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La rabdomiólisis es un síndrome caracterizado por la destrucción del músculo esquelético y liberación de elementos intracelulares a la circulación. La triada clásica de dolor muscular, debilidad y orina oscura no es muy común en la edad pediátrica, prevaleciendo una sintomatología más atípica cuanto menor sea la edad del afectado. La etiología puede ser adquirida o hereditaria, siendo las causas más frecuentes las infecciones, miopatías y el ejercicio físico. La severidad de la enfermedad es muy variable, desde una elevación aislada de las enzimas musculares hasta una patología más grave con alteraciones hidroelectrolíticas e insuficiencia renal. A continuación, se describen tres casos clínicos en los que tener un alto índice de sospecha resultó esencial para poder iniciar un tratamiento precoz con hidratación intravenosa y así garantizar una evolución favorable hasta la recuperación.

One effort to improve nutritional status is consuming nutritious food and nutrition education for children to instill healthy eating habits from an early age. The purpose of this study was to analyze the effectiveness of providing snacks on the nutritional status and nutritional intake of adolescents. This type of research was a quasi-experimental design with a one-group pre-posttest design without a control group. The research subjects were adolescents aged 11-14 years. Snacks are given for 1 month that meets ± 20% energy and ± 8% protein and ± 15% fat. T-test to analyze the nutritional status of adolescents and nutrient intake before and after giving the distraction food. The results of this study showed that providing distracting food could increase body mass index (p-value=0,000), student weight (p-value=0,000), intake of protein (p-value=0,000), vitamin C (p-value=0,0008), and zinc (p-value=0,0004), but height, carbohydrate intake, and iron intake had no significant effect (p-value>0,05). This study concluded that the provision of snack food effectively increased students' nutritional knowledge, student weight, and intake of protein, vitamin C, and zinc, but height and body mass index, as well as carbohydrates and iron, did not increase significantly. The suggestion from this study is that distraction for adolescents is highly recommended to improve nutritional status so schools should be able to make a policy in providing distracting food as a program to improve adolescent nutrition at school.

This study aims to examine the effect of budget characteristics and organizational commitment on the performance of the nagari government in the nagari government in Dharmasraya Regency, the research sample was determined using the non-probability sampling method with a sample of 52 villages. Quantitative data is the data selected in this study in the form of written responses from the questionnaire. The source of data used is primary data obtained from the nagari government. Methods Questionnaire data was collected by giving a set of oral questions or written questions to respondents to answer. The results showed that budget participation, clarity of budget objectives, budget feedback and organizational commitment had an effect on the performance of the nagari government. Budget evaluation and the difficulty of budget objectives have no effect on the performance of the nagari government.

Desa Soropaten merupakan salah satu desa yang terletak di Kecamatan Karanganom, Kabupaten Klaten, Provinsi Jawa Tengah. Data BPS menunjukkan luas lahan sawah setempat per 2021 seluas 121,57 (Ha) dari luas seluruh wilayah seluas 166,44 (Ha) yang didominasi oleh tanaman pangan berupa jagung dan padi. Kendala yang dialami oleh petani setempat adalah adanya penurunan produktivitas karena serangan hama. Hama wereng pada padi dan hama ulat grayak pada jagung menjadi hama yang merugikan petani. Kegiatan pengabdian masyarakat ini menginisiasi gerakan penyemprotan hama padi dan jagung secara massal bersama Gapoktan. Kegiatan pengabdian ini dilakukan untuk menambah pengetahuan petani dalam mengendalikan hama pada tanaman budidaya dalam gerakan penyemprotan massal. Gerakan penyemprotan dapat terlaksana melalui pembekalan pengetahuan melalui tahapan kegiatan yang meliputi (1) perencanaan program; 2) sosialisasi program; 3) penyuluhan pertanian; 4) penyemprotan hama jagung; dan 5) penyemprotan hama padi. Melalui kegiatan ini, petani diharapkan senantiasa melakukan kegiatan serupa secara rutin sebagai upaya pengendalian hama.

Background: Breast cancer has the highest incidence of all cancers in women worldwide. A molecular subtype of breast cancer, degree of differentiation, and lymph node metastasis are prognostic and predictive factors of breast cancer. This study aims to explore the relationship between molecular subtype, degree of differentiation, and lymph node metastasis with overall survival and disease-free survival of breast cancer patients at Dr. M. Djamil General Hospital Padang. Methods: This study was an analytic observational study with a retrospective cohort approach using secondary data from 68 subjects. The test variables in this study were the molecular subtype of breast cancer, the degree of differentiation, and lymph node metastasis which were obtained from secondary data and medical records. Another test variable is patient survival, namely overall survival (OS) and disease-free survival (DFS). Data analysis with the help of SPSS software in univariate, bivariate, and multivariate. Results: Patients with lymph node metastases were 7.94 times more likely to experience an event (death) (HR=7.94 95% CI: 0.91–78.2). Patients with lymph node metastases were 10.2 times more likely to experience an event (recurrence) (HR=10.2 95% CI: 1.03–101.1). Conclusion: Lymph node metastases are the factors most related to survival (overall survival and disease-free survival) of breast cancer patients at Dr. M. Djamil General Hospital, Padang, Indonesia.

