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Telomeres are natural nucleoprotein structures that cover the ends of chromosomes. The phenomenon of telomere shortening, which plays a crucial role in maintaining the stability of the genome, occurs gradually over time when cells undergo division due to the end replication issue. Multiple studies have demonstrated a correlation between telomere shortening and a range of illnesses, including diabetes, dyslipidemia, cardiovascular disease, cancer, and mortality. Diet and lifestyle can affect telomere length. There exists a beneficial association between telomere length and the Mediterranean diet, particularly with regards to the consumption of dietary fiber derived from whole grains and vegetables. Micronutrients such as vitamins and trace elements also play a role in cell metabolism. Some micronutrients, such as vitamin D, folate, and vitamin B12, are associated with telomere biology and cellular aging. Vitamin B12 is essential for DNA synthesis and epigenetic methylation processes. The present systematic review examines the results from clinical trials conducted in humans evaluating the role of vitamin B12 on telomere length. Cellular senescence is a state characterized by inflammation, altered cellular metabolism, genomic instability, and telomere dysfunction, which can be induced by changes in methylation patterns and oxidative stress. Vitamin B12 maintains antioxidative defense. Through these pathways, sufficient amounts of vitamin B12 may potentially play a role in the restoration of DNA damage. Most of the evidence is based on very few randomized clinical trials. Therefore, more extensive prospective cohort studies and better-designed randomized clinical trials are required to validate the correlations outlined in this review.

Copyright of Journal of Physical Medicine & Rehabilitation Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Fenerbahce University Journal of Health Sciences (FBU-JOSH) / Fenerbahçe Üniversitesi Sağlık Bilimleri Dergisi is the property of Fenerbahce University Journal of Health Sciences (FBU-JOSH) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Van Health Sciences Journal / Van Sağlık Bilimleri Dergisi is the property of Van Yuzuncu Yil University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: Accumulating data demonstrated that raised homocysteine is a risk factor for ischemic stroke. However, it remains unclear whether high homocysteine level is also a risk factor for hemorrhagic stroke, which accounts for about one-fifth of stroke patients. Our aim was to measure the plasma homocysteine levels in patients with hemorrhagic stroke to explore a possible link. Materıals and Methods: We included thirty patients with ischemic stroke, thirty patients with hemorrhagic stroke, and thirty healthy volunteers. All participants were examined for traditional risk factors and levels of folic acid, homocysteine, and vitamin B12. Results: Hypertension was higher in both ischemic stroke and hemorrhagic stroke patients than in healthy participants (p=0.029). Homocysteine levels were significantly higher in both ischemic stroke and hemorrhagic stroke groups than in the control group (p=0.001), with no statistically difference between each other (p>0.05). Vitamin B12 levels were significantly lower in both ischemic stroke and hemorrhagic stroke patients than in the controls (p=0.001), with no statistically difference between each other (p>0.05). Folic acid levels did not significantly differ between the groups (p>0.05). We did not find correlation between homocysteine, vitamin B12 and folic acid levels (p>0.05). Conclusion: Our study indicated that the homocysteine levels were high in patients with hemorrhagic stroke. Larger cohorts are needed to clarify the role of homocysteine in hemorrhagic stroke.

Background and Design: No evidence suggests that any micronutrients are associated with seborrheic dermatitis (SD). The etiopathogenesis of SD is attributed to excessive proliferation of Malassezia species in the skin, deterioration in epidermal barrier functions, and inflammation. Vitamin B12 affects the immune system. Moreover, the ferritin molecule can act as a proinflammatory cytokine and has immunomodulating effects. Vitamin D has immunomodulatory effects and affects the epidermal barrier. Therefore, we thought that low serum levels of these parameters might affect immune responses against Malassezia species that caused SD. The study aimed to compare the serum vitamin B12, ferritin, and vitamin D levels of patients with SD with healthy controls. Materials and Methods: Patients aged 18-50 years who applied to the dermatology outpatient clinic and were found to have SD during dermatological examination were retrospectively reviewed. Serum vitamin B12, ferritin, and vitamin D levels of 63 patients with SD and 37 healthy controls were compared. Categorical variables were compared using chi-square analysis. Student's t-test was used to compare constant variables, and Pearson's correlation test was applied for the correlation analysis. P

Aim:Nowadays, insufficiency and deficiency of vitamin B12 and folate are seen as an important health problem. The purpose of the present study was to determine the frequency of vitamin B12 and folate deficiencies in pregnant women and their babies at birth.Materials and Methods:The study group consisted of 117 pregnant women and their single, term babies in İzmir Ege Maternity Hospital. Analysis of vitamin B12, folate and homocysteine levels were performed from venous blood samples which were obtained from the mother and cord blood at birth. Additionally, a questionnaire using a face-to-face interview method was performed with the pregnant women included in this study. The mean duration of pregnancy was 39.1±0.89 weeks and the mean age of the mothers was 28.2±6.2 years.Results:Vitamin B12 deficiency (8 µmol/L) in 58.1% of mothers and 63.2% of babies. There was a significant correlation between maternal and cord blood vitamin B12, folate and homocysteine levels (p

Copyright of Etlik Veteriner Mikrobiyoloji Dergisi is the property of Veteriner Kontrol Merkez Arastirma Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives: It is known that vitamins have some effects such as suppressing viral replication, developing anti-inflammatory responses and that they increase immunity in COVID-19. This study aimed to investigate the correlation between the vitamin B12 (Vit B12) serum levels and the prognosis of the disease in patients with COVID-19. Material and Method: A total of 408 participants were included in the study. Sociodemographic information such as age, educational status, serum vitamin B12 levels, hemogram parameters, and clinical findings of the patients who were admitted for follow-up after the end of COVID-19 infection was evaluated retrospectively. Serum vitamin B12 level between 150-200 pg/mL was assessed as mild deficiency, the value between 100-150 pg/mL as severe deficiency and the value under 100 pg/mL as extremely severe deficiency. Results: Median age of the participants was 44.51 (18-88) years. The median Vit B12 level of the patients was 179.50 (75-641). Of the patients, 248 (60.70%) had Vit B12 deficiency. The rates of pneumonia and hospitalization were higher and fatigue and loss of taste/smell were more in patients with Vit B12 deficiency. NLR and PLR which are the inflammatory markers were higher in patients with Vit B12 deficiency. The rates of pneumonia and hospitalization were the highest in the severe Vit B12 deficiency group among the Vit B12 deficiency groups. Conclusion: The clinical progression was worse in COVID-19 patients with Vit B12 deficiency than those who had no Vit B12 deficiency. Therefore, it has been concluded that Vitamin B12 supplement can have positive effects on COVID-19 patients; however, more comprehensive further studies with longer duration and higher number of patients are needed.

