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2 results on '"Abbati D."'

1. Septic shock due to NSTI caused by Actinomyces Turicensis: the role of clinical pharmacology. Case report and review of the literature

Author

Laura Elisa Gasparini, Daniela Abbati, Milo Gatti, Francesco Scaglione, Roberto Fumagalli, Paolo Brioschi, Stefano Clemente, Chiara Grimaldi, Gatti, M, Gasparini, L, Grimaldi, C, Abbati, D, Clemente, S, Brioschi, P, Fumagalli, R, Scaglione, F, Gatti M., Gasparini L.E., Grimaldi C.M., Abbati D., Clemente S., Brioschi P.R., Fumagalli R., and Scaglione F.

Subjects
0301 basic medicine, medicine.medical_specialty, Necrotizing soft tissue infection, 030106 microbiology, Therapeutic drug monitoring, Actinomycosi, Actinomycosis, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Septic shock, Antibiotic therapy, Anti-Bacterial Agent, Actinomyces Turicensi, medicine, Actinomyces, Humans, Pharmacology (medical), 030212 general & internal medicine, Actinomyce, Intensive care medicine, Pharmacology, Clinical pharmacology, medicine.diagnostic_test, business.industry, Soft Tissue Infections, Clinical Pharmacology, Middle Aged, medicine.disease, Shock, Septic, Anti-Bacterial Agents, Infectious Diseases, Debridement, Oncology, NSTI, Pharmacology, Clinical, Ampicillin, Female, Actinomyces turicensis, business, Human
Abstract

Critical septic patients affected by necrotizing soft tissue infections (NSTI) require an early, aggressive and multidisciplinary treatment. Pharmacokinetic alterations in antibiotic therapy are peculiar in these infections. Clinical pharmacology represents a first step in this setting. We report a case of septic shock due to NSTI in which clinical pharmacology is taken into account.

Published
2017

2. Flow cytometry data mining by cytoChain identifies determinants of exhaustion and stemness in TCR‐engineered T cells

Author

Francesca Clemente, Chiara Bonini, Silvia Buonanno, Maria Pia Protti, Paolo Dellabona, Francesco Manfredi, Danilo Abbati, Maddalena Noviello, Claudia de Lalla, Chiara Balestrieri, Erica Carnevale, Beatrice Claudia Cianciotti, Matteo Doglio, Giulia Casorati, Elena Tassi, Eliana Ruggiero, Anna Mondino, Alessia Potenza, Zulma Magnani, Lorena Stasi, Manfredi, F., Abbati, D., Cianciotti, B. C., Stasi, L., Potenza, A., Ruggiero, E., Magnani, Z., Carnevale, E., Doglio, M., Noviello, M., Tassi, E., Balestrieri, C., Buonanno, S., Clemente, F., De Lalla, C., Protti, M. P., Mondino, A., Casorati, G., Dellabona, P., and Bonini, C.

Subjects
0301 basic medicine, Coronavirus disease 2019 (COVID-19), T-Lymphocytes, Adoptive T-cell therapy, Immunology, Population, Receptors, Antigen, T-Cell, Computational biology, Biology, Immunotherapy, Adoptive, Immunophenotyping, Flow cytometry, 03 medical and health sciences, 0302 clinical medicine, High-dimensional analysis, medicine, Data Mining, Humans, Immunology and Allergy, education, Data limited, education.field_of_study, Receptors, Chimeric Antigen, medicine.diagnostic_test, SARS-CoV-2, Immune exhaustion, T-cell receptor, COVID-19, Flow Cytometry, Phenotype, 030104 developmental biology, Cytokines, Genetic Engineering, Immunologic Memory, Cytometry, Function (biology), 030215 immunology
Abstract

The phenotype of infused cells is a major determinant of Adoptive T-cell therapy (ACT) efficacy. Yet, the difficulty in deciphering multiparametric cytometry data limited the fine characterization of cellular products. To allow the analysis of dynamic and complex flow cytometry samples, we developed cytoChain, a novel dataset mining tool and a new analytical workflow. CytoChain was challenged to compare state-of-the-art and innovative culture conditions to generate stem-like memory cells (TSCM ) suitable for ACT. Noticeably, the combination of IL-7/15 and superoxides scavenging sustained the emergence of a previously unidentified nonexhausted Fit-TSCM signature, overlooked by manual gating and endowed with superior expansion potential. CytoChain proficiently traced back this population in independent datasets, and in T-cell receptor engineered lymphocytes. CytoChain flexibility and function were then further validated on a published dataset from circulating T cells in COVID-19 patients. Collectively, our results support the use of cytoChain to identify novel, functionally critical immunophenotypes for ACT and patients immunomonitoring.

Published
2021

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