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The assessment of a country's food security level is a crucial task due to the need to ensure a stable supply of food during periods of economic and social upheaval, particularly during military conflicts or other emergencies. For Ukraine, amid ongoing hostilities, issues of food security and mitigating the negative effects of disruptions in agricultural production are of particular importance. As of today, there is no universally accepted scientific approach to assessing the level of food resilience that takes into account the specifics of each region and the country as a whole, allowing for analytical comparisons and providing scientifically grounded data for the formation of effective policies in this area. The aim of this study is to justify methodological recommendations for determining the level of food resilience using Ukraine as a case study. Accordingly, the proposed methodological recommendations include a set of indicators based on the selection of those that most comprehensively characterize the country’s food security in structural and cyclical aspects. It has been determined that the level of a country's food resilience is the degree of stability, adaptation, and recovery from external and internal shocks that affect the food system's ability to provide the population with sufficient, safe, and nutritious food. The results of the assessment of Ukraine's food resilience level using the Integrated Food Resilience Index in 2022 indicate an adequate level. The country has favourable conditions for food supply, although there are some issues in certain cyclical and structural aspects. The food system is developed despite the war, but there are opportunities for improvement.

In this article, effective 3D printing modeling technology of smart bio-medical polymeric hydrogel transdermal materials based on gelatin and sodium alginate, modified by humic acids, was researched. Such smart biologically active polymeric hydrogel materials showed interesting applicability in tissue engineering fields due to their intrinsic biological compatibility, adaptability, and capacity to replicate the extracellular matrix environment. A literature review was carried out and proved that 3D printing modeling technology is a perspective for the functional effect on the smart bio-medical polymer hydrogel transdermal properties. Smart biomedical polymeric transdermal hydrogel patches were produced using a micromolding technique. A stereolithography (SLA) 3D printer was used to print the master mold. The three-stage technology of lignite humic acids modification of smart biologically active polymeric hydrogel transdermal microneedles patches based on gelatin, hydroxypropyl methylcellulose, and sodium alginate was designed. It was shown that modification of gelatin-sodium alginate and hydroxypropyl methylcellulose-sodium alginate biopolymer hydrogels by humic acids makes it possible to obtain smart biologically active polymeric hydrogel transdermal materials with an increased swelling degree and ability to improve the skin moisture-lipid balance (from the initial moisture 34–36 % and fatness 8–10, they increase to 58–66 % and 52–60 %). Finally, the developed 3D printing modeling technology of smart bio-medical polymeric hydrogel transdermal materials hydrogel based on gelatin sodium alginate, modified by humic acids, is a transdermal material with required properties.

At the present stage of economic development, the leading role in ensuring the competitiveness of both an singular enterprise and the country as a whole, as well as in creating conditions for the transition to sustainable development, is played by the successful implementation of the latest scientific developments in production processes, comprehensive support for the strategy of innovative development. The development and implementation of innovations is a complex dynamic process that requires the use of special research methods. Such a method is system dynamics, which makes it possible to take into account the nonlinearity of the impact of innovation on the state of the economy. The paper considers the methodology for building a model for managing innovation processes, taking into account the self-organization of the logistic type. The main danger that can accompany the evolution of innovation processes is the emergence of unacceptable dynamic modes, so one of the tasks of the study was to determine the conditions capable of ensuring the stability of equilibrium states of a complex dynamic system according to the proposed models. The object of research is a complex dynamic system, between the elements of which there is both positive and negative feedback. To build a model of the dynamics of innovation processes, the mathematical apparatus of the theory of differential equations was applied, which made it possible to consider the development of the innovation process in continuous time. With the help of the instrumentarium of nonlinear dynamics, a study of the stability of diffusion of innovations depending on the parameters of the control influence was carried out. The conditions for the transition of the system to a critical state, which may be accompanied by the occurrence of bifurcations and chaos, have been determined. Particular attention was paid to determining the structural stability of the regulated innovation process in the case when both equilibrium positions are close in terms of parameter values. It is expedient to apply the proposed model to solve the problem of innovation management both at the State level and at the level of an individual industry or an individual enterprise. The obtained theoretical conclusions were confirmed through the use of simulation modeling.

The population, its physical well-being and development is a defining feature of society, the basis of the state's strength. Taking into account demographic trends is important in shaping strategies for economic development. Understanding the impact of population changes on the labour market, consumer demand, investment climate, and population expenditures is crucial for creating a sustainable and competitive economy. The demographic resilience of a country is determined by its ability to ensure quantitative and qualitative reproduction of demographic structures at various stages of historical development. Demographic resilience is a dynamic category that changes over time, and the level of a country's demographic resilience is defined by the parameters of its functioning. The level of demographic resilience depends on trends in population reproduction and mortality, demographic dependency, migration processes, gender equality, and the development of the healthcare system. Under these conditions, the assessment of the demographic resilience of the Visegrad Group countries was carried out in the context of these specified directions, allowing for the calculation of an indicator of the level of demographic resilience for Poland, the Czech Republic, Slovakia, and Hungary. The analysis of the level of demographic resilience in the Visegrad Group countries indicates an average value. However, the analysis of reproduction and mortality indicators suggests the presence of demographic crises in these countries. Population decline, falling birth rates, and an increase in mortality rates are key characteristics of the demographic crisis. Therefore, the Visegrad Group countries need to implement effective policy measures to ensure the development and efficient use of human capital, as well as social protection for migrants, refugees, and citizens, at a sufficient level through a politically and financially stable system.

