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1. Longitudinal Asthma Patterns in Italian Adult General Population Samples: Host and Environmental Risk Factors

Author

Maio, S., Baldacci, S., Simoni, M., Angino, A., La Grutta, S., Muggeo, V., Fasola, S., Viegi, G., Angino, AGAVE Sudy Group: A., Bresciani, M., Carrozzi, L., Cerrai, S., Martini, F., Pala, A. P., Pistelli, F., Sarno, G., and Silvi, P.

Subjects
medicine.medical_specialty, Population, lcsh:Medicine, comorbidities, Article, 03 medical and health sciences, 0302 clinical medicine, Environmental risk, Internal medicine, Epidemiology, medicine, 030212 general & internal medicine, education, Asthma, Multinomial logistic regression, vehicular traffic, education.field_of_study, business.industry, lcsh:R, Asthma symptoms, latent transition analysis, General Medicine, cohort, asthma, medicine.disease, respiratory tract diseases, 030228 respiratory system, smoke, epidemiology, Cohort, Latent transition analysis, business
Abstract

Background: Asthma patterns are not well established in epidemiological studies. Aim: To assess asthma patterns and risk factors in an adult general population sample. Methods: In total, 452 individuals reporting asthma symptoms/diagnosis in previous surveys participated in the AGAVE survey (2011–2014). Latent transition analysis (LTA) was performed to detect baseline and 12-month follow-up asthma phenotypes and longitudinal patterns. Risk factors associated with longitudinal patterns were assessed through multinomial logistic regression. Results: LTA detected four longitudinal patterns: persistent asthma diagnosis with symptoms, 27.2%, persistent asthma diagnosis without symptoms, 4.6%, persistent asthma symptoms without diagnosis, 44.0%, and ex -asthma, 24.1%. The longitudinal patterns were differently associated with asthma comorbidities. Persistent asthma diagnosis with symptoms showed associations with passive smoke (OR 2.64, 95% CI 1.10–6.33) and traffic exposure (OR 1.86, 95% CI 1.02–3.38), while persistent asthma symptoms (without diagnosis) with passive smoke (OR 3.28, 95% CI 1.41–7.66) and active smoke (OR 6.24, 95% CI 2.68–14.51). Conclusions: LTA identified three cross-sectional phenotypes and their four longitudinal patterns in a real-life setting. The results highlight the necessity of a careful monitoring of exposure to active/passive smoke and vehicular traffic, possible determinants of occurrence of asthma symptoms (with or without diagnosis). Such information could help affected patients and physicians in prevention and management strategies.

Published
2020
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2. RItA: The Italian severe/uncontrolled asthma registry

Author

Maio, S., Baldacci, S., Bresciani, M., Simoni, M., Latorre, M., Murgia, N., Spinozzi, F., Braschi, M., Antonicelli, L., Brunetto, B., Iacovacci, P., Roazzi, P., Pini, C., Pata, M., La Grasta, L., Paggiaro, P., Viegi, G., Angino, A., Carrozzi, L., Cerrai, S., Di Pede, F., Martini, F., Pala, A. P., Pistelli, F., Sarno, G., Silvi, P., Novelli, F., Ferri, M., and Bonifazi, F.

Subjects
Adult, Male, severe/uncontrolled asthma, medicine.medical_specialty, Exacerbation, Immunology, NO, 03 medical and health sciences, 0302 clinical medicine, exacerbations, pharmacological treatment, Internal medicine, eosinophilic inflammation, medicine, Humans, Immunology and Allergy, Nasal polyps, Registries, 030212 general & internal medicine, Sinusitis, Aged, Asthma, business.industry, Comorbidity, Eosinophilic inflammation, Exacerbations, Pharmacological treatment, Severe/uncontrolled asthma, Emergency department, Middle Aged, medicine.disease, Obesity, Allergic conjunctivitis, comorbidity, Italy, 030228 respiratory system, comorbidity, eosinophilic inflammation, exacerbations, pharmacological treatment, severe/uncontrolled asthma, Physical therapy, Female, business
Abstract

Background The Italian severe/uncontrolled asthma (SUA) web-based registry encompasses demographic, clinical, functional, inflammatory data; it aims to raise SUA awareness, identifying specific phenotypes and promoting optimal care. Methods 493 adult patients from 27 Italian centres (recruited in 2011-2014) were analyzed. Results Mean age was 53.8yrs. SUA patients were more frequently female (60.6%), with allergic asthma (83.1%). About 30% showed late onset of asthma diagnosis/symptoms (>40yrs); the mean age for asthma symptoms onset was 30.2yrs and for asthma diagnosis 34.4yrs. 97.1% used ICS (dose 2000 BDP), 93.6% LABA in association with ICS, 53.3% LTRAs, 64.1% anti-IgE, 10.7% theophylline, 16.0% oral corticosteroids. Mean FEV1% pred of 75.1%, median values of 300/mm3 of blood eosinophil count, 323 kU/l of serum total IgE, 24 ppb of FENO were shown. Most common comorbidities were allergic rhinitis (62.4%), gastroesophageal reflux (42.1%), sinusitis (37.9%), nasal polyposis (30.2%), allergic conjunctivitis (30.2%). 55.7% of SUA patients had exacerbations in the last 12 months, 9.7% emergency department visits, 7.3% hospitalizations. Factors associated with exacerbation risk were: obesity (OR, 95%CI 2.46, 1.11-5.41), psychic disorders (2.87, 0.89-9.30 - borderline), nasal polyps (1.86, 0.88-3.89 - borderline), partial/poor asthma treatment adherence (2.54, 0.97-6.67 - borderline), anti-IgE use in a protective way (0.26, 0.12-0.53). Comparisons to severe asthma multicentre studies and available registries showed data consistency across European and American populations. Conclusions An international effort in the implementation of SUA patients registries could help to better understand the clinical features and to manage severe asthma, representing a non negligible socio-economic burden for health services. This article is protected by copyright. All rights reserved.