This research discusses implicature in the Anime Blue Period. The purpose of the this research is to explain how the meaning and intent of implicatures in the Anime Blue Period. The research uses the theory proposed by Yule (1996) on implicature and uses is a the analysis theory means ends by Leech(1993). The research method uses is a qualitative descriptive method. The data is obtained by listening to the converversation spoken by the characters, and then the utterances containing implicatures will be recorded and marked. The result of this study found as many as 20 implicature data in the Anime Blue Period, namely 7 refuse implicature, 4 mocking implicatures, 3 commanding implicatures, 4 insinuating implicatures, and 2 invites implicatures. Key Words: Implicature, cooperation principle, theory means-end. Abstrak Penelitian ini membahas tentang implikatur dalam Anime Blue Period. Tujuan penelitian ini adalah untuk menjelaskan bagaimana fungsi implikatur dalam Anime Blue Period. Penelitian ini menggunakan teori implikatur dari Yule (1996) dan menggunakan teori analisis cara-tujuan oleh Leech (1993). Metode yang digunakan adalah metode deskriptif kualitatif. Data diperoleh dengan cara menyimak percakapan yang dituturkan oleh para tokoh, kemudian peneliti mencatat dan menandai tuturan yang mengandung implikatur dalam Anime Blue Period. Hasil penelitian ditemukan 20 data implikatur dalam Anime Blue Period yaitu, tujuh implikatur menolak, empat implikatur mengejek, tiga implikatur memerintah, empat implikatur menyindir, dan dua implikatur mengajak. Kata Kunci: Implikatur, prinsip kerjasama, teori cara-tujuan.

This study aims to obtain empirical evidence and determine the effect of governance, organizational commitment and rewards on the implementation of performance-based budgeting. The population in this study was OPD in West Sumatra Province with 100 samples taken. The sampling technique used total sampling. The source of data in this study is primary data with data collection techniques using questionnaires. The data analysis method in this study uses multiple linear regression analysis with the application of performance-based budgeting as the dependent variable and governance, organizational commitment and reward as independent variables. The results of this study indicate that governance, organizational commitment and rewards have no effect on the implementation of performance-based budgeting.

Usia dini merupakan usia terjadi pola tumbuh kembang yang sangat pesat. Hal ini harus diiringi dengan diberikannya edukasi yang benar mengenai tumbuh kembangnya, jika tidak maka dalam usia ini anak akan mudah terkena kelainan. Kelainan tersebut dapat berupa gangguan gait. Salah satu bagian terpenting yang mempengaruhi struktur biomekanik dan musculoskeletal pada kaki adalah lengkung kaki atau arcus pedis. Akibat dari arkus yang tidak tumbuh secara normal diantaranya yaitu gangguan keseimbangan, lelah saat berjalan lama, deformitas yang berlanjut, serta rasa nyeri. Flat foot adalah deformitas atau kelainan pada kaki yang paling umum terjadi pada anak. Kegiatan dilakukan di sekolah TK-KB Al-Quran Terpadu Bintangku Surakarta dengan jumlah 60 anak. Tujuan dari kegiatan ini yaitu untuk melihat prevalensi flat foot serta upaya preventif disampaikan dalam bentuk deteksi dini menggunakan clarke’s angle test. Program ini dilakukan pada Mei 2022. Hasil dari kegiatan ini memiliki dampak yang baik dalam membantu meningkatkan pengetahuan anak-anak tentang flat foot serta didapatkan prevalensi kasus terbanyak dialami oleh jenis kelamin laki-laki daripada perempuan. Penulis berharap sekolah dapat terus meruntinkan kegiatan pengecekan rutin flat foot mengingat flat foot sering kali tidak menimbulkan gejala sehingga diperlukan screening usia dini.

This study aims to determine the factors that influence the implementation of SAK EMKM on UMKM in the city of Padang. The data used in this study are primary data sourced from questionnaires given to the owners of UMKM in the city of Padang. Testing is done by using regression. The results showed that simultaneously the independent variables consisting of socialization of SAK EMKM, utilization of information technology, accounting knowledge, education level of the owner, omzet and length of business did not significantly affect the dependent variable, namely the implementation of SAK EMKM. Partially, the socialization of SAK EMKM and the owner's level of education have a positive effect on the implementation of SAK EMKM. While the use of information technology, accounting knowledge, omzet and length of business have no significant effect on the implementation of SAK EMKM in Padang City.

