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Objectives: A few clinical screening tools for auditory processing disorder (APD) are currently available. However, most of these tools are in English and cannot be used to screen individuals with a first language other than English. This study aimed to develop an APD screening test battery in French and to assess its psychometric properties in detecting school-age children at risk of APD. Method: Prior to their complete audiological APD assessment, 53 children (7–12 years old) were recruited from an audiology clinic. The APD assessment lasted between 2 and 3 hr, including 15–20 min for the screening test battery. The screening test battery was composed of four behavioral subtests and two questionnaires (parent and teacher). Results: When combined, two among the four behavioral subtests showed a sensitivity of 100% and a specificity of 80%. Conclusion: The newly developed screening tool could help reduce the number of unnecessary APD assessments, therefore allowing early diagnosis in children with APD and increasing their chances of receiving adequate intervention.

Purpose: The main purpose of this retrospective study was to identify auditory dysfunctions related to traumatic brain injury (TBI) in individuals evaluated in an Audiology clinic. Method: Peripheral and central auditory evaluations were performed from March 2014 to June 2018 in 26 patients (14 males) with TBI. The age of the participants ranged from 9 to 59 years old (34.24 ± 15.21). Six participants had blast-related TBI and 20 had blunt force TBI. Sixteen experienced a single TBI event whereas ten experienced several. Correlation analyses were performed to verify the relationship, if any, between the number of auditory tests failed and the number, type, and severity of TBIs. Result: All participants failed at least one auditory test. Nearly 60% had abnormal results on degraded speech tests (compressed and echoed, filtered or in background noise) and 25% had a high frequency hearing loss. There was no statistically significant correlation between the number of auditory tests failed and the number, type, and severity of TBIs. Conclusion: Results indicated negative and heterogenous effects of TBI on peripheral and central auditory function and highlighted the need for a more extensive auditory assessment in individuals with TBI.

Objectif : produire une traduction en français canadien de l’AMSTAR 2, en affirmer la validité de contenu et en examiner la fidélité interjuges. Méthodologie : selon une approche adaptée de celle proposée par Vallerand, des traductions directes et renversées ont été effectuées. Ensuite, en examinant les traductions, un premier comité d’experts a créé la version expérimentale préliminaire. Celle-ci a été modifiée par un deuxième comité d’experts. Vingt futurs professionnels de la santé ont évalué la nouvelle version avec une échelle d’ambiguïté (de 1 à 7). Les cochercheurs principaux ont examiné les éléments problématiques pour affermir la version préofficielle. Afin d’assurer la validité de contenu, une dernière rétrotraduction a été effectuée, validant une version officielle. Ensuite, 4 juges ont évalué 13 revues systématiques publiées en français à l’aide de la version officielle. Le coefficient kappa a été utilisé afin d’examiner la fidélité interjuges. Résultats : cette adaptation a permis la création d’une version franco-canadienne de l’AMSTAR 2. Son utilisation a démontré très peu d’ambiguïté (moyenne 1,15; ÉT 0,26) et une bonne fidélité interjuges (Kappa global > 0,64). Conclusion : la version franco-canadienne de l’AMSTAR 2 pourrait servir de soutien aux cliniciens, aux éducateurs et aux gestionnaires francophones au Canada lorsqu’ils cherchent à adopter une pratique factuelle.

In this research, the effect of inference nudging is tested on adherence to environmental-friendly behavior of people. Here, environment-friendly behavior of the participants is tested, by looking at the use of coffee cups. This is done over the course of two months. For this, I worked together with an organisation.

The study of the transitions among different regimes in thermal convection has been an issue of paramount importance in fluid mechanics. While the bifurcations at low Rayleigh number, when the flow is laminar or moderately chaotic, have been fully understood for a long time, transitions at higher Rayleigh number are much more difficult to be clearly identified. Here, through a numerical study of the two-dimensional Rayleigh-Bénard convection covering four decades in Rayleigh number for two different Prandtl numbers, we find a clear-cut transition by considering the fluctuations of the heat flux through a horizontal plane, rather than its mean value. More specifically, we have found that this sharp transition is displayed by a jump of the ratio of the root-mean-square fluctuations of the heat flux to its mean value and occurs at $Ra/Pr \approx 10^9$. Above the transition, this ratio is found to be constant in all regions of the flow, while taking different values in the bulk and at the boundaries. Below the transition instead, different behaviors are observed at the boundaries and in the bulk: at the boundaries, this ratio decreases with respect to the Rayleigh number whereas it is found to be constant in the bulk for all values of the Rayleigh number. Through this numerical evidence and an analytical reasoning we confirm what was already observed in experiments, that is the decrease of the ratio of root-mean-square fluctuations of the heat flux to its mean value, observed at the boundaries below the transition, can understood in terms of the law of large numbers., 20 pages, 8 figures