Background. Clinical studies of urate-lowering therapy (ULT) use in multimorbid patients, including those with chronic kidney disease (CKD), are important in modern medical science. The purpose was to determine the efficacy and safety of ULT in patients with hyperuricemia and comorbid conditions, including people with chronic kidney disease, in real clinical practice. Materials and methods. This prospective comparative clinical study “Liquestia: comparative efficacy and safety in gouty arthritis patients with comorbid diseases and in patients with hyperuricemia and chronic kidney disease” was conducted in real clinical practice with the involvement of 124 patients with hyperuricemia, who were prescribed either febuxostat (Liquestia, JSC “Farmak”/Adenuric, Berlin Chemie) or allopurinol as ULT. Results. Individuals who received febuxostat significantly more often and faster reached the target levels of uric acid compared to patients who underwent treatment by allopurinol, regardless of glomerular filtration rate (GFR), except those from dialysis subgroup, and the presence of comorbidities. Patients in febuxostat subgroups during the study showed an increase in GFR after 6 months of treatment — at the level of the trend in the group with baseline GFR ≥ 60 ml/min and at a statistically significant level — in CKD stage 3–4, which could be the evidence of renoprotective effect of febuxostat with reduced GFR, while people receiving allopurinol tended to further decrease of GFR in 31.8 % of cases. Conclusions. The use of Liquestia for the treatment of patients with hyperuricemia and various comorbid conditions is no less effective than the use of Adenuric and more effective than allopurinol and helps achieve the target levels of uric acid in 90 % of cases within 6 months of treatment, which accompanied by a statistically significant increase in GFR in patients with CKD stage 3–4.

The development of agricultural cooperation in Ukraine is one of the main vectors for rapid recovery of agricultural production after the Russian-Ukrainian war, increasing its competitiveness, ensuring sustainable development of rural areas, increasing employment and welfare of rural population. However, agricultural service cooperatives are not developed in Ukraine. The purpose of this study was to find the main drivers of agricultural service cooperatives’ development in Ukraine, to outline on this basis promising directions for development of agricultural policy in terms of stimulating their development as a counterweight to the dominance of agricultural holdings. It is proven that the main restraining factor in the development of agricultural service cooperatives in Ukraine is institutional memory of a peasant, which was formed during collectivization in Soviet times and which in modern conditions is associated with the concept of “cooperative”. This creates opposition from agricultural producers towards the national policy on the development of agricultural cooperatives, which meet international cooperative principles, and which have proven their advantages in increasing competitiveness of farmers on the example of developed countries of the world. It is emphasized that before changing formal institutions through legislation, it is necessary to form proper informal institutions that will strengthen, and not oppose, the introduction of formal ones. This paper is of practical importance for scientists and representatives of public administration in the field of forming strategic state and regional programs for agricultural development. Compliance of national policy measures according to the identified drivers of agricultural service cooperation’ development, requires further research

Статтю присвячено огляду мемуарних праць, авторами яких є діячі українських урядів доби Центральної Ради. Праці безпосередніх учасників Українських національно-визвольних змагань 1917–1921 рр. загалом добре відомі науковцям і вже кілька десятиліть залучені до вивчення проблематики Української революції. Але їхній інформативний потенціал досі не вичерпаний. Спогади колишніх генеральних секретарів і народних міністрів дають можливість зазирнути за лаштунки діяльності українського уряду, побачити події очима очевидців, проаналізувати їхню аргументацію власної позиції. У статті проаналізовано праці українських політиків, які працювали у складі Генерального Секретаріату та Ради Народних Міністрів за доби Центральної Ради. Зазначено, що не всі автори однаково ґрунтовно підійшли до висвітлення зазначеної теми. З іншого боку, на глибину та об’єктивність викладення матеріалу великий вплив мала партійна належність авторів спогадів. Тому при аналізі зазначених праць було застосовано як універсальні методи наукового аналізу, синтезу та спеціальні методи історичних досліджень (порівняльно-історичний, біографічний), так і метод критичного аналізу джерел, без якого неможливе джерелознавче дослідження. Ключові слова: Українська Народна Республіка, Центральна Рада, Генеральний Секретаріат, Рада Народних Міністрів, вертикаль виконавчої влади, мемуари.

Инфекция мочевых путей – одна из самых распространенных бактериальных инфекций у детей, которая в 30% случаев может быть первым проявлением у ребенка врожденных аномалий развития мочевых путей и нарушений уродинамики. Несвоевременные диагностика, начало терапии, выбор неадекватного противомикробного препарата увеличивает риски прогрессирования заболевания, развития нефросклероза и инвалидизации пациента. Цель – изучить микробный пейзаж при инфекции мочевых путей, его антибиотикорезистентность у новорожденных детей с аномалиями развития мочевыделительной системы. Материалы и методы. Проанализированы результаты микробиологического исследования мочи у новорожденных детей с инфекциями мочевых путей на фоне аномалий развития мочевых путей. Эти дети находились на лечении в отделениях реанимации и патологии новорожденных в период 2016–2020 гг. Результаты. Основными возбудителями инфекций мочевых путей у новорожденных детей с аномалиями развития мочевыделительной системы являются Enterobacterales (63,4%), в 13,8% – продуценты бета-лактамаз расширенного спектра. Наибольшую активность в отношении Escherichia coli проявили цефоперазон / сульбактам, амикацин, меропенем и нитрофурантоин. В отношении остальных представителей порядка Enterobacterales высоко активен был только амикацин. Штаммы Enterococcus spp., выявленные в 20%, в каждом четвертом случае были устойчивы к резервному ванкомицину. Представители неферментирующих грамотрицательных бактерий обнаружены в 6,4% случаев, резистентность к основным титруемым антибиотикам колебалась от 44,4% до 100%. Выводы. Основными возбудителями инфекций мочевых путей у новорожденных детей с аномалиями развития мочевыделительной системы являются представители порядка Enterobacterales, Enterococcus spp. и неферментирующие грамнегативные бактерии, которые характеризовались высокой резистентностью, в том числе и к антибиотикам резерва. Высокие показатели устойчивости выделенной микрофлоры затрудняют выбор эффективной антибактериальной терапии у данной категории пациентов и требуют в большинстве случаев комбинированной антибиотикотерапии. Исследование выполнено в соответствии с принципами Хельсинкской декларации. Протокол исследования одобрен Локальным этическим комитетом всех участвующих учреждений. На проведение исследований получено информированное согласие родителей детей. Авторы заявляют об отсутствии конфликта интересов.

