topsakal, Ramazan, and Oğuzhan, Abdurrahman
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ACUTE myeloid leukemia , *ACUTE leukemia , *PULMONARY aspergillosis , *HEADACHE , *ABSCESSES , *FLOW cytometry , *ECHOCARDIOGRAPHY - Abstract
We present a case report of a 25-year-old female who developed acute myelogenous leukemia (AML) associated with subaortic mass. The patient was admitted to emergency service with generalized weakness, headache, echhymosis on the upper extremities. Examination of bone marrow and flow cytometric analysis indicated AML-M2. The patient was complete remission antileukemic chemotherapy. Multiple cerebral fungal abscesses developed in patient. magnetic resonance imaging showed cerebral abscesses. A stereotaxic biopsy showed hypha. Aspergillus spp was isolated abscesses culture. Transthoracic echocardiography (TTE) revealed that 2,5x1,4x1,2 cm smooth-shaped, mobile, subaortic mass. Her condition deteriorated rapidly and the patient died. [ABSTRACT FROM AUTHOR]
- Published
- 2009
14. THYROID ABSCESS IN A PATIENT WITH ACUTE LYMPHOBLASTIC LEUKEMIA DURING CHEMOTHERAPY INDUCED NEUTROPENIA.
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Bahat, Gülistan, Erten, Nilgün, Saka, Bülent, Akal, Didem, Çakır, Ali, Karan, Mehmet Akif, Taşçıoğlu, Cemil, and Kaysı, Abdülkadir
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FEBRILE neutropenia , *BLOOD disease treatment , *DISEASE complications , *LYMPHOBLASTIC leukemia , *DRUG therapy - Abstract
Febrile neutropenia is a commonly encountered complication during the treatment of hematological malignancies. Respiratory system, skin, gastrointestinal system and genitourinary system infections are the common causes of febrile neutropenia. The infection of thyroid gland is rarely seen even in neutropenic patients. Here, we describe a patient with acute lymphoblastic leukemia who was treated with intensive chemotherapy and developed suppurative thyroiditis during neutropenic period. It is proposed that prior neutropenia and preceding cellulitis around the thyroid gland, which might be subsequent to oral mucosal damage induced by anticancer drugs, may play a role in the development of gland infection. Thyroid gland infection should be considered a potential complication of aggressive chemotherapy for leukemia. [ABSTRACT FROM AUTHOR]
- Published
- 2006
15. The effect of alopesia on body image and self-esteem in acute leukemia patients
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Doğan, Dilek, Kahraman, Beyza Nur, Bursa Uludağ Üniversitesi/Sağlık Bilimleri Fakültesi/Hemşirelik Bölümü/İç Hastalıkları Hemşireliği Anabilim Dalı., Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Hematoloji Bilim Dalı., Pehlivan, Seda, and Özkalemkaş, Fahir
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Acute leukemia ,Body image ,Alopesi ,Self-esteem ,Alopecia ,Akut lösemi ,Beden imajı ,Benlik saygısı - Abstract
I. Uluslararası İç Hastalıkları Hemşireliği Kongresi’nde sözel bildiri olarak sunulmuştur (25-27 Kasım 2018, Antalya). Çalışma, akut lösemi hastalarında alopesinin beden imajı ve benlik saygısına etkisini belirlemek ve sağlıklı bireylerle karşılaştırmak amacıyla planlandı. Tanımlayıcı nitelikte olan çalışmaya, 6 aylık sürede hematoloji polikliniği, kliniği ve ayaktan kemoterapi ünitesinde tedavi gören 91 akut lösemi hastası ile 94 sağlıklı birey dahil edildi. Çalışmanın verileri, Hasta/Sağlıklı Bilgi Formu, Kemoterapiye Bağlı Alopeside Yaşam Kalitesi Ölçeği (KBAYKÖ), Rosenberg Benlik Saygısı Ölçeği ve Beden İmajı Ölçeği ile toplandı. Verilerin değerlendirilmesinde; SPSS kullanılarak, yüzdelik, ki-kare, student t testi, ANOVA ve Pearson korelasyon analizleri yapıldı. Alopesi görülme oranı akut lösemi hastalarında %63.7, sağlıklı bireylerde ise %57.4 olarak bulundu (p>0.05). Ancak alopesi düzeyinin hastaların %84.5’inde gözle açıkça görülebilir, sağlıklı bireylerde ise %75’inde gözle belli belirsiz görülebilir şeklinde olduğu saptandı (p=0.000). Hastaların genel sağlık puanı ile benlik saygısı (p=0.000) ve beden imajı (p=0.000) arasında pozitif ilişki olduğu belirlendi. Alopesinin akut lösemi hastalarında benlik saygısını olumsuz etkilediği, beden imajını etkilemediği saptandı. Akut lösemi hastalarında genel sağlık ile ilişkisi göz önüne alındığında, alopesinin hastalar üzerindeki etkisi, benlik saygısı ve beden imajının değerlendirilmesinin gerektiği düşünülmektedir. The aim of study was to determine the effect of alopecia on body image and self-esteem in acute leukemia patients and to compare with healthy individuals. The descriptive study was performed at the hematology outpatient polyclinic, clinic and chemotherapy unit within 6 months. 