Based on her earlier work on the city of Rheims in Champagne, France—a Family Reconstitution study covering all social scales—the article proposes a new comprehensive classification of reconstructed female life courses from the author’s existing and refreshed nominative database (1668–1802). This fresh scrutiny of digital files will allow series of qualitative and quantitative approaches, making hopefully preindustrial urban women at last visible along their individual life-trajectory. Thanks to rich archival sources, socio-demographic trends are better known, including a general early shift to contraceptive behaviour in pre-1789 Rheims. At the end of the Ancien Régime, there was growing individual female labour migration to this major town of Western Europe. It was attracted by domestic service and the textile sector. The sex ratio became so unbalanced that many women remained single, and only a few widows remarried. Numerous women managed their living without a husband, through the many economic and sanitary crises which characterised the period.

To evaluate the quality of the reporting of exercise interventions with Pilates method for the treatment of lower back pain (LBP) in adults. Two independent evaluators selected randomized controlled trials (RCTs) of moderate and high methodological quality included in a Cochrane Systematic Review (SR) and from an additional updated search in the following databases: CENTRAL, MEDLINE, EMBASE, CINAHL, PEDro and SPORTDiscus. Three assessment tools (Consensus on Therapeutic Exercise Training (CONTENT) scale, Template for Intervention Description and Replication (TIDieR) checklist and Consensus on Exercise Reporting Template (CERT) checklist) were utilized by three pairs of two independent researchers trained. The scales’ concordance was measured using the Kappa coefficient. Ten RCTs were included. The CONTENT scale score was 5.3 (± 1.33) out of 9 points; the TIDieR checklist was 8.5 (± 1.71) out of 12 points and the CERT checklist was 9.5 (± 3.62) out of 19 points. The CONTENT and CERT had moderate concordance, while there was fair concordance between the other tools. The overall reporting quality for the Pilates exercises in ten moderate-to-high quality RTCs for the management of LBP was low according to CONTENT scale and CERT checklist and high according to TIDieR checklist.Implications for RehabilitationReporting of Pilates exercise program in moderate-to-high quality RCTs for the management of lower back pain remains incomplete.Pilates exercise program should be personalized and contextualized to individual participants.There may be a need to consider adding to or combining the information available from various trials. Reporting of Pilates exercise program in moderate-to-high quality RCTs for the management of lower back pain remains incomplete. Pilates exercise program should be personalized and contextualized to individual participants. There may be a need to consider adding to or combining the information available from various trials.

In his seminal work on turbulence, Kolmogorov made use of the stationary hypothesis to determine the Power Density Spectra of velocity field in turbulent flows. However to our knowledge, the constraints that stationary processes impose on the fluctuations of power have never been used in the context of turbulence. Here we recall that the Power Density Spectra of the fluctuations of the injected power, the dissipated power and the energy flux have to converge to a common value at vanishing frequency. Hence, we show that the intermittent GOY-shell model fulfills these constraints on the power as well as on the energy fluxes. We argue that they can be related to intermittency. Indeed, we find that the constraints on the power fluctuations imply a relation between scaling exponents, which is consistent with the GOY-shell model and in agreement with the She-Leveque formula. It also fixes the intermittent parameter of the log-normal model at a realistic value. The relevance of these results for real turbulence is drawn in the concluding remarks.

We report a laboratory study of the transport of angular momentum by a turbulent flow of an electrically conducting fluid confined in a thin disk. When the electromagnetic force applied to the liquid metal is large enough, the corresponding volume injection of angular momentum produces a turbulent flow characterized by a time-averaged Keplerian rotation rate $\bar{\Omega}\sim r^{-3/2}$. Two contributions to the local angular momentum transport are identified: one from the poloidal recirculation induced by the presence of boundaries, and the other from turbulent fluctuations in the bulk. The latter produces efficient angular momentum transport independent of the molecular viscosity of the fluid, and leads to Kraichnan's prediction $\text{Nu}_\Omega\propto\sqrt{\text{Ta}}$. In this so-called ultimate regime, the experiment, therefore, provides a configuration analogous to accretion disks, allowing the prediction of accretion rates induced by Keplerian turbulence., Comment: 6 pages, 5 figures, accepted in Phys. Rev. Lett