Published
2017
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3. Effects of particulate matter and self-reported risk factors on incidence of airway diseases

Author

Francesco Forastiere, Stafoggia M, Maio S, Viegi G, Baldacci S, La Grutta S, Salvatore Fasola, and Gariazzo C

Subjects
Global and Planetary Change, medicine.medical_specialty, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Internal medicine, Incidence (epidemiology), Public Health, Environmental and Occupational Health, medicine, Particulates, business, Airway, Pollution
Published
2019
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4. Air quality of nursing homes and its effect on the lung health of elderly residents

Author

Maio S, Baldacci S, Giuseppe Sarno, Isabella Annesi-Maesano, and G Viegi

Subjects
Pulmonary and Respiratory Medicine, Lung Diseases, medicine.medical_specialty, Population, Indoor air quality, Risk Factors, Environmental health, Epidemiology, medicine, Immunology and Allergy, Humans, Intensive care medicine, education, Air quality index, Aged, Aged, 80 and over, education.field_of_study, Air Pollutants, Air pollutant concentrations, business.industry, Public Health, Environmental and Occupational Health, Ventilation, Nursing Homes, Lung health, Air Pollution, Indoor, Nursing homes, business, Developed country
Abstract

In industrialized countries the elderly spend most of their time indoors. The elderly may be at a higher risk of suffering from indoor air pollution-related diseases compared to the rest of the population, because of their increased exposure to potential indoor risk factors. This editorial aims to critically analyze the recent literature regarding this important topic. Results of studies performed on the elderly living in nursing homes clearly highlight that they are at risk of respiratory health impairment, even at moderate air pollutant concentrations, particularly if they are over 80 years of age and living in poorly ventilated nursing homes. The future epidemiological research on ageing and respiratory diseases should investigate the underlying biological and physiological mechanisms, in addition to the adverse health effects of potential indoor risk factors, in order to help defining effective strategies for healthy ageing.

Published
2015

5. Environmental indicators in EpiAir2 project: Air quality data for epidemiological surveillance [Indicatori ambientali nello studio EpiAir2: I dati di qualità dell'aria per la sorveglianza epidemiologica]

Author

Gandini, M., Berti, G., Cattani, G., Faustini, A., Scarinzi, C., Donato, F., Accetta, G., Angiuli, L., Caldara, S., Carreras, G., Casale, P., Di Biagio, K., Giannini, S., Iuzzolino, C., Lanzani, G., Lauriola, P., Leuci, P., Mariuz, M., Marchesi, S., Nocioni, A., Pistollato, S., Pizzi, L., Ranzi, A., Serinelli, M., Stagnaro, E., Vianello, L., Vigotti, M., Zauli-Sajani, S., Cadum, E., Alessandrini, E. R., Angelini, P., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Biggeri, A., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Casale, G., Casella, C., Casetta, A., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Girolamo, G., Togni, A., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Forastiere, F., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., La Torretta, T., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Mariottini, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nuvolone, D., Onorati, R. N. G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scondotto, S., Selle, V., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Massimo Stafoggia, Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.

Published
2013

6. Effects of the Home Environment on Respiratory Symptoms of a General Population Sample in Middle Italy

Author

Viegi, G., Carrozzi, L., Paoletti, P., Vellutini, M., Diviggiano, E., Baldacci, S., Modena, P., Pedreschi, M., Giuntini, C., Mammini, U., and Pede, C. D.

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Respiratory Tract Diseases, Population, Aged, Aged, 80 and over, Air Pollution, Indoor, Child, Female, Heating, Humans, Middle Aged, Smoking, Air Pollution, Wheeze, Environmental health, Epidemiology, 80 and over, medicine, Environmental Chemistry, Indoor, education, General Environmental Science, Asthma, Smoke, education.field_of_study, business.industry, Public Health, Environmental and Occupational Health, Odds ratio, medicine.disease, Stove, Rural area, medicine.symptom, business
Abstract

The effects of home environment characteristics were evaluated in a multistage, stratified, cluster sample (N = 3,866) of the general population who lived in the district of Pisa (middle Italy). Each subject completed a standardized interviewer-administered questionnaire that contained questions about respiratory symptoms/diseases and risk factors (e.g., type of heating, fuels used for cooking and heating). Cough and asthma were significantly more frequent in men who did not smoke and who did not use natural gas for cooking and heating. Attacks of shortness of breath accompanied by wheeze, dyspnea, and cardiovascular conditions in female nonsmokers were associated with use of a stove or forced-air circulation for heating; the type of fuel used did not affect this result. Multiple logistic models, which accounted for independent effects of age, smoking status, pack-years, childhood respiratory illness, education, zone of residence, and work exposure to dusts, chemicals, or fumes, showed significantly increased odds ratios for (a) cough and phlegm in males (associated with bottled gas for cooking), (b) wheeze and shortness of breath with wheeze in females (associated with the use of a stove or forced-air circulation). These results, which confirm our previous observations in an unpolluted rural area of north Italy, indicate that characteristics of the home environment, as assessed by questionnaire, may be linked to mild adverse health effects, i.e., respiratory symptoms, in the general population. The results also identify the need to better characterize the dose-response relationship in indoor air pollution monitoring studies that include subsamples of this population.

Published
1992
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9. The Po River Delta epidemiological survey: reference values of total serum IgE levels in a normal population sample of North Italy (8-78 yrs)

Author

Simoni, M., Biavati, P., Baldacci, S., Carrozzi, L., Pedreschi, M., Di Pede, F., Sapigni, T., and Viegi, G.