Purpose: We aimed to investigate the relationship between first trimester vitamin D, vitamin B12 and ferritin levels with preeclampsia and neonatal outcomes. Materials and Methods: 191 patients diagnosed with preeclampsia (PE) and 99 healthy pregnant women were included in the study.. Age, gravida, parity, body mass index (BMI), mode of delivery, birth weight, APGAR score, neonatal intensive care unit (NICU) admission and delivery week were recorded. First trimester vitamin D, vitamin B12 and ferritin levels were determined in laboratory analyzes. Evaluation was made by separating three groups as without PE, with PE and with severe PE. Results: Differences were found between BMI measurements, birth weeks, birth weights and NICU acceptance values (p=0.003; 0.001; 0.001; 0.001 respectively). Babies in the PE group had lower mean birth weeks, birth weights and APGAR scores. In the PE group had a higher rate of cesarean section (p=0.001). The vitamin D level of the PE group was lower than the group without PE. It was found that the vitamin D level decreased in proportion to the severity of PE. The B12 level of the non-PE group was higher than PE group (p=0.001). The ferritin level of the non-PE group was found to be lower than the PE group (p=0.001). Conclusion: Low vitamin D and B12 levels and high ferritin levels in the first trimester may be beneficial in predicting preeclampsia. We think that especially vitamin D, B12 and iron supplementation is a simple but effective approach to reduce perinatal morbidity and mortality in preeclampsia.

Amaç: Bu çalışmada, vitamin B12 eksikliği olan çocuklarda oksidatif stres belirteci olarak tiyol/disülfit dengesinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya vitamin B12 eksikliği olan 61 çocuk hasta ve 62 sağlıklı çocuk kontrol grubu olarak dahil edildi. Katılımcıların vitamin B12, homosistein, tam kan sayımı ve tiyol/disülfit dengesi parametreleri ölçüldü. Grupların klinik ve laboratuvar parametreleri karşılaştırıldı. Tiyol/disülfit dengesi parametreleri ile vitamin B12 ve homosistein arasındaki ilişki araştırıldı. Bulgular: Gruplar yaş ve cinsiyet dağılımı açısından benzerdi. Medyan vitamin B12 düzeyi hasta grubunda 179 (98-199) pg/ml, kontrol grubunda 298 (201-965) pg/ml idi. Hasta ve kontrol grubu arasında; homosistein, nativ tiyol, total tiyol, disülfit, disülfit/nativ tiyol oranı, disülfit/total tiyol oranı ve nativ tiyol/total tiyol oranı açısından anlamlı fark saptanmadı. Hasta ve kontrol grubunda, tiyol/disülfit dengesi parametreleri ile vitamin B12 ve homosistein düzeyleri arasında anlamlı korelasyon saptanmadı. Sonuç: Hasta grubumuzda vitamin B12 düzeyinin belirgin düşük olmaması nedeniyle homosistein düzeyinde anlamlı artış olmadığı düşünülmüştür. Homosisteini artırmayan bir vitamin B12 eksikliğinin, oksidatif stresi artırmayacağı, dolayısıyla antioksidan kapasiteyi de artırmayacağı öngörülebilir.

Aim: Vitamin B12 is essential for DNA synthesis and hematopoiesis, and its severe deficiency not only causes anemia, but may also result in thrombocytopenia and leucopenia. In this study, we analysed the relationship between hematological status and vitamin B12 deficiency and draw attention to this issue. Material and Method: The data gathered from our institute Gaziantep University Hospital outpatient clinics electronic database. Six hundred forty children were evaluated. The inclusion criteria were child patients with less than 200 ng/l vitamin B12 levels. Results: Four hundred seventy-seven patients (74.5%) had no hematological abnormalities. Anemia was detected in 99 patients (15.5 %), two patients (0.3%) had a Hb-level lt; 7 g/dl, anemia without macrocytosis in 91 (14.2 %), anemia with macrocytosis in 8 (1.3 %), leucopenia in 8 (1.3 %), neutropenia in 22 (3.4 %), lymphopenia in 9 (1.4 %), thrombocytopenia in 6 (0.9 %), and pancytopenia in 3 patients (0.4 %). An examination of the correlation, there were no correlations between vitamin B12 levels and hematological parameters. Conclusion: Our results showed that hematological abnormalities were detected in only 25.5% of patients with Vitamin B12 deficiency, and anemia and neutropenia were the most common hematological abnormalities. In addition, serum vitamin B12 levels were not significantly correlated with the complete blood count parameters.