Pharmacology is a vital course in nursing involving numerous concepts, making it challenging for educators and students to teach and learn the course, respectively. As YouTube videos become a powerful academic resource in understanding challenging courses, most studies demonstrate that online educational videos effectively improve students' learning process. However, what makes these videos effective in teaching has yet to be discovered.This paper typified the teaching strategies of nursing pharmacology YouTube videos to manage cognitive load and promote student engagement. Additionally, the use of these strategies was correlated with the videos' Video Power Indexes [VPIs].This study employed a mixed methods design. 52 YouTube videos about nursing pharmacology were used for analysis. Watching these videos generated transcriptions to typify teaching strategies using thematic content analysis. Quantitative parameters such as likes, dislikes, and videos were computed to get the Video Power Index [VPI]. VPI of the videos was correlated with the identified strategies using Pearson's correlation coefficient (r).With the comprehensive characterization of strategies from the videos, this study uncovered two themes, Infoxication Antagonists and Attention Agonists, as the composition of the V-CAPS: Video's Constructive and Adaptive Pedagogical Strategies. This model describes how nurse YouTubers simplify complex pharmacology concepts while maintaining the viewers' concentration in watching the videos. Results also revealed that Infoxication Antagonists and the duration of the videos have significantly moderate influence, and Attention Agonists have a significantly weak correlation with the VPIs.The study's findings present teaching strategies to reduce cognitive load and promote student engagement. These can provide valuable insights for nursing educators in teaching the course and using videos to promote the students' optimum learning.

Workplace harassment, particularly sexual harassment, has substantial negative implications for individuals and organizations and for scientific advancement. The National Institutes of Health (NIH) is uniquely positioned to lead the effort to prevent sexual harassment in the scientific community and mitigate its detrimental effects. Recognizing the need for benchmark data, NIH developed and validated the 2019 NIH Workplace Climate and Harassment Survey. The goal was to use best practices in survey design methods to create an instrument for rigorous assessment of harassment incidence and organizational climate predictors of sexual harassment in scientific research environments. This article summarizes the processes used to design and administer the NIH survey and provides brief descriptions of 3 products of the process developed to guide scientific institutions wishing to embark on a data-driven approach to assess and prevent harassment: a document detailing survey development and methods, a survey implementation guide, and the key findings obtained from the survey, including recommendations for interventions targeting the organizational climate at NIH and limitations of the survey. The survey identified that 1 in 5 respondents had experienced sexual harassment in the 12 months preceding their participation in the survey and that women, sexual and gender minorities, younger respondents, trainees/students, and individuals with a disability were more likely to have experienced sexual harassment. Those who had experienced sexual harassment during that period were also more likely to have experienced incivility, bullying, and intimidating behaviors in the workplace. NIH intends to use the survey findings as a quality assurance and quality improvement guide to inform future activities to prevent and address harassment across NIH.

Haywood’s translations remain almost wholly overlooked, yet they represent a considerable part of Haywood’s contemporary output and her original international audience. As such, they are an important to understanding Haywood’s popularity. Perhaps surprisingly, not only were her late-career domestic novels frequently translated; her amatory fictions from the 1720s also continued to have a rich continental afterlife from the 1750s onwards. This chapter examines the French and subsequent Dutch translations of Idalia; or the Unfortunate Mistress (1727), arguing that, to cater to the sentimental literary climate of the latter half of the century, the translators adapted the novel and omitted Haywood’s erotic undertones while amplifying the sentimental undercurrents that run throughout the text, encouraging the reader to identify with the emotional experiences of the characters rather than relive their sexual escapades. However, as contemporary reviews indicate, readers failed to connect with her characters and lamented the absence of “warm descriptions,” indicating that Haywood’s erotic and passionate discourse is crucial to her agenda. In this way, this chapter not only takes the first tentative steps towards establishing a pan-European approach to Haywood’s publications, it also contributes to our understanding of Haywood more generally by highlighting the complexity of her amatory discourse.

We investigate the spatio-temporal quantity of coherence for turbulent velocity fluctuations at spatial distances of the order or larger than the integral length scale $l_{0}$. Using controlled laboratory experiments, an exponential decay as a function of distance is observed with a decay rate which depends on the flow properties. The same law is observed in two different flows indicating that it can be a generic property of turbulent flows.