Subjects
Adult, Male, Analysis of Variance, Adolescent, Atopy, Diagnostic efficiency, Epidemiological survey, Reference values, Total serum IgE, Aged, Asthma, Child, Female, Humans, Immunoglobulin E, Italy, Middle Aged, Predictive Value of Tests, ROC Curve, Reference Values, Rhinitis, Sampling Studies, Sensitivity and Specificity, Seroepidemiologic Studies
Abstract

The aim of this paper was to define, for the first time in Italy, normal levels of total serum IgE in a general population sample of North Italy. Total serum IgE in 1905 subjects, living in Po Delta area (near Venice), were measured by PRIST method. Normal values were derived from 558 subjects without asthma and/or asthmatic/rhinitic symptoms, noncurrent smokers, skin prick-test negatives ('normals'). Cut-off values to differentiate 'normals' from the remaining part of the sample ('others'), from asthmatic, and from rhinitic subjects, were established with the IgE value midway between the upper limit of the 95% confidence intervals (CI) of the geometric mean for 'normals' and the lower limit for 'others', asthmatics, and rhinitics, respectively. Geometric mean of normal children-adolescents was 45 kU/L (SD: 2.6; 95% CI: 38-63). In normal adults geometric mean was 29 kU/L (SD: 3.3; 95% CI: 25-40) in males and 19 kU/L (SD: 3.8; 95% CI: 16-22) in females. The diagnostic sensitivity of IgE test was low, while the specificity was very high. A good positive predictive value in discriminating 'normals' from 'others' was found, on the contrary, we found a good negative predictive value in discriminating 'normals' from asthmatics or from rhinitics. In conclusion, our results confirm that it is necessary to provide separate total serum IgE reference values for what concerns age in children-adolescents and in adults, and gender, in adults. Low serum IgE are helpful to exclude allergic asthma or rhinitis level of total.

Published
2001

10. Prevalence of airways obstruction in a general population: European Respiratory Society vs American Thoracic Society definition

Author

Viegi, G., Pedreschi, M., Pistelli, F., Di Pede, F., Baldacci, S., Carrozzi, L., and Giuntini, C.

Subjects
Adult, Male, Adolescent, International Cooperation, Vital Capacity, Severity of Illness Index, Predictive Value of Tests, Forced Expiratory Volume, Prevalence, Pulmonary Medicine, COPD, Humans, Longitudinal Studies, Airways obstruction definition, Epidemiological survey, FEV, 1, FVC, General population, Child, Societies, Medical, Aged, Reproducibility of Results, Middle Aged, United States, Airway Obstruction, Cross-Sectional Studies, Italy, Population Surveillance, Female
Abstract

To evaluate the distribution of airways obstruction in a general population sample.Cross-sectional epidemiologic survey of a general population sample living in Po Delta area (North Italy). Data on respiratory symptoms, diseases, and risk factors were collected through standardized interviewer-administered questionnaires. Lung function tests were performed, with criteria for defining airways obstruction based on the 1995 European Respiratory Society (ERS) statement (FEV(1)/vital capacity ratio88% predicted and89% predicted in men and women, respectively), "clinical" criteria (FEV(1)/FVC ratio70%), and the 1986 American Thoracic Society (ATS) statement (FEV(1)/FVC ratio75%).A total of 1,727 subjects aged25 years investigated from 1988 to 1991 were included. Prevalence rates of airways obstruction for subjects 25 to 45 years old and subjects/= 46 years old were as follows: ERS, 10.8% and 12.2%; clinical, 9.9% and 28.8%; and ATS, 27% and 57%, respectively. When considering only moderate/severe obstruction, the rates were as follows: ERS, 0.4% and 3.6%; clinical, 0.3% and 4.4%; and ATS, 0.5% and 5.2%, respectively. The trend was confirmed after stratifying for smoking habit and the presence/absence of respiratory symptoms/diseases. The highest specificity and predictive value for any respiratory symptom/disease was shown by the ERS, and the lowest was shown by the ATS criterion, while the reverse was true for sensitivity; overall accuracy was slightly lower for the ATS criterion. Multiple logistic regression models indicated a higher number of significant associations with known risk factors for airways obstruction according to clinical and ATS criteria than ERS criterion.The prevalence of COPD in a general population depends very much on the criterion used for definition of airways obstruction. Further research is needed to reach a standardized and epidemiologically consistent criterion for airways obstruction.

Published
2000

11. Distribution of bronchial responsiveness in a general population: effect of sex, age, smoking, and level of pulmonary function

Author

Paoletti, P., Carrozzi, L., Viegi, G., Modena, P., Ballerin, L., Di Pede, F., Grado, L., Baldacci, S., Pedreschi, M., Vellutini, M., Paggiaro, P., Mammini, U., Leonardo Fabbri, and Giuntini, C.

