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1. [Biochemical and physico-chemical changes in albumin in dynamics of experimental allergic encephalomyelitis].

Author

Metal'nykova NP, Gurina NM, Khaniuchenko SI, Osadchyĭ PV, and Kovalyshyn IaF

Subjects
Animals, Chemical Phenomena, Chemistry, Physical, Female, Guinea Pigs, Male, Protein Binding, Protein Denaturation, Encephalomyelitis, Autoimmune, Experimental blood, Serum Albumin metabolism
Abstract

The experiments on guinea pig with experimental allergic encephalomyelitis (EAE) have shown that the most significant changes in the content, binding ability and thermodynamic characteristics of serum albumin are found at the early stages preceding the appearance of neurological characters. The plasma perfusion through granulated carbon-activated sorbents increases the binding ability and decreases the temperature denaturation of albumin down to the normal level.

Published
1990

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