Neisseria gonorrhoeae (N. gonorrhoeae) es el agente causal de la gonorrea, infección de transmisión sexual (ITS) que corresponde a la segunda causa más frecuente de ITS a nivel mundial, provocando una alta morbilidad y costo en atención de salud. En las últimas décadas han aumentado los reportes a nivel mundial de cepas resistentes a penicilina, sulfonamidas, tetraciclina, macrólidos y fluoroquinolonas, y más recientemente a azitromicina y cefalosporinas de espectro extendido como ceftriaxona y cefixima. El objetivo principal de este estudio fue determinar la sensibilidad a los antimicrobianos en cepas de N. gonorrhoeae que fueron enviadas al Laboratorio Central de Salud Pública (LCSP), por los centros colaboradores de la Red de Vigilancia Laboratorial de la Resistencia a los Antimicrobianos (RAM). Para ello, se realizó un estudio prospectivo de corte transversal de enero a diciembre de 2021. Se caracterizaron 128 cepas como N. gonorrhoeae a las cuales se le realizaron pruebas de susceptibilidad obteniéndose 48% de resistencia y 52% de sensibilidad intermedia a penicilina. El 70% presentó resistencia a ciprofloxacina y el 19% a tetraciclina. Se obtuvo 100% de sensibilidad a ceftriaxona y cefixima. El fenotipo de resistencia de mayor prevalencia fue QRNG, asociado con resistencia a ciprofloxacina, seguido del fenotipo PPNG-QRNG, asociado con resistencia a penicilina y ciprofloxacina. Ante estos hallazgos y frente a la emergencia mundial de la resistencia a los antimicrobianos, especialmente de cefalosporinas de espectro extendido, se recomienda que los laboratorios de bacteriología fortalezcan la vigilancia para apoyar la detección de casos y proporcionar el tratamiento adecuado.

The emergence and explosion of the internet in this technological era has provided an online business platform for services and products. One of them is the food delivery industry. Online food delivery is a service that allows customers to purchase food from a website or mobile app and have it delivered to their home. This study aims to determine and explain the effect of purchasing experience on customer trust and customer satisfaction with Grab Food customers. The choice of location for this research considers that customers who usually buy food using Grab Food are customers whose market segments are in large urban communities. The exogenous variable in this study is the buying experience, while the endogenous variable is customer trust and satisfaction. This study provides insight into customer satisfaction with mobile food delivery apps from the new norm of a COVID-19 scalable perspective. The quality of the application website and the convenience of using the application are revealed as important factors that significantly affect customer satisfaction during the pandemic.

This study aims to determine the effect of Regional Government Characteristics (Regional Financial Independence, Degree of Decentralization, and Population) and Financial Factors (Efficiency Ratio, Growth Ratio, and Effectiveness Ratio) on financial difficulties in Regency/City local governments in Indonesia in 2017-2019. . This study uses secondary data from BPK and BPS. The sampling technique used is a simple random sampling technique. So that obtained a sample of 170 districts and 54 cities per year. Data analysis is multiple linear regression analysis. This study found that (1) regional financial independence had a significant positive effect on financial distress, (2) the degree of decentralization had a significant negative effect on financial distress, (3) the population had a significant negative effect on financial distress, (4) the efficiency ratio had a significant positive effect on financial distress, (5) the growth ratio has a positive and insignificant effect on financial distress, (6) the effectiveness ratio has a positive and significant effect on financial distress

Las tertulias musicales dialógicas (TMD) consisten en construir el aprendizaje de manera colectiva compartiendo y dialogando sobre las mejores creaciones musicales de la humanidad. El funcionamiento se basa en los siete principios del aprendizaje dialógico: diálogo igualitario, inteligencia cultural, transformación, dimensión instrumental, creación de sentido, solidaridad e igualdad de diferencias. La experiencia se lleva a cabo en dos grupos de 1.º de Educación Secundaria Obligatoria. Los resultados muestran la evolución en términos de actitud hacia la música clásica y clima de aula tras la participación en las seis tertulias llevadas a cabo.

Objective: Today, stress monitoring on wearable devices is challenged by the tension between high-detection accuracy and battery lifetime driven by multimodal data acquisition and processing. Limited research has addressed the classification cost on multimodal wearable sensors, particularly when the features are cost-dependent. Thus, we design a Cost-Aware Feature Selection (CAFS) methodology that trades-off between prediction-power and energy-cost for multimodal stress monitoring. Methods: CAFS selects the most important features under different energy-constraints, which allows us to obtain energy-scalable stress monitoring models. We further propose a self-aware stress monitoring method that intelligently switches among the energy-scalable models, reducing energy consumption. Results: Using CAFS methodology on experimental data and simulation, we reduce the energy-cost of the stress model designed without energy constrains up to 94.37%. We obtain 90.98% and 95.74% as the best accuracy and confidence values, respectively, on unseen data, outperforming state-of-the-art studies. Analyzing our interpretable and energy-scalable models, we showed that simple models that use only heart rate (HR) or skin conductance level (SCL), confidently predict stress for HR >93.30 BPM and non-stress for SCL