At the present stage, the subject of intensive research is the study of the transmission mechanisms of molecular signals of the conserved Notch signaling pathway in the development of liver pathologies. The review article summarizes current scientific evidence on the role of the signaling pathway in liver fibrogenesis. Literature analysis indicates that the role of the Notch signaling pathway in the regulation of stellate cells and hepatocytes activation, macrophage polarization and its interaction with other signaling pathways in fibrogenesis has not been fully studied. It should be noted that the study of changes in the activity of the signaling cascade is of great therapeutic importance in the development of a medical guidelines for fibrosis using new antifibrotic medications.

Предметом досліджень статті є виродження першої форми при моногармонійній зміні коефіцієнта форми та за умови, коли частота пульсації «форм» коливань досягає другої парціальної частоти. Метою є оцінка можливості виродження i-ої форми коливань при різних законах зміни збуджуючого впливу та аналіз даного явища. Завдання дослідження полягають у побудові принципів оцінки впливу високочастотних пульсацій параметрів системи на вільні коливання останньої. Застосовувані методи: описання динамічних моделей диференційними рівняннями; частотний аналіз; формування амплітудно-частотних характеристик. Отримані результати: для динамічної моделі з певними показниками приводу та веденої ланки визначено, що при гармонійній зміні функції руху з частотою пульсації, що перевищує одиницю при співвідношенні коефіцієнтів демпфування більше одиниці спостерігається ефект виродження першої форми коливань, в результаті чого частота коливань веденої ланки практично відповідає другій формі. Практична значущість роботи полягає у побудові моделі формування частотних характеристик динамічної моделі при високочастотній пульсації параметрів останньої. Для виявлення цих ефектів доводиться відмовлятися від традиційних уявлень про малість інерційних складових, викликаних нестаціонарністю форм коливань.

Aim. To improve the results of surgical treatment of tumor thrombosis of the inferior vena cava and right atrium in patients with renal cell carcinoma. Materials and Methods. The results of clinical examination, laboratory, instrumental, intraoperative observations and morphological studies were analyzed in 83 patients with renal cell carcinoma, complicated with tumor venous thrombosis, who were hospitalized to the vascular surgery department of Lviv regional clinical hospital for the period from 1993 to 2018. For a comparative analysis, all patients were divided into two groups: the first, main, group included 61 patients (39 men and 20 women, mean age 58,1±2,7 years old; two children, 5 and 9 years old) with renal cell carcinoma, complicated with tumor thrombosis of inferior vena cava and right atrium. The second, control, group included 22 patients (19 men and 3 women, mean age 58,3±4,3 years old) with renal cell carcinoma and renal vein invasion. Thepatients’ examination included laboratory and instrumental methods: ultrasound; computer or magnetic resonance imaging with intravenous contrast enhancement of the abdominal and chest cavity;excretory urography; echo-cardiography; veno-cavagraphy according to indications. Kaplan-Meier method was used to evaluate the long-term survival of patients with renal cell carcinoma, complicated with tumor venous thrombosis. Results and Discussions. Surgical treatment included radical nephrectomy in combination with thrombectomy from the inferior vena cava and right atrium. The using of Cell-Saver system has significantly reduced the need for donor blood. Despite the significant volume and trauma of surgical interventions in patients of the first group, the risk of most postoperative complications did not predominate in eithergroup. Survival indicators were evaluated among 76 patients with renal cell carcinoma, complicated with venous invasion - in 55 patients of the first and 21 patients of the second group. The median follow-up was 53,2 months. The median survival rate for patients in the first group was 33,3 months; for patients in the second group - 118,2 months. The cumulative 2-, 5-, and 10-year survival rates for patients in the second group (80,0%, 59,1%, 52,5%) were significantly higher compared to the first group (57,8%, 38,5%, 23,4%) (p0,2). Regarding the level of the tumor thrombus of the inferior vena cava, there was no significant difference in survival as well (p>0,29). Conclusions. A detailed preoperative assessment of the prevalence of neoprocess, the improvement of surgical procedure, an effective prevention of thromboembolic and hemorrhagic complications allow providing acceptable long-term survival rates of patients with renal cell carcinoma with venous invasion.