Objective: This study aims to determine the frequency of vitamin B12 deficiency in children and how it varies according to age groups. Vitamin B12 is an essential vitamin that has an important role in nucleic acid synthesis, erythrocyte maturation, and nervous system development. Vitamin B12 deficiency commonly causes anemia. However, severe deficiency in children can cause permanent neurological damage. Therefore, early detection and treatment of vitamin B12 deficiency make it possible to prevent its permanent effects. In addition, determining the age groups at risk allows early diagnosis. Material and Method: The study included children aged 0-18 years admitted to anambulatory pediatric outpatient clinic. Serum vitamin B12 values of children were examined. Vitamin B12 levels below 200 pg/mL were considered a deficiency and between 200-300 pg/mL a marginal level. Descriptive methods, Chi-square, and Independent Samples T-Test were used in the statistical analysis of the data. Results: The study evaluated data from 3115 children. 49.6% of the participants were girls, and 50.4% were boys. The mean age was 8.2±5.4 years. The mean serum vitamin B12 level was 436±174 pg/mL. This mean was 442±172 pg/mL in girls and 431±177 pg/mL in boys. Mean vitamin B12 levels did not differ by gender. The frequency of serum vitamin B12 deficiency was 4.1%. However, it was significantly higher in boys than in girls (5.2%-3.0%). The frequency of marginal level was 18.4%. The frequency of vitamin B12 deficiency differed according to age groups. Serum vitamin B12 deficiency was seen at the highest rate between 0-6 months, with 11%. This rate was 7.1% in the 6-24-month group. Conclusion: This study showed the frequency of serum vitamin B12 deficiency in children admitted to anambulatory pediatric outpatient clinic and in certain age groups. In addition, it was seen that vitamin B12 deficiency was common, especially in infancy and adolescence. However, multicenter prospective studies are needed to determine the prevalence and causes of deficiency in a wide area. [ABSTRACT FROM AUTHOR]

Background: Deep vein thrombosis (DVT) is an important cause of mortality and morbidity and may be associated with many different causes. Autoimmune diseases, malignancies, previous major surgical interventions, immobility, hyperhomocysteinemia and some metabolic diseases predispose to DVT. There are studies suggesting that vitamin B12 and vitamin D deficiency, which affect homocysteine metabolism, may be associated with the development of DVT. In our study, we aimed to compare vitamin B12 and vitamin D levels in patients with DVT compared to the control group. Materials and Methods: Between December 2015 and December 2020, 97 patients with DVT and 91 individuals without DVT were included in our study. Serum vitamin B12 and vitamin D levels, clinical and other examination results of the patient and control groups were evaluated retrospectively from the hospital information system. Results: There was no difference in demographic characteristics between the patient and control group included in the study. Serum vitamin D (19.64±8.68 vs 23.63±7.99, p<0.001) and vitamin B12 levels (252.94±101.17 vs 338.51±102.76, p<0.001) were found to be significantly lower in the group of DVT. In multivariate analysis, vitamin B12 level was found to be an independent predictor for DVT. (OR=0.991, 95% CI; 0.987-0.995, p<0.001). Conclusions: Vitamin B12 and vitamin D levels can be easily measured in the blood. In our study, both vitamin levels were found to be low in patients with DVT. It can be used as a possible simple indicator of the development of DVT, especially in patients with risk factors for DVT. [ABSTRACT FROM AUTHOR]

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim:In this study, we aimed to compare the levels of vitamin B12 and folate in children with Attention Deficit and Hyperactivity Disorder (ADHD) and Attention Deficit and Hyperactivity Disorder-Not Otherwise Specified (ADHD-NOS).Materials and Methods:This study was planned as a cross-sectional, retrospective study. Patients were recruited between January 2012 and January 2013 and 205 case records were evaluated. The ADHD and ADHA-NOS groups were compared according to vitamin B12 and folate levels. Symptom severity was evaluated by the Turgay DSM-IV-Based Child and Adolescent Behavior Disorders Screening and Rating scale. Anxiety symptom severity was assessed by The Screen for Anxiety Related Emotional Disorders.Results:The average age of the children in the ADHD group was 10.88±3.02 (n=99) years, and the average age of the children in the ADHD-NOS group was 9.93±2.49 (n=106) years. There was no statistically significant difference between two groups in terms of Vitamin B12 level and folate level (p>0.05). A statistically significant negative correlation between the total number of diagnoses of a child and vitamin B12 levels was found. Folate levels correlated significantly with anxiety total scores generalized anxiety subscale.Conclusion:Vitamin B12 levels may be affected in children with impairing ADHD symptoms and increased comorbidities. The results of the study should be supported by future studies.

Amaç: Vitamin B12 insan vücudunda üretilemeyen ve sadece hayvansal gıdalar ile alınan bir vitamindir. Vitamin B12 DNA sentezinde önemli rol oynar ve eksikliğinde DNA sentezi bozulur. Sonuç olarak megaloblastik anemi gelişir. Bunun sonucunda psikiyatrik, nörolojik ve hematolojik birçok bozukluk meydana gelebilir. Çalışmamızda kliniğimize başvuran bilinen kronik hastalığı ve herhangi bir kronik ilaç kullanım öyküsü olmayan 2-12 yaş arası hastalarda vitamin B12 düzeyleri ile tam kan parametreleri arasındaki ilişkiyi belirlemeyi amaçladık. Gereç ve Yöntem: Çalışmaya Ocak 2016 ile Aralık 2019 tarihleri arasında Gülhane Eğitim ve Araştırma Hastanesi çocuk hematolojisi polikliniğine başvuran, vitamin B12 düzeyi bakılmış 2-12 yaş arası 98 hasta dahil edildi. Hastalar vitamin B12 düzeyi normal (vitamin B12 düzeyi ≥200 pg/ml; Grup 1) olan ve vitamin B12 eksikliği (serum vitamin B12 düzeyi lt;200 pg/ml; Grup 2) olan olarak iki gruba ayrıldı. Bulgular: Grup 1 ve 2 nin vitamin B12 düzeyi sıra ile 311±43.5; 104.8±15.7 olarak bulundu (p lt;0.05), (Tablo). Grup 1 ve 2 nin beyaz küre ve trombosit sayıları arasında istatistisel olarak bir fark bulunmadı, sıra ile beyaz küre sayıları 7.6±4.1; 6.9±3.5, sıra ile trombosit sayıları 273.5±74.6; 267.6±95.2 (p gt;0.05), (Tablo). Sonuç: Sonuç olarak vitamin B12 eksikliğine toplumumuzda sık olarak karşılaşılmaktadır. Tam kan parametreleri olan beyaz küre, trombosit, RDW, MPV ve MCV değerleri birçok durumda tanıda yeterli olmamaktadır. Vitamin B12 düşüklüğünden şüphelenilen hastalarda mutlaka tanı serum vitamin B12 düzeyi ölçülerek kontrol edilmelidir.