Over the 20th century, the state has acquired a prominent role in the administration of old-age pensions in Latin America, expanding legal coverage to the majority of the employed population. However, gaps in effective coverage remained large as a result of the high incidence of informal work. Over the last two decades of the 20th century, the almost exclusive role of the state in old-age protection was deeply challenged. Starting with Chile in 1981, several countries implemented structural pension reforms that shifted to individual accounts and private pension administration, thus completely reshaping the public-private balance in the pension system. Private schemes were presented as a new and more effective way to manage old-age security and promote economic growth. But these schemes also faced shortcomings, including high administrative costs, financial market risks, and problems of coverage, equity, and adequacy. Over the 2000s, as governments with a more progressive policy agenda took office in a context of favorable macroeconomic conditions, the state gained ground in the administration of old-age security. This more active role of the state has strengthened public pensions compared to two or three decades back, with better instruments for basic protection, new systems of administrative registry of contributors and pensioners, and broader coverage of the population across the territory.

This chapter presents the Latin American section and provides an overview of its main findings. It discusses the governance and management for social policy in a region with high levels of inequality, informal employment, low fiscal efforts, and major weaknesses in terms of social risks and state capacity. Besides these similarities, wide variations also exist in social policy regimes across countries in terms of governance, administrative arrangements, levels of decentralization, and mixes of public services and private services. Innovations in social policy over the 21st century have produced a range of mixed systems that are not always consistent, distributionally sound, or sustainable. The chapters in this section contribute to understanding these trends and their implications for the governance and management of social policy in Latin America.

This chapter puts the region’s social protection policy models into historical, political, and social context. It distinguishes four major stages in Latin American welfare state models, clearly associated with four stages in Latin American state-building: the minimalist “welfare” state of the primary export period; the contribution-based welfare state under the import substitution model; the turn to the reluctant welfare state and the introduction of the market into social affairs that characterized the Washington Consensus era; and finally, the expansionary stage of post-Washington Consensus until the mid-2010s. In the initial stages, the state role was minimal, focusing on primary education and boosting urban sanitation infrastructure. In the import substitution period, there was a strong push for modern social protection, tied firmly to protection for formal workers. However, informal labor markets and incomplete protection against a variety of risks produced a stratified model of social security with incomplete coverages. The liberal turn led to a focus on extreme poverty along with an increased reliance on market mechanisms in healthcare, education, and pensions. As the 20th century came to an end, pressures for more inclusive social policies promoted the expansion of coverage and benefits. The return and resilience of democracy, an export-oriented external stance, and the substantial economic growth of the first decade and a half of the 21st century were all factors that contributed to this new and still unstable social citizenship contract.

Boiler merupakan suatu bejana tertutup yang berfungsi untuk merubah air menjadi air panas atau uap yang bertekanan dan memiliki temperatur yang tinggi. Double drum cross section water tube boiler merupakan boiler yang menggunakan dua drum (steam drum dan water drum) yang terhubung dengan water tube dan superheater sebagai tempat terjadinya proses proses pemanasan air dan uap air. Dimana posisi tube disusun secara melintang dengan tujuan memperluas area tube sehingga luas area perpindahan panas pada boiler menjadi lebih besar kemudian menggunakan kemiringan pada tube sebesar 65º dengan tujuan agar mempercepat penguapan pada molekul air. Bahan bakar yang digunakan pada penelitian kali ini menggunakan bahan bakar cair yaitu solar. Dari hasil penelitian menghasikan kinerja alat Water Tube Boiler yang baik yaitu pada rasio udara bahan bakar 9,75 (excess 18%) , dimana efisiensi Thermal yang didapatkan sebesar 67,3%, dengan temperature steam sebesar 206,9?, tekanan steam sudah mencapai tekanan optimum yaitu sebesar 5 bar. Kendala yang terjadi yaitu pada komponen yang tidak bisa menahan tekanan dan temperatur yang tinggi sehingga menyebabkan produksi steam yang dihasilkan menjadi tidak optimal. Sehingga penelitian kali ini dilakukan pengupgradean pada sistem Injection Boiler Feed Water dengan penambahan sistem Drain yang diharapkan mampu menahan turbulensi pada level gauge saat terjadinya proses kontinyu. dan sistem Secondary agar produksi steam yang didapatkan berlangsung secara steady state atau Non steady state sehingga didapatkan hasil pembakaran dan produksi steam yang optimal.

