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Background. Obtaining biologically active natural compounds involved in the regulation of metabolism is an important goal in biotechnology. Colostrum is a unique natural source of various biologically active compounds. However, the extremely high natural variability of colostrum composition does not meet the existing requirements for standardization in pharmaceutical preparations. Objective. To develop a method for separating colostrum into its basic components (lipids, casein, and protein fractions), thereby reducing the variability of whole colostrum composition, obtaining several target products, and demonstrating the possibility of acquiring new protein substances from different sources. Methods. Colostrum separation was carried out through centrifugation and membrane filtration. Plant proteins (sunflower) and milk proteins were used to obtain protein substances from different sources. The composition of proteins, carbohydrates, and nucleic acids was determined using mass spectrometry, centrifugation, and membrane filtration. Results. The proposed method for obtaining basic substances from colostrum significantly reduced the vari­ability in composition compared to whole colostrum. The efficiency of protein sedimentation in concentrated protein solutions by centrifugation and ultrafiltration was shown to depend on protein concentration. Additionally, the formation of non-specific protein aggregates in the centrifugal field allowed the extraction of protein substances from various natural sources, which is relevant for functional nutrition. Conclusions. The proposed selective-integrative technology for obtaining different substances from colostrum significantly reduces the high variability of whole colostrum composition. It increases the efficiency of component separation into lipid, casein fractions, low molecular weight protein fractions, and ultrafiltrate, while also enabling the acquisition of protein substances from diverse sources.

In this research, the radial Schr¨odinger equation is solved analytically using the Nikiforov-Uvarov method with the Cornell potential. The energy spectrum and the corresponding wave function are obtained in close form. The effect of Topological Defect on the thermal properties and mass spectra of heavy mesons such as charmonium and bottomonium are studied with the obtained energy spectrum. It is found that the presence of the Topological Defect increases the mass spectra and moves the values close to the experimental data. Our results agreed with the experimental data and are seen to be improved when compared with other works.

In this work, the comparison of the mass spectra of heavy quarkonium system with an interacting potential (Class of Yukawa potential) was studied. The Schrodinger equation is analytically solved using Nikiforov- Uvarov (NU) method and series expansion method (SEM). The approximate solutions of the eigen energy equation and corresponding eigenfunction in terms of Laguerre polynomials were obtained using the NU method and the solutions of the eigen energy equation were also obtained with the SEM. The mass spectra for heavy quarkonium system (HQS) for the potential under study were obtained for bottomonium and charmonium HQS. We compared the results obtained between NU and SEM. It was noticed that SEM solutions yield mass spectra very close to experimental data compared to solutions with NU method. The obtained results were also compared with works by some other authors and were found to be improved. This study can be extended by using other exponential-type potential models with other analytical approach and a different approximation schemes to obtain the mass spectra of heavy quarkonium system. The relativistic properties using Klein-Gordon or Dirac equations can be explored to obtain the mass spectra of light quarkonia. Finally, the information entailed in the normalized wave-functions can also be studied.