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, Rural Population, medicine.medical_specialty, Adolescent, Bronchoconstriction, Population, Critical Care and Intensive Care Medicine, Gastroenterology, Bronchial Provocation Tests, Pulmonary function testing, FEV1/FVC ratio, Sex Factors, Internal medicine, medicine, Humans, Lung volumes, Longitudinal Studies, Lung Diseases, Obstructive, Prospective Studies, education, Prospective cohort study, Child, Methacholine Chloride, Aged, education.field_of_study, COPD, Sex Characteristics, business.industry, Cumulative dose, Smoking, Age Factors, respiratory system, Middle Aged, medicine.disease, respiratory tract diseases, Surgery, Respiratory Function Tests, Italy, Methacholine, Female, Bronchial Hyperreactivity, business, medicine.drug
Abstract

Bronchial responsiveness (BR) was assessed by the methacholine challenge test in 1,694 subjects from a sample of the general population (aged 8 to 73 yr) enrolled in a prospective epidemiologic study on the natural history of chronic obstructive pulmonary disease (COPD). Information on respiratory symptoms and risk factors for COPD were obtained with a standardized questionnaire. The provocative dose causing a 10%, 15%, and 20% decrease in FEV1 was reached in 939 (55%), 658 (39%), and 447 (26%) subjects, respectively, after the last cumulative dose of methacholine (i.e., 4.8 mg). The slope of the dose-response curve was also computed in order to attribute a parameter to subjects who did not reach the provocative dose. After natural log transformation, the slope (Ln Slope) of the curve showed a significant association with the degree of airway obstruction, as assessed by FEV1% predicted, FEV1/VC%, and FEV1/FVC%. Therefore, relationships between BR, sex, age, and smoking were evaluated after adjustments for the initial airway caliber (FEV1, FEV1 adjusted for height, and FEV1/VC%). Females showed significantly higher values of Ln Slope than did males after adjustments were made for baseline lung function. In males, higher BR was observed in childhood-adolescence age groups and at older ages, while in females a higher level of BR was observed during childhood. Significantly higher Ln Slope values were found for females who currently smoked than for non- and ex-smokers. No difference was observed in males in relation to smoking habit. (ABSTRACT TRUNCATED AT 250 WORDS)

Published
1995

12. Bronchial reactivity in a general population of north Italy: relationships with occupational exposure

Author

Viegi, G., Fialdini, A. M., Vellutini, M., Carrozzi, L., Di Pede, F., Modena, P., Pedreschi, M., Baldacci, S., Paoletti, P., and Giuntini, C.

Subjects
Adult, Male, Cross-Sectional Studies, Adolescent, Italy, Occupational Exposure, Surveys and Questionnaires, Humans, Female, Bronchial Hyperreactivity, Middle Aged, Child, Aged
Abstract

Two thousand eight hundred and forty one subjects, aged 8-73 yrs, took part in the second cross-sectional survey in the Po River Delta area: among them, a subsample of currently employed people, aged 14-71 yrs, was chosen to establish the relationship between occupational exposure to dusts, chemicals or gases and respiratory symptoms, lung function and bronchial reactivity. Each subject filled out the Italian National Research Council (CNR) standardized questionnaire concerning respiratory symptoms, diseases and risk factors. A variable proportion of subjects performed acceptable forced and slow vital capacity manoeuvres, diffusing capacity of carbon monoxide and bronchial challenge test to methacholine. Occupational exposure appeared to be related to prevalence rate of respiratory symptoms (wheeze, dyspnoea, presence of at least one respiratory symptom) and bronchial asthma. Consistent effects on lung function were not evident. With respect to the bronchial challenge test, using the measurement of the provocative dose producing a 20% fall in forced expiratory volume in one second (PD20) a significantly higher percentage of hyperreactive subjects was found among ex-smoker exposed men; a borderline higher percentage of hyperreactive subjects was also found in non-smoker exposed women. The study findings support the suggestion that occupational exposure may play a role in the development of airway obstructive diseases.

Published
1994

13. Residual volume in a general population. Effects of body size, age, cigarette smoking, and respiratory symptoms

Author

Paoletti, P., Viegi, G., Carrozzi, L., Di Pede, F., Modena, P., Ballerin, L., Baldacci, S., Pedreschi, M., Pistelli, G., and Giuntini, C.

Subjects
Adult, Male, Adolescent, Respiratory Tract Diseases, Smoking, Total Lung Capacity, Age Factors, Middle Aged, Residual Volume, Reference Values, Body Constitution, Humans, Pulmonary Diffusing Capacity, Female, Child
Abstract

Residual volume (RV) was obtained by subtracting vital capacity from total lung capacity determined by the single breath helium dilution (TLCsb) to measure CO diffusing capacity in 2,680 subjects (8 to 64 years old) of a general population sample. There were 712 normal subjects (243 male and 469 female subjects) selected to evaluate the pattern of RV by age and to derive reference values for internal comparisons. From 8 to 20 years old, RV showed an increase because of the cross-sectional body size effect; after 20 to 30 years, RV was still increasing, however, at a lower level. Age and height coefficients were significantly related to RV in younger and older ages, both in male and female subjects. The RV percent predicted and RV/TLC percent were higher in smokers when compared to nonsmokers and exsmokers (the difference was significant in male subjects). A dose-response effect was observed between RV percent predicted, RV/TLC percent, and pack-years. The RV percent predicted and RV/TLC percent were significantly higher in smokers and nonsmokers with FEV1 percent predicted below the normal limit (the difference was significant in male subjects). Moreover, higher values of RV percent predicted and RV/TLC percent were observed in subjects with wheezy symptoms in male smokers and nonsmokers. A negative significant correlation was observed between RV/TLC percent and the diffusing capacity adjusted for lung volume (DL/VA) in smokers, exsmokers and nonsmokers of both sexes, confirming the hypothesis that the decrease in DL/VA may be ascribed to the enlargement of terminal air spaces. In conclusion, determination of RV by the single breath helium dilution method is suitable in epidemiology, and it allows additional important information for understanding the physiopathologic mechanisms related to the pathogenesis of chronic obstructive lung disease.