This study investigated the optimum transport condition for heart tissue to recover single-cell cardiomyocytes for future in-vitro or in-vivo studies. The heart tissues were obtained from removing excessive myocardium discharged during the repair surgery of an excessive right atrial hypertrophy due to a congenital disease. The transportation temperature studied was the most used temperature (4 °C) or the conventional condition, compared to a physiological temperature(37 °C). The heart tissues were transported from the operating theatre to the lab maintained less than 30 min consistently. Single-cell isolation was enzymatically and mechanically performed using collagenase-V (160 U/mg) and proteinase-XXIV (7-14 U/mg) following the previously described protocol. The impact of temperature differences was observed by the density of cells harvested per mg tissue, cell viability, and the senescence signals, identified by the p21, p53 and caspase-9 mRNA expressions. Results the heart tissue transported at 37 °C yielded significantly higher viable cell density (p 0.01) yielded viable cells significantly higher density (p 0.01) than the 4 °C; 2,335 ± 849 cells per mg tissue, and 732 ± 425 cells per mg tissue, respectively. The percentage of viable cells in both groups showed no difference. Although the 37 °C group expressed the apoptosis genes such as p21, p53 and caspase9 by 2.5-, 5.41-, 5-fold respectively (p 0.05). Nonetheless, the Nk×2.5 and MHC genes were expressed 1,7- and 3.56-fold higher than the 4 °C. and the c-Kit+ expression was 17.56-fold, however, statistically insignificant. Conclusion When needed for single-cell isolation, a heart tissue transported at 37 °C yielded higher cell density per mg tissue compared to at 4 °C, while other indicators of gene expressions for apoptosis, cardiac structural proteins, cardiac progenitor cells showed no difference. Further investigations of the isolated cells at different temperature conditions towards their proliferation and differentiation capacities in a 3-D scaffold would be essential.

Ozaki et al. first performed aortic valve replacement using autologous pericardium in 2007. Compared to mechanical and bioprosthetic valves which have apparent disadvantages, this technique has been an alternative with a promising safety and efficacy result. A comprehensive search was carried out in 4 databases (Pubmed, Cochrane Library, Proquest, Scopus) from February to March 2021 using search terms “autologous pericardium”, “aortic valve replacement”, and “aortic valve reconstruction”. Outcomes measured in this study were mortality, freedom of operation, thromboembolic and endocarditis event, and echocardiography finding. Risk bias of all studies was measured using MINORS criteria. A total of 12 studies involving 1427 subjects were included. The mean age was 64.95 years and 52.1% subjects were male. Mortality due to cardiac and noncardiac cause was 1.75%. Reoperation was needed in 1.12% subjects. Thromboembolic and endocarditis events occurred in 0.21% and 0.91% respectively. All studies reported lower average peak pressure gradient after surgery. Aortic valve replacement using autologous pericardium has a tolerable safety and efficacy. Resumen: Ozaki et al. realizaron por primera vez el reemplazo de la válvula aórtica utilizando pericardio autólogo en 2007. En comparación con las válvulas mecánicas y bioprotésicas, que tienen aparentes desventajas, esta técnica ha sido una alternativa con un resultado prometedor de seguridad y eficacia. Se realizó una búsqueda exhaustiva en 4 bases de datos (Pubmed, Cochrane Library, Proquest y Scopus) de febrero a marzo de 2021 utilizando los términos de búsqueda pericardio autólogo, reemplazo valvular aórtico y reconstrucción valvular aórtica. Los resultados medidos en este estudio fueron mortalidad, libertad de operación, evento tromboembólico y hallazgo ecocardiográfico. El sesgo de riesgo de todos los estudios se midió mediante los criterios MINORS. Se incluyeron un total de 12 estudios con 1.427 sujetos. La edad media fue de 64,95 años y el 52,1% de los sujetos eran varones. La mortalidad por causa cardíaca y no cardíaca fue del 1,75%. Se produjeron episodios tromboembólicos y endocarditis en un 0,21% y un 0,91%, respectivamente. Todos los estudios informaron de un gradiente de presión máxima promedio más bajo después de la cirugía. La sustitución valvular aórtica mediante pericardio autólogo tiene una seguridad y eficacia tolerables.

A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs during early hematopoiesis is challenging. Here, we generated a human inducible pluripotent stem cell (hiPSC) model with doxycycline dose-dependent MLL-AF9 expression. We exploit MLL-AF9 expression as an oncogenic hit to uncover epigenetic and transcriptomic effects on iPSC-derived hematopoietic development and the transformation into (pre-)leukemic states. In doing so, we observed disruption of early myelomonocytic development and expansion of a CD34+ early hematopoietic progenitor compartment upon MLL-AF9 activation. In agreement, we identified gene profiles consistent with primary MLL-AF9 AML and uncovered highly confident MLL-AF9-associated core genes that faithfully represent primary MLL-AF9 AML, including known and thus far unknown factors. Our system allows for careful chemically controlled and stepwise in vitro hiPSC-derived differentiation under serum-free and feeder-free conditions. For a disease that currently lacks effective precision medicine, our system provides a novel entry-point into exploring potential novel biomarkers and targets for personalized therapeutic strategies.