Aim:Vitamin B12 is naturally obtained from animal-derived foods and is important for the development and wellbeing of babies. Vitamin B12 deficiency is a general health concern in developing countries. This study aimed to investigate the effects of different feeding practices on vitamin B12 levels and hemogram parameters in infants aged 6-9 months.Materials and Methods:A total of 120 infants (61 boys, 59 girls) aged 6-9 months were retrospectively evaluated. These babies were assigned to three groups according to feeding practices: 1) only breast milk, 2) breast milk and formula, and 3) only formula in addition to complementary foods. Laboratory data (vitamin B12, hemoglobin, hematocrit, mean corpuscular volume, white blood cell count, and absolute neutrophil count) of the patients were retrospectively compared.Results:The mean and median age of the patients was 6.6±1.1 months. The vitamin B12 levels in babies that only received formula were statistically significantly higher than those in babies taking only breast milk or taking both breast milk and formula (p

Copyright of Journal of Physical Medicine & Rehabilitation Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The aim of this study is to investigate the relation between anemia, vitamin deficiency, thyroid dysfunction, and the cognitive status of patients admitted to the medical board due to symptoms of cognitive retardation, a condition that is common in childhood and affects school success negatively. Materials and Methods: In this study, between January 2016- June 2018, serum vitamin B12, ferritin, hemogram and thyroid function tests of 71 pediatric patients, who were found to have had cognitive deficiencies and were admitted to the secondary level state hospital to obtain a medical committee report, were assessed retrospectively. Results: Among 71 children included in the study, 35.2% (n=25) were female and 64.8% (n=46) were male. Mean age was 11.5±2.1. Iron deficiency was detected in 9% of them. While 53.5% of them had normal vitamin B12 levels, the remaining had various degrees of vitamin B12 deficiencies. Thyroid dysfunction was not detected in any patient. There was no significant difference in vitamin B12 (p=0.2) and ferritin (p=0.6) levels in both genders. Normal intelligence score was obtained in 16 (22.5%) of all cases. Mild mental retardation was detected in 8 of the patients with vitamin B12 deficiency, borderline cognitive dysfunction was detected in 19 patients and cognitive dysfunction scores in 6 patients. While 10 of 38 patients without deficiency had normal intelligence quotient scores, 28 had at least 1 level of mental retardation. When the intelligence quotient of the patients with vitamin B12 deficiency and those with normal serum vitamin B12 were compared, no significant difference was found (p=0.13). There was no significant difference in vitamin B12 and ferritin levels when comparing patients with at least one level of mental retardation and normal intelligence scores (p=0.2; p=0.9). Conclusion: During the evaluation of the patients with cognitive retardation, nutritional vitamin-mineral deficiency and anemia status should be evaluated at the initial examination and the cognitive status of the patients should be re-evaluated after treatment. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to investigate the thiol/disulfide balance as a marker of oxidative stress in children with vitamin B12 deficiency. Materials and Methods: Sixty one pediatric patients with vitamin B12 deficiency and 62 healthy children as a control group was included in the study. Vitamin B12, homocysteine, complete blood count and thiol/disulfide balance parameters of the participants were measured. The relationship between thiol/disulfide balance parameters and vitamin B12 and homocysteine was investigated. Results: The groups were similar in terms of age and gender distribution. Median vitamin B12 level was 179 (98- 199) pg/ml in the patient group and 298 (201-965) pg/ml in the control group. Median homocysteine level was 11.2 (0.08-64.3) μmol/L in the patient group and 12 (4.5-26.6) μmol/L in the control group. Median values of homocysteine levels were within the normal range in both groups. Between the patient and control groups; no significant difference was found in terms of homocysteine, native thiol, total thiol, disulfide, disulfide/native thiol ratio, disulfide/total thiol ratio and native thiol/total thiol ratio. There was no significant correlation between thiol/disulfide balance parameters and vitamin B12 and homocysteine levels in the patient and control groups. Conclusion: There was no significant increase in homocysteine level, since the vitamin B12 level was not significantly low in our patient group. It can be predicted that a vitamin B12 deficiency that does not increase homocysteine will not increase oxidative stress and therefore will not increase antioxidant capacity. [ABSTRACT FROM AUTHOR]

Copyright of Medical Journal of Ankara Training & Research Hospital is the property of Medical Journal of Ankara Training & Research Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Vitamin B12 ve folik asit DNA sentezi, tamiri ve ekspresyonunda önemli görevler alırlar. Bu çalışmada çocukluk çağı kanserleri ile vitamin B12 ve folik asit düzeyleri arasındaki ilişki araştırıldı.Gereç ve Yöntem: Kasım 2013 ve Aralık 2015 arasında yeni tanı alan solid tümörlü 125, lenfoproliferatif/miyeloproliferatif malign hastalığı olan 113 hasta ve 63 kontrol çalışmaya dahil edildi. Vitamin B12 ve folik asit düzeyleri tanısal çalışmaların bir parçası olarak tanı anında ölçüldü.Bulgular: Vitamin B12 ve folik asit düzeyleri malign hastalığı olan çocuklarda kontrol grubuna oranla anlamlı olarak düşük bulundu. Homosistein düzeyleri ise kontrol grubuna göre istatistiksel olarak daha yüksekti. Folik asit düzeyleri lenfoproliferatif/miyeloproliferatif malign hastalığı olanlarda solid tümör grubuna oranla daha düşüktü.Sonuç: Düşük vitamin B12 ve folik asit düzeyleri kanser tanısında destekleyici belirteçler olarak kullanılabilir. Bu ilişkinin gelecekte daha geniş serilerle ortaya konması gerekmektedir.