91 patients with acute leukemia and 94 healthy individuals were included in the study. Data were collected by Patient/Healthy Information Form, Chemotherapy Induced Alopecia Quality of Life Scale (CIAQLS), Rosenberg Self-Esteem Scale and Body Image Scale. Percentage, chi-square, student t test, ANOVA and Pearson correlation analyzes were performed by using SPSS. The rate of alopecia was 63.7% in acute leukemia patients and 57.4% in healthy individuals (p>0.05). However, alopecia level was found clearly seen in 84.5% of the patients and visibly invisible 75% in healthy individuals (p=0.000). It was determined that there was a positive relationship between the general health score of the patients and self-esteem and body image (p=0.000). Alopecia had negative effects on self-esteem in patients with acute leukemia and did not affect body image. Considering its relationship with general health in patients with acute leukemia, the effect of alopecia on patients, self-esteem and body image are thought to be evaluated.
- Published
- 2019
16. Aksama ile getirilen bir akut lösemi vakası.
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Cavkaytar, Özlem, Aytaç, Selin, Çakır, Meltem Didem, and Tekşam, Özlem
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ACUTE leukemia , *SYMPTOMS in children , *LYMPHOBLASTIC leukemia in children , *PEDIATRIC emergency services , *MUSCULOSKELETAL system diseases , *CANCER , *CHILD mortality - Abstract
Limping is defined as an abnormal pattern of ambulation in which the swing and the stance phases of gait are markedly asymmetric according to the age and gender of the child. Limping should be considered as a serious complaint, which accounts for an important portion of the applications to the pediatric emergency services. In such a condition, the important thing is to differentiate the life-threatening causes. Acute trauma and many musculoskeletal diseases caused by neurologic rheumatologic and infectious conditions can give rise to limping. Limping can also be the first symptom of hematologic and oncologic malignancies such as leukemia, Ewing sarcoma and osteosarcoma, which may result in serious mortality and morbidity if there is a delay in diagnosis. In this article, a child with limping who was diagnosed as acute lymphoblastic leukemia is reported. [ABSTRACT FROM AUTHOR]
- Published
- 2010
17. POLYCYTHEMIA VERA: UPDATE ON PATHOGENESIS, DIAGNOSIS AND MANAGEMENT
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Fatma Deniz Sargin and Ipek Yonal
- Subjects
Acute leukemia ,medicine.medical_specialty ,Myeloid ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Gastroenterology ,Thrombosis ,Pathogenesis ,Bone marrow examination ,medicine.anatomical_structure ,Polycythemia vera ,Health Care Sciences and Services ,Internal medicine ,Immunology ,Acute leukemia transformation,Myeloproliferative neoplasm,Polycythemia vera,Thromboticcomplications ,Medicine ,Platelet ,Sağlık Bilimleri ve Hizmetleri ,business ,Myeloproliferative neoplasm ,Akut lösemiye dönüşüm,Miyeloproliferatif neoplazi,Polisitemia vera,Trombotik komplikasyonlar - Abstract
Polisitemia vera (PV), eritrosit kitlesinde mutlak artış ile karakterize, sıklıkla granülosit ve trombositlerin aşırı üretiminin ve splenomegalinin eşlik ettiği bir miyeloproliferatif neoplazidir. JAK2V617F mutasyonu, PV tanılı olguların %95’inden fazlasında görülmektedir. Kemik iliği incelemesinde eritroid, miyeloid ve megakaryositik seride proliferasyon görülür. PV’nın prognozu, klinik seyir sırasında ortaya çıkan komplikasyonların ciddiyetine bağlıdır. PV’da morbidite ve mortalitenin ana nedeni trombotik komplikasyonlardır. Yaşam, hastalığın pletorik fazında uygun tedavinin başlanıp başlanmamasından etkilenmektedir. Kontrol edilemeyen eritrositoz varlığında tromboz riski belirgin şekilde artış gösterir. Bazı çalışmalarda PV’nın normal veya normale yakın yaşam süresi ile ilişkisi gösterilmiştir. Fakat, birçok