One of the greatest assessment challenges is providing fair and valid tests for multilingual pupils. Since language proficiency impacts their results on content tests, accommodations are suggested ...

The use of non-dominant linguistic repertoires is often not valued in educational practices, let alone in educational assessment. The competences of multilingual learners are traditionally assessed by tests designed for monolinguals that do not represent the true capabilities of multilingual pupils, because their level of language proficiency in the text language does not reflect their wider abilities. Assessment needs to shift from evaluating a pupil in only the language of schooling towards assessment where the full multilingual repertoire can be used to demonstrate knowledge and competences. In this study, assessment preferences of multilingual pupils are explored, both in assessment accommodations for large-scale testing and in classroom-based assessment that is aligned with assessment for learning. Interviews with 35 pupils in fifth-grade of primary education (age 10–11) in Belgium were conducted. Results indicate that accommodations that use pupils’ first languages are not necessarily the most popular ones, that pupils are in favour of portfolios and oral assessments and that they need more feedback. The findings of this study suggest the need for instruction and evaluation to become more integrated, which would be beneficial for all pupils and could be more inclusive of emergent bilinguals rather than treating them as a separate group.

The inferior colliculus (IC) is a large midbrain nucleus that integrates inputs from many auditory brainstem and cortical structures. Despite its prominent role in auditory processing, the various cell types and their connections within the IC are not well characterized. To further separate GABAergic and non-GABAergic neuron types according to their physiological properties, we used a mouse model that expresses channelrhodopsin and enhanced yellow fluorescent protein in all GABAergic neurons and allows identification of GABAergic cells by light stimulation. Neuron types were classified upon electrophysiological measurements of the hyperpolarizing-activated current ( Ih) in acute brain slices of young adult mice. All GABAergic neurons from our sample displayed slow-activating Ih with moderate amplitudes, whereas a subset of excitatory neurons showed fast-activating Ih with large amplitudes. This is in agreement with our finding that immunoreactivity against the fast-gating hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) channel was present around excitatory neurons, whereas the slow-gating HCN4 channel was found perisomatically around most inhibitory neurons. Ih properties and neurotransmitter types were correlated with firing patterns to depolarizing current pulses. All GABAergic neurons displayed adapting firing patterns very similar to the majority of glutamatergic neurons. About 15% of the glutamatergic neurons showed an onset spiking pattern, always in combination with large and fast Ih. We conclude that HCN channel subtypes are differentially distributed in IC neuron types and correlate with neurotransmitter type and firing pattern. In contrast to many other brain regions, membrane properties and firing patterns were similar in GABAergic neurons and about one-third of the excitatory neurons. NEW & NOTEWORTHY Neuron types in the central nucleus of the auditory midbrain are not well characterized regarding their transmitter type, ion channel composition, and firing pattern. The present study shows that GABAergic neurons have slowly activating hyperpolarizing-activated current ( Ih) and an adaptive firing pattern whereas at least four types of glutamatergic neurons exist regarding their Ih properties and firing patterns. Many of the glutamatergic neurons were almost indistinguishable from the GABAergic neurons regarding Ih properties and firing pattern.

International audience; We present a short review of the experimental observations and mechanisms related to the generation of quasipatterns and superlattices by the Faraday instability with two-frequency forcing. We show how two frequency forcing makes possible triad interactions that generate hexagonal patterns, twelvefold quasipatterns or superlattices that consists of two hexagonal patterns rotated by an angle α relative to each other. We then consider which patterns could be observed when α does not belong to the set of prescribed values that give rise to periodic superlattices. Using the Swift-Hohenberg equation as a model, we find that quasipattern solutions exist for nearly all values of α . However, these quasipatterns have not been observed in experiments with the Faraday instability for α 6 = π/ 6. We discuss possible reasons and mention a simpler framework that could give some hint about this problem.; Nous présentons une courte revue des observations expérimentales et des mécanismes qui ont permis d'engendrer des structures quasi-cristallines à l'aide de l'instabilité de Faraday sous l'effet d'une excitation périodique comportant deux fréquences. Nous montrons comment l'excitation à excitation`excitation à deux fréquences permet d'obtenir des triades de vecteurs d'onde résonantes qui induisent la formation de structures hexagonales, de structures quasi-cristallines dodécagonales ou de super-réseaux résultant de la superposition de deux réseaux d'hexagones tournés l'un par rapport à rapport`rapport à l'autre d'un angle α. Nous considérons ensuite quelles sont les structures obtenues lorsque α ne prend pas la série de valeurs discrètes conduisant à conduisant`conduisant à un super-réseau périodique. Nous montrons sur l'´ équation de Swift-Hohenberg qu'il existe dans ce cas des solutions à solutions`solutions à symétrie quasi-cristalline pour presque toutes les valeurs de α. Nous discutons les raisons possibles pour lesquelles ces solutions n'ont pas été observées expérimentalement pour α = π/6 et nous mentionnons un cadre plus simple qui permettrait d'éclaircir cette question.

