13 results on '"Aminata, Fofana"'
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2. Para Testicular Pseudotumeurs of Calcified Gait: A Case Report from the Nianankoro Fomba Segou Hospital (Mali)
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Ibrahim Kone Sory, Brehima Samaké, Abdoulaye Kassogué, Mahamoudou Keita, Tidiani Traoré, Thierno Boubacar Bagayogo, Adama Bah, Alpha Sanogo, Damissa Coulibaly, Abdoulaye Nouhoum Coulibaly, Mamadou Togo, and Aminata Fofana
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General Medicine - Published
- 2022
3. A Surveillance System for the Maternal and Child Health (MCH) Population During the COVID-19 Pandemic
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Krystal Ruiz, Aminata Fofana, Victoria Hawley, and Elizabeth Armstrong-Mensah
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medicine.medical_specialty ,Sub saharan ,Human immunodeficiency virus (HIV) ,Antiretroviral Therapy ,Perinatal ,medicine.disease_cause ,Perinatal hiv ,03 medical and health sciences ,0302 clinical medicine ,Safer sex ,Commentary | Perinatal HIV Transmission ,Environmental health ,parasitic diseases ,medicine ,030212 general & internal medicine ,030505 public health ,Sub-Saharan Africa ,Transmission (medicine) ,business.industry ,Public health ,General Engineering ,HIV ,Antiretroviral therapy ,HIV Prevention ,Public aspects of medicine ,RA1-1270 ,0305 other medical science ,business ,Mother to Child HIV Transmission - Abstract
About 86 percent of the estimated 160,000 children newly-infected with the human immunodeficiency virus (HIV) live in sub-Saharan Africa. Despite global efforts to reduce perinatal HIV transmission, this phenomenon continues to be a public health problem in sub-Saharan Africa. This paper discusses challenges associated with perinatal HIV transmission prevention in sub-Saharan Africa and offers strategies for the way forward. These strategies include safe sex education and behavioral change, increased access to integrated antenatal care, training of unskilled traditional birth attendants into formal delivery systems, access to antiretroviral therapy, and investing in virologic testing. Key words: • HIV • Perinatal • Antiretroviral Therapy • Mother to Child HIV Transmission • HIV Prevention • Sub-Saharan Africa Copyright © 2020 Armstrong-Mensah, et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
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- 2020
4. Mapping substrate use across a permafrost thaw gradient
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Aminata Fofana, Darya Anderson, Carmody K. McCalley, Suzanne Hodgkins, Rachel M. Wilson, Dylan Cronin, Nicole Raab, Mohammad Torabi, Ruth K. Varner, Patrick Crill, Scott R. Saleska, Jeffrey P. Chanton, Malak M. Tfaily, and Virginia I. Rich
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Soil Science ,Microbiology - Published
- 2022
5. Microbiota Composition in Anopheles Mosquitoes After Amoxicillin Treatment via the Blood Meal
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Aminata Fofana, Mathilde Gendrin, Ottavia Romoli, Armel Bienvenu Yarbanga, George Anicet Ouédraogo, Serge Rakiswende Yerbanga, Jean-Bosco Ouédraogo
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- 2021
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6. Microbiota Composition in Anopheles Mosquitoes After Amoxicillin Treatment via the Blood Meal
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Serge Yerbanga, Jean-Bosco Ouédraogo, Aminata Fofana, Armel Bienvenu Yarbanga, Mathilde Gendrin, George Anicet Ouédraogo, and Ottavia Romoli
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0303 health sciences ,food.ingredient ,030306 microbiology ,medicine.drug_class ,Elizabethkingia ,Antibiotics ,Anopheles ,Biology ,Amoxicillin ,biology.organism_classification ,Blood meal ,3. Good health ,Microbiology ,03 medical and health sciences ,food ,Wigglesworthia ,parasitic diseases ,medicine ,Microbiome ,Digestion ,030304 developmental biology ,medicine.drug - Abstract
The microbiota of Anopheles mosquitoes influences malaria transmission. Antibiotics ingested during a blood meal impact the mosquito microbiome and malaria transmission, with substantial differences between drugs. Here, we assessed if amoxicillin affects the mosquito microbiota . We collected Anopheles larvae in Burkina Faso, kept them in semi-field conditions and offered a blood meal to adult females. We tested the impact of blood supplementation with two alternative amoxicillin preparations on microbiota composition, determined by high-throughput sequencing in individual gut samples. Our mosquitoes harbored four main genera, Elizabethkingia, Wigglesworthia, Asaia and Serratia . The antibiotic treatment significantly affected overall microbiota composition, with a specific decrease in the relative abundance of Elizabethkingia and Asaia during blood digestion. Besides its interest on the influence of amoxicillin on the mosquito microbiota, our study proposes a thorough approach to report negative-control data of high-throughput sequencing studies on samples with a reduced microbial load.