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Earth can act as a transducer to convert ultralight bosonic dark matter (axions and hidden photons) into an oscillating magnetic field with a characteristic pattern across its surface. Here we describe the first results of a dedicated experiment, the Search for Non-Interacting Particles Experimental Hunt (SNIPE Hunt), that aims to detect such dark-matter-induced magnetic-field patterns by performing correlated measurements with a network of magnetometers in relatively quiet magnetic environments (in the wilderness far from human-generated magnetic noise). Our experiment constrains parameter space describing hidden-photon and axion dark matter with Compton frequencies in the 0.5-5.0 Hz range. Limits on the kinetic-mixing parameter for hidden-photon dark matter represent the best experimental bounds to date in this frequency range.

A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs during early hematopoiesis is challenging. Here, we generated a human inducible pluripotent stem cell (hiPSC) model with a doxycycline dose-dependent MLL-AF9 expression. We exploited MLL-AF9 expression as an oncogenic hit to uncover epigenetic and transcriptomic effects on iPSC-derived hematopoietic development and the transformation into (pre-)leukemic states. In doing so, we observed a disruption in early myelomonocytic development. Accordingly, we identified gene profiles that were consistent with primary MLL-AF9 AML and uncovered high-confidence MLL-AF9-associated core genes that are faithfully represented in primary MLL-AF9 AML, including known and presently unknown factors. Using single-cell RNA-sequencing, we identified an increase of CD34 expressing early hematopoietic progenitor-like cell states as well as granulocyte-monocyte progenitor-like cells upon MLL-AF9 activation. Our system allows for careful chemically controlled and stepwise in vitro hiPSC-derived differentiation under serum-free and feeder-free conditions. For a disease that currently lacks effective precision medicine, our system provides a novel entry-point into exploring potential novel targets for personalized therapeutic strategies.

Resumen Objetivo Evaluar el impacto de la implantacion de la guia «Valoracion del riesgo y prevencion de ulceras por presion» sobre la adherencia a las recomendaciones de la guia, la prevalencia de lesiones por presion (LPP) y sostenibilidad de los resultados, asi como analizar las estrategias de implantacion, la sostenibilidad y las barreras detectadas. Metodo Estudio observacional retrospectivo (de junio del 2015 a diciembre del 2018). Se estudiaron 2 periodos (P1: preparacion y P2: sostenibilidad). Se analizaron las memorias del programa y los datos de la historia clinica de pacientes dados de alta en los 4 hospitales participantes sobre la adherencia de las recomendaciones preventivas y los resultados en salud en terminos de presencia de LPP por cada centro. Resultados Se incluyo a 13.515 pacientes, de los cuales 4.523 tenian riesgo de LPP y 722 tenian LPP. El 82,9% de los pacientes recibieron una valoracion del riesgo de LPP al ingreso. Se observo una disminucion de esta valoracion al ingreso: P1: 89,1% vs. P2: 81%; p El compromiso institucional, la designacion de lideres, elaboracion de planes de accion y la formacion son estrategias destacables en todos los centros. Conclusiones El presente estudio muestra la existencia de una adecuada adherencia a las principales recomendaciones de la guia, observandose una mejoria estadisticamente significativa en la adherencia a 2 de las 3 recomendaciones evaluadas. Las estrategias de implantacion y sostenibilidad puestas en marcha han contribuido en el mantenimiento o mejora de los resultados en el tiempo.

Aim To assess the impact of implementing the “Risk Assessment and Prevention of Pressure Injuries (PI)” guideline on adherence to its recommendations, the prevalence of PI and the sustainability of results, and to analyse the implementation strategies, sustainability and barriers detected. Methods A retrospective observational study (June 2015 to December 2018). Two periods were studied (P1: Preparation and P2: Sustainability). The programme reports and data from the medical records of patients discharged from the 4 participating hospitals were analysed with regard to adherence to preventive recommendations and health outcomes in terms of the presence of pressure injuries per centre. Results A total of 13,515 patients were included, of whom 4523 were at risk for PI and 722 had PI. Of the patients, 82.9% underwent a risk assessment for PI on admission. A decrease in this assessment on admission was observed between P1:89.1% vs. P2: 81% p Institutional commitment, the appointment of leaders, drawing up of action plans, and training are outstanding strategies in all the centres. Conclusions This study shows that there is adequate adherence to the main recommendations of the guideline. A statistically significant improvement was observed in adherence to 2 out of the 3 recommendations assessed. The implantation and sustainability strategies implemented have been contributed to maintenance and/or improving results over time.

This study aims to determine the Effect of Competence, Internal Control System, Role of Village Apparatus and Quality of Financial Statement Presentation on Village Government Accountability in Managing Village Fund Allocation (ADD) (Empirical Study in Nagari district of Solok). The data in this study used primary data obtained from the village apparatus. The sampling technique used random sampling method. The sample used in this study were 24 nagari in the district of Solok and the respondents were village officials who worked in the Wali Nagari office as many as 72 village officials. The village apparatus consists of the Village Head, Secretary, and Treasurer. Data analysis using multiple regression analysis. The results of this study indicate that (1) Competence has a positive and significant effect on Village Government Accountability in Managing Village Fund Allocations (ADD), (2) Internal Control System has a positive and significant impact on Village Government Accountability in Managing Village Fund Allocations (ADD), (3) The role of Village Apparatus has a positive and significant effect on Village Government Accountability in Managing Village Fund Allocations (ADD), (4) Quality of Financial Statement Presentation has a positive and significant impact on Village Government Accountability in Managing Village Fund Allocations (ADD).