A challenge in designing tests is ensuring fairness for all test takers. Pupils who are not yet sufficiently proficient in the language of schooling taking a test that was designed for native speak...

The flow of an electrically conducting fluid in a thin disc under the action of an azimuthal Lorentz force is studied experimentally. At small forcing, the Lorentz force is balanced by either viscosity or inertia, yielding quasi-Keplerian velocity profiles. For very large current and moderate magnetic field, we observe a new regime, fully turbulent, which exhibits large fluctuations and a Keplerian mean rotation profile $\Omega\sim \frac{\sqrt{IB}}{r^{3/2}}$. In this turbulent regime, the dynamics is typical of thin layer turbulence, characterized by a direct cascade of energy towards the small scales and an inverse cascade to large scale. Finally, at very large magnetic field, this turbulent flow bifurcates to a quasi-bidimensional turbulent flow involving the formation of a large scale condensate in the horizontal plane. These results are well understood as resulting from an instability of the B\"odewadt-Hartmann layers at large Reynolds number and discussed in the framework of similar astrophysical flows., Comment: 30 pages, 12 figures

The helium cryoplant and cryo distribution system (CDS) are key elements of the new superconducting Linac Coherent Light Source (LCLS-II) and will provide superfluid helium to the accelerator. The cryoplant consists of two helium refrigerators with an equivalent 4.5 K refrigeration capacity of 18 kW each. The 37 cryomodules of the LINAC will be operated at a temperature of 2.0 K to accelerate a 4 GeV electron beam that will generate extremely bright X-ray laser light. Two five-stage cold compressor cold boxes will be utilized to provide superfluid helium II for the superconducting cavity structures with a total cooling capacity of 8 kW at 2.0 K. This paper describes the installation of the LCLS-II cryoplant and CDS. The LCLS-II cryoplant was designed and contributed by Jefferson Lab. To expedite the project completion the reuse of proven design and technology from the Jefferson Lab CHL-2 cryoplant was the preferred strategy. The CDS consists of ∼260 m thermally shielded and vacuum super insulated transfer lines, two distribution boxes and eight feed and end caps, and was designed and contributed by Fermilab. SLAC installed the cryoplant components into a newly erected building and the CDS components into the existing accelerator tunnel and klystron gallery with strong engineering support from both partner labs.

LCLS-II is major up-grade to the SLAC Facility. It adds a 4 GeV superconducting accelerator, which will generate an extremely bright and continuous (million pulses/sec) X-ray laser beam. The LCLS-II superconducting accelerator comprises 37 cryomodules connected through a complex distribution system to two large Helium Refrigerators. A single Helium cryogenic plant is expected to deliver 4.0 kW of cooling capacity at 2.0 K. Each cryogenic plant has a set of five operating compressors with an additional spare compressor that provides the required mechanical power (∼ 4.5 MW / cryogenic plant). In this paper, we describe the recent commissioning and performance test results of the LCLS-II compressor system.

We study the bifurcations of the large scale jets in the turbulent regime of a forced shear flow using direct numerical simulations of the Navier-Stokes equations. The bifurcations are seen in the probability density function (PDF) of the largest scale mode with the control parameter being the Reynolds number based on the friction coefficient denoted as $Rh$. As one increases $Rh$ in the turbulent regime, the PDF of the large scale mode first bifurcates from a Gaussian to a bimodal behaviour, signifying the emergence of reversals of the large scale flow where the flow fluctuates between two distinct turbulent states. Further increase in $Rh$ leads to a bifurcation from bimodal to unimodal PDF which denotes the disappearance of the reversals of the largest scale mode. We attribute the latter transition to the long-time memory that the large scale flow exhibits related to low frequency $1/f^\alpha$ type of noise with $0 < \alpha < 2$. We also demonstrate that a minimal model with 15 modes, obtained from the truncated Euler equation, is able to capture the bifurcations of the large scale jets exhibited by the Navier-Stokes equations., Comment: 12 pages, 7 figures

Review of Jennie Batchelor and Manushag N. Powell, eds, Women’s Periodicals and Print Culture in Britain, 1690–1820s (2018).