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- 2021
7. Analyzing gut microbiota composition in individual Anopheles mosquitoes after experimental treatment
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Aminata Fofana, Rakiswendé S. Yerbanga, Ottavia Romoli, G. Armel Bienvenu Yarbanga, Jean-Bosco Ouédraogo, Mathilde Gendrin, Georges Anicet Ouedraogo, Institut de Recherche en Sciences de la Santé (IRSS), CNRST, Université Polytechnique Nazi Boni Bobo-Dioulasso (UNB), Microbiote des insectes vecteurs / Microbiota of Insect Vectors [Cayenne, Guyane française], Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Institut des Sciences et Techniques [Bobo Dioulasso, Burkina Faso], This project was supported by Developing Excellence in Leadership and Genetics training for Malaria Elimination in Sub-Sahara Africa (DELGEME PhD Program fellowship, grant n° DELGEME 041/18) funding to AF. MG and OR are supported by the French Government's Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' (grant no. ANR-10-LABX-62-IBEID) and by ANR JCJC MosMi to MG (grant no. ANR-18-CE15-0007). Sequencing and initial bioinformatic analysis were funded by EU H2020 INFRAVEC2 (Project no. 731060)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-18-CE15-0007,MosMi,Remodelage du microbiote de moustique pour étudier son impact sur la transmission du paludisme(2018), and European Project: 731060,INFRAVEC2(2017)
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Multidisciplinary ,food.ingredient ,Science ,[SDV]Life Sciences [q-bio] ,Elizabethkingia ,Anopheles ,Zoology ,Biology ,Amoxicillin ,Gut flora ,Blood meal ,biology.organism_classification ,Article ,[SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,food ,Wigglesworthia ,parasitic diseases ,medicine ,Microbiome ,Digestion ,Entomology ,medicine.drug - Abstract
Summary The microbiota of Anopheles mosquitoes influences malaria transmission. Antibiotics ingested during a blood meal impact the mosquito microbiome and malaria transmission, with substantial differences between drugs. Here, we assessed if amoxicillin affects the gut mosquito microbiota. We collected Anopheles larvae in Burkina Faso, kept them in semi-field conditions, and offered a blood meal to adult females. We tested the impact of blood supplementation with two alternative amoxicillin preparations on microbiota composition, determined by high-throughput sequencing in individual gut samples. Our analysis detected four major genera, Elizabethkingia, Wigglesworthia, Asaia, and Serratia. The antibiotic treatment significantly affected overall microbiota composition, with a specific decrease in the relative abundance of Elizabethkingia and Asaia during blood digestion. Besides its interest on the influence of amoxicillin on the mosquito microbiota, our study proposes a thorough approach to report negative-control data of high-throughput sequencing studies on samples with a reduced microbial load., Graphical abstract, Highlights • We sequenced bacterial 16S in mosquitoes collected as larvae in Burkina Faso • Elizabethkingia, Wigglesworthia, Asaia, and Serratia dominate the gut microbiota • Amoxicillin treatment and potentially gametocyte presence influence the microbiota • We set up methods to consider mock controls after sequencing low-biomass samples, Entomology; Microbiome
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- 2021
8. Complications of Hydrocephalus Surgery in Children: Study of 18 Cases at the University Hospital Center of Conakry
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Aminata Fofana, Hugues Ghislain Atakla, Ibrahima Sory Junior Souare, Daniel Boubane Tama, and Ibrahima Sory Souare