Актуальність. Статтю присвячено розгляду двох фортепіанних сонат О. Скрябіна. Двочастинна Соната № 2, що класифікується як музичний пейзаж, розглядається в порівнянні виконавських версій С. Ріхтера та В. Ашкеназі. Одночастинна Соната № 9, яка дістала назву «Чорна Меса», розглядається у виконавських інтерпретаціях В. Софроницького та В. Горовиця. Мета статті. За допомогою компаративного методу аналізу, уперше застосованого в цій статті стосовно творів О. Скрябіна, підтвердити універсальність скрябінського письма. Результати. Розгляд двох фортепіанних сонат О. Скрябіна, які в комплексі репрезентують особливості його фортепіанного стилю як цілісного феномену, засвідчив, що скрябінський фортепіанний стиль за своєю природою є змішаним, композиторсько-виконавчим. Зазначено: його грандіозний макроцикл з 10 сонат постає як компендіум принципів фортепіанного мислення, характерних для постромантичної доби. Висновки. Скрябінське письмо є універсальним, композиторсько-виконавчим, що підтверджується компаративним аналізом.

Aim. To show the effectiveness of endovascular embolization of posttraumatic arterial tibial pseudoaneurysms in the young. Material and Methods. The results of examination and endovascular embolization of arterial posttraumatic pseudoaneusysms in a 14-year-old girl and a 25-year-old man are described. Results and Discussions. In the first case, a 14-year-old girl contracted a closed right tibial fracture in the middle third with dislodgement of the fragments on Feb 10, 2017. The patient underwent internal metal osteosynthesis on Feb 20, 2017. During the intervention, arterial bleeding occurred, which was stopped by massive suturing of the tissues. On March 1, 2017 the child developed a tense formation in the popliteal fossa and shin edema. Posttraumatic pseudoaneurysm of the tibioperonal trunk was confirmed with Doppler investigation. The artery was embolized, and surgical drainage of the popliteal hematoma was performed. In the second case, a 25-year-old man acquired an open left tibial trauma on Nov 27, 2016 with fracture of both bones in the middle third and fragment dislodgement, followed by the Ilizarov apparatus osteosynthesis. On Feb 2, 2017, a tense formation emerged on the posterior surface of the shin. Dopplerography diagnosed pseudoaneurysm of the posterior tibial artery. The latter was embolized. In both cases the arterial posttraumatic pseudoaneurysms were obliterated with sufficient blood supply of the foot via the anterior tibial artery. Conclusions. Endovascular embolization is an effective method for treatment of posttraumatic arterial tibial pseudoaneurysms.

Зміну показників функції нирок (сечовини, азоту сечовини і креатиніну) проаналізували у 81 пацієнта із стенозом ниркових артерій (СНА) в поєднанні з ІХС. Залежно від термінів проведення стентування СНА по відношенню до операції шунтування коронарних артерій (ШКА) пацієнти були розділені на 4 групи. Аналіз отриманих даних показав, що незалежно від часу виконаного стентування або навіть без усунення СНА, досліджувані показники функції нирок практично не змінювалися, очевидним було зниження АТ у всіх групах. Ретроспективний аналіз отриманих даних показав, що усунення СНА, не мали позитивної дії на функцію нирок, проте сприяли зниженню артеріального тиску. Рутинне застосування стентування ниркових артерій з метою поліпшення функції нирок перед операцією ШКА не має переваг.

Обговорене діагностичне значення звивистості вінцевих артерій (ВА), її прогностична роль у виникненні хронічної ішемії міокарда, гострого порушення коронарного кровообігу та ішемічної хвороби серця (ІХС) у пацієнтів без ангіографічних ознак атеросклеросклерозу (АС) стінки судин. Мета дослідження: вивчення ролі звивистої конфігурації ВА в порушенні коронарного кровообігу. Матеріали і методи. У дослідження включені 816 пацієнтів без змін конфігурації ВА і 588 - у яких виявлено звивистість ВА. Обстеження проводили з використанням загальноклінічних методів дослідження, електрокардіографії, ехокардіографії (ЕХО–КГ), велоергометрії, коронаровентрикулографії (КВГ), стрес-векторехокардіографії (стрес–ВЕХО–КГ). Результати. У пацієнтів з звивистими ВА, за відсутності ангіографічних ознак їх гемодинамічно значущого стенозу, виявляли типовий больовий синдром, клінічні ознаки стенокардії напруження та хронічної недостатності кровообігу. У пацієнтів з ангіографічними ознаками гемодинамічно значущого стенозу звивистість ВА зумовлювала збільшення частоти виникнення аневризми лівого шлуночка. Висновки. Звивистість ВА є фактором, здатним спричинити порушення перфузії міокарда, що створює підґрунтя для несприятливого прогнозу перебігу ІХС, незалежно від наявності АС ВА. Ключові слова: ішемічна хвороба серця; звивистість вінцевих артерій; порушення коронарної гемодинаміки.

The influence of chloride, ammonium sulfate and ammonium carbonate solutions on the osmotic control of the kidneys at intragastric administration to rats under water loading was assessed. It is established that the degree and nature of their effect is determined, basically, by the anion in the composition of the salts.

In this article deals with assurance of uniformity of optical measurements used in biomedical measuring instruments. Computer refractometric analyzer «PLAZMONTEST» is designed to determine the composition and properties of substances-analytes through the registration the angle of minimum intensity of reflection in conditions of surface plasmon resonance in monochrome light in visible spectrum from the sensor substrate. Non-invasive computer photogammetry (portable) ФГНК(П)1-01 is designed to measure the concentration of the total hemoglobin in the blood vessels of the microcirculatory bloodstream of human biological tissues or other living organism. Computer four-channel photoplethysmograph (portable) ФПК(П)4 is designed for diagnostics and point registration changes absorbance region of interest of the body. Meter of optical power IT 1703S is designed to measure optical power in optical fibers, optical components of intelligent sensors and optical fiber transmission system. The features of the development of measurement procedures and metrological certification of biomedical measuring instruments, manufacturing measures and metrological certification of measures, the calculation of the calibration dependence are considered, and all of this is with account for the requirements of Normative Technical Documentation in the field of metrology in the field of optical measurements.

The article is aimed at analyzing the economic problems arising from the contradictions of commercialization of the higher education in Ukraine, as well as formulation of recommendations for the State policy in the sphere of higher education. The contradictions between the contemporary postindustrial technological method of production and the market industrial relations have been formulated. The contradictions between the general cultural purpose of higher education and its commercialization in the conditions of postindustrial system have been disclosed. The article analyzes the problems of commercialization of the higher education of Ukraine, such as: disparities in the labor market, problem of common accessibility of knowledge, problem of maintaining the quality of education, imbalance of the interaction of science, education and production; problem of depreciation of higher education, reduction of its quality. The practical significance of results of the study is developing an integrated program for reforming the State regulation system of higher education that involves considering the interrelationships between problems, challenges and recommendations for the State policy and is disclosed in two following spheres: 1) educational standards and 2) organization of activity of the higher education system.

Gozhenko A. I., Badyuk N. S., Lebedeva T. L., Goncharenko O. O., Zukow W. Theoretical foundations and innovative model of occupational health. Journal of Education, Health and Sport. 2016;6(11):383-389. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.168237 http://ojs.ukw.edu.pl/index.php/johs/article/view/4011 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.11.2016. Revised 12.11.2016. Accepted: 23.11.2016. Theoretical foundations and innovative model of occupational health Gozhenko A. I.1, Badyuk N. S.1, Lebedeva T. L.1, Goncharenko O. O.1, Zukow W.2 1Ukrainian Research Institute of Transport Medicine, Odessa, Ukraine 2Kazimierz Wielki University, Bydgoszcz, Poland Abstract Health is a basic human value. One of the main criteria for health is still a rate of a, which in civilization’s countries is constantly decreasing, which causes the lengthening of life. However, along with this significantly changes the structure of morbidity: reduction of infectious diseases accompanied by increased infectious. All of these diseases can be divided into professional and vocational-conditioned. Key words: health, disease, occupational diseases, professional diseases due to.

У процесі пошуку науково обґрунтованого методу оцінки ситуацій, які можуть складатися на підприємстві, визначено послідовність реалізації управлінських рішень щодо кон’юнктури трудових ресурсів; виділено ситуації, пов’язані з попитом і пропозицією трудових ресурсів; проведено їх ранжування відносно показників попиту. Визначено критерій оптимізації. Надано рекомендації з прийняття управлінських рішень оптимального розвитку підприємства.

In the work the modification of a method of detection and localization of regions of the integrity violation in the digital image obtained as a result of cloning is developed. Aim: The aim of the work is to increase the accuracy of detection of integrity violation regions of the digital image by development of modification of a method of detection and localization of cloning regions based on the block oriented approach due to simultaneous use in case of expertize of the image with square, triangular, round blocks and of irregular shape blocks. Materials and Methods: Further development of the block oriented approach to the solution of problem of cloning results detection in digital image is provided. Modification of the method of detection and localization of the cloning regions developed by authors earlier, based on the accounting of closeness of the matrix blocks which is quantitatively evaluated by means of different variants of the metrics assignment is offered. Results: The technique of simultaneous use of square, triangular, round blocks and blocks of irregular shape in case of the expertize of the image based on the block oriented approach is developed. Providing the computational experiment the accuracy increase of determination of integrity violation regions of the digital image when using of the offered modification of the method of detection and localization of fields of cloning in case of simultaneous use in case of expertize of different partitioning types blocks is set: the relative value of the area of the revealed region from real region of a clone increases by 1.6 times in comparison with results of operation of algorithmic implementation of the method taken as a basis.

Lebedeva T. L., Gozhenko A. I. Влияние введения крысам растворов хлорида, сульфата и карбоната аммония на экскреторную и осморегулирующую функции почек при водной нагрузке (Сообщение 1. Экскреторная функция почек) = Effect of chloride, sulfate and ammonium carbonate solutions injected to rats at osmoregulation and excretory renal function at the water load (Post 1. Excretory function of the kidneys) Journal of Education, Health and Sport. 2016;6(10):557-565. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.168410 http://ojs.ukw.edu.pl/index.php/johs/article/view/4012 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.09.2016. Revised 24.09.2016. Accepted: 30.10.2016. Влияние введения крысам растворов хлорида, сульфата и карбоната аммония на экскреторную и осморегулирующую функции почек при водной нагрузке (Сообщение 1. Экскреторная функция почек) Т. Л. Лебедева, А. И. Гоженко ГП Украинский НИИ медицины транспорта МЗ Украины, г. Одесса Реферат Изучено влияние на экскреторную функцию почек внутрижелудочного введения крысам растворов хлорида, сульфата и карбоната аммония при водной нагрузке. Установлено наличие особенностей в выведении воды, осмотически активных веществ, ионов натрия, калия, водорода, неорганического фосфора, хлоридов, титруемых кислот и аммиака в зависимости от введенного аниона. Поскольку все вводимые растворы солей содержали катион аммония, экскреторная функция почек была направлена на регуляцию преимущественно анионного состава внеклеточной жидкости. Ионорегулирующая функция почек, по-видимому, состоит не только в регуляции катионного состава внеклеточной жидкости, но и в поддержании анионного постоянства. Ключевые слова: почки, ионорегулирующая функция, анионы, экскреторная функция Effect of chloride, sulfate and ammonium carbonate solutions injected to rats at osmoregulation and excretory renal function at the water load (Post 1. Excretory function of the kidneys) T. L. Lebedeva, A. I. Gozhenko Ukrainian Research Institute of Transport Medicine, Odessa, Ukraine Summary The effect on the excretory function of the kidneys prior intragastric administration to rats of chloride, sulfate and ammonium carbonate solutions at water load has been studied. The presence of water, osmotically active compounds, sodium, potassium, hydrogen, inorganic phosphorus, chloride, titratable acids and ammonia excretion peculiarities depending upon the introduced anion have been revealed. Since all the input salt solutions contained ammonium cation, excretory kidney function was primarily directed at the regulation of the anion composition of the extracellular fluid. Ion-regulating renal function apparently is not only in the regulation of extracellular fluid cationic composition, but also in maintaining the constancy of the anion. Key words: kidneys, ion-regulating renal function, anions, excretory renal function

The widespread using of fake pictures in information wars, lawsuits, politics, etc., needs to develop new detection methods of photomontage. One of them is a method of photomontage detection based on the analysis of singular values of matrix blocks of digital images. Aim: The aim of this research is to check the application area of photomontage detection method based on analysis of singular values of matrix blocks of digital images in the absence of restrictions on the degree of their compression. Materials and Methods: The basis of this method is the detection of the differences between the images when they have different degrees of compression: values of the zero singular values matrix of blocks corresponding to foreign part of image. We distinguish this area on the background of the main image, that allows to detect falsification. The mentioned method was investigated under certain restrictions imposed on the used test photos. An advanced experiment with images was held, for which there are no restrictions on the degree of compression. Results: The falsification was detected in 44.4% of cases in experimental study while saving the digital image after photomontage in lossless format, and in 53.3% of cases when saving the losses. Montage was detected most often when the difference between the quality factor Q of the main image and the replacing area was more than two.

Effective management of agricultural production in the Polesie Ukraine traditionally was complicated through the low natural land fertility, their high acidity, perevolotsky valley. During the centrally planned economic system that the natural contrast of the Polesie land had been somewhat neglected by the state through differentiation of purchase prices for agricultural products, which gave the possibility of redistribution of the rent in favor of the farms with poorer land. With transition to market relations the role of the state, and hence the possibility of its influence on this situation has changed dramatically. Economic conditions have become more profitable for the farmers that are occupying the best lands. However, the situation in the regions has not yet been investigated systematically taking into account the modern complex socio-economic processes and phenomena caused by increased environmental stress on land resources. One of the most pernicious environmental effects of the Chernobyl accident was radioactive contamination of agricultural land, defined in the final stage of transfer of radionuclides in the human body and further irradiation. The main danger of the accumulation by plants of radionuclides lies in the fact that they are a major link in the migratory chain of transmission of radionuclides to the more radiosensitive species and, above all, human. Economic feature of agricultural production in the study area is insufficient pricesambien, transformation of land use, violations of industrial-economic relations, the structure of agricultural production, changes in the natural-cost structure commodity products, the reform of the organizational structure of agricultural production. In the farms located in contaminated areas, the necessary conversion of dairy cattle for meat. In conditions of high pollution, the production of milk requires a serious sanitary objections in that time, as meat production is more environmentally friendly. The suspension of activities and the provision of radioactively clean food products led to the growth of volumes of consumption of contaminated food of local production, the increase in the number of people exceeding the doses of internal irradiation and the deterioration of the health status of the people of radioactively contaminated territories. The main component of the mechanism by contaminated land is agricultural activities (placement of crops, depending on the ability to accumulate radionuclides, soil treatment), agrochemical activities (liming of acidic soils, application of mineral and organic fertilizers and the use of sorbents, change of mode of feeding of animals and processing of animal products to reduce the content of radionuclides. Of course, the above list of events is far from complete, this is only the basic that require mandatory implementation in agricultural production. Among the measures of rehabilitation of polluted areas leading place belongs to the radical improvement of meadows and pastures, which in turn requires a considerable amount of seeds of cereals and legumes. The analysis of economic efficiency of growing of the testes, including radioactively contaminated region shows that even in marginal soils of Polesye in low yield of the seed farms have substantial profits. On soils with acidity the most common and affordable event reduce radionuclide accumulation in products is liming, which not only reduces the accumulation of radionuclides in agricultural crops but also improves soil fertility, increases yield and contributes to the dilution of radionuclides per unit mass of crop production. Only a comprehensive use of differentiated areas of contaminated land will allow some measure to improve the ecological situation on the territory of the object.

The complexes of MBr2 (M = Co, Zn) with N-substituted thiocarbamoyl-N’-pent amethylenesulphenamides (L) of composition [MLBr2] are synthesized and their influence on thermooxidative structurization of oligobutadiene of brand KRASOL LB-2000 is studied. Possibility of receiption of varnish and paint type coverages is shown in the process of thermal hardening of oligobutadiene at the use of complexes [CoLBr2] as catalysts.

The important problem in design of rubber-metal products is the optimization of their mass without sacrificing of proportionality factor is in the limits of standard. Aim: The aim of this work is to improve the computer-aided systems by development and implementation of improved optimization method in rubber-metal CAD systems for designers based on the reverse optimization. Materials and Methods: The paper studies the matters of computer-aided structural design of technical composite products composed of anisotropic materials that are essentially different in properties. Results: The structure of CAD systems for designers solving the problems of such design is offered and the work principles of its subsystems are described. It is shown that complicated systems optimization in CAD systems must consider as restrictions the entitative connection between separate elements of these systems within the area of the optimizing arguments. Conclusions: The problem of the “reverse” optimization when objective functions are the connectivity area parameters is considered. In many cases, this allows receiving solutions that are more effective during the computer-aided design process. The developed CAD system for designers was used during the production of rubber-metal shock absorbers at the Odessa Rubber Technical Articles Plant. The positive technical and economic effect was obtained.

Lebedeva T. L. Проблемні питання безпеки дорожнього руху в Україні (повідомлення 2) = Topical issues of road-traffic safety in Ukraine (report 2). Journal of Education, Health and Sport. 2015;5(7):542-552. ISSN 2391-8306. DOI 10.5281/zenodo.28044 http://dx.doi.org/10.5281/zenodo.28044 https://pbn.nauka.gov.pl/works/607575 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%287%29%3A542-552 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 20.06.2015. Revised 15.07.2015. Accepted: 25.07.2015. ПРОБЛЕМНІ ПИТАННЯ БЕЗПЕКИ ДОРОЖНЬОГО РУХУ В УКРАЇНІ (ПОВІДОМЛЕННЯ 2) TOPICAL ISSUES OF ROAD-TRAFFIC SAFETY IN UKRAINE (report 2) Т. Л. Лєбєдєва T. L. Lebedeva ДП Український НДІ медицини транспорту МОЗ України, м. Одеса State Enterprise Ukrainian Research Institute for Medicine of Transport of the Ministry of Health Care of Ukraine, Odessa Abstract The influence of human’s psycho physiological peculiarities on the accident risk has been shown. The necessity of human’s psycho physiological peculiarities reporting at the planning crush rate measures decrease has been determined. The introduction of a compulsory psycho physiological examination for the accident participants with the aim of timely rehabilitative procedures conduction has been offered. Keywords: road traffic injuries, psychophysiology, post-traumatic stress. Резюме Показаний вплив психофізіологічних особливостей людини на ризик виникнення ДТП. Визначена необхідність врахування психофізіологічних особливостей людини при плануванні заходів щодо зниження дорожньо-транспортної аварійності. Запропоновано введення обов’язкового психофізіологічного обстеження учасників ДТП для своєчасного проведення реабілітаційних заходів. Ключові слова: дорожньо-транспортний травматизм, психофізіологія, посттравматичний стрес. Резюме ПРОБЛЕМНЫЕ ВОПРОСЫ БЕЗОПАСНОСТИ ДОРОЖНОГО ДВИЖЕНИЯ В УКРАИНЕ (СООБЩЕНИЕ 2). Показано влияние психофизиологических особенностей человека на риск возникновения ДТП. Определена необходимость учета психофизиологических особенностей человека при планировании мероприятий по снижению дорожно-транспортной аварийности. Предложено введение обязательного психофизиологического обследования участников ДТП для своевременного проведения реабилитационных мероприятий. Ключевые слова: дорожно-транспортный травматизм, психофизиология, посттравматический стресс.

Lebedeva T. L. Проблемні питання безпеки дорожнього руху в Україні (повідомлення 1) = Topical issues of road-traffic safety in Ukraine (report 1). Journal of Education, Health and Sport. 2015;5(6):472-481. ISSN 2391-8306. DOI 10.5281/zenodo.27404 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%286%29%3A472-481 https://pbn.nauka.gov.pl/works/605083 http://dx.doi.org/10.5281/zenodo.27404 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 21.04.2015. Revised 28.05.2015. Accepted: 24.06.2015. ПРОБЛЕМНІ ПИТАННЯ БЕЗПЕКИ ДОРОЖНЬОГО РУХУ В УКРАЇНІ (ПОВІДОМЛЕННЯ 1) TOPICAL ISSUES OF ROAD-TRAFFIC SAFETY IN UKRAINE (report 1) Т. Л. Лєбєдєва T. L. Lebedeva ДП Український НДІ медицини транспорту МОЗ України, м. Одеса State Enterprise ”Ukrainian Research Institute for Medicine of Transport”, Odessa Absrtact The analysis of crush rate in Ukrainian traffic road during 1990-2014 has been made. The necessity of system-wide approach for decrease of accident risk has been substantiated. It has been suggested to estimate accident severity by calculating the number of victims and persons traumatize on 100 accidents with sufferers when analyze crush rate. Keywords: road traffic injuries, statistics, killed, injured. Резюме Проведено аналіз дорожньо-транспортного травматизму на автошляхах України за 1990-2014 роки. Визначена необхідність системного підходу для зниження аварійності. Запропоновано при аналізі аварійності оцінювати важкість наслідків ДТП за розрахунком кількості загиблих та травмованих на 100 ДТП з постраждалими. Ключові слова: дорожньо-транспортний травматизм, статистика, загиблі, травмовані. Резюме ПРОБЛЕМНЫЕ ВОПРОСЫ БЕЗОПАСНОСТИ ДОРОЖНОГО ДВИЖЕНИЯ В УКРАИНЕ (СООБЩЕНИЕ 1). Проведен анализ дорожно-транспортного травматизма на автодорогах Украины за 1990-2014 годы. Показана необходимость системного подхода для снижения аварийности. Предложено при анализе аварийности оценивать тяжесть последствий ДТП по расчету количества погибших и травмированных на 100 ДТП с пострадавшими. Ключевые слова: дорожно-транспортный травматизм, статистика, погибшие, травмированные.

