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We have reported here a case of a 68-year-old female patient with hypertension and a history of spinal fixation 4 years ago. She was admitted to the intensive care unit for sepsis. She presented with lower back pain, sciatica in her left lower limb, saddle hypoesthesia, urine incontinence, and an inability to walk or stand. Three days before her admission, she had developed a fever. A review of her medical history revealed repeated consumption of unpasteurized milk and cheese. Blood culture tested positive for Brucella infection, which was supported by the results of the positive Rose Bengal test and tube agglutination test. The spine magnetic resonance imaging revealed an abnormal enhancement of the cauda equina. The patient received treatment with gentamicin, rifampicin, and doxycycline for 6 months, which yielded an excellent response. After 6 months, laboratory data and radiological findings normalized and neurological signs resolved completely.