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Microbiology (medical) ,medicine.medical_specialty ,business.industry ,Immunology ,Ethics committee ,Abnormal dilation ,Context (language use) ,medicine.disease ,University hospital ,Hydrocephalus ,Shunt (medical) ,Surgery ,medicine ,Immunology and Allergy ,Observational study ,Risk factor ,business - Abstract
Context and Objective: Hydrocephalus is the active abnormal dilation of the cerebral ventricular cavities and leads to a disorder of cerebrospinal fluid dynamics. Ventriculoperitoneal shunt and ventriculocisternostomy shunt are the most frequently used techniques in our context. However, a number of complications can occur. Our goal is to contribute to the improvement of the prevention of complications in the surgical management of hydrocephalus. Patients and Method: This is an observational study, over a period of five years and six months, of children aged 0-15 years who have undergone hydrocephalus surgery. All these data and their correlations were analyzed on Excel and EPI Info tables in version 7.2.3.1. The study was previously submitted to the ethics committee for approval. Anonymity and compliance with ethical rules were the norm. Results: We collected 18 cases of complications, i.e. 11.92%. Infants were the most affected with 16.70%. Most of the patients had a risk factor of neighborhood skin lesions. These were mainly infectious complications 50% and mechanical complications 33.30%. For the management of complications, equipment removal and revision/replacement were the procedures most frequently adopted, with frequencies of 50% and 22.20%. 66.70% were improved. Conclusion: The management of hydrocephalus is essentially neurosurgical and involves ventriculoperitoneal shunt and ventriculocisternostomy shunt, which, despite their effectiveness, are sometimes accompanied by various complications, including infectious ones, which were found to be at the forefront of this study. Even if the evolution has been favorable for 2/3 of the children studied, we believe that the constant search for risk factors for complications and the education of the parents of the children will limit the occurrence of the complications found.
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- 2021
9. Cervico-facial and thoracic cellulitis in a disadvantaged environment in Ségou, Mali
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Aminata Fofana, Mohamed Keita, Seydina Alioune Beye, Kadiatou Doumbia-Singaré, Boubacar M Dramé, Samba K Timbo, Boubacar K Diallo, and Alhousseini Ag Mohamed
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Medicine ,Microbiology ,QR1-502 - Abstract
Cervico-facial and thoracic cellulitis is a cellular diffusion from an infectious focus to cellulo-adipose tissues.The objective of this work was to review the management of this condition, to describe the descriptive study of the factors favoring it, to describe our experience of cellulite management and to identify the factors favoring it. Prognostic factors.This was a retrospective and descriptive study from October 2015 to March 2016 at the Ccentre Hhospitalier Nianankoro Fomba de Ségou. It involved 09 patients, 05 men for 4 women. The front door was essentially dental. We noticed 02 pregnancy cases associated with cellulite. We observed cervical and thoracic necrosis in 6 cases and cervical swelling in 03 cases. Cervical swelling in 03 cases. (Review title of study)The treatment was medical based on a triple with antibiotic and surgical treatment in all cases. The surgical treatment consisted of debridement - excision of the necrotic tissues and abundant washing with hydrogen peroxide and Dakin with a multiple drainage. Thoracic drainage was performed in 3 patients.The progression was favorable in 7 cases with complete cure and 2 cases of death in a sudden death chart. Mediastinitis.Cervico-facial cellulitis is a serious pathology of the young subject that can be life-threatening in the absence of a fast and adapted and multidisciplinary care
