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Your search keyword '"Hyperalgesia chemically induced"' showing total 2 results
Start Over Descriptor "Hyperalgesia chemically induced" Language ukrainian
2 results on '"Hyperalgesia chemically induced"'

1. [THE CHOICE OF THE ANESTHESY OPTIMAL METHOD, USING DETERMINATION OF THE TOLL-LIKE RECEPTORS LEVEL IN THE PLASM AS A MARKER OF HYPERALGESIA IN EARLY POSTOPERATIVE PERIOD].

Author

Dmytriyev DV

Subjects
Abdominal Neoplasms pathology, Abdominal Neoplasms surgery, Adolescent, Analgesics, Opioid adverse effects, Anesthesia, Epidural methods, Anesthesia, Spinal methods, Biomarkers blood, Child, Female, Gene Expression, Humans, Hyperalgesia blood, Hyperalgesia chemically induced, Male, Pain Measurement, Pain, Postoperative blood, Pain, Postoperative physiopathology, Postoperative Period, Retroperitoneal Neoplasms pathology, Retroperitoneal Neoplasms surgery, Toll-Like Receptor 4 genetics, Anesthetics, Local therapeutic use, Bupivacaine therapeutic use, Hyperalgesia diagnosis, Hyperalgesia prevention & control, Pain, Postoperative drug therapy, Toll-Like Receptor 4 blood
Abstract

There were examined 47 children, operated on for tumors of abdominal cavity and retroperitoneal space. The opioid-induced hyperalgesia may occur in early postoperative period. The anesthesia conduction of m. transverses abdominis (TAP-block), using 0.375% bupivacaine solution and combined spinal epidural analgesia (CSEA) for postoperative anesthesia have promoted the hyperalgesia severity reduction. Hyperalgesia in early postoperative period was demonstrated by upgrading of the toll-like receptors (TLR-4) level in the blood. The TLR-4 expression increased in the blood was noted while application of a TAP-block and CSEA.

Published
2016

2. [MORPHOLOGICAL CHANGES OF SKIN IN OPERATIVE WOUND IN SYNDROME OF OPIOID-INDUCED HYPERALGESIA].

Author

Dmytriyev DV and Konoplytskyi VS

Subjects
Abdominal Cavity innervation, Abdominal Cavity pathology, Abdominal Cavity surgery, Abdominal Neoplasms pathology, Administration, Cutaneous, Adolescent, Child, Edema chemically induced, Edema physiopathology, Female, Humans, Hyperalgesia chemically induced, Hyperalgesia physiopathology, Male, Nerve Fibers pathology, Postoperative Period, Skin pathology, Abdominal Neoplasms surgery, Analgesics, Opioid adverse effects, Edema pathology, Fentanyl adverse effects, Hyperalgesia pathology
Abstract

Morphological changes of skin in region of operative wound were investigated. There was established, that while application of fentanyl in high doses, using constant infusion for anesthesia in early postoperative period in children, operated for abdominal cavity tumors, the opioid-induced hyperalgesia occurrence is possible, what is accompanied by morphological changes in skin around operative wound, necrosis in centre of focus, pronounced perifocal reactive changes in a kind of significant inflammation and essential disorder of microcirculation with formation of small neural fibers on the 14th day. Pronounced fibrosis of derma, formation of big quantity of collagen fibers with edema, stratification.

Published
2015

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