çalışmada PV’da trombotik komplikasyonlar ve akut lösemiye dönüşüm sonucunda artmış mortalite olduğu bildirilmiştir. Bu derlemenin amacı, PV tanılı olgularda patogenez, tanı yöntemleri ve güncel tedaviyi vurgulamaktır., Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by increased red blood cell mass and usually overproduction of granulocytes and platelets and increased spleen size. JAK2V617F mutation is present in more than 95% of PV patients. Bone marrow examination reveals excessive proliferation of erythroid, myeloid, and megakaryocytic elements. The prognosis of PV depends on the severity of the complications occurring during the clinical course. Thrombotic complications are the main cause of morbidity and mortality in PV. Survival is affected whether appropriate therapy is applied during the erythrocytotic phase of the disease. Uncontrolled erythrocytosis poses very high risk for development of thrombosis. Some studies suggest that PV patients have a normal or near-normal lifeexpectancy. Most studies, however, report excess mortality caused by thrombotic complications and acute leukemia transformation during course of PV. This review aims to highlight the pathogenesis, diagnosis and current management in PV
- Published
- 2015
18. CD79a, CD56 ve CD5 ko-ekspresyonu gösteren ve bifenotipik lösemi ile karışan AML M1’li çocuk olgu
- Author
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Ayşen Türedi Yıldırım, Hüseyin Gülen, Celal Bayar Üniversitesi, Tıp Fakültesi, Pediatrik Hematoloji Kliniği, TR202783, TR109580, and 0-Belirlenecek
- Subjects
lcsh:R5-920 ,Biphenotypic acute leukemia ,Acute myeloid leukemia ,hemic and lymphatic diseases ,Ko-ekspresyon ,lcsh:R ,lcsh:Medicine ,Coexpression ,Akut myelositer lösemi ,acute myeloid leukemia ,lcsh:Medicine (General) ,Bifenotipik akut lösemi - Abstract
Bifenotipik akut lösemi (BAL), lösemik blastlarda aynı hücre üzerinde birden çok antijen ko-ekspresyonu varlığı veya iki farklı türde blast popülasyonu bulunması olarak tanımlanır. Burada öncelikle BAL tanısı alan, sonraki tetkiklerinde akut myelositer lösemi M1 (AML-M1) olduğu saptanan bir hasta sunuldu. Dört yaşında erkek hasta, iki aydır olan yüksek ateş, halsizlik, iştahsızlık ve kilo kaybı şikayeti ile başvurdu. Kemik iliği aspirasyonu incelemesinde %96 L2 tipi blastlar saptandı ve flow-sitometride CD79a, CD56, CD5, CD13, CD33, ve MPO pozitifiliği gözlendi. Bu sonuçlar “European Group for the Immunological Characterization of Leukemias (EGIL)” sınıflamasına göre değerlendirildiğinde BAL tanısı düşünüldü. Steroid tedavisine cevap vermemesi üzerine, flowsitometri sonuçları “Dünya Sağlık Örgütü (WHO)”nun sınıflaması- na göre tekrar değerlendirildi. BAL tanısı dışlandı ve AML M1 tanısı düşünüldü. Flowsitometrideki CD79a, CD56 ve CD5 pozitifliği ise ko-ekspresyon olarak değerlendirildi. AML tanısına yönelik verilen kemoterapiye dramatik olarak cevap verdi. Bu vaka BAL tanısında EGİL kriterlerinin kullanımının hatalı sonuçlara yol açabileceğini, WHO sı- nıflamasının kullanılmasının daha uygun olacağını vurgulamak amacıyla sunuldu. Biphenotypic acute leukemia (BAL) is defined as the existence of multiple antigen coexpression in leukemic blasts or two different types of blast population. In this study, a patient who was first diagnosed with BAL and later with acute myeloid leukemia M1 (AML-M1) is presented. The patient was four-year-old male and had complaints about high fever, fatigue, lack of appetite, and weight loss for two months. % 96 L2 type blasts were identified in bone marrow aspiration, and positive values for CD79a, CD56, CD5, CD13, CD33, and MPO were observed in flow-cytometry. These findings, evaluated on the basis of “European Group for the Immunological Characterization of Leukemias (EGİL)” criteria, suggested BAL. As the steroid treatment returned no response, the flow-cytometry findings were reevaluated based on “World Health Organization (WHO)” criteria. BAL was excluded and AML M1 was considered as a diagnosis. The positive values for CD79a, CD56 , and CD5 were evaluated as coexpression. Chemotherapy was given as AML treatment, and the dramatic response was reported. This case is presented to show that, using EGİL criteria to evaluate BAL may be misleading , and thus using WHO criteria to evaluate BAL may be more appropriate.