Aim: It was aimed to compare with healthy volunteers the changes in heat shock protein (HSP) 90 alpha and vitamin levels during exacerbation and remission periods in our patients with familial Mediterranean fever (FMF), to research whether these molecules will benefit in control of FMF exacerbation and prevention of amyloid accumulation, and also to investigate the relationship of these molecules with FMF gene mutations. Patients and Methods: HSP 90 alpha, vitamin A, vitamin B 12, vitamin D, vitamin E and folic acid levels were studied in 30 patients with AAA diagnosed in our hospital's pediatric nephrology department during the exacerbation and remission periods and 30 healthy volunteer s and the results were compared. Results: Nineteen of the patients were male, 11 were female, with a mean age of 11 years. Although HSP 90 alpha was the highest in the exacerbation group and the lowest in the remission group, there was no significant difference between the groups. Vitamin B12 was significantly different between the groups and the highest value was in the control group. Vitamin D was significantly different between the exacerbation and the remission groups and the highest value was in the exacerbation group. Vitamin D levels were significantly higher in boys. There was no significant difference between vitamin A, vitamin E and folic acid levels. FMF gene mutations did not af fect HSP 90 alpha and vitamin levels. Conclusion: Our findings showed that serum HSP 90 alpha, vitamin D, vitamin E and folic acid levels were normal in AAA, but vitamin B12 and vitamin A levels were low during exacerbation and remission. [ABSTRACT FROM AUTHOR]

Aim: The aim of our study is evaluate the association between serum vitB12 levels at time of diagnosis and clinical and laboratory signs in multiple (MM) myeloma patients Patients and Methods: Patienst diagnosed MM between 2010-2020 were evaluated. Patients were divided into two groups; those had low and normal levels of vitB12. Groups were analized by using independent simple T, Mann Whitney U and chi-square tests considering by distrubition characteristics of data. Results: Two hundred-and-twelve patients' records were examined retrospectively. Forty-one (32%) patients had low vitB12 levels. In patients with low vit B12 levels, bone marrow plasma cell ratios were also significantly lower than those found normal vit B12 levels (median %30 vs %50, respectively) (p: 0,024). There was no statistically significant difference between the two groups in terms of age, lytic bone lesion numbers, and serum levels of total protein, lactate dehydrogenase, IS2-microglobulin, calcium, creatinin, albumin. However, 11 patients (%26,8) in low vitB12 group had anemia, while 44 (%50,5) patients in normal vitB12 group had. So, anemia was more often in vitamin B12 normal group patients (p: 0,019). No difference was found in terms of myeloma ISS and R-ISS stages in two patient groups. Conclusions: Bone marrow median plasma cell ratio was also low in the group with low vit B12 levels. Our data could not show its clinical reflection. Further studies with larger groups are required to evaluate the response to treatment, survival and recurrence rate. [ABSTRACT FROM AUTHOR]

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim:Vitamin B12 deficiency is an important problem in pregnancy because it affects not only mothers but also their infants. Although vitamin B12 deficiency is seen all over the world and all age groups, its frequency is much higher in population which has low socio-economic level. The aim of this study was to evaluate the maternal vitamin B12 status and their effect on neonatal vitamin B12 status and to detect risk factors for vitamin B12 deficiency in Bağcılar where is a low socio-economic region in Istanbul.Materials and Methods:A total of 71 pregnant women and 71 infants were included in this study between March 2016 and March 2017. Age, gender, weight, gestational age, weight gain during pregnancy, body mass index (BMI), number of parity, socio-economic status, diet, daily vitamin intake were recorded. Blood samples for whole blood count and vitamin B12 were taken all subjects. The pregnant women and newborns were divided into groups based on their vitamin B12 levels. The risk factors were analyzed for vitamin B12 deficiency.Results:The mean vitamin B12 level was 172.23±102 pg/ml for pregnant women. The number of pregnant women in deficient group (

Radioisotopes used in the field of health for treatment or diagnosis are generally produced by cyclotron or reactors. The reaction is produced by the radioisotopes, the energy of the projectile particles to be used in production, the target core and the cross-sections of the reaction are determined. In cases where experimenting is difficult and expensive, performing simulation studies first saves time and economy. Therefore, simulation study of obtaining 57Co radioisotopes with reactions induced with alpha becomes important. Studies for the production of 57Co radioisotopes with different reactions were carried out for the first time with Talys. The 57Co radioisotope is generally used in the Schilling test for vitamin B12 deficiency. Gastrointestinal vitamin B12 absorption assay is among the first tests offered by nuclear medicine laboratories. In this study, the excitation functions of 57Co radioisotope production reactions were investigated by 55Mn(⍺,2n), 54Fe(⍺,p), 56Fe (⍺,2n+p), 59Co(⍺,2n+⍺), 59Co(⍺,x) and 58Ni(⍺,p+⍺) reactions. The theoretical cross sections were calculated with TALYS 1.8 nuclear reaction code, and compared with experimental data obtained from EXFOR library. As a result of this study, there are three reactions whose cross sections are close to each other and are the highest. From these reactions, the energy of the bullet cores is less than the other two reactions, and the 54Fe(⍺,p) reaction stands out in the production of the 57Co radioisotope. [ABSTRACT FROM AUTHOR]

Background: Vitamin B12 deficiency is one of the common diseases in the community which can cause hematological and neurological symptoms and signs. It is usually treated by intramuscular injection after diagnosis. The aim of this study was to compare oral and intramuscular B12 replacement therapy. Materials and Methods: The study was started with the decision dated 24/07/2013 and numbered 2013-646 of the Scientific Research Evaluation Commission of Ankara Numune Training and Research Hospital. Patients who were admitted to the internal medicine outpatient clinic between May-October 2012 and whom were recently diagnosed with vitamin B12 deficiency, that received oral or intramuscular therapy, and came to the control one month later, were included in the study. Statistical analysis was performed with "SPSS for Windows 20.0" SS package program. Results: 56 patients with oral vitamin B12 replacement therapy and 46 patients with intramuscular vitamin B12 replacement therapy were found. According to baseline values, significant increase in vitamin B12 levels was observed in all patients. (220.73 ± 243.47 pg / ml, p <0.001). Vitamin B12 increase was 252,91 ± 297,23 pg / ml in oral treatment group and 182,96 ± 152,90 pg / ml in intramuscular treatment group respectively. There were no significant differences between two groups (p> 0.05). Conclusion: In a study that was divided into oral and intramuscular B12 replacement therapy, an increase in vitamin B12 levels was found with oral and intramuscular treatment after 90 days of treatment, but the groups were not compared in terms of efficacy. In our study, since there was no difference between oral and intramuscular B12 replacement therapies in patients with vitamin B12 deficiency, may suggest that oral replacement therapy may be an alternative to intramuscular therapy. Further comprehensive randomized controlled studies are required to determine the efficiency of intramuscular B12 replacement therapy. [ABSTRACT FROM AUTHOR]