Factor Xa (FXa) inhibitors are widely used for stroke prevention in patients with nonvalvular atrial fibrillation, and for the treatment and prevention of deep venous thrombosis and pulmonary embolism. Compared with warfarin, individual FXa inhibitors are associated with a lower risk of major bleeding. Nevertheless, bleeding remains a feared complication of any anticoagulant therapy. Despite their demonstrated safety, implementation of FXa inhibitors in clinical practice may have been limited by the lack of a specific antidote. Recently, however, the United States Food and Drug Administration and the European Medicines Agency approved andexanet alfa for reversal of anticoagulation in patients treated with rivaroxaban or apixaban who have life-threatening or uncontrolled bleeding. This review will discuss andexanet alfa's mode of action, indication for use and efficacy, with a focus on its appropriate use in clinical practice. Unnecessary usage should be prevented as this may compromise patient safety. Assessment of potentially suitable patients by a multidisciplinary team, use according to the institutional protocol and central storage, all contribute to proper use of andexanet alfa. A practical tool to direct appropriate use of andexanet alfa is proposed.

The objective of this study was to evaluate the correlation between venous pressure gradients (VPGs) and intravascular ultrasound (IVUS) for the diagnosis of caval-iliac venous obstructions in patients with advanced chronic venous insufficiency.Fifty patients with advanced chronic venous insufficiency symptoms (Clinical, Etiology, Anatomy, and Pathophysiology class 3 to 6) were prospectively submitted to multiplanar venography (MV) with intravenous pressure measurements and IVUS. The patients' lower limbs were divided accordingly: group I, limbs with 50% obstruction on IVUS (n = 49); and group II, limbs with ≥50% obstruction on IVUS (n = 51). Receiver operating characteristic curves compared the diagnostic performance of the VPGs. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy assessed the performance of VPGs in categories to determine the presence of significant obstruction. Logistic regression assessed the capacity of the VPGs to identify significant obstruction.The most frequent point of venous compression according to IVUS was the proximal left common iliac vein (70%; P .05). Group II showed a greater prevalence of transpelvic (group I, 8.2%; group II, 74.5%; P .001) and paravertebral collaterals (group I, 4.1%; group II, 45.1%; P .001) on MV. The femoral vein pressures at rest and after reactive hyperemia as well as the femorocaval gradient after reactive hyperemia (FCG-rh) and the femoral gradient after reactive hyperemia were significantly higher in group II (P = .001, P .001, P = .002, and P = .006). The FCG-rh and the femoral gradient after reactive hyperemia presented the best diagnostic performance among the VPGs (P = .004 and P = .007) in the receiver operating characteristic curve analysis, although no significant differences between them were found. All the gradients presented low values of sensitivity (40%), negative predictive value (60%), and accuracy (30%). Logistic regression showed that FCG-rh was significantly independent of MV (OR, 8.1; P = .011) in identifying significant obstructions.There is correlation between the VPGs and significant obstructions with IVUS. However, this correlation does not translate to a good diagnostic performance of these VPGs. Only the FCG-rh added significant information to MV in identifying significant caval-iliac vein obstructions.

The active ingredients from 5 chemotherapeutant formulations (Slice® [active ingredient [AI] emamectin benzoate), Salmosan® (AI azimethiphos), Alphamax® (AI deltamethrin), Excis® (AI cypermethrin), and Interox® Paramove 50 (AI hydrogen peroxide) that have been used or continue to be used to treat sea lice infestations in salmon aquaculture were examined to generate data on their environmental partitioning and persistence in water-sediment microcosms, as well as their acute and subchronic toxicity to representative classes of marine organisms. Emamectin benzoate, cypermethrin and deltamethrin partitioned mainly to the sediment phase; azimethiphos and hydrogen peroxide remained mainly in the water phase. The persistence of chemicals in water was: CP > DM > AZ > HP (half-lives: 19.8, 17.9, 12.7 d, and 8.9 h, respectively). In sediments, the following trend in calculated half-lives was observed: CP > EB > DM (half-lives: 557, 230 and 45 d, respectively). Toxicity test results with a wide variety of marine organisms (macroalgae, echinoderms, bivalves, crustaceans and fish) showed no susceptibility trend for any species, or inherent toxicity trend for any chemical, although DM tended to be the most toxic and HP the least toxic to the majority of species. This information is useful for identifying risks; specifically, toxicological parameters calculated for several of the non-target marine organisms examined, indicate that recommended treatment concentrations could result in non-target organism toxicity following release in the immediate vicinity of aquaculture sites before significant dilution. This study provides valuable data on the environmental fate and associated risks of chemotherapeutant use to non-target marine organisms whose habitat coincides with salmon aquaculture sites.