Published
1992

14. Air pollution and mortality in twenty-five Italian cities: Results of the EpiAir2 Project,Inquinamento atmosferico e mortalità in venticinque città Italiane: Risultati del progetto EpiAir2

Author

Alessandrini, E. R., Faustini, A., Chiusolo, M., Stafoggia, M., Gandini, M., Demaria, M., Antonelli, A., Arena, P., Biggeri, A., Canova, C., Casale, G., Cernigliaro, A., Garrone, E., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Iuzzolino, C., Lauriola, P., Mariottini, M., Pasetti, P., Randi, G., Andrea Ranzi, Santoro, M., Selle, V., Serinelli, M., Stivanello, E., Tominz, R., Vigotti, M., Zauli-Sajani, S., Forastiere, F., Cadum, E., Accetta, G., Angelini, P., Angiuli, L., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Caldara, S., Calzolari, R., Canossa, E., Caramia, G., Carreras, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Ganzi, A., Gatti, G., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., La Torretta, T., Lanzani, G., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Rosa, M., Rubini, G., Sacco, F., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stagnaro, E., Starnino, G., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.

15. Exposure to environmental tobacco smoke is associated with lower plasma β-carotene levels among nonsmoking women married to a smoker

Author

Farchi, S., Forastiere, F., Pistelli, R., Baldacci, S., Simoni, M., Perucci, C. A., Viegi, G., Mallone, S., Lo Presti, E., Pistelli, F., Simone, M., Scalera, A., Pedreschi, M., Corbo, G., Rapiti, E., Nera Agabiti, Basso, S., Chiaffi, L., Mattelli, G., Di Pede, F., Carrozzi, L., Puntoni, R., Bigazzi, A., Sampietro, T., Licitra, R., Bigazzi, F., Patricelli, A., Rosellini, A., Angino, A., Attisani, B., Martini, F., Piegaia, B., Lazzeri, G., Silvi, P., Zen, L., Baraldi, E., Prosdocimi, M. T., and Quercia, A.

Subjects
Adult, Male, Lung Neoplasms, Myocardial Ischemia, Ascorbic Acid, Environmental Exposure, Middle Aged, beta Carotene, Cross-Sectional Studies, Humans, Female, Tobacco Smoke Pollution, Spouses, Aged
Abstract

We evaluated the association between exposure to environmental tobacco smoke (ETS) from husbands who smoke and plasma levels of antioxidant vitamins among nonsmoking women. A total of 1249 women from four areas in Italy answered a self-administered questionnaire, reported their diets on a food frequency questionnaire, had a medical examination, and gave their blood for alpha and beta-carotene, retinol, L-ascorbic acid, alpha-tocopherol, and lycopene determinations. Urinary cotinine was used to evaluate the level of recent exposure to ETS. After adjusting for study center, age and education, we found no association between ETS exposure and daily nutrient intake of beta-carotene, retinol, L-ascorbic acid, and alpha-tocopherol. However, we found an inverse dose-response relationship between intensity of current husband's smoke and concentrations of plasma beta-carotene and L-ascorbic acid. The associations remained even after controlling for daily beta-carotene and vitamin C intake and for other potential confounders (vitamin supplementation, alcohol consumption, and body mass index). Moreover, when urinary cotinine was considered as the exposure variable, a significant inverse association with plasma beta-carotene was found. The findings may be of interest to explain the biological mechanism that link ETS exposure with lung cancer and ischemic heart diseases.

17. Asthma in Immigrants

Author

Viegi, G., Simoni, M., Cerrai, S., Sarno, G., Maio, S., Baldacci, S., Francesco Pistelli, and Carrozzi, L.

18. Policies for the promotion of sustainable mobility and the reduction of traffic-related air pollution in the cities participating in the EpiAir2 project,Le politiche per la promozione della mobilità sostenibile e la riduzione dell'inquinamento atmosferico causato dal traffico veicolare nelle città partecipanti allo studio EpiAir2

Author

Di Lonardo, S., Nuvolone, D., Forastiere, F., Cadum, E., Barchielli, A., Accetta, G., Alessandrini, E. R., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baccini, M., FLAVIA BALDACCHINI, Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Biggeri, A., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Caldara, S., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Carreras, G., Casale, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Lauriola, P., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Ranzi, A., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Selle, V., Serinelli, M., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Stagnaro, E., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., Zauli-Sajani, S., and Zero, F.

21. Air pollution and urgent hospital admissions in 25 Italian cities: Results from the EpiAir2 project,Inquinamento atmosferico e ricoveri ospedalieri urgenti in 25 città Italiane: Risultati del progetto EpiAir2

Author

Scarinzi, C., Alessandrini, E. R., Chiusolo, M., Galassi, C., Baldini, M., Serinelli, M., Pandolfi, P., Bruni, A., Biggeri, A., Togni, A., Carreras, G., Casella, C., Canova, C., Randi, G., Andrea Ranzi, Morassuto, C., Cernigliaro, A., Giannini, S., Lauriola, P., Minichilli, F., Gherardi, B., Zauli-Sajani, S., Stafoggia, M., Casale, P., Gianicolo, E. A. L., Piovesan, C., Tominz, R., Porcaro, L., Cadum, E., Accetta, G., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Caldara, S., Calzolari, R., Canossa, E., Caramia, G., Casale, G., Casetta, A., Cattani, G., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Forastiere, F., Fruzzetti, R., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Mircea, M., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Protti, M., Puppo, A., Raciti, M., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scondotto, S., Selle, V., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stagnaro, E., Starnino, G., Stivanello, E., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.