Copyright of Firat Universitesi Saglik Bilimleri Veteriner Dergisi is the property of Firat Universitesiu, Saglik Bilimleri Enstitusu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Physical Medicine & Rehabilitation Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: We aimed to determine the frequency of vitamin B12 deficiency in children with tension-type headache and to investigate the relationship between tension-type headache and vitamin B12 deficiency. Methods: The children diagnosed with tension-type headache between June 1, 2018 and December 31, 2018 in the pediatric neurology clinic were included in the study. Children with chronic disease, receiving dietary supplementation or any medication were excluded from the study. Demographic characteristics, complete blood count, the levels of serum vitamin B12, folate, homocysteine and urine methylmalonic acid were recorded. The control group consisted of children without an acute or chronic disease and who did not use dietary supplements or medications. Results: A total of 155 children were participated in the study including 76 children (57 girls, 19 boys) with tension-type headache and 79 children (51 girls, 28 boys) in the control group. The mean serum vitamin B12 level was 210.6±104 pg/mL (43-534 pg/mL) in patients with tension-type headache and 260.6±109 pg/mL in the control group (104-712 pg/mL). There was a statistically significant difference between the two groups in terms of the level of vitamin B12 (p=0.005). Forty-six patients (61%) with tension-type headache and 30 children (38%) in the control group had vitamin B12 deficiency. There was a statistically significant difference between the two groups in terms of vitamin B12 deficiency (p=0.032). Conclusion: We found vitamin B12 deficiency in more than half of the children with tension-type headache. We conclude that it is important to evaluate children with tension-type headache in terms of vitamin B12 deficiency. [ABSTRACT FROM AUTHOR]

Objective: Vitamin D deficiency is known to have important effects on the musculoskeletal system, immune system and many other mechanisms, and vitamin B12 deficiency has different effects on several mechanisms and various diseases, especially neurocognitive functions. Therefore, the levels of these vitamins must be within the desired limits in children in the rapid development stage. Our objective in this study was to investigate vitamin D and vitamin B12 levels in children aged 1 month to 14 years who were hospitalized with a lower respiratory tract infection. Methods: A total of 103 patients with lower respiratory tract infection diagnoses between January 2018 and April 2018 at Bahçelievler State Hospital, Department of Pediatrics were included in this study. In the study conducted with 103 children aged between 1 month and 14 years without any chronic or systemic diseases, patients whose cases were examined for values of serum 25 (OH) vitamin D and vitamin B12, were evaluated retrospectively. Results: The study was carried out between January 2018 and April 2018 at Bahçelievler State Hospital Children's Clinic with a total of 103 children, 38.8% (n=40) of whom were female and 61.2% (n=63) were male. The average in vitamin D measurements was 23.9±13.7 ng/mL. While 2.9% of the children had severe vitamin D deficiency, the vitamin D levels in 13.6% of children were deficient, and in 32.0% they were insufficient. The average in vitamin B12 measurements of the children was 301.7±153.8 pg/mL. Vitamin B12 levels of 51.5% of the children were found to be lower than the desired level. Moreover, vitamin B12 levels were not found to be statistically significant in association to the presence of vitamin D deficiency in children. Conclusion: Since 25 (OH) vitamin D deficiency, which is also known to have immunomodulatory effects, may be a risk factor in patients hospitalized due to infectious diseases, giving vitamin D replacement to patients who measure low in serum 25 (OH) vitamin D levels should be considered. Vitamin B12 deficiency is still considerably high in developing countries like our country. The fact that vitamin D deficiency and vitamin B12 deficiency are not statistically associated might be due to differences in their primary intake sources (sunlight and nutrition). [ABSTRACT FROM AUTHOR]

Autism is a complex neurodevelopmental disorder characterised by repetitive and restricted behaviors as well as inadequate social communication behaviors. The pathogenetic mechanism of autism has not yet been clarified. However, changes in cellular methylation capacity and antioxidant capacity indicate a metabolic disorder. Furthermore, many research studies have shown that the dietary intake and plasma levels of folat and vitamin B12, which play a crucial role in cognitive functions, in autistic children are different than healthy children. Vitamin B12 is an important cofactor involved in antioxidant system and cellular methylation. Therefore, it is claimed that B12 therapy may be effective in the treatment of autistic children and / or in the treatment of various symptoms of autism.

Vitamin B12 is found in animal foods acts as cofactor in two enzyme systems in human body. Vitamin B12 shows the majority of its physiological effects via to its contribution to the homocysteine methionine cycle. Vitamin B12 deficiency is mostly caused by disorders related to absorption mechanisms and is associated with many diseases primarily neurological and hematological diseases. Due to increasing measurement uncertainty, serum vitamin B12 levels should be determined as well as homocysteine levels. Finally, parenteral treatment approaches is accepted as a more accurate method with vitamin B12 deficiency. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study is to determine the possible nutrient and protein deficiency in the first six months after sleeve gastrectomy and to determine its effect on some biochemical parameters. Material and Methods: This study is an intervention study including 102 patients (75 female and 27 male) aged between 18-65 years, who had undergone sleeve gastrectomy operation at the General Surgery Clinic of Şişli Florence Nightingale Hospital between 13.07.2017 and 06.01.2018 and been followed up by a dietician for at least six months postoperatively. Anthropometric measurements, three-day food intake, and biochemical parameters were followed pre-operatively and during the first six months. Results: There was a 27.4% decrease in body weight of the patients in first six months after surgery. Both decrease in body weight, and decrease in body fat ratio and body mass index were found statistically significant (p<0.001). A statistically significant difference was found between preoperative and postoperative 6th month biochemical parameters; serum HbA1c, insulin, uric acid, total protein, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, iron, iron binding capacity, ferritin, zinc, vitamin D, calcium, parathormone, folate and vitamin B12 levels of the patients (p<0.001). The difference between 6th month serum total protein levels of patients using and not using whey protein powder in the first month after sleeve gastrectomy was found statistically significant (p=0.002). Conclusion: It should be kept in mind that regulating patients' lifestyle with post-operative multidisciplinary team and regular follow-up, and supporting with active life are necessary for obesity treatment to be sustainable. [ABSTRACT FROM AUTHOR]

