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Alkylated phenol and methoxytoluene derivatives were catalytically and selectively oxidized to the corresponding 1,4-benzoquinones in good conversions and yields. Reactions were performed with hydrogen peroxide (H2O2)/methyltrioxorhenium (CH3ReO3) in 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4, a neutral ionic liquid. Compounds were tested in vitro for their antifungal activity against the growth of several widespread soil fungi. Some of them were proved to be potent inhibitors of Fusarium sp. than ketoconazole, a commercially available and expensive antifungal agent.

Department of Chemistry, Govt. College, Ajmer-305 001, Rajasthan, India Department of Pure & Applied Chemistry, M. D. S. University, Ajmer-305 009, Rajasthan, India E-mail : kgojha_mdsu@rediffmail.com Fax : 91-145-2670484 Manuscript received 6 August 2008, accepted 1 October 2008 An environmentally benign solvent-free microwave-assisted synthesis of biologically active 2,5-diarylamino- 3,6-dihalo-1,4-benzoquinones by the condensation of substituted anilines and chloranil has been reported on the inorganic solid support of silica gel.