23. Air pollution and urgent hospital admissions in 25 Italian cities: Results from the EpiAir2 project | Inquinamento atmosferico e ricoveri ospedalieri urgenti in 25 città Italiane: Risultati del progetto EpiAir2

Author

Scarinzi, C., Alessandrini, E. R., Chiusolo, M., Galassi, C., Baldini, M., Serinelli, M., Pandolfi, P., Bruni, A., Biggeri, A., Togni, A., Carreras, G., Casella, C., Canova, C., Randi, G., Ranzi, A., Morassuto, C., Cernigliaro, A., Giannini, S., Lauriola, P., Minichilli, F., Gherardi, B., Zauli-Sajani, S., Stafoggia, M., Casale, P., Gianicolo, E. A. L., Piovesan, C., Tominz, R., Porcaro, L., Cadum, E., Accetta, G., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Fabio Barbone, Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Caldara, S., Calzolari, R., Canossa, E., Caramia, G., Casale, G., Casetta, A., Cattani, G., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Forastiere, F., Fruzzetti, R., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Mircea, M., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Protti, M., Puppo, A., Raciti, M., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scondotto, S., Selle, V., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stagnaro, E., Starnino, G., Stivanello, E., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.

24. Environmental indicators in EpiAir2 project: Air quality data for epidemiological surveillance,Indicatori ambientali nello studio EpiAir2: I dati di qualità dell'aria per la sorveglianza epidemiologica

Author

Gandini, M., Berti, G., Cattani, G., Faustini, A., Scarinzi, C., Donato, F., Accetta, G., Angiuli, L., Caldara, S., Carreras, G., Casale, P., Di Biagio, K., Giannini, S., Iuzzolino, C., Lanzani, G., Lauriola, P., Leuci, P., Mariuz, M., Marchesi, S., Nocioni, A., Pistollato, S., Pizzi, L., Ranzi, A., Serinelli, M., Stagnaro, E., Vianello, L., Vigotti, M., Zauli-Sajani, S., Cadum, E., Alessandrini, E. R., Angelini, P., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Biggeri, A., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Casale, G., Casella, C., Casetta, A., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Girolamo, G., Togni, A., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Forastiere, F., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., La Torretta, T., Ferdinando Luberto, Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Mariottini, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nuvolone, D., Onorati, R. N. G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scondotto, S., Selle, V., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.

25. The burden of asthma revisited

Author

Cuttitta, G., Cibella, F., La Grutta, S., Melis, M. R., Baldacci, S., SARA MAIO, Simoni, M., Pistelli, F., Carrozzi, L., and Viegi, G.

Subjects
Asthma • Prevalence • Mortality • Risk factors • Epidemiology • Economic cost

26. Short-term impact of air pollution among Italian cities covered by the EpiAir2 project,Impatto a breve termine dell'inquinamento dell'aria nelle città coperte dalla sorveglianza epidemiologica EpiAir2

Author

Baccini, M., Biggeri, A., Accetta, G., Alessandrini, E. R., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Cadum, E., Caldara, S., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Carreras, G., Casale, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Francesca K. de'Donato, Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Forastiere, F., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Lauriola, P., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Ranzi, A., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Selle, V., Serinelli, M., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Stagnaro, E., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., Zauli-Sajani, S., and Zero, F.

29. [Atmospheric pollution and human health.in the literature and interpretation of environmental. toxicological and epidemiologic studies].,Inquinamento atmosferico e salute umana. Ovvero come orientarsi nella lettura e interpretazione di studi ambientali, tossicologici ed epidemiologici

Author

Baldacci, S., Maio, S., Viegi, G., Gruppo Collaborativo EpiAir, Forastiere, F., Bisanti, L., Randi, G., Rognoni, M., Simonato, L., Tessari, R., Berti, G., Ennio Cadum, Chiusolo, M., Grosa, M. M., Ivaldi, C., Pelosini, R., Poncino, S., Galassi, C., Pacelli, B., Pandolfi, P., Scarnato, C., Miglio, R., Caranci, N., Pace, G., Zanini, G., Grechi, D., Chellini, E., Mallone, S., Accetta, G., Barchielli, A., Nuvolone, D., Baccini, M., Biggeri, A., Vigotti, M., Colais, P., Faustini, A., Perucci, C. A., Stafoggia, M., Minerba, S., Serinelli, M., Dessì, P. M., Cernigliaro, A., and Scondotto, S.

30. Short-term impact of air pollution among Italian cities covered by the EpiAir2 project | Impatto a breve termine dell'inquinamento dell'aria nelle città coperte dalla sorveglianza epidemiologica EpiAir2

Author

Baccini, M., Biggeri, A., Accetta, G., Alessandrini, E. R., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Cadum, E., Caldara, S., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Carreras, G., Casale, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Forastiere, F., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Lauriola, P., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Fabrizio Minichilli, Mircea, M., Morassuto, C., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Ranzi, A., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Selle, V., Serinelli, M., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Stagnaro, E., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., Zauli-Sajani, S., and Zero, F.

31. [Atmospheric pollution and human health.in the literature and interpretation of environmental. toxicological and epidemiologic studies]. | Inquinamento atmosferico e salute umana. Ovvero come orientarsi nella lettura e interpretazione di studi ambientali, tossicologici ed epidemiologici

Author

Baldacci, S., Maio, S., Viegi, G., Gruppo Collaborativo EpiAir, Forastiere, F., Bisanti, L., Randi, G., Rognoni, M., Simonato, L., Tessari, R., Berti, G., Cadum, E., Chiusolo, M., Grosa, M. M., Ivaldi, C., Pelosini, R., Poncino, S., Galassi, C., Pacelli, B., Pandolfi, P., Scarnato, C., Miglio, R., Caranci, N., Pace, G., Zanini, G., Grechi, D., Chellini, E., Mallone, S., Gabriele Accetta, Barchielli, A., Nuvolone, D., Baccini, M., Biggeri, A., Vigotti, M., Colais, P., Faustini, A., Perucci, C. A., Stafoggia, M., Minerba, S., Serinelli, M., Dessì, P. M., Cernigliaro, A., and Scondotto, S.