Copyright of Online Turkish Journal of Health Sciences (OTJHS) / Online Türk Sağlık Bilimleri Dergisi is the property of Oguz KARABAY and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The aim of this study was to investigate the sociodemographic characteristics and nutritional history of the patients with anemia after routine laboratory results in our pediatric clinic. Methods: 148 patients who were admitted between March - November 2017, aged between 6-18 months and whose anemia was detected in routine laboratory results were included in the study. The parents of the cases; educational status, family income level, cases; demographic information, breastfeeding times, formula and transition to supplementary food and duration of feeding were evaluated. Results: A total of 148 children (53 girls, 95 boys) were included in the study. Mothers; 52.7% of the fathers and 53.4% of them are primary school graduates; family income levels were moderate in 59.5%, low in 37.8%, 94.6% of the cases were breastfed in the first month of life, but this rate was 81.1% in the 6th month of life It was observed that it decreased to 44.6%. MCV and ferritin levels were significantly lower in boys and vitamin B12 levels were significantly lower in females. No difference was found between the income levels of the families and hematological parameters. In the first 6 months, there was a statistically significant decrease in vitamin B12 levels in the breastfed group and ferritin levels in the breastfed group, but no difference was found between these two groups in terms of other laboratory parameters. Conclusion: It is important to investigate nutrition in infant age group and to associate it with common vitamin deficiencies such as Iron, B12 and Folate, to intervene in deficiencies and to raise awareness and raise awareness of the society. [ABSTRACT FROM AUTHOR]

Objective: Chronic spontaneous urticaria (CSU) is a chronic, common and debilitating disease and associated with severely impaired quality of life (QoL). The main aim of this study is to explore the presence of Chronic Widespread Pain (CWP) in patients with CSU and to reveal the possible associations between CWP and CSU on the clinical features, laboratory markers and urticaria activity scores with QoL. Methods: There were assessed the 91 patients with CSU for CWP in a tertiary outpatient clinic. CWP (pain in four or more out of five bodily regions, i.e., the four quadrants and axially at least for three months) was defined in a rheumatology outpatient clinic in patients with CSU. We also analyzed the test results of anti-nuclear antibody (ANA), blood sedimentation rate, CRP (C-reactive protein), B12, total IgE, and anti-TPO. Patients were specified for their onset and duration of disease, comorbidities, the occurrence of angioedema and history of atopy, and nocturnal pruritus with disturbed sleep. Patients disease activity were detected by the urticaria control test (UCT), urticaria activity score (UAS) and visual analog scale of physician and patient's global assessment. Furthermore, patients completed a questionnaire to assess the quality of life (QoL) for dermatologic diseases. Results: 91 patients with CSU assigned for CWP, 23 (25.3%) were positive. CWP + patients with CSU had significantly higher physician global assessment score (p=0.003), Patients global assessment score (p=0.005), UAS (p=0.046), dermatologic QoL (p<0.001) and lower UCT (p=0.005) scores. Nine of 23 CWP + patients had asthma (39.1%) as a comorbidity (p=0.008). Conclusion: The presence of CWP in patients with urticaria may have a negative impact on the quality of life of the patients and disease scores. [ABSTRACT FROM AUTHOR]

Vitamin deficiency is an important public health problem. In this study, it was aimed to demonstrate a case with vitamin B12 deficiency and discuss differential diagnosis. A 69-year-old male patient admitted to our primary care outpatient clinic with excessive fatigue, weight loss, jaundace of the eyes, and impaired balance for 4-5 months. Retired, lonely patient did not report alcohol or smoking. There was no known chronic illness. Physical examination revealed that the patient had cachexia and scleral icteria, the liver was palpabl 2 cm. under the costal margin, and there were wheezes in the lungs. Pancytopenia and MCV elevation were present in the blood tests of the patient. Other blood tests, abdominal ultrasonography and direct coombs test were normal. Blood transfusion was performed and 1000 mcg B12 vitamin (cyanocobalamin) and 5 mg folic acid treatment were started. As the patient was older than 65 years and gave a story of living alone, it was diagnosed as Vitamin B12 deficiency because of the nutritional reasons. This case was presented because it was a demostratative and instructive example of Vitamin B12 deficiency which is one of the most common community health problems. [ABSTRACT FROM AUTHOR]

Vitamin B12 (cobalamin) deficiency during infancy is seen most commonly in exclusively breast-fed infants born to mothers with inadequate vitamin B12 stores. In addition to megaoblastic anemia, physical, social and neuromotor retardation may be seen in affected patients. In severe cases, thrombocytopenia and neutropenia may accompany anemia mimicking leukemia or aplastic anemia. Patients may rarely develop cerebral cortical atrophy evident on neuroimaging. In this article, a 12-month-old female infant with psychomotor developmental retardation who was referred to our hospital with the initial diagnosis of leukemia due to the finding of pancytopenia is presented. Further investigations revealed severe nutritional vitamin B12 deficiency in this case. Cranial magnetic resonance imaging (MRI) showed cerebral cortical atrophy. Replacement therapy with vitamin B12 resulted in marked improvement of psychomotor status, and cranial MRI performed 7 months following the diagnosis and treatment initiation revealed resolution of cortical atrophy. [Cukurova Med J 2016; 41(1.000): 152-160]