- Published
- 2015
19. Two cases of H1N1 influenza infection as the initial presentation of acute leukemia
- Author
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Yildirim, Afra, Sivgin, Serdar, Kaynar, Leylagül, Baspinar, Osman, Kurnaz, Fatih, and Metan, Gökhan
- Subjects
Key words: H1N1 virus,influenza infection,acute leukemia ,viruses ,virus diseases ,General Medicine ,respiratory tract diseases - Abstract
Pandemic 2009 influenza A virus (H1N1) is a new influenza virus causing illness in human populations. Immunocompromised patients are at high risk for the acquisition of influenza and serious influenza-associated complications. However, there are no reports about patients with both newly diagnosed acute leukemia and H IN I influenza infection. We reported 2 cases of previously healthy patients with H1N1 influenza infection as the initial presentation of acute leukemia.
- Published
- 2014
20. Determination of minimal residual disease in acute leukaemia using flow cytometry and it’s correlation with relapse
- Author
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Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Hematoloji Bilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Klinik Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı., Ozan, Ülkü, Özkalemkaş, Fahir, Ali, Rıdvan, Budak, Ferah, Göral, Güher, Özkocaman, Vildan, Özçelik, Tülay, and Tunalı, Ahmet
- Subjects
Acute leukemia ,Minimal residual disease ,Minimal residüel hastalık ,Akut lösemi ,Flow cytometry ,Prognosis ,Akım sitometrisi ,Prognoz - Abstract
Çalışma Blood (Journal of the American Society of Hematology) Vol 94, No 10, Supplement 1, 1999’da abstract olarak yayınlanmıştır. Morfolojik olarak tam remisyonda kabul edilen akut lösemi olgularında kemik iliğindeki rezidüel lösemik hücrelerin relapsa yol açtığı bilinmektedir. Bu çalışmanın amacı, minimal residüel hastalık (MRD) tesbitinde akım sitometrisinin kullanımını ve MRD ile hastalıksız yaşam arasındaki korelasyonu değerlendirmektir. Biz önce 89 akut lösemi olgusunda tanıdaki immünfenotip sonuçlarını değerlendirdik ve %73’ünde nadir görülen koekspresyonlar saptadık. Daha sonra, halen hayatta olan 16 olgunun başlangıçta ve komplet remisyondaki (KR) koekspresyon düzeyleri karşılaştırıldı ve 28-40 haftalık takip süresince KR’da kalan 8 olguda anlamlı azalma gözlendi. Buna karşın, olguların 3’ünde, remisyondaki koekspresyon düzeylerinin tanıda belirlenene yakın olduğu dikkati çekti ve bunlardan 2’si 19 ve 30 hafta sonrasında nüksettiler. Bu veriler, rezidüel hastalığın relapsın habercisi olduğunu ve bunu belirlemede akım sitometrisi yönteminin kullanılabileceğini desteklemektedir. It’s known that many acute leukemia patients in morphologic remission would eventually relapse due to the persistence of residual leukemic cells. The aim of this study was to evaluate the use of flow cytometry (FC) to detect minimal residual disease (MRD) and the correlation between MRD and relapse-free survival. We have first evaluated the immunophenotypic outcomes of 89 acute leukemia patients during admission and rarely seen coexpressions (UC) were found in 73% of them. Then the initial levels of UC were compared with the levels during complete remission (CR) in 16 alive cases and a significant decrease was observed in 8 cases who have remained in CR for 28-40 weeks of follow-up. However, in 3 cases, coexpression levels in remission were almost the same with the initial levels and 2 of them relapsed after 19 and 30 weeks. These results confirm that FC would be useful in the assessment of MRD and a gradual increase of leukemic cells would be suggestive for subsequent relapse.
- Published
- 2004
21. Evaluation of angiogenesis in acute leukemia patients
- Author
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Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Hematoloji Bilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı., Özçelik, Tülay, Ali, Rıdvan, Özkalemkaş, Fahir, Özkocaman, Vildan, Ozan, Ülkü, Öztürk, Hülya, and Tunalı, Ahmet
- Subjects
Acute leukemia ,Anjiyogenezis ,Akut lösemi ,Angiogenesis - Abstract
Anjiogenezisin solid tümörlerdeki önemi iyi bilinmektedir. Fakat, hematolojik neoplazmlar için az sayıda veri bulunmaktadır. Çalışmamızda tedavi edilmemiş akut lösemili hastaların kemik iliklerinde anjiogenezisin rolünü araştırmayı amaçladık. Tedavi edilmemiş hastaların kemik iliğindeki mikrodamar sayıları, kontrol olgularının ve komplet remisyon dönemindeki olguların mikrodamar sayıları ile karşılaştırıldı. Çalışmaya on üç hasta alındı. Kemik iliği örnekleri immunohistokimyasal olarak von Willebrand faktör ile boyandı. Her kemik iliği örneğinde damar yoğunluğunun en fazla olduğu alanlardan iki tanesinde mikrodamar sayımı yapıldı. Anjiogenezis, 400’lük büyütmedeki damarların sayısı olarak ifade edildi. Kemik iliği mikrodamar sayısı akut lösemili hastalarda kontrol grubuyla karşılaştırıldığında önemli oranda artmış bulundu (p
- Published
- 2003
22. Clinical and microbial features of the episodes of febrile neutropenia in acute leukemia patients
- Author
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Çelebi H., Turgut M., Yücel I., and Ondokuz Mayıs Üniversitesi
- Subjects
Acute leukemia ,Febrile neutropenia ,Bacteremia ,Infections - Abstract
Infections are the major causes of morbidity and mortality in acute leukemia patients. We retrospectively analyzed the episode of febrile neurtopenia in acute leukemia patients. This study included 50 patients. Median neutropenia duration was 15 day. Bacteremia was confirmed in 27 episodes (54%) of which 15 (56%) were caused by Gram-negative bacilli and 12 (44%) by Gram-positive cocci. The predominant organisms were: E.coli (8), Coagulase negative staphylococci (7), Enterecoccia (6), Staphylococcus aereus (6), Candida (3). In eleven episodes (22%) clinical infections were diagnosed. All patients were started empirically on antibacterial agents. A combination of betalactums and aminoglycoside were used in 15 episodes. Antifungal therapy with amphotericin B (18) or fluconazole (6) was added because of persistent fever despite broad antibacterial coverage. Six patients died (12%) of infections complications in this study. Our results show that infections with Gram-negative bacteria continue to predominate. A trend toward a higher mortality of infections caused by Gram-positive cocci and pneumonia were noted.
- Published
- 2003
23. Mitoxantrone as a single agent in adult patients with refractory and/or relapsed acute leukemia
- Author
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Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Hematoloji Bilim Dalı., Manavoğlu, Osman, Tunalı, Ahmet, Özkalemkaş, Fahri, Sakar, Mehmet, and Ali, Rıdvan
- Subjects
Acute leukemia ,Mitoksantron ,Akut lösemi ,Mitoxantrone - Abstract
Günümüzde halen relaps gösteren ve/veya refrakter erişkin akut lösemi olguları ile blastik dönüşüm gösteren KML olgularında (KML-B2) prognozu iyileştirecek yeni tedavi imkanları araştırılmaktadır. Tek ajan olarak mitoksantronun 12 mg/m-/gün IV 1-5 gün uygulanması ile bu hastaların tedavisinde umut verici sonuçlar alındığı bildirilmiştir. Biz de bu tedavinin klinik etkinliğini araştırmak amacıyla 4'ü ALL, 2'si ANLL ve 2'si KML-B olmak üzere toplam 8 refrakter olguda tek başına mitoksantron uyguladık. 1 olgu indüksiyon sırasında kaybedildi, 1 olgu cevapsız kaldı, 6 olguda 3-7 günlerde belirginleşen lökopeni gelişti. Bu 6 olgudan 3'ünde 3 haftayı aşan miyelosupresyon oluştu . Tedavi hastalar tarafından çok iyi tolere edildi. Herhangi bir kardiak, hepatik ya da renal yan etki saptanmadı. Research are ongoing in recent days for achieving better prognosis for refractory and/or relapsed acute leukemia cases and CML cases with blastic transformation (KML-B). In recent reports promising results are reported for the therapy of these patients using mitoxantrone 12 mg/m2/day IV 1- 5 days as a single agent. In order to test the clinical efficacy of this therapy we performed mitoxantrone as a single agent in 8 refractory cases (4 ALL, 2 ANLL, 2 CML-B). 1 case was died white induction, 1 case had no answer the therapy. In 6 cases leukopenia has been seen in 3-7 days. 3 of these 6 patients there has been a myelosuppression more than 3 weeks. Therapy is well tolerated by the patients. No hepatic, renal or cardiac side effect has been determined.
- Published
- 1993
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