32. Knowledge and Health Care resource allocation: CME/CPD course guidelines-based efficacy

Author

Braido, F., Comaschi, M., Valle, I., Delgado, L., Coccini, A., Guerrera, P., Stagi, E., Canonica, G. W., Angino, A., Baldacci, S., Borbotti, M., Cerrai, S., Di Pede, F., Maio, S., Mangione, M., Martini, F., Pala, A. P., Piegaia, B., Sarno, G., Silvi, P., Viegi, G., Dente, F., Bacci, E., Paggiaro, P., Bancalari, L., Foschino, M. P., Moscato, G., Pilucchi, A., Bresciani, M., Pierimarchi, P., Brunetto, B., Iacovacci, P., Pini, C., Tinghino, R., Forestiere, F., Perucci, C. A., Porta, D., Ancona, L., Protasi, S., Lazazzera, B., Ziroli, V., D Armini, E., Campanile, S. F., Ferri, M., Lorusso, P., Pistelli, R., Salotti, R., Santagati, M., Agea, E., Casciari, C., Nicola MURGIA, Spinozzi, F., Bonifazi, A. F., Antonicelli, L., Braschi, M. C., Conti, V., Filippelli, A., Corbi, G. M., Russomanno, G., Baiardini, I., Balbi, F., Ferraioli, G., Bordo, A., Cerveri, I., Corsico, A., and Grosso, A.

Subjects
diagnostic procedures, cost, spirometry, continuing medical education, guidelines, Asthma, continuing professional development, drugs, hospitalization, medico-economic assessment

33. Policies for the promotion of sustainable mobility and the reduction of traffic-related air pollution in the cities participating in the EpiAir2 project | Le politiche per la promozione della mobilità sostenibile e la riduzione dell'inquinamento atmosferico causato dal traffico veicolare nelle città partecipanti allo studio EpiAir2

Author

Di Lonardo, S., Nuvolone, D., Forastiere, F., Cadum, E., Barchielli, A., Accetta, G., Alessandrini, E. R., Angelini, P., Angiuli, L., Antonelli, A., Arena, P., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Fabio Barbone, Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Biggeri, A., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Caldara, S., Calzolari, R., Canossa, E., Canova, C., Caramia, G., Carreras, G., Casale, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cernigliaro, A., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Chiusolo, M., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Faustini, A., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Gandini, M., Ganzi, A., Garrone, E., Gatti, G., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., Iuzzolino, C., La Torretta, T., Lanzani, G., Lauriola, P., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariottini, M., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pasetti, P., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Randi, G., Ranzi, A., Rosa, M., Rubini, G., Sacco, F., Santoro, M., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Selle, V., Serinelli, M., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stafoggia, M., Stagnaro, E., Starnino, G., Stivanello, E., Tominz, R., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., Zauli-Sajani, S., and Zero, F.

34. Air pollution and mortality in twenty-five Italian cities: Results of the EpiAir2 Project | Inquinamento atmosferico e mortalità in venticinque città Italiane: Risultati del progetto EpiAir2

Author

Alessandrini, E. R., Faustini, A., Chiusolo, M., Stafoggia, M., Gandini, M., Demaria, M., Antonelli, A., Arena, P., Biggeri, A., Canova, C., Casale, G., Cernigliaro, A., Garrone, E., Gherardi, B., Gianicolo, E. A. L., Giannini, S., Iuzzolino, C., Lauriola, P., Mariottini, M., Pasetti, P., Randi, G., Ranzi, A., Santoro, M., Selle, V., Serinelli, M., Stivanello, E., Tominz, R., Vigotti, M., Stefano Zauli Sajani, Forastiere, F., Cadum, E., Accetta, G., Angelini, P., Angiuli, L., Assennato, G., Baccini, M., Baldacchini, F., Baldacci, S., Baldini, M., Baldo, V., Ballarino, G., Balzi, D., Barban, I., Barbati, G., Barbone, F., Barchielli, A., Baroni, S., Barontini, R., Bartolacci, S., Bellodi, S., Berico, M., Berti, G., Bisanti, L., Bonfanti, M., Bonomolo, A., Bonvicini, L., Bovenzi, M., Brescianini, C., Broccoli, S., Bruni, A., Caldara, S., Calzolari, R., Canossa, E., Caramia, G., Carreras, G., Casale, P., Casella, C., Casetta, A., Cattani, G., Cerrai, S., Cervino, M., Cestari, L., Chellini, E., Ciaccia, G., Cibella, F., Cocchio, S., Crosetto, L., Cuccaro, F., Daris, F., Donato, F., Girolamo, G., Togni, A., Di Biagio, K., Di Leo, A., Di Lonardo, S., Dessì, M. P., Evangelista, A., Faccini, F., Fallani, G., Fruzzetti, R., Galassi, C., Gallo, G., Gallo, L., Ganzi, A., Gatti, G., Giua, R., Goldoni, C. A., Grechi, D., Grosa, M., Guerrini, N., Impallomeni, M., La Torretta, T., Lanzani, G., Leuci, P., Luberto, F., Lupi, A., Madonia, G., Maio, S., Malaguti, A., Mangia, C., Marchesi, S., Mariuz, M., Marotta, A., Martini, A., Menegotto, M., Merlo, F., Migliore, E., Minerba, S., Minichilli, F., Mircea, M., Morassuto, C., Nocioni, A., Nuvolone, D., Nuzzi, R., Onorati, G., Padolecchia, G., Palazzi, B., Pandolfi, P., Parodi, S., Pensato, A., Piersanti, A., Piovesan, C., Pistollato, S., Pizzi, L., Pizzuti, R., Addario, S. P., Porcaro, L., Protti, M., Puppo, A., Raciti, M., Rosa, M., Rubini, G., Sacco, F., Sarno, G., Scala, D., Scarinzi, C., Scondotto, S., Simeoni, R., Simonato, L., Simoni, M., Spagnolo, G., Stagnaro, E., Starnino, G., Troiano, F., Vercelli, M., Vianello, L., Viegi, G., Vigotti, M. A., Volta, C., Zanini, G., and Zero, F.