AimExact etiology of multifactorial anencephaly is still unclear. For a better understanding of the etiology, we sought to determine serum levels of folate and vitamin B12 as well as genetic variations including Factor V Leiden, Factor II g.20210G>A, MTHFR c.667C>T and MTHFR c.1298A>C in pregnant Turkish women with fetal anencephaly, and healthy pregnant women to point out significant differences.Material-MethodsWe compared the concentration of serum folate, vitamin B12 and genotype related with Factor V Leiden (FVL), Factor II (FII) G20210A, MTHFR C667T and MTHFR A1298C variations in 10 pregnant mothers with fetal anencephaly, and 32 mothers with healthy pregnancies. Gene polymorphisms were genotyped using Real-Time PCR.ResultsWe found a significant difference in serum folate concentrations and MTHFR A1298C genotypes between groups. However, serum B12 vitamin concentrations and Factor V Leiden, Factor II G20210A, and MTHFR C667T genotypes were not significantly different in mothers with fetal anencephaly, compared to controls.ConclusionLow maternal folate level is a known factor in the development of anencephaly and neural tube defects. Studies indicating an association with MTHFR gene polymorphisms are also present. We have determined that the lack of folic acid plays an important role in the etiology of anencephaly, however other factors are not significant. We believe that more research is needed as the etiology of anencephaly is still not fully understood.

INTRODUCTION: Familial Mediterranean fever (FMF) is an auto inflammatory disease characterized by acute, short episodes of serosal membrane inflammation and fever. Regular prophylactic treatment with colchicine at a dose of 1 - 2 mg daily prevents or substantially reduces FMF attacks and complications. The aim of this study is to evaluate the serum vitamin B12 levels in pediatric FMF patients and also compare the duration and dosage of colchicine therapy and vitamin B12 levels. METHODS: Ninety-eight pediatric FMF patients on at least one-year colchicine therapy and age and sex matched 49 healthy controls were enrolled. Complete blood count and vitamin B12 levels were measured. Patients were divided into two groups according to the duration (more than 3 years and less than 3 years) and dosage (more than 1mg/day and less than 1mg/day) of colchicine therapy. RESULTS: The mean vitamin B12 values were not significantly different between the patient and control groups (295.14 ± 171.62 pg/mL vs. 301.55 ± 148.86 pg/mL, p=0.66). Mean vitamin B12 level of the patients that were on colchicine therapy for more than 3 years (208.37±40.57 pg/ml) was not significantly different from the patients who were on colchicine therapy for less than 3 years (390.77±124.19) (p=0.0001, p<0.005). Median vitamin B12 levels were significantly lower in patients who received 1mg/day and higher colchicine therapy than the patients that received less than 1mg/day colchicine therapy (275 pg/ml vs. 197 pg/ml, p=0.04). DISCUSSION and CONCLUSION: According to our study results there is no need to evaluate serum vitamin B12 levels regularly in patients receiving colchicine treatment. On the other hand vitamin B12 levels may be decreased in patients on high dosage of colchicine. [ABSTRACT FROM AUTHOR]

Purpose: Vitamin B12 deficiency in infancy can cause severe demyelinating central nervous system disorder. Most cases are exclusively breast-fed infants born to mothers with deficient vitamin B12 stores. As maternal vitamin B12 stores are the main determinant of neonatal vitamin B12 status, we aimed to determine the vitamin B12 status of pregnant women at term in our region. Materials and Methods: Serum vitamin B12, folate and plasma homocysteine concentrations in addition to routine testings were measured 1-24 hour(s) before delivery in 62 pregnant women. Besides, infants born to mothers with laboratory evidence of vitamin B12 deficiency were referred to pediatric hematology unit for evaluation. Results: Thirty-six (58.1%) women had a low serum vitamin B12 level (9.99 and micro;mol/L). All of the 20 infants examined had normal neurodevelopmental findings. Vitamin B12 supplementation resulted in normalization of vitamin B12 and homocysteine levels in all the cases. Conclusion: The frequency of neonatal vitamin B12 deficiency secondary to maternal deficiency may be higher than thought in Samsun province of Turkey. Large-scale screening studies may reveal its prevalence more accurately, and may help in taking preventive measurements. [Cukurova Med J 2014; 39(4.000): 840-847]

Amaç: B12 vitamin eksikliği toplumda sık görülen bir megaloblastik anemidir. B12 tedavisi kemik iliğindeki tüm serileri stimüle edebilir. Biz bu çalışmada B12 tedavisi sırasında periferik kana genç, aktif ve büyük trombositlerin salınıp salınmadığını ve bu trombositlerin varlığının iyi bir göstergesi olan ortalama trombosit hacmi (OTH) seviyesini araştırmayı amaçladık. Materyal ve Metod: Bu çalışmaya 40 erkek ve 160 kadın toplam 204 hasta dahil edildi. Kobalamin intramuskuler (İM) enjeksiyon yoluyla uygulandı. B12 tedavisinden önce ve tedaviden bir ay sonra hematolojik ve biyokimyasal testleri değerlendirdik. Bulgular: Hastaların yaş ortalaması 40.1 ± 17.4 yıl idi. Tedavi öncesi grupta, B12 vitamin seviyeleri 151.2 ± 34.6 pg/mL ve OTH 7.8 ± 1.4 fL idi. Tedavi sonrası grupta, B12 vitamin seviyeleri 638 ± 608 pg/mL ve OTH 8.3 ± 1.3 idi. Tedavi sonrası grupta B12 vitamin (P < 0.001) ve OTH (P < 0.001) tedavi öncesi gruptan anlamlı yüksekti. Sonuç: B12 eksikliği olan hastalarda İM kobalamin tedavisinin 1. ayı sonunda tedavi öncesi değerlere göre B12 ve OTH değerinin arttığı MCV değerinin düştüğü bulundu. Çalışmamızın sonuçları gösterdi ki İM B12 tedavisi sırasında büyük ve aktif trombositler perifere daha çok salınabilir; trombotik hastalıklara yatkın olan hastalarda dikkatli olmak gerekebilir.