Nutrition education for children is important to instill healthy eating habits from an early age. The aim of the study was to analyze the effect of nutrition education on nutritional knowledge and intake of vitamin C and iron for students of SMPN 1 Bayang. This type of research is a quasi experimental design with a pre-post control group design approach. The research was conducted in February - September 2020 at SMPN 2 Bayang. Nutritional education using a zoom application and accompanied by social media (whatsapp group) carried out every 2 weeks for 6 weeks as much as 3 times nutrition education. Data collection was carried out by phone and google form. Data analysis using paired sample t-test analyzed the mean differences in the level of knowledge, and intake of micronutrients (vitamin c and iron). Results Based on the social media-based nutrition education, it was found that nutritional knowledge and vitamin C intake increased significantly (P

Cardiovascular disease is the second highest cause of death across the globe. Myocardial infarction is one of the heart diseases that cause permanent impairment of the heart wall leads to heart failure. Cellular therapy might give hope to regenerate the damaged myocardium. Single cells isolated from an excess heart tissue obtained from the correction of the right ventricular hypertrophy in patients with Tetralogy of Fallot for future heart study were investigated. Methods: Once resected, the heart tissues were transported at 37 °C, in Dulbecco's Modified Eagle's medium/ DMEM (4.5 g.L−1, antibiotic–antimycotic 3x, PRP10% (v/v)), to reach the lab within 30 min, weighted and grouped into less than 500 mg and more than 1000 mg (n = 4). Each sample was digested with 250 U.mL−1 Collagenase type V and 4U.mL−1 Proteinase XXIV in the MACS™ C-tube (Milltenyi, Germany), then dissociated using the MACS™ Octo Dissociator with Heater (Milltenyi, Germany) for 60 min at 37 °C. Results: All cells isolated were rod-shaped cells; viability was up to 90%. The cell density obtained from the 500 mg group were 4,867 ± 899 cells.mg−1 tissue weight, significantly higher compared to the 1,000 mg group; had 557 ± 490 cells.mg−1 tissue weight (mean of (n = 3) ± 95% C.l). The isolated cells were analyzed using FACs BD Flowcytometer, expressed cTnT + 13.38%, PECAM-1 + /VCAM-1- 32.25%, cKit + 7.85%, ICAM + 85.53%, indicating the cardiomyocyte progenitor cells. Conclusion: Cardiomyocytes taken from the wasted heart tissue might be a candidate of cardiomyocytes source to study interventions to the heart as it contained up to 13.38% cardiomyocytes, and 32.25% of cardiac progenitor cells. Moreover, perhaps when cardiac cell therapy needs autologous cardiomyocytes, less than 500 mg tissue weight can be considered as sufficient.

This study aims to determine the effect of communication, human resource competence, resistance to change and leadership commitment to the readiness of the apparatus in managing village funds during the pandemic. The population of this research is all Nagari apparatus in XX Koto District. The sample used is 72 respondents with total sampling technique. This study uses quantitative methods by distributing questionnaires directly. This study was tested using multiple regression analysis. The results obtained from this study indicate that communication and resistance to change have no significant effect on the readiness of village officials in managing village funds during the pandemic, while human resource competence and leadership commitment have a significant positive effect on the readiness of village officials in managing village funds during the pandemic.

This study aims to determine the effect of the size of the local government, the age of the local government, the status of the local government, the total population, the total of SKPD, employee expenditure and leverage on regional financial independence. The population in this study is Regency/City in West Sumatra Province in 2015-2019. This study uses secondary data. The sampling technique used the Total Sampling method with a sample of 19 districts/cities with a period of 5 years. Data analysis used multiple linear regression analysis. The results of the study indicate that the status of local government, population and leverage affect regional financial independence. Meanwhile, the size of the local government, the age of the local government, the number of SKPD and employee expenditures have no effect on regional financial independence.

This study was to determine the influence of intellectual capital and corporate social responsibility on firm value. This research method is quantitative. The population in this study is the mining sector companies on the Indonesia Stock Exchange from 2018 to 2020. The sample of this study was determined by purposive sampling. Data analysis techniques for hypothesis testing using multiple regression analysis. The results show that intellectual capital has no significant effect as well as corporate social responsibility on firm value. This is due to the low interest of investors in other aspects outside of physical and financial assets. investors are more focused on maximizing profit as a short term goal. it can be suggested that: (1) Companies should increase their assets to increase company size so that companies have more financial funds to manage their IC performance and create more added value, and (2) For future researchers, it is recommended to increase the number of sample companies, adding other variables and using other proxies in further research.