The first quantitative experimental study of thermal convection has been performed by Henri Benard, who presented his results in two articles published in the Comptes rendus in 1900. After describing the first experiments of Benard and the ones he performed later with his students, we discuss some theoretical steps that led to the full understanding of Benard's experiments more than fifty years later. We then shortly review some more recent aspects of pattern-forming instabilities that are directly related to the experimental work conducted by Benard and his students.

International audience; The solubility of hydrogen sulfide in aqueous NaCl solutions has been investigated by calculation of Henry constants through Monte Carlo simulations and using a nonpolarizable force field. The Lorentz-Berthelot combining rules appeared the most appropriate to simulate this system compared to other usual rules. The physical behavior and the trends experimentally observed are qualitatively well reproduced by this purely predictive approach for the binary system H2S + H2O as well as for the salted system H2S + H2O + NaCl: as experimentally expected, the simulations indicate a maximum in the Henry constant curve with temperature and an increase of the Henry constant with the salt concentration (salting-out effect). From a quantitative point of view, Henry constants are systematically overestimated, and more specifically for high temperatures. By introducing an empirical temperature-independent binary interaction coefficient between water and hydrogen sulfide, it is possible to obtain a good agreement between experiments and calculated Henry constants for both salt-free and salted systems, over a large temperature range (290–590 K) and salinity ranging from 0 to 6 mol/kg. For temperatures less than 400 K, the deviations are smaller and within the experimental uncertainties. At higher temperatures, deviations are higher but only few experimental data are available to confirm this result. Considering statistical and experimental uncertainties, this approach can thus provide a reasonable estimation of H2S solubility in NaCl aqueous solution in conditions encountered in geological formations. For a given temperature, the variation of the Henry constant with salt concentration is not exactly the same as the variation experimentally observed, and the salting-out effect is overestimated. This suggests for future works that additional forces such as polarization have to be taken into account for modeling high salt concentration systems.

The research presented below is an early-stage research project regarding the role and importance of backstory in an augmented reality application for cultural heritage. Literature and desk research show little attention for backstory when developing a storyline for extended reality applications in the cultural heritage field. However when looking at cinematic productions, theme parks and games for example, it can be stated that backstory plays an important role as a storytelling element to create a cohesive and immersive narrative. The hypothesis presented by Scan4Stories is that adding a backstory to the applications designed for cultural heritage sites, could help enhance the immersivity of the experience. To test the hypothesis presented above, we will develop a prototype, examining how the backstory of characters can be presented to the audience in an extended reality application on a cultural heritage site. By eventually combining the results from literature research and the development of a prototype we aim to formulate preliminary results concerning the use of backstory in cultural heritage extended reality applications.

Preterm birth is associated with proinflammatory conditions and alterations in adult cardiac shape and function. Neonatal exposure to high oxygen, a rat model of prematurity-related conditions, leads to cardiac remodeling, fibrosis, and dysfunction. TLR (Toll-like receptor) 4 signaling is a critical link between oxidative stress, inflammation, and the pathogenesis of cardiovascular diseases. The current study sought to investigate the role of TLR4 signaling in neonatal oxygen-induced cardiomyopathy. Male Sprague-Dawley pups were kept in 80% oxygen or room air from day 3 to 10 of life and treated with TLR4 antagonist lipopolysaccharide from the photosynthetic bacterium Rhodobacter sphaeroides (LPS-RS) or saline. Echocardiography was performed at 4, 7, and 12 weeks. At 12 weeks, intraarterial blood pressure was measured before euthanization for histological and biochemical analyses. At day 10, cardiac TLR4, Il (interleukin) 18, and Il1β expression were increased in oxygen-exposed compared with room air controls. At 4 weeks, compared with room air-saline, saline-, but not LPS-RS treated-, oxygen-exposed animals, exhibited increased left ventricle mass index, reduced ejection fraction, and cardiac output index. Findings were similar at 7 and 12 weeks. LPS-RS did not influence echocardiography in 12 weeks room air animals. Systolic blood pressure was higher in saline- but not LPS-RS treated-oxygen-exposed animals compared with room air-saline and -LPS-RS controls. LPS-RS prevented cardiac fibrosis and cardiomyocytes hypertrophy, the increased TLR4, Myd88, and Il18 gene expression, TRIF expression, and CD68+ macrophages infiltration associated with neonatal oxygen exposure, without impact in room air rats. This study indicates that neonatal exposure to high oxygen programs TLR4 activation, which contributes to cardiac remodeling and dysfunction.