Developing methods aiming at identification of digital images integrity violation is an important problem of complex system of information security. Cloning method, realized in the most of graphic editors, is often used to compromise the integrity of the image related to unauthorized changes. Therefore, the task of cloning identification is a relevant one. In addition to the cloning identification it is also important to clarify the contours of the cloned area. In this paper we propose a polynomial comprehensive method to identify areas of cloning as a falsification of the digital image. It allows to locate the cloned areas with a higher precision compared to modern analogues. Complex method is based on two modern clone detection techniques, using a common approach to the analysis of the state and technology of the information system functioning. It includes two stages: “fast rough” cloning area identification and a “slow” identification of the contour of the cloning area using a limited image subarea containing a clone. The method proposed can be adapted for the digital video.

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В статті розглядається концепція соціальної дії М. Вебера як складова його «розуміючої соціології» та її вплив на становлення німецької кому нікативної філософії. Автор наголошує на тому, що веберівське розуміння соціальної дії та раціональності лежить в основі концепції К.-О. Апеля і Ю. Хабермаса, а також опосередковано вплинуло на формування системної теорії Н. Лумана.

The problems of improving the efficiency of the design process and decision-making processes support at the design stage are considered. In particular, proposed is to use an information structural statistical model under conditions of heterogeneity and incompleteness of the initial data about the design object elementary basis characteristics. Due to the modeling object’s morphological similarity it allows to analyze the object’s structural reliability by estimating the failure-free operation probabilities. Proposed are several variances to define the reliability function type depending on the statistical sampling set scattering power and options of structural resiliency index calculation. The proposed structural information statistical model allows to conduct the real-time statistical experiment removing at each step one element of the model structure. It also allows to calculate the probability of failure-free operation index on the average value.

Application of information management system is an important element of ensuring business effectiveness for any modern enterprise. However, the permanent growth of the cost of such systems requires application of new approaches to assessment of influence of complex information systems upon the level of stock. The article describes a structure of the model and specifically those elements that allow assessment of reduction of delays connected with automation. It offers to assess a change of the stock level with the use of methods of system dynamics. The results are based on imitation experiments of the stock level in the production and sales system with the use of the AnyLogic software system.

Розглянуто проблему переломів та рестенозів стентів. Сформульовано гіпотезу, що циклічні (систоло-діастолічні) механічні деформації коронарних артерій є патогенетичним фактором розвитку рестенозу в стенті. Йдеться про створення програмної системи для автоматизації запропонованої методики оцінки деформацій коронарних артерій під час вибору методу реваскуляризації міокарду — стентування або аорто-коронарне шунтування. Реалізовано алгоритм підтримки прийняття рішень лікарем-кардіохірургом, що дозволяє врахувати циклічні деформації коронарних артерій при оцінці оптимального методу хірургічного втручання під час проведення коронарографії. Розроблена програмна система відображає 3D-реконструкцію коронарних артерій. Отримані результати дозволяють сподіватись на поліпшення віддалених результатів лікування, зниження ймовірності повторної госпіталізації, а також зменшення вартості самого лікування.

This article highlights the basic concepts of state bodies, types of state bodies, characteristics and functions of state bodies. The tasks of the legislative, executive and judicial authorities and their features are considered. The formation of forms of government is studied. The concept of monarchy as the most ancient form of government its existing forms and the republic as a form of government are considered. The relationship between state bodies and government has been studied. That is, the work of public authorities in the context of social transformations and changes in public administration and modern structural and functional models of public authorities. [ABSTRACT FROM AUTHOR]

The article considers the concept, features and content of administrative activities, the difference between administrative activities and other activities of government, features of administrative activities, regulation of administrative activities. [ABSTRACT FROM AUTHOR]

The main directions of reforming the system of administrative management in Ukraine are investigated in the article. Modern systems of administrative management are analyzed and it is suggested to concentrate on five main directions of improvement of the system of administrative management: 1. Privatization and decentralization of public administration; 2. Reduction of excessive state regulation; 3. Improving the quality of public services; 4. Improving the efficiency and effectiveness of government; 5. Increasing the information openness of the authorities. [ABSTRACT FROM AUTHOR]

In order to optimize the conditions for ensuring the administrative and legal development of regions in Ukraine on the basis of strengthening and enhancing their administrative and legal potential, the article analyzes and systematizes approaches to the peculiarities of the implementation of the mechanism of state influence on local governments, aimed at increasing the efficiency of the execution of the powers of local governments, which will allow to take into account the functional links between the components of management, ensure the rational use of available resources, rationalize work and minimize risks, as well as increase the efficiency of local government bodies. [ABSTRACT FROM AUTHOR]

The statute is assigned to the theoretical foundations of the sphere of public administration, and the very establishment of such theories and practices in the organs of the microscopic selfregulation and organs of the viconavcha power. The foreign and the vital theoretical foundations were analyzed, as well as the prospects of that success in the future in Ukraine. The main changes and shortcomings of the technologies and theories are indicated. There is a lot of visnovka and boule presented propositions, as well as a thorough understanding of the introduction of new and old theoretical aspects of administration, as well as the introduction of new and new theoretical foundations of administration in public administration. For a large bulo, a sufficiently well-primed progress has been made for the present day of an unviable problem for our state and the world. That is, at the present moment, we are guilty of admitting the basic theory of administrative control at the public administration, among other common topics we are guilty of the main thesis, to which an article is assigned [ABSTRACT FROM AUTHOR]