35. Respiratory disease phenotypes in a general population sample: latent transition analysis

Author

Laura Carrozzi, Vito M. R. Muggeo, S. La Grutta, Sara Maio, Salvatore Fasola, Giovanni Viegi, Marzia Simoni, F Pistelli, S. Baldacci, and Maio S, Fasola S, Baldacci S, Carrozzi L, Pistelli F, Simoni M, La Grutta S, Muggeo V, Viegi G

Subjects
COPD, medicine.medical_specialty, education.field_of_study, business.industry, Phlegm, Respiratory disease, Population, Disease, medicine.disease, Logistic regression, epidemiology, asthma, copd, Internal medicine, Epidemiology, medicine, medicine.symptom, business, education, Asthma
Abstract

Background: Few data are available on the temporal pattern of respiratory disease phenotypes in general population. Aim: To detect longitudinal patterns of disease phenotypes related to risk factors and physician visits. Methods: Pisan general population sample from 2 cross-sectional studies (PI1: 1991-93; PI2: 2009-11; n=1107), questionnaire-based data. Latent transition analysis (LTA) was performed to assess respiratory disease phenotypes at PI1 and PI2, labelled according to disease/symptom occurrence. Possible patterns were persistence, worsening and improvement of the phenotype. Multiple logistic regression models were estimated to assess the association among phenotype patterns, risk factors (smoking habits-SH and occupational exposure-OE) and physician visits, adjusting for age, sex and educational level. Results: 4 cross-sectional phenotypes were ranked by severity in PI1 and in PI2: healthy (H) (59 and 55%), allergic rhinitis (AR) (28 and 27%), cough/phlegm (CP) (11 and 15%), asthma (A) (3 and 4%). The longitudinal patterns were: persistent H (53%), persistent AR (27%), persistent CP (9%), improvement (2%), worsening (10%). Significant Associations: persistent CP with persistent SH (OR 5.9), persistent OE (OR 2.9) and incident OE (OR 2.2); persistent CP and worsening of phenotype with current visits of family physician (OR 5.4 and OR 4.7, respectively) and of specialist (OR 2.7 and OR 3.9, respectively). Conclusions: LTA allowed to identify four different phenotypes based on respiratory symptoms/diseases and their longitudinal patterns over 18 years. Such analysis brings new perspectives in the analyses of population-based data.

Published
2018
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36. Questionnaires, spirometry and PEF monitoring in epidemiological studies on elderly respiratory patients

Author

Nicola Scichilone, R. Hopps, Pierluigi Paggiaro, Mario Spatafora, D. Giannini, Francesco Pistelli, Sandra Baldacci, Giovanni Viegi, Vincenzo Bellia, F Di Pede, Laura Carrozzi, Filippo Catalano, Bellia, V., Pistelli, F., Giannini, D., Scichilone, N., Catalano, F., Spatafora, M., Hopps, R., Carrozzi, L., Baldacci, S., Di Pede, F., Paggiaro, P., and Viegi, G.

Subjects
Pulmonary and Respiratory Medicine, Spirometry, Adult, Male, medicine.medical_specialty, peak expiratory flow, Respiratory Tract Diseases, MEDLINE, Validity, Peak Expiratory Flow Rate, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Elderly, Reference Values, Risk Factors, Air Pollution, Surveys and Questionnaires, Epidemiology, Elderly, peak expiratory flow, questionnaires, reference values, spirometry, Medicine, media_common.cataloged_instance, Humans, Reference Value, European union, Respiratory Tract Disease, Reliability (statistics), media_common, Aged, medicine.diagnostic_test, business.industry, Risk Factor, Respiratory disease, Cognition, questionnaires, medicine.disease, Epidemiologic Studie, Surgery, Epidemiologic Studies, Physical therapy, Female, business, Human
Abstract

Questionnaires are the most used subjective instrument of measurement in respiratory epidemiology. The standardisation of the questionnaires aims to limit bias by maximising validity and reliability, and comparability. Within the European Union project BIOMED1, a compendium of respiratory standard questionnaires (CORSQ) was developed for adults covering 18 topics from general information to early life events, through environmental risk factors and respiratory symptoms and diseases. Reliable spirometry data needs a rigorous quality control programme, as in the "Salute Respiratoria nell'Anziano" (Sa.R.A.) project, Italian for "Respiratory Health in the Elderly". Reproducibility rates were 95.8% for forced expiratory volume in one second (FEV1). Male sex and age were independent risk factors for a poorer reproducibility, as well as cognitive and physical impairment (shorter 6-min walking distance) and lower educational level for a poorer acceptability. Reference values for people aged 65-85 yrs have been produced; these results suggest that the effect of aging should be corrected for physical and mental disability. A revision of interpretative strategies included in current guidelines is needed. Peak expiratory flow monitoring has several methodological problems: reliability and sensitivity of the measurement in order to detect changes in airway calibre; compliance with long-term monitoring; choice of the best variability index; difference between asthmatic and nonasthmatic subjects; age-related differences. Despite these methodological problems, peak expiratory flow monitoring has been successfully used in the evaluation of the effects of air pollution in normal and asthmatic subjects, and in the elderly.

Published
2003

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