1. Estimating Average Treatment Effects Utilizing Fractional Imputation when Confounders are Subject to Missingness
- Author
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Shu Yang and Nathan Corder
- Subjects
FOS: Computer and information sciences ,Statistics and Probability ,multiple imputation ,Average treatment effect ,Context (language use) ,01 natural sciences ,QA273-280 ,Methodology (stat.ME) ,missing data ,010104 statistics & probability ,03 medical and health sciences ,0302 clinical medicine ,Statistics ,QA1-939 ,Statistics::Methodology ,030212 general & internal medicine ,Imputation (statistics) ,0101 mathematics ,62f12 ,Statistics - Methodology ,fractional imputation ,Mathematics ,62f30 ,Statistics::Applications ,Other Statistics (stat.OT) ,Confounding ,Estimator ,Variance (accounting) ,Missing data ,Quantitative Biology::Genomics ,Regression ,Statistics - Other Statistics ,Statistics, Probability and Uncertainty ,Probabilities. Mathematical statistics - Abstract
The problem of missingness in observational data is ubiquitous. When the confounders are missing at random, multiple imputation is commonly used; however, the method requires congeniality conditions for valid inferences, which may not be satisfied when estimating average causal treatment effects. Alternatively, fractional imputation, proposed by Kim 2011, has been implemented to handling missing values in regression context. In this article, we develop fractional imputation methods for estimating the average treatment effects with confounders missing at random. We show that the fractional imputation estimator of the average treatment effect is asymptotically normal, which permits a consistent variance estimate. Via simulation study, we compare fractional imputation’s accuracy and precision with that of multiple imputation.
- Published
- 2020
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