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Object: Rejections observed in live donor liver transplants (LDLT) after the 6th month are defined as "late acute rejection" (LAR). Liver biopsy is still the gold standard for diagnosis of these cases. However, considering the morbidity and complications caused by this biopsy, can the non-invasive elevated serum eosinophil count be used as a predictive biomarker for LAR? Materials and Methods: Our research included patients with LDLT performed from June 2000 to June 2017 at Dokuz Eylül University Faculty of Medicine General Surgery Liver Transplant Unit, aged over 18 years and surviving at least 6 months. Patients developing late acute rejection were investigated in terms of demographic data, necessary graft weight/graft weight present ratio, cold ischemia duration, Child and MELD scores, doses of immunosuppressive agents before rejection, serum therapeutic levels and comorbidities. Our study retrospectively screened blood laboratory samples before biopsy and pathologic results of liver biopsies performed on patients with suspected LAR. Elevated serum eosinophil values were investigated and their effective role in diagnosis of LAR was researched. Results: Of 240 liver transplant cases included in the study, 65 (26.9%) had liver biopsy performed due to consideration of rejection linked to elevated liver function tests during follow-up. Of the biopsy transplant cases, 28 (43%) had LAR identified, while 37 (57%) had no finding of rejection encountered. The distribution of rejection in cases with rejection diagnosis was 10 (35.7%) mild, 13 (46.4%) moderate and 5 (17.9%) severe according to Banff pathology scoring. Of patients 21 (75%) were male and 7 (25%) were female. The mean follow-up duration was 3056 days (184-4877). The mean time of liver biopsy was the postoperative 660th day (180- 4354). There was a statistically significant correlation identified between elevated eosinophil count found in blood laboratory values before biopsy with LAR (p<0.001). Discussion and Conclusion: For diagnosis of LAR which may occur during follow-up of LDLT, the non-invasive method compared to liver biopsy of elevated serum eosinophil values may be used as a predictive marker. [ABSTRACT FROM AUTHOR]