Cognitive workload affects operators' performance principally in high-risk or time-demanding situations and when multitasking is required. An online cognitive workload monitoring system can provide valuable inputs to decision-making instances, such as the operator's state of mind and resulting performance. Therefore, it can allow potential adaptive support to the operator. This work presents a new design of a wearable embedded system for online cognitive workload monitoring. This new wearable system consists of, on the hardware side, a multi-channel physiological signals acquisition (respiration cycles, heart rate, skin temperature, and pulse waveform) and a low-power processing platform. Further, on the software side, our wearable embedded system includes a novel energy-aware bio-signal processing algorithm. We also use the concept of application self-awareness to enable energy-scalable embedded machine learning algorithms and methods for online subjects' cognitive workload monitoring. Our results show that this new wearable system can continuously monitor multiple bio-signals, compute their key features, and provide reliable detection of high and low cognitive workload levels with a time resolution of 1 minute and a battery lifetime of 14.58 h in our experimental conditions. It achieves a detection accuracy of 76.6% (2.6% lower than analogous offline computer-based analysis) with a sensitivity of 77.04% and a specificity of 81.75%, on a simulated drone rescue mission task. Moreover, by applying our self-aware monitoring to exploit different energy-scalable modes, we can increase battery lifetime by 51.6% (up to 22.11 hours) while incurring an insignificant accuracy loss of 1.07%.

Kondisi pandemi Covid-19 saat ini akan semakin memperburuk kondisi anak stunting jika ibu atau pengasuh anak tidak memperhatikan pengasuhan anak yang layak. Tujuan dari penelitian ini yaitu menganalisis perbedaan pengetahuan dan sikap ibu tentang ASI Ekslusif dan MP ASI setelah diberikan.edukasi gizi berbasis media sosial. Penelitian ini merupakan eksperimen semu dengan desain adalah quasy experimental pre-post test with control group design. Sampel sebanyak 30 ibu dibagi menjadi dua kelompok yaitu kelompok intervensi dan kelompok kontrol. Penelitian dilakukan pada bulan Juli-September 2020. Analisis data dilakukan dengan uji paired sample T-test karena data terdistribusi nornal. Hasil penelitian menunjukkan bahwa ada perbedaan yang signifikan antara pengetahuan ibu tentang ASI eksklusif sebelum dan sesudah intervensi (p = 0,036) dengan sikap dalam pemberian MP ASI (p = 0,013). Namun, tidak ada perbedaan yang signifikan pada pengetahuan MPASI sebelum dan sesudah pendidikan masing-masing (p = 0,78) dan Sikap ibu tentang ASI ekslusif (p = 0,86). Edukasi gizi melalui WhatsApp group efektif untuk meningkatkan pengetahuan ibu dalam memberikan ASI eksklusif dan sikap ibu dalam memberikan MP ASI.

Consumption of healthy snacks in children is very important to note, this is because it will have an impact on the health and nutritional status of the child. The nutritional status of children will affect the quality of human resources from school to productive age. The purpose of this activity is to increase the knowledge of junior high school students about healthy snack menus based on local food. The method of this activity is to conduct nutrition education and evaluate the increase in student's knowledge by using a questionnaire. This activity begins with an introduction and continues with a pre-test. Furthermore, nutrition education in the form of providing interesting materials and videos in choosing healthy snacks based on local food, post-test, discussion, and question and answer. To increase the enthusiasm of the participants, prizes were given. The results of the activities obtained by nutrition education at SMPN 2 Bayang can increase the knowledge of junior high school children about how to choose healthy snacks based on local food. This can be seen from the difference in the level of students' knowledge before (pre-test) and after (post-test) regarding the nutrition education provided. Besides, when students are served some snacks, students can choose and explain healthy and unhealthy foods. Some of the various local snacks and processed forms such as sweet potatoes, corn, taro can also be described in detail by students. From the activities that have been carried out, it can be concluded that nutrition education increases student’s knowledge about how to choose healthy snacks based on local food.

The emergence of SARS-CoV-2 has caused worldwide pandemic of COVID-19. Infection is difficult to diagnose early as some patients remain asymptomatic and may carry this virus to other people. Currently, qRT-PCR is the widely accepted mode for detection. However, the need for sophisticated instrument and trained personnel may hinder its application, especially in remote and facility-lacking areas. Reverse transcription loop-mediated isothermal amplification (RT-LAMP) may serve as a potential approach for detection of SARS-CoV-2 as the resources needed in its application is far less complex than those of qRT-PCR. Herein, we evaluated RT-LAMP based analytical method (COVIDNow), relative to qRT-PCR, in detecting SARS-CoV-2 by using 63 clinical respiratory samples. Based on our finding, COVIDNow exhibited sensitivity and specificity values of 87.5% and 80.6%, respectively. Taken together, RT-LAMP based detection of SARS-CoV-2 by utilizing COVIDNow might serves as a valuable diagnostic tool in the management of global COVID-19 pandemic condition.