1. Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease
- Author
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Gad A. Marshall, Kathryn V. Papp, Noah Snyder, Aubryn Samaroo, Dorene M. Rentz, Michael J. Properzi, Aaron P. Schultz, Rachel F. Buckley, Olivia R Schneider, Raya Kumar, Jane G Burke, Iván García-Magariño, Rebecca E. Amariglio, Keith A. Johnson, Yakeel T. Quiroz, Reisa A. Sperling, Hsiang-Chin Chou, Daniel Soberanes, and Stephanie Hsieh
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,preclinical Alzheimer's disease ,RC952-954.6 ,Cognition ,Disease ,mobile testing ,Cognitive test ,unsupervised assessment ,Psychiatry and Mental health ,Physical medicine and rehabilitation ,Geriatrics ,digital biomarkers ,Positron emission tomography ,medicine ,Cognitive & Behavioral Assessment ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,Cognitive decline ,RC346-429 ,business ,Neurocognitive ,Research Article - Abstract
Introduction Unsupervised digital cognitive testing is an appealing means to capture subtle cognitive decline in preclinical Alzheimer's disease (AD). Here, we describe development, feasibility, and validity of the Boston Remote Assessment for Neurocognitive Health (BRANCH) against in‐person cognitive testing and amyloid/tau burden. Methods BRANCH is web‐based, self‐guided, and assesses memory processes vulnerable in AD. Clinically normal participants (n = 234; aged 50–89) completed BRANCH; a subset underwent in‐person cognitive testing and positron emission tomography imaging. Mean accuracy across BRANCH tests (Categories, Face‐Name‐Occupation, Groceries, Signs) was calculated. Results BRANCH was feasible to complete on participants’ own devices (primarily smartphones). Technical difficulties and invalid/unusable data were infrequent. BRANCH psychometric properties were sound, including good retest reliability. BRANCH was correlated with in‐person cognitive testing (r = 0.617, P
- Published
- 2021
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