Background We aimed to compare the rate of neurological events in patients with or without cerebral embolic protection (CEP) during transcatheter aortic valve replacement (TAVR). Methods and Results Data on clinical end points including neurological events ≤30 days post-TAVR were collected for all patients who underwent transfemoral TAVR in 2 academic tertiary care institutions. Patients were matched through propensity scoring, which resulted in 333 pairs of patients with versus without CEP out of a total of 831 consecutive patients. The median age was 81 (76-85) years, and the median logistic EuroScore was 14% (9%-20%). The CEP group experienced less neurological events at 24 hours (1% versus 4%; P=0.035) and at 30 days (3% versus 7%; P=0.029). There were significantly more disabling strokes in unprotected patients at 30 days (1% versus 4%; P=0.039). CEP was associated with significantly fewer neurological events at 24 hours after TAVR (odds ratio, 0.20; 95% CI, 0.06-0.73; P=0.015) by multiple regression analysis, while age and valve type did not contribute significantly. Overall, 67% (2 of 3) in the CEP versus 83% (10 of 12) in the non-CEP cohort experienced neurological events in protected areas (ie, not dependent on the left vertebral artery). Conclusions The use of filter-based CEP during TAVR was associated with less neurological events, especially in CEP-protected brain territories.

The inferior colliculus (IC) is a large midbrain nucleus that integrates inputs from many auditory brainstem and cortical structures. Despite its prominent role in auditory processing, the various cell types and their connections within the IC are not well characterized. To further separate GABAergic and non-GABAergic neuron types according to their physiological properties, we used a mouse model that expresses channelrhodopsin and enhanced yellow fluorescent protein in all GABAergic neurons and allows identification of GABAergic cells by light stimulation. Neuron types were classified upon electrophysiological measurements of the hyperpolarizing-activated current (

A shear flow of liquid metal (Galinstan) is driven in an annular channel by counter-rotating traveling magnetic fields imposed at the endcaps. When the traveling velocities are large, the flow is turbulent and its azimuthal component displays random reversals. Power spectra of the velocity field exhibit a $1/f^\alpha$ power law on several decades and are related to power-law probability distributions $P(\tau)\sim\tau^{-\beta}$ of the waiting times between successive reversals. This $1/f$ type spectrum is observed only when the Reynolds number is large enough. In addition, the exponents $\alpha$ and $\beta$ are controlled by the symmetry of the system : a continuous transition between two different types of Flicker noise is observed as the equatorial symmetry of the flow is broken, in agreement with theoretical predictions., Comment: 5 pages, 7 figures

Background: We aimed to compare the rate of neurological events in patients with or without cerebral embolic protection (CEP) during transcatheter aortic valve replacement (TAVR). Methods and Results: Data on clinical end points including neurological events ≤30 days post-TAVR were collected for all patients who underwent transfemoral TAVR in 2 academic tertiary care institutions. Patients were matched through propensity scoring, which resulted in 333 pairs of patients with versus without CEP out of a total of 831 consecutive patients. The median age was 81 (76–85) years, and the median logistic EuroScore was 14% (9%–20%). The CEP group experienced less neurological events at 24 hours (1% versus 4%; P =0.035) and at 30 days (3% versus 7%; P =0.029). There were significantly more disabling strokes in unprotected patients at 30 days (1% versus 4%; P =0.039). CEP was associated with significantly fewer neurological events at 24 hours after TAVR (odds ratio, 0.20; 95% CI, 0.06–0.73; P =0.015) by multiple regression analysis, while age and valve type did not contribute significantly. Overall, 67% (2 of 3) in the CEP versus 83% (10 of 12) in the non-CEP cohort experienced neurological events in protected areas (ie, not dependent on the left vertebral artery). Conclusions: The use of filter-based CEP during TAVR was associated with less neurological events, especially in CEP-protected brain territories.