1. Kişiye Özgü Geliştirilen Antijen Reseptörü ile Hücre Tedavisi (CAR-T).
- Author
-
GÖK, Özlem and ASLAN, Abdullah
- Subjects
- *
CHIMERIC antigen receptors , *CHRONIC lymphocytic leukemia , *SKIN cancer , *TUMOR treatment , *T cell receptors , *RITUXIMAB ,BONE marrow cancer ,BONE marrow examination - Abstract
Given the use of the body's own immune system, immunotherapy; promises a more effective and durable treatment than traditional treatments to treat cancer. A type of immunotherapy chimeric antigen receptor-T (CAR-T) cell therapy is a promising new T cell immunotherapy in cancer treatment. CAR-T a fusion protein comprising an antigen recognition fragment and T cell signaling sites. CAR-T cell, predominantly; acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), lymphoma (lymph cancer), multiple myeloma (bone marrow cancer) have been used in the treatment of hematological cancers. CAR-T cell; melanoma (skin cancer), breast cancer and sarcoma (tumor in the connective tissue), such as the treatment of tumors promises great promise. Studies are underway to improve chimeric antigen receptor technology to increase safety and efficacy, reduce production costs and make it more applicable than hematological cancers, and the number of clinical trials continues to grow exponentially. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF