1. Erken Gebelik Kaylplarlnda Trombofîlik Faktörlerin Önemi.
- Author
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ŞEN, Serdar, HIZLP, Deniz, TAŞÇI, Yasemin, and DİLBAZ, Serdar
- Subjects
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BLOOD coagulation factors , *FETAL death , *PROTEIN C , *ANTITHROMBIN III , *PROTEIN S deficiency , *ANTICARDIOLIPIN antibodies , *CHI-squared test , *T-test (Statistics) - Abstract
Objective: The aim of the present study was to investigate the role of thrombophilic factors in fetal losses at 10-16 gestational weeks. Materials and Methods: Between April 2003 and May 2004, 50 women who were hospitalized due to fetal loss at 10-16 gestational weeks were defined as study group and 50 women with at least 1 healthy term infant and had no previous miscarriage history were defined as control group. Activated protein C resistance, anti-thrombin III deficiency, protein S deficiency and the presence of anticardiolipin antibodies were evaluated. Chi- square test and independent sample t-test were used for statistical analysis. The cut-off value for statistical significance was set at p <0.05. Results: The groups were similar with regard to mean serum antithrombin III, anticardiolipin antibodies and protein S level. However, activated protein C resistance was more frequent in the study group (22% vs 6%, p=0,047). Moreover, thrombophilia prevelance was higher in study group when compared to control group (42% vs 16%, p=0.001). Conclusion: High prevelance of of thrombophilia found in patients with fetal loss at >10 gestational weeks suggests that thrombophilia screening should be a part of the management of these patients. [ABSTRACT FROM AUTHOR] more...
- Published
- 2013