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- 2017
10. OC 8721 WANECAM II – A CLINICAL TRIAL PROGRAMME TO ASSESS SAFETY, EFFICACY AND TRANSMISSION-BLOCKING PROPERTIES OF A NEW ANTIMALARIAL KAF156 (GANAPLACIDE) IN UNCOMPLICATED MALARIA IN WEST AND CENTRAL AFRICA
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Jean-Bosco Ouedraogo, Aminata Fofana, Aminatou Kone, Ghyslain Mombo-Ngoma, Issiaka Soulama, Abdoulaye Djimde, David Hughes, Sophie Biguenet, José Pedro Gil, Sodiomon B. Sirima, Cornelis Winnips, Laurent Dembele, Eric Adehossi, Edithe Ilboudo-Sanogo, Stéphane Picot, Anders Björkman, Issaka Sagara, Bakary Fofana, Rella Zoleko Manego, Steffen Borrmann, Alassane Dicko, Colin J. Sutherland, Ogobara K. Doumbo, Martin P. Grobusch, Issaka Zongo, and Stephan Duparc
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medicine.medical_specialty ,business.industry ,Health Policy ,Public health ,Public Health, Environmental and Occupational Health ,Capacity building ,Context (language use) ,medicine.disease ,Lumefantrine ,Clinical trial ,chemistry.chemical_compound ,chemistry ,Drug development ,medicine ,Artemisinin ,Intensive care medicine ,business ,Malaria ,medicine.drug - Abstract
BackgroundDespite major progress in the past decade, malaria remains a major public health problem in sub-Saharan Africa. West and Central Africa account for nearly 2/3 of the burden currently attributable to falciparum malaria. Artemisinin-based combination therapies (ACT) are a cornerstone of our strategy for controlling and eventually eliminating malaria. However, reduced responsiveness/resistance to artemisinin derivatives and to ACTs, an increasing problem in South-East Asia is a major concern. It is of utmost importance to develop new antimalarial drugs from novel chemical classes that can replace ACTs. KAF156, an imidazolepiperazine, is a leading candidate in the antimalarial drug development pipeline. Combination of KAF156 with a Solid Dispersion Formulation of lumefantrine (LUM-SDF) is expected to be fast acting, fully curative, improve patient adherence and can potentially reduce malaria transmission.MethodsWANECAM II proposes to advance the clinical development of KAF156 through clinical trials in adults and children, with integrated capacity building and infrastructure development activities. The trial programme will be undertaken in the context of networking, team-building, leadership development and community engagement schemes that will involve intra-European, European-African and intra-African collaborative activities. WANECAM II will accelerate the clinical study of children less than 2 years of age which are the key target for new antimalarial treatments.ResultsBy the end of the project, the results are expected to contribute to the registration of KAF156/LUM-SDF through stringent regulatory health authorities, increase biomedical research capacity in the consortium and effectively promote networking among the respective teams. A new clinical research team in Niger, a grossly underrepresented country in the African research landscape, will be developed and further increase capacity and infrastructure in the consortium.ConclusionProviding a new antimalarial drug combination that does not contain an artemisinin derivative and is effective against resistant P. falciparum strains as well as gametocytes and that is likely to be taken in 3 or fewer single doses will be a major advance in the field. The new combination of KAF156 with LUM-SDF is expected to provide such major advance upon successful conclusion of the WANECAM II project.
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- 2019
11. RANDOMIZED TRIAL TO ASSESS EFFECT OF REPEATED TREATMENT OF DHA-PQ AND AL ON QTC INTERVAL IN PATIENTS PRESENTING WITH UNCOMPLICATED MALARIA IN BOBO-DIOULASSO, BURKINA FASO
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Issaka Zongo, Abdoulaye Djimde, Karidia Werme, Frederic Nikiema, Naomie Kaboré, Nouhoun Barry, Aminata Fofana, Fabrice A. Somé, Zachari Kabré, Bosco Ouedraogo, and Daniel Compaore
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medicine.medical_specialty ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,medicine.disease ,QT interval ,Surgery ,law.invention ,Repeated treatment ,Randomized controlled trial ,law ,Drug tolerance ,Internal medicine ,medicine ,In patient ,Artemisinin ,Adverse effect ,business ,Malaria ,medicine.drug - Abstract
Background Artemisinin combination therapies (ACTs) are widely used for the management of malaria and even tested for chemoprevention. In single episode efficacy studies, these drugs were clinically well tolerated but cardiac effects over repeated treatment are less investigated. Methods We conducted a prospective randomised controlled trial in Bobo-Dioulasso from August to October 2013 where patients aged 6 months and over were randomly allocated to receive either dihydroartemisinin-piperaquine (DHAPQ) or artemether-lumefantrine (AL) on first and subsequent episodes. Each participant was screened against inclusion criteria including the ECG which was repeated again 2 hours after the last dose. We considered that a QTc interval more than 30 ms compared to the baseline value is abnormal, but a prolonged QTc interval over 450 ms was reported as adverse event. QTc values were categorised into less or greater or equal to 450 ms. Drug tolerance was compared using Chi-square test, and p-value of less than 0.5 is significant. Results Patients were randomised to receive DHAPQ (n=224) or AL (n=236). During the 2 years follow-up we observed a total of 130 (in 1173 electrocardiogram performed on day 2 monitoring) prolonged QTc more than 450 ms (96/548 for DHAPQ and 34/625 for AL, p Conclusions The proportion of prolonged QTc was higher in DHAPQ group compared to the AL group but decreased along with the number of retreatments. Otherwise, DHAPQ and AL were well tolerated despite repeated treatment of malaria, which seemed to improve over consecutive episodes.
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- 2017
12. TO VALUE THE EFFICIENCY OF PYRONARIDINE-ARTESUNATE AND ARTEMETHER-LUMEFANTRINE IN THE TREATMENT OF UNCOMPLICATED MALARIA OFPLASMODIUMSPP. IN BURKINA FASO
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Fréderic Nikèma, Jean Ouédraogo, Aminata Fofana, Zachari Kabré, Daniel Compaore, Fabrice A. Somé, Abdoulaye Djimde, Naomie Kaboré, Nouhoun Barry, and Issaka Zongo
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Pyronaridine ,medicine.medical_specialty ,Artemether/lumefantrine ,business.industry ,Malaria vaccine ,Health Policy ,Public Health, Environmental and Occupational Health ,medicine.disease ,Uncomplicated malaria ,Surgery ,chemistry.chemical_compound ,Repeated treatment ,chemistry ,Artesunate ,Who guidelines ,Internal medicine ,parasitic diseases ,Medicine ,business ,Malaria ,medicine.drug - Abstract
Background No safe and highly effective malaria vaccine is available today. The treatment drugs currently in use remain insufficient. Moreover, resistance to these drugs makes malaria control difficult. The development of new therapeutic drugs is required. This abstract is part of a survey from the WANECAM study entitled ‘Randomised trial to assess the effect of repeated treatment of pyronaridine-artesunate (PA), dihydroartemisinin-piperaquine (DHA-PQ) and artemether-lumefantrine (AL) in patients presenting uncomplicated malaria in Bobo-Dioulasso, Burkina Faso’. We present here the analysis of the first episodes on the therapeutic efficiency of PA compared to AL, which is the first-line antimarial used in Burkina Faso. Methods A total of 448 subjects were randomised to receive treatment (224 subjects in each arm). Malaria diagnosis was assessed by microscopy. Subjects were follow-up during 42 days. Treatment response was measured according to standard of care as per WHO guidelines of 2003. The correction of the cases of treatment failure by molecular biology techniques is under analysis. Results On Day 28, the therapeutic failures were 3.35% in the PA group as against 18,10% for the AL group. On Day 42, a significant increase of the treatment failures in every group is observed with a higher rate in the AL group (31.43%), against 17.22% in the PA group. Conclusions This survey shows that less cases of treatment failure occurred in the patients9 group treated with PA compared to the group treated with AL. These findings contributed to evidence base for a change in malaria treatment policy guidelines for uncomplicated malaria in Burkina Faso.
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- 2017
13. Analyzing gut microbiota composition in individual Anopheles mosquitoes after experimental treatment
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'Aminata Fofana
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