1. Evaluation Of Serum And Ascitic Fluid Proteomes In Dogs With Dilated Cardiomyopathy
- Author
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Kocaturk, Meric, Baykal, Ahmet Tarik, Turkseven, Seyma, Acioglu, Cigdem, Agudelo, Carlos Fernando, and Yilmaz, Zeki
- Abstract
The aim of the study was to investigate serum global proteomes in dogs with overt dilated cardiomyopathy (DCM) and to evaluate protein expression in serum with that in ascitic fluid. Eight healthy dogs (control group) and 8 dogs with DCM were included in the study. DCM was diagnosed based on echocardiographic evidence including increased left ventricular dimension at diastole and systole, increased E point to septal separation, and decreased fractional shortening. Serum and ascitic fluid samples were analyzed for proteomes using a label-free LC-MS/ MS method. Proteome analyses revealed significantly different expressions of eight proteins in all samples. Expressions in serum of apolipoprotein (Apo) A1, Ig heavy chain V, superoxide dismutase and plasminogen were